Elena V Tchetina, Kseniya E Glemba, Galina A Markova, Svetlana I Glukhova, Maksim A Makarov, Aleksandr M Lila
UNLABELLED: Knee osteoarthritis (KOA) is characterized by low-grade inflammation, loss of articular cartilage, subchondral bone remodeling, synovitis, osteophyte formation, and pain. Strong, continuous pain may indicate the need for joint replacement in patients with end-stage OA, although postoperative pain (POP) of at least a two-month duration persists in 10-40% of patients with OA. STUDY PURPOSE: The inflammation observed in joint tissues is linked to pain caused by the production of proinflammatory cytokines...
March 29, 2024: International Journal of Molecular Sciences