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https://www.readbyqxmd.com/read/28945057/global-leishmaniasis-update-2006%C3%A2-2015-a-turning-point-in-leishmaniasis-surveillance
#1
(no author information available yet)
No abstract text is available yet for this article.
September 22, 2017: Relevé épidémiologique Hebdomadaire
https://www.readbyqxmd.com/read/28944989/the-combination-of-valsartan-and-sacubitril-in-the-treatment-of-hypertension-and-heart-failure-an-update
#2
Peter Munch Nielsen, Daniela Grimm, Markus Wehland, Ulf Simonsen, Marcus Krüger
A novel antihypertensive drug, LCZ696 (Entresto(®) ), has recently been introduced, which combines the action of an antagonist of the renin-angiotensin-aldosterone-system (RAAS), effectively decreasing the blood pressure, with an inhibition of neprilysin, which is responsible for metabolizing natriuretic peptides exerting anti-hypertensive and anti-fibrotic effects. In this MiniReview, we describe the pharmacokinetics and -dynamics, efficacy and side effects of the combined angiotensin receptor antagonist and neprilysin inhibitor LCZ696...
September 25, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28944806/egg-derived-bioactive-peptides-with-ace-inhibitory-properties-a-literature-update
#3
REVIEW
Charlotte Grootaert, Bea Matthijs, Stefan Voorspoels, Sam Possemiers, Guy Smagghe, John Van Camp
Egg proteins contain a wide set of peptide sequences which have an impact on cardiovascular health. Their modes-of-action involve, among others, the inhibition of angiotensin-converting enzyme (ACE) and antioxidant and anti-inflammatory properties. In this review, we focus particularly on ACE-inhibition and discuss recent findings in: (i) production methods for egg protein-derived ACE-inhibitory peptides, (ii) in vitro functionality of these peptides, (iii) their intestinal digestion and absorption in order to reach the target tissue, (iv) the impact of ACE-inhibitory egg-derived peptides in vivo and (v) future perspectives for the implementation of egg-derived ACE-inhibitory peptides as functional foods...
September 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28944738/an-industry-update-the-latest-developments-in-therapeutic-delivery
#4
Oliver C Steinbach
The present industry update covers the period 1-30 June 2017, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. The combination of drug and devices such as improved, safer injectables (see various market reports, companies Adamis and Baxter), patches (Microdermis) and (nano)carriers are moving increasingly from the R&D stage into clinical trials and toward the market. This addresses increased safety and effectiveness requirements, limiting physico-chemical properties of active ingredients, cost-effectiveness and patient comfort through ease of use...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28944515/methods-report-european-s3-guideline-on-the-systemic-treatment-of-psoriasis-vulgaris-update-apremilast-and-secukinumab-edf-in-cooperation-with-eadv-and-ipc
#5
C Dressler, S Rosumeck, R N Werner, G van der Kraaij, P van Lumig, M Wakkee, P Spuls, A Nast
No abstract text is available yet for this article.
September 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28944505/taxonomy-of-cns-tumours-a-series-of-three-short-reviews-on-the-who-2016-classification-and-beyond
#6
EDITORIAL
Pieter Wesseling, Thomas S Jacques
In May 2016, an update of the 4th edition of the World Health Organization (WHO) Classification of Tumours of the Central Nervous System (CNS) was officially released [1]. This revised 4th edition represents a paradigm shift as, for the first time, the definition of multiple CNS tumour entities is now partly based on particular genotypic characteristics. Additionally, compared to the 4th edition (published in 2007), some splitting and lumping of entities occurred because of new insights in the genetic underpinnings of CNS tumours and/or based on more recently published clinico-pathologic studies...
September 25, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28944433/pharmacogenetics-of-lipid-lowering-agents-an-update-review-on-genotype-dependent-effects-of-hdl-targetingand-statin-therapies
#7
REVIEW
Nathan Messas, Marie-Pierre Dubé, Jean-Claude Tardif
PURPOSE OF REVIEW: High-density lipoproteins (HDL) are involved in reverse cholesterol transport. Results from randomized trials of HDL-targeting therapies, including cholesteryl ester transfer protein (CETP) inhibitors, have shown a lack of benefit in unsegmented populations. These observations could be explained by inter-individual variability of clinical responses to such agents depending on the patients' genotypes. In parallel, although lowering of LDL cholesterol (LDL-c) with statin therapy reduces the risk of vascular events in a wide range of individuals, inter-individual variability exists with regard to LDL-c-lowering response as well as efficacy in reducing major cardiovascular events...
September 25, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28944398/characteristics-of-international-staff-victims-of-psychiatric-patient-assaults-review-of-published-findings-2013-2017
#8
REVIEW
Raymond B Flannery, Grace Wyshak, Georgina J Flannery
Psychiatric patient assaults on staff are a worldwide occupational hazard for health care staff that results in human suffering and dollar cost expense. International research through 2012 documented the frequency of these assaults and a continuing high risk for nursing personnel. This present paper reviewed the international published literature on staff victims of patient assaults during the next five year period of 2013-2017. The findings indicate that assaults on staff remain a serious worldwide issue as it has been since the 1990s, even with new policy initiatives in place meant to reduce such violence...
September 25, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28944298/hippocampal-diencephalic-cingulate-networks-for-memory-and-emotion-an-anatomical-guide
#9
Emma J Bubb, Lisa Kinnavane, John P Aggleton
This review brings together current knowledge from tract tracing studies to update and reconsider those limbic connections initially highlighted by Papez (1937) for their presumed role in emotion. These connections link hippocampal and parahippocampal regions with the mammillary bodies, the anterior thalamic nuclei, and the cingulate gyrus, all structures now strongly implicated in memory functions. An additional goal of this review is to describe the routes taken by the various connections within this network...
August 4, 2017: Brain and neuroscience advances
https://www.readbyqxmd.com/read/28944177/isolated-septal-myectomy-for-hypertrophic-obstructive-cardiomyopathy-an-update-on-the-toronto-general-hospital-experience
#10
Rachel D Vanderlaan, Anna Woo, Anthony Ralph-Edwards
BACKGROUND: Isolated septal myectomy is considered the gold standard for refractory left ventricular outflow tract (LVOT) obstruction at centers with dedicated hypertrophic obstructive cardiomyopathy (HOCM) surgeons. In this paper, we provide an update on the Toronto General Hospital (TGH) experience for isolated septal myectomy and comment on the safety and efficacy of myectomy in patients with thin basal septal thickness at our institution. METHODS: We retrospectively reviewed all patients undergoing surgical myectomy at our institution from January 2012 to August 2016...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28944175/long-term-outcome-of-simultaneous-septal-myectomy-and-anterior-mitral-leaflet-retention-plasty-in-hypertrophic-obstructive-cardiomyopathy-the-berlin-experience
#11
Eva Maria Delmo Walter, Mariano Francisco Javier, Roland Hetzer
BACKGROUND: Various surgical strategies designed to relieve left ventricular outflow tract obstruction (LVOTO) and correct mitral regurgitation (MR) in hypertrophic obstructive cardiomyopathy (HOCM) have evolved, yet reports on the long-term outcomes of each technique are scarce. We provide an update on over 20 years' experience at our institution in the standardized surgical treatment of HOCM. METHODS: Between April 1986 and April 2014, 320 cases of endomyocardial resection and 305 septal myectomies were performed at our institution...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28944170/implantable-cardioverter-defibrillator-therapy-in-hypertrophic-cardiomyopathy-an-updated-systematic-review-and-meta-analysis-of-outcomes-and-complications
#12
REVIEW
Nelson Wang, Ashleigh Xie, Richard Tjahjono, David H Tian, Steven Phan, Tristan D Yan, Pietro Bajona, Kevin Phan
BACKGROUND: Since the introduction of the implantable cardioverter-defibrillator (ICD) in patients with hypertrophic cardiomyopathy (HCM), the incidence of sudden cardiac death (SCD) has been significantly reduced. Given its widespread use, it is important to identify the outcomes associated with ICD use in patients with HCM. The present paper is a systematic review and meta-analysis of the rates of appropriate and inappropriate interventions, mortality, and device complications in HCM patients with an ICD...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28944162/an-update-on-treatment-of-pediatric-chronic-non-infectious-uveitis
#13
Arjun B Sood, Sheila T Angeles-Han
There are no standardized treatment protocols for pediatric non-infectious uveitis. Topical corticosteroids are the typical first-line agent, although systemic corticosteroids are used in intermediate, posterior and panuveitic uveitis. Corticosteroids are not considered to be long-term therapy due to potential ocular and systemic side effects. In children with severe and/or refractory uveitis, timely management with higher dose disease-modifying antirheumatic drugs (DMARDs) and biologic agents is important...
March 2017: Current Treatment Options in Rheumatology
https://www.readbyqxmd.com/read/28944141/nationwide-trends-of-hospitalizations-for-cystic-fibrosis-in-the-united-states-from-2003-to-2013
#14
Abhinav Agrawal, Abhishek Agarwal, Dhruv Mehta, Rutuja R Sikachi, Doantrang Du, Janice Wang
Cystic fibrosis (CF) is a multisystem autosomal recessive genetic disorder with significant advances in early diagnosis and treatment in the last decade. It is important to provide updated information regarding these changing demographics as they also reflect a considerable improvement in survival. We analyzed the National Inpatient Sample Database (NIS) in the United States for all patients in which CF was the primary discharge diagnosis (ICD-9: 277.0-277.09) from 2003 to 2013 to evaluate the rate of hospitalizations and determine the cost and mortality associated with CF along with other epidemiological findings...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28943527/crossing-bridges-between-extra-and-intra-cellular-events-in-thoracic-aortic-aneurysms
#15
Yoshito Yamashiro, Hiromi Yanagisawa
Thoracic aortic aneurysms (TAAs) are common, life-threatening diseases and are a major cause of mortality and morbidity. Over the past decade, genetic approaches have revealed that 1) activation of the transforming growth factor beta (TGF-β) signaling, 2) alterations in the contractile apparatus of vascular smooth muscle cells (SMCs), and 3) defects in the extracellular matrix (ECM) were responsible for development of TAAs. Most recently, a fourth mechanism has been proposed in that dysfunction of mechanosensing in the aortic wall in response to hemodynamic stress may be a key driver of TAAs...
September 22, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28943227/-french-practical-guidelines-for-the-diagnosis-and-management-of-idiopathic-pulmonary-fibrosis-2017%C3%A2-update-full-length-update
#16
V Cottin, B Crestani, J Cadranel, J-F Cordier, S Marchand-Adam, G Prévot, B Wallaert, E Bergot, P Camus, J-C Dalphin, C Dromer, E Gomez, D Israel-Biet, S Jouneau, R Kessler, C-H Marquette, M Reynaud-Gaubert, B Aguilaniu, D Bonnet, P Carré, C Danel, J-B Faivre, G Ferretti, N Just, F Lebargy, B Philippe, P Terrioux, F Thivolet-Béjui, B Trumbic, D Valeyre
No abstract text is available yet for this article.
September 21, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28943112/update-on-food-safety-of-monosodium-l-glutamate-msg
#17
REVIEW
Helen Nonye Henry-Unaeze
OBJECTIVE: This evidence-based safety review of the flavor enhancer monosodium l-glutamate (MSG) was triggered by its global use and recent studies expressing some safety concerns. METHODOLOGY: This article obtained information through search of evidence-based scientific databases, especially the US National Library of Medicine NIH. RESULTS: (A) MSG is a water-soluble salt of glutamate, a non-essential amino acid, normally synthesized in the body and prevalent in protein foods...
September 18, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28943096/the-incidence-rate-of-cancer-in-patients-with-schizophrenia-a-meta-analysis-of-cohort-studies
#18
REVIEW
Hailong Li, Jiasi Li, Xiya Yu, Huiwen Zheng, Xu Sun, Yue Lu, Yanbo Zhang, Chunbo Li, Xiaoying Bi
BACKGROUND: Numerous studies report that cancer prevalence in patients with schizophrenia might be different from the general population, but findings remain controversial. AIM: Our updated meta-analysis of cohort studies aims to analyze the data from cohort studies concerning the incidence risk of overall cancer and some site-specific cancers in patients with schizophrenia. METHOD: We performed a systemic search through electronic databases...
September 21, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28942821/medicinal-plant-products-targeting-quorum-sensing-for-combating-bacterial-infections
#19
REVIEW
Abdelhakim Bouyahya, Nadia Dakka, Abdeslam Et-Touys, Jamal Abrini, Youssef Bakri
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28942820/domestic-reptiles-as-source-of-zoonotic-bacteria-a-mini-review
#20
REVIEW
Valentina Virginia Ebani
Captive reptiles, always more often present in domestic environment as pets, may harbor and excrete a large variety of zoonotic pathogens. Among them, Salmonella is the most well-known agent, whereas there are very scant data about infections by mycobacteria, chlamydiae and leptospirae in cold-blooded animals. However, the investigations that found antibody reactions and/or the bacteria in samples collected from free-ranging and captive reptiles show that herpetofauna may be involved in the epidemiology of these infections...
August 2017: Asian Pacific Journal of Tropical Medicine
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