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https://www.readbyqxmd.com/read/28937501/patients-less-likely-to-lose-weight-following-a-knee-replacement-results-from-the-osteoarthritis-initiative
#1
Christine A Pellegrini, Jing Song, Pamela A Semanik, Rowland W Chang, Jungwha Lee, Abigail L Gilbert, Daniel Pinto, Linda Ehrlich-Jones, Dorothy D Dunlop
BACKGROUND: Knee replacement typically results in reduced pain and improved function, but it is unclear if these improvements lead to weight loss. OBJECTIVE: The purpose of this study was to examine weight change patterns preoperatively and postoperatively among overweight/obese knee replacement patients. METHODS: The study evaluated 210 overweight/obese patients from the Osteoarthritis Initiative who underwent a knee replacement during an 8-year longitudinal study...
September 21, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937470/patients-less-likely-to-lose-weight-following-a-knee-replacement-results-from-the-osteoarthritis-initiative
#2
Christine A Pellegrini, Jing Song, Pamela A Semanik, Rowland W Chang, Jungwha Lee, Abigail L Gilbert, Daniel Pinto, Linda Ehrlich-Jones, Dorothy D Dunlop
BACKGROUND: Knee replacement typically results in reduced pain and improved function, but it is unclear if these improvements lead to weight loss. OBJECTIVE: The purpose of this study was to examine weight change patterns preoperatively and postoperatively among overweight/obese knee replacement patients. METHODS: The study evaluated 210 overweight/obese patients from the Osteoarthritis Initiative who underwent a knee replacement during an 8-year longitudinal study...
October 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28936909/predictors-of-chronic-pain-following-total-knee-replacement-in-females-and-males-an-exploratory-study
#3
Tanja Bossmann, Torsten Brauner, Scott Wearing, Thomas Horstmann
AIM: This study explored whether nociceptive (NS) and autonomic nervous system (ANS) dysregulation and psychological distress were predictive of pain 6 months after primary total knee replacement. PATIENTS & METHODS: ANS and NS regulation, psychological distress and self-reported pain, stiffness and function were evaluated preoperatively in 56 patients. Pain severity measured 6 months after surgery was used as the primary outcome in an analysis of covariance model...
September 22, 2017: Pain Management
https://www.readbyqxmd.com/read/28936684/kinematics-of-mobile-bearing-unicompartmental-knee-arthroplasty-compared-to-native-results-from-an-in-vitro-study
#4
Geert Peersman, Josh Slane, Philippe Vuylsteke, Susanne Fuchs-Winkelmann, Philipp Dworschak, Thomas Heyse, Lennart Scheys
INTRODUCTION: Fixed-bearing unicompartmental knee arthroplasty (UKA) closely replicates native knee kinematics. As few studies have assessed kinematics following mobile-bearing (MB) UKA, the current study aimed to investigate whether MB UKA preserves natural knee kinematics. MATERIALS AND METHODS: Seven fresh-frozen full-leg cadaver specimens were prepared and mounted in a kinematic rig that allowed all degrees of freedom at the knee. Three motion patterns, passive flexion-extension (0°-110° flexion), open-chain extension (5°-70° flexion) and squatting (30°-100° flexion), were performed pre- and post-implantation of a medial MB UKA and compared in terms of rotational and translational knee joint kinematics in the different anatomical planes, respectively...
September 21, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28936362/albumin-protein-cleavage-affects-the-wear-and-friction-of-ultra-high-molecular-weight-polyethylene
#5
Yasha Dwivedi, Michel P Laurent, Shravan Sarvepalli, Thomas M Schmid, Markus A Wimmer
It is well established that the total protein concentration and albumin-to-globulin ratio influence the wear of ultra-high molecular polyethylene (UHMWPE, "polyethylene") in joint prostheses. A factor on wear not yet studied, but of possible clinical relevance, is protein cleavage. Such cleavage is expected in the presence of an inflammatory response and as a result of wear processes at the articular interface. The aim of this study was to compare the tribological behavior of polyethylene articulated against an orthopedic wrought CoCrMo alloy for three lubricants: cleaved albumin, uncleaved albumin, and newborn calf serum (control)...
September 2017: Lubricants
https://www.readbyqxmd.com/read/28934966/effectiveness-of-an-interactive-telerehabilitation-system-with-home-based-exercise-training-in-patients-after-total-hip-or-knee-replacement-study-protocol-for-a-multicenter-superiority-no-blinded-randomized-controlled-trial
#6
Sarah Eichler, Sophie Rabe, Annett Salzwedel, Steffen Müller, Josefine Stoll, Nina Tilgner, Michael John, Karl Wegscheider, Frank Mayer, Heinz Völler
BACKGROUND: Total hip or knee replacement is one of the most frequently performed surgical procedures. Physical rehabilitation following total hip or knee replacement is an essential part of the therapy to improve functional outcomes and quality of life. After discharge from inpatient rehabilitation, a subsequent postoperative exercise therapy is needed to maintain functional mobility. Telerehabilitation may be a potential innovative treatment approach. We aim to investigate the superiority of an interactive telerehabilitation intervention for patients after total hip or knee replacement, in comparison to usual care, regarding physical performance, functional mobility, quality of life and pain...
September 21, 2017: Trials
https://www.readbyqxmd.com/read/28933332/the-impact-of-caregivers-anxiety-on-patients-anxiety-before-fast-track-knee-arthroplasty
#7
P Zietek, B Zarzycka, J Zietek, M Stepien-Slodkowska, E Sienko-Awierianow, D Kotrych, K Dobiecki
PURPOSE OF THE STUDY Anxiety may have negative repercussions on the surgery including poorer outcomes. On the other hand, the majority of patients reporting preoperative anxiety fear not receiving enough attention from a caregiver. In patients undergoing fast-track knee arthroplasty, we determined the relationship between patients' preoperative anxiety and the anxiety the patient's caregiver. We also analyzed the influence of selected psychosocial and demographic variables on the relationship between caregivers' and patients' anxiety...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28932503/effect-of-high-tibial-osteotomy-on-hip-biomechanics-in-patients-with-genu-varum-a%C3%A2-prospective-cohort-study
#8
Mehdi Moghtadaei, Ali Yeganeh, Bahram Boddouhi, Atefe Alaee, Hossein Farahini, Babak Otoukesh
BACKGROUND AND AIMS: The aim of this study is to evaluate the effect of proximal tibia osteotomy on hip biomechanics. METHODS: This cohort study was conducted on 50 knees of 37 patients divided into two groups of unilateral and bilateral surgeries during 2015-2016. Patients underwent medial open-wedge osteotomy of proximal tibia. Axial alignment of lower limb radiography was carried out for the patients before and after the osteotomy. RESULTS: Findings from unilateral and bilateral high tibial osteotomies demonstrated that the average of greater trochanter (GT) angle from femoral head center and also the average angle of knee varus were significantly decreased (P = 0...
June 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28929828/increased-risk-of-aseptic-loosening-for-43-525-rotating-platform-vs-fixed-bearing-total-knee-replacements
#9
Oystein Gothesen, Stein Hakon L Lygre, Michelle Lorimer, Stephen Graves, Ove Furnes
Background and purpose - Given similar functional outcomes with mobile and fixed bearings, a difference in survivorship may favor either. This study investigated the risk of aseptic loosening for the most used subtypes of mobile-bearing rotating-platform knees, in Norway and Australia. Patients and methods - Primary TKRs reported to the Norwegian and Australian joint registries, between 2003 and 2014, were analyzed with aseptic loosening as primary end-point and all revisions as secondary end-point. We hypothesized that no difference would be found in the rate of revision between rotating-platform and the most used fixed-bearing TKRs, or between keeled and non-keeled tibia...
September 20, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28928498/innovative-application-of-cox-flexion-distraction-decompression-to-the-knee-a-retrospective-case-series
#10
Luigi Albano
OBJECTIVE: The purpose of this study is to introduce the application of Cox flexion distraction decompression as an innovative approach to treating knee pain and osteoarthritis. METHODS: Six months of clinical files from one chiropractic practice were retrospectively screened for patients who had been treated for knee pain. Twenty-five patients met the criteria for inclusion. The treatment provided was Cox flexion distraction decompression. Pre-treatment and post-treatment visual analog pain scales (VAS) were used to measure the results...
August 2017: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28926095/model-based-assessment-using-conventional-bioequivalence-limits-to-ensure-safety-and-efficacy-of-rivaroxaban-in-patients-undergoing-hip-or-knee-replacement
#11
Mario González-Sales, Lanyan Fang, Myong-Jin Kim, Liang Zhao
We evaluated whether the current bioequivalence limit is adequate to ensure safety and efficacy of rivaroxaban in patients under total hip arthroplasty and total knee arthroplasty based on its model informed benefit/risk profile. Clinical data from a total of 7145 patients from 3 phase 2 and 4 phase 3 clinical trials were included in the current model-based exposure-response analysis. The relationships between rivaroxaban exposure measurements (ie, minimum or trough, maximum, average concentration, and area under the concentration-time curve [AUC] at steady state) and clinical outcomes (ie, the probabilities of major bleeding [MB] and venous thromboembolism [VTE]) were modeled using NONMEM 7...
September 19, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28918788/-fast-track-total-knee-arthroplasty
#12
Kirill Gromov, Billy B Kristensen, Christoffer Calov Jørgensen, Torben Bæk Hansen, Henrik Kehlet, Henrik Husted
Fast-track total knee arthroplasty (TKA) is a well-established concept including optimized logistics and evidence-based treatment, focusing on minimizing surgical stress and improved post-operative recovery, thus leading to lower mortality and morbidity as well as high patient satisfaction. All patients are eligible for fast-track TKA, and hence the fast-track concept should be standard at all joint replacement facilities. Future challenges of fast-track TKA include safe introduction of outpatient protocols, acute and chronic pain after surgery and optimal utilization of post-operative physiotherapy...
September 18, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28918227/bone-remodeling-of-the-distal-femur-after-uncemented-total-knee-arthroplasty-a-2-year-prospective-dxa-study
#13
Mikkel Rathsach Andersen, Nikolaj S Winther, Thomas Lind, Henrik M Schrøder, Michael Mørk Petersen
Loss of bone stock as a response to the bone trauma, immobilization, and stress shielding related to joint replacement surgery increases the risk of fracture of the distal femur after total knee arthroplasty. Previous studies of uncemented femoral components have reported very high levels of bone loss in the distal femur. This study investigates the adaptive bone remodeling of the distal femur after uncemented total knee arthroplasty. We performed a 2-year follow-up of 53 patients (mean age 61.5 [38-70] years, F/M = 27/26, body mass index 29...
September 13, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28918008/a-finite-element-study-on-the-mechanical-response-of-the-head-neck-interface-of-hip-implants-under-realistic-forces-and-moments-of-daily-activities-part-2
#14
Khosro Fallahnezhad, Hamidreza Farhoudi, Reza H Oskouei, Mark Taylor
A finite element model was developed to investigate the effect of loading regimes caused by various daily activities on the mechanical behaviour of the head-neck taper junction in modular hip replacements. The activities included stair up, stair down, sit to stand, stand to sit, one leg standing and knee bending. To present the real mechanical environment of the junction, in addition to the force components, the frictional moments produced by the frictional sliding of the head and cup were applied to a CoCr/CoCr junction having a 12/14 taper with a proximal mismatch angle of 0...
September 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28917618/gap-balancing-sacrifices-joint-line-maintenance-to-improve-gap-symmetry-5-year-follow-up-of-a-randomized-controlled-trial
#15
Sina Babazadeh, Michelle M Dowsey, Michael G Vasimalla, James D Stoney, Peter F M Choong
BACKGROUND: Gap balancing (GB) has been noted to sacrifice joint-line maintenance to improve gap symmetry. This study aims to determine whether this change affects function or quality of life in the midterm. METHODS: A prospective blinded randomized controlled trial was completed with 103 patients randomized to measured resection (n = 52) or GB (n = 51). Primary outcome measured was femoral component rotation. Secondary outcomes measured were joint-line change, gap symmetry, and function and quality-of-life outcomes...
August 24, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28917522/does-physical-activity-change-following-hip-and-knee-replacement-matched-case-control-study-evaluating-physical-activity-scale-for-the-elderly-data-from-the-osteoarthritis-initiative
#16
T O Smith, M Mansfield, J Dainty, G Hilton, C J V Mann, C M Sackley
OBJECTIVES: To determine whether physical activity measured using the Physical Activity Scale for the Elderly (PASE), changes during the initial 24 months post-total hip (THR) or knee replacement (TKR), and how this compares to a matched non-arthroplasty cohort. DESIGN: Case-controlled study analysis of a prospectively collected dataset. SETTING: USA community-based. PARTICIPANTS: 116 people post-THR, 105 people post-TKR compared to 663 people who had not undergone THR or TKR, or had hip or knee osteoarthritis...
September 13, 2017: Physiotherapy
https://www.readbyqxmd.com/read/28914503/testosterone-therapy-preserves-muscle-strength-and-power-in-aging-men-with-type-2-diabetes-a-randomized-controlled-trial
#17
L V Magnussen, L G Hvid, A P Hermann, D M Hougaard, B Gram, P Caserotti, M S Andersen
The purpose of the study was to evaluate whether testosterone replacement therapy improves muscle mechanical and physical function in addition to increasing lean leg mass and total lean body mass in aging men with type 2 diabetes and lowered bio-available testosterone (BioT) levels. Thirty-nine men aged 50-70 years with type 2 diabetes and BioT levels <7.3 nmol/L were included from an academic tertiary-care medical center. Patients were randomized to testosterone gel (testosterone replacement therapy, n = 20) or placebo (n = 19) for 24 weeks, applying a double-blinded design...
September 2017: Andrology
https://www.readbyqxmd.com/read/28914139/the-influence-of-geometric-design-variables-on-the-kinematic-performance-of-a-surface-guided-total-knee-replacement
#18
Shabnam Pejhan, Eric Bohm, Jan-Mels Brandt, Urs Wyss
OBJECTIVE: Tibiofemoral geometries in a total knee replacement (TKR) affect the performance of an implant during activities of daily living. The specially shaped components of a surface-guided TKR aim to control the tibiofemoral motion, such that a normal pattern of motion is achieved, even at high flexion angles. The purpose of this study was to assess the influence of the design parameters on the kinematic behavior of such an implant. A combination of design variables was determined that resulted in the least deviation from the design kinematic target...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28914105/bone-and-subcutaneous-adipose-tissue-pharmacokinetics-of-vancomycin-in-total-knee-replacement-patients
#19
Mats Bue, Mikkel Tøttrup, Pelle Hanberg, Otto Langhoff, Hanne Birke-Sørensen, Theis M Thillemann, Torben L Andersson, Kjeld Søballe
Background and purpose - The incidence of orthopedic methicillin-resistant Staphylococcus aureus (MRSA) infections is increasing. Vancomycin may therefore play an increasingly important role in orthopedic perioperative antimicrobial prophylaxis. Studies investigating perioperative bone and soft tissue concentrations of vancomycin are sparse and challenged by a lack of appropriate methods. We assessed single-dose plasma, subcutaneous adipose tissue (SCT) and bone concentrations of vancomycin using microdialysis in male patients undergoing total knee replacement...
September 15, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28913405/post-acute-care-disparities-in-total-joint-arthroplasty
#20
Roy H Lan, Atul F Kamath
BACKGROUND: Understanding the socioeconomic factors that influence hospitalization and post-discharge metrics after joint replacement is important for identifying key areas of improvement in the delivery of orthopaedic care. METHODS: An institutional administrative data set of 2869 patients from an academic arthroplasty referral center was analyzed to quantify the relationship between socioeconomic factors and post-acute rehabilitation care received, length of stay, and cost of care...
September 2017: Arthroplasty Today
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