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https://www.readbyqxmd.com/read/29329525/reporting-of-heterogeneity-of-treatment-effect-in-cohort-studies-a-review-of-the-literature
#1
Meryl Dahan, Caroline Scemama, Raphael Porcher, David J Biau
BACKGROUND: This article corresponds to a literature review and analyze how heterogeneity of treatment (HTE) is reported and addressed in cohort studies and to evaluate the use of the different measures to HTE analysis. METHODS: prospective cohort studies, in English language, measuring the effect of a treatment (pharmacological, interventional, or other) published among 119 core clinical journals (defined by the National Library of Medicine) in the last 16 years were selected in the following data source: Medline...
January 12, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29306063/many-rcts-may-not-be-justified-a-cross-sectional-analysis-of-the-ethics-and-science-of-randomized-clinical-trials
#2
Julie De Meulemeester, Mark Fedyk, Lucas Jurkovic, Michael Reaume, Dar Dowlatshahi, Grant Stotts, Michel Shamy
OBJECTIVE: We have proposed that three scientific criteria are important to the ethical justification of RCTs: (1) they should be designed around a clear hypothesis; (2) uncertainty should exist around that hypothesis; (3) that uncertainty should be as established through a systematic review. We hypothesized that the majority of a sample of recently-published RCTs would not explicitly incorporate these criteria, therefore rendering them potentially unjustified on scientific grounds. STUDY DESIGN AND SETTING: Cross-sectional analysis of all RCTs published in the New England Journal of Medicine (NEJM) and the Journal of the American Medical Association (JAMA) in 2015...
January 3, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29298301/mapping-of-global-scientific-research-in-comorbidity-and-multimorbidity-a-cross-sectional-analysis
#3
Ferrán Catalá-López, Adolfo Alonso-Arroyo, Matthew J Page, Brian Hutton, Rafael Tabarés-Seisdedos, Rafael Aleixandre-Benavent
BACKGROUND: The management of comorbidity and multimorbidity poses major challenges to health services around the world. Analysis of scientific research in comorbidity and multimorbidity is limited in the biomedical literature. This study aimed to map global scientific research in comorbidity and multimorbidity to understand the maturity and growth of the area during the past decades. METHODS AND FINDINGS: This was a cross-sectional analysis of the Web of Science...
2018: PloS One
https://www.readbyqxmd.com/read/29228640/comparison-of-primary-endpoints-between-publications-registries-and-protocols-of-phase-iii-cancer-clinical-trials
#4
Fei Liang, Xinmei Guo, Sheng Zhang, Hongxi Xue, Qiang Chen, Xichun Hu
Background: Decisions by leading journals to require trial registration and to make protocols of phase III randomized clinical trials (RCTs) publicly accessible were landmark events in clinical trial reporting. Materials and Methods: We identified phase III cancer RCTs published between 2013 and 2015 in New England Journal of Medicine (NEJM), The Lancet, The lancet Oncology, JAMA and Journal of Clinical Oncology (JCO). Results: We identified 345 reports of phase III RCTs of which 217 (62...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29080199/to-be-or-not-to-be-the-calculated-politics-of-acupuncture-in-jama
#5
Chang-Zhen Gong, Wei Liu
Ten acupuncture-related articles were published in The Journal of the American Medical Association (JAMA) between 1998 and 2017. Five studies showed positive results in terms of the effectiveness of acupuncture/Chinese medicine (CM); five studies showed negative results. This article summarizes the acupuncturerelated clinical trials published over the last 20 years in JAMA, and addresses what seems to be a fundamental ambivalence in Western medical journals regarding the scientific validity of acupuncture/CM...
November 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29040893/quality-of-online-information-on-breast-cancer-treatment-options
#6
Nadia Arif, Pietro Ghezzi
Offering breast cancer patients treatment choice has become a priority as the involvement of patients in the decision-making process is associated with improved physical and psychological outcomes. As the Internet is increasingly being used by patients as a source of medical information, it is important to evaluate the quality of information relating to breast cancer on the Internet. We analysed 200 websites returned by google.co.uk searching "breast cancer treatment options" in terms of their typology and treatment options described...
October 14, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29033241/gender-differences-in-the-authorship-of-original-research-in-pediatric-journals-2001-2016
#7
Michael Fishman, Wadsworth A Williams, Denise M Goodman, Lainie Friedman Ross
OBJECTIVES: To examine the gender of authors of original research in 3 high-impact pediatric journals between 2001 and 2016, given the importance of publishing on academic promotion, and to compare authorship gender with the percentage of women on editorial boards and with academic faculty composition. STUDY DESIGN: We assessed the prevalence of female first and senior (last-listed) authorship of original research articles published in 3 pediatric-focused journals Pediatrics, JAMA Pediatrics (entitled Archives of Pediatric and Adolescent Medicine until 2013), and The Journal of Pediatrics...
October 12, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28993088/hip-and-knee-arthroplasty-orthopedic-literature-in-medical-journals-is-it-negatively-biased
#8
Ronald E Delanois, Chukwuweike U Gwam, Nicolas S Piuzzi, Morad Chughtai, Arthur L Malkani, Peter M Bonutti, Michael A Mont
BACKGROUND: Healthcare policy is often determined by well-designed studies most often published in high-impact medical journals. However, concern about the presence of publication bias against lower-extremity arthroplasty-related studies has called into question some of the validity of certain reports. There are only a few studies investigating the presence of the bias in high-impact medical journals against lower-extremity arthroplasty intervention, particularly in the Journal of American Medical Association (JAMA), New England Journal of Medicine (NEJM), and the Lancet...
September 19, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28973284/jama-internal-medicine
#9
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28892536/notice-of-retraction-and-replacement-colla-et-al-association-between-medicare-accountable-care-organization-implementation-and-spending-among-clinically-vulnerable-beneficiaries-jama-internal-medicine-2016-176-8-1167-1175
#10
Carrie H Colla, Valerie A Lewis, Lee-Sien Kao, A James O'Malley, Chiang-Hua Chang, Elliott S Fisher
No abstract text is available yet for this article.
November 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28873197/jama-internal-medicine
#11
(no author information available yet)
No abstract text is available yet for this article.
September 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28783838/jama-internal-medicine
#12
(no author information available yet)
No abstract text is available yet for this article.
August 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28720618/interpretation-of-cis-in-clinical-trials-with-non-significant-results-systematic-review-and-recommendations
#13
Jennifer S Gewandter, Michael P McDermott, Rachel A Kitt, Jenna Chaudari, James G Koch, Scott R Evans, Robert A Gross, John D Markman, Dennis C Turk, Robert H Dworkin
OBJECTIVES: Interpretation of CIs in randomised clinical trials (RCTs) with treatment effects that are not statistically significant can distinguish between results that are 'negative' (the data are not consistent with a clinically meaningful treatment effect) or 'inconclusive' (the data remain consistent with the possibility of a clinically meaningful treatment effect). This interpretation is important to ensure that potentially beneficial treatments are not prematurely abandoned in future research or clinical practice based on invalid conclusions...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28672366/jama-internal-medicine
#14
(no author information available yet)
No abstract text is available yet for this article.
July 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28672294/sharing-medicine-a-jama-internal-medicine-series
#15
Robert Steinbrook, Rita F Redberg
No abstract text is available yet for this article.
September 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28586813/jama-internal-medicine
#16
(no author information available yet)
No abstract text is available yet for this article.
June 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28580651/data-fabrication-and-other-reasons-for-non-random-sampling-in-5087-randomised-controlled-trials-in-anaesthetic-and-general-medical-journals
#17
J B Carlisle
Randomised, controlled trials have been retracted after publication because of data fabrication and inadequate ethical approval. Fabricated data have included baseline variables, for instance, age, height or weight. Statistical tests can determine the probability of the distribution of means, given their standard deviation and the number of participants in each group. Randomised, controlled trials have been retracted after the data distributions have been calculated as improbable. Most retracted trials have been written by anaesthetists and published by specialist anaesthetic journals...
June 4, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28508696/a-bibliometric-analysis-of-occupational-therapy-publications
#18
Ted Brown, Sharon A Gutman, Yuh-Shan Ho, Kenneth N K Fong
BACKGROUND: Bibliometrics involves the statistical analysis of the publications in a specific discipline or subject area. A bibliometric analysis of the occupational therapy refereed literature is needed. AIM: A bibliometric analysis was completed of the occupational therapy literature from 1991-2014, indexed in the Science Citation Index-Expanded or the Social Sciences Citation Index. METHOD: Publications were searched by title, abstract, keywords, and KeyWords Plus...
May 16, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28492943/jama-internal-medicine
#19
(no author information available yet)
No abstract text is available yet for this article.
May 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28400294/the-distribution-of-p-values-in-medical-research-articles-suggested-selective-reporting-associated-with-statistical-significance
#20
Thomas V Perneger, Christophe Combescure
OBJECTIVES: Published P-values provide a window into the global enterprise of medical research. The aim of this study was to use the distribution of published P-values to estimate the relative frequencies of null and alternative hypotheses and to seek irregularities suggestive of publication bias. STUDY DESIGN AND SETTING: This cross-sectional study included P-values published in 120 medical research articles in 2016 (30 each from the BMJ, JAMA, Lancet, and New England Journal of Medicine)...
July 2017: Journal of Clinical Epidemiology
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