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https://www.readbyqxmd.com/read/29240976/clopidogrel-plus-aspirin-versus-aspirin-alone-for-preventing-cardiovascular-events
#1
REVIEW
Alessandro Squizzato, Marta Bellesini, Andrea Takeda, Saskia Middeldorp, Marco Paolo Donadini
BACKGROUND: Aspirin is the prophylactic antiplatelet drug of choice for people with cardiovascular disease. Adding a second antiplatelet drug to aspirin may produce additional benefit for people at high risk and people with established cardiovascular disease. This is an update to a previously published review from 2011. OBJECTIVES: To review the benefit and harm of adding clopidogrel to aspirin therapy for preventing cardiovascular events in people who have coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease, or were at high risk of atherothrombotic disease, but did not have a coronary stent...
December 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29240957/non-coding-rnas-in-cardiac-%C3%AF-brosis-emerging-biomarkers-and-therapeutic-targets
#2
Zhongxiu Chen, Chen Li, Ke Lin, Huawei Cai, Weiqiang Ruan, Junyang Han, Li Rao
Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins. ncRNAs are involved in cell proliferation, apoptosis, differentiation, metabolism, and other physiological processes as well as the pathogenesis of diseases. Cardiac fibrosis is increasingly recognized as a common final pathway in advanced heart diseases. Many studies have shown that the occurrence and development of cardiac fibrosis is closely related to the regulation of ncRNAs. This review will highlight recent updates regarding the involvement of ncRNAs in cardiac fibrosis, and their potential as emerging biomarkers and therapeutic targets...
December 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29240949/nitric-oxide-production-in-plants-an-update
#3
Jeremy Astier, Inonge Gross, Jörg Durner
Nitric oxide (NO) is a key signaling molecule in plant physiology. However, its production in photosynthetic organisms remains partially unresolved. The best characterized NO production route involves the reduction of nitrite to NO via different non-enzymatic or enzymatic mechanisms. Nitrate reductases (NRs), the mitochondrial electron transport chain, and the new complex between NR and NOFNiR (nitric oxide-forming nitrite reductase) described in Chlamydomonas reinhardtii are the main enzymatic systems that perform this reductive NO production in plants...
December 12, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29240924/effect-of-omega-3-fatty-acids-on-cognition-an-updated-systematic-review-of-randomized-clinical-trials
#4
Oscar D Rangel-Huerta, Angel Gil
Context: The increasing number of studies on the effects of n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) on health, particularly cognition, in the last 5 years reflects the growing interest in this area of research. Objective: The aim for this systematic review was to evaluate the scientific evidence published in the last 5 years (2012-2017) on the effects of n-3 LC-PUFA intake on cognition, cognitive development, and cognitive decline to determine whether n-3 LC-PUFAs support cognitive development and prevent cognitive decline...
December 12, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29240909/cohort-profile-update-the-1993-pelotas-brazil-birth-cohort-follow-up-at-22-years
#5
Helen Gonçalves, Fernando C Wehrmeister, Maria C F Assunção, Luciana Tovo-Rodrigues, Isabel O de Oliveira, Joseph Murray, Luciana Anselmi, Fernando C Barros, Cesar G Victora, Ana M B Menezes
No abstract text is available yet for this article.
December 11, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29240827/diagnostic-accuracy-research-in-glaucoma-is-still-incompletely-reported-an-application-of-standards-for-reporting-of-diagnostic-accuracy-studies-stard-2015
#6
Manuele Michelessi, Ersilia Lucenteforte, Alba Miele, Francesco Oddone, Giada Crescioli, Valeria Fameli, Daniël A Korevaar, Gianni Virgili
BACKGROUND: Research has shown a modest adherence of diagnostic test accuracy (DTA) studies in glaucoma to the Standards for Reporting of Diagnostic Accuracy Studies (STARD). We have applied the updated 30-item STARD 2015 checklist to a set of studies included in a Cochrane DTA systematic review of imaging tools for diagnosing manifest glaucoma. METHODS: Three pairs of reviewers, including one senior reviewer who assessed all studies, independently checked the adherence of each study to STARD 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29240816/the-sociotype-construct-gauging-the-structure-and-dynamics-of-human-sociality
#7
Pedro C Marijuán, Jesús Montero-Marín, Jorge Navarro, Javier García-Campayo, Raquel Del Moral
Exploring the pertinence of a "sociotype" construct, established along the conceptual chain genotype-phenotype-sociotype, is the essential purpose of the present paper. Further, by following the sociotype's conceptual guidelines, a new psychometric indicator has been developed in order to gauge the level of social interaction around each individual-the sociotype questionnaire (SOCQ). A first version of this questionnaire has been elaborated by gathering data about the different classes of social bonds (family, friends, acquaintances, and work/study colleagues) in general population and about the dynamic update of these bonds via face-to-face conversation and other modes of interaction...
2017: PloS One
https://www.readbyqxmd.com/read/29240743/potential-for-public-health-success-in-tackling-the-hepatitis-c-virus-epidemic
#8
Ian Sheerin
New Zealand and Australia both now have the potential for a major public health success in controlling the hepatitis C virus epidemic. The burden of advanced liver disease and drug-related harm is increasing. However, a new range of anti-viral therapies have become available which offer a potential cure for most people with few side-effects. The epidemic is potentially preventable and hepatitis C is now curable. Although public health strategies for blood-borne viruses have been updated, they fall short of what is needed and should be upgraded with more emphasis on prevention, in order to achieve control of this epidemic...
December 15, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29240621/30th-annual-aprn-legislative-update-improving-access-to-healthcare-one-state-at-a-time
#9
Susanne J Phillips
The Annual Legislative Update describes recent legislative changes to practice, reimbursement, and prescriptive authority that have the most impact on NPs and other advanced practice nurses across the country.
January 15, 2018: Nurse Practitioner
https://www.readbyqxmd.com/read/29240340/update-on-current-care-guideline-memory-disorders
#10
(no author information available yet)
Any complaint about memory should be examined. Diagnosis is based on international criteria. Basic evaluation consists of medical history, clinical evaluation, cognitive tests and brain imaging. When a diagnosis of Alzheimer's disease (AD), AD with cerebrovascular disease or with Lewy Body disease (LBD), or Dementia associated with Parkinson's disease or LBD is made, evidence-based medical therapy (acetylcholine esterase inhibitor or memantine) is indicated as a part of comprehensive care. In frontotemporal degenerations, these drugs are ineffective...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29240321/medicare-program-hospital-outpatient-prospective-payment-and-ambulatory-surgical-center-payment-systems-and-quality-reporting-programs-final-rule-with-comment-period
#11
(no author information available yet)
This final rule with comment period revises the Medicare hospital outpatient prospective payment system (OPPS) and the Medicare ambulatory surgical center (ASC) payment system for CY 2018 to implement changes arising from our continuing experience with these systems. In this final rule with comment period, we describe the changes to the amounts and factors used to determine the payment rates for Medicare services paid under the OPPS and those paid under the ASC payment system. In addition, this final rule with comment period updates and refines the requirements for the Hospital Outpatient Quality Reporting (OQR) Program and the ASC Quality Reporting (ASCQR) Program...
December 14, 2017: Federal Register
https://www.readbyqxmd.com/read/29240099/two-years-of-tutorials-editorial
#12
P Scott Carney
Editor-in-Chief P. Scott Carney gives an update on JOSA A tutorials.
December 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29240078/erratum-laboratory-diagnosis-of-biotinidase-deficiency-2017-update-a-technical-standard-and-guideline-of-the-american-college-of-medical-genetics-and-genomics
#13
Erin T Strovel, Tina M Cowan, Anna I Scott, Barry Wolf
This corrects the article DOI: 10.1038/gim.2017.84.
December 14, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29239812/dosimetric-impact-of-inter-observer-catheter-reconstruction-variability-in-ultrasound-based-high-dose-rate-prostate-brachytherapy
#14
Alexandru Nicolae, Jure Murgic, Ivan Kruljac, Lior Dubnitzky, Laura D'Alimonte, Lin Lu, Aaron Cumal, Niki Law, Gerard Morton, Andrew Loblaw, Hans T Chung, Ananth Ravi
PURPOSE: To investigate the dosimetric impact of interobserver catheter reconstruction variability in transrectal ultrasound-guided prostate high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: Twenty consecutive patients with intermediate- or high-risk prostate cancer were treated with a single, 15-Gy HDR brachytherapy boost as part of this study. The treated plan was used as the study reference plan (PR). Three expert treatment planners (observers) manually reconstructed the catheter paths on the static three-dimensional transrectal ultrasound images, and new plans were generated from the updated positions (POBS); subsequently, the dwell time and positions from the POBS plans were superimposed on the PR catheter paths to evaluate the dosimetric effect of the interobserver variations (PEVAL)...
November 24, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29239576/living-donor-kidney-transplantation
#15
Ilkka Helanterä, Eero Honkanen, Jutta Huhti, Helena Isoniemi, Hannu Jalanko, Marko Lempinen, Marja Miettinen, Arno Nordin, Risto Tertti, Satu Mäkelä
While the majority of kidney transplantations in Finland have been traditionally performed from deceased donors, the frequency of living donors should be increased. Kidney donation is a safe procedure for a carefully examined donor, and for the recipient living donation enables elective surgery and preemptive transplantation. Potential risks for the donor must be minimized, but according to current recommendations, mild hypertension or obesity are not absolute contraindications for donation. Guidelines for donor selection and examination have been updated to simplify the process for all parties...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29239538/-do-degenerative-meniscal-tears-need-surgery
#16
Julien Billières, Hermès Miozzari, Anne Lübbeke, Didier Hannouche
Degenerative meniscal tears (DMT) are common, often asymptomatic, and are associated with early-stage knee osteoarthritis in patients over 35 years of age. Conservative treatment, including exercise, physiotherapy and pain medication, should be offered as a first management approach for patients with symptomatic DMT. The indication for partial arthroscopic meniscectomy should be considered carefully, and based on specific criteria. Recently, several randomized controlled studies comparing partial medial meniscectomy to conservative treatment or to a sham procedure have questioned the effectiveness of surgical treatment of these lesions...
December 13, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29239137/medical-management-of-gastric-cancer-a-2017-update
#17
REVIEW
Nikolaos Charalampakis, Panagiota Economopoulou, Ioannis Kotsantis, Maria Tolia, Dimitrios Schizas, Theodore Liakakos, Elena Elimova, Jaffer A Ajani, Amanda Psyrri
Gastric cancer remains a considerable health burden throughout the world. The Cancer Genome Atlas (TCGA) analysis has recently unveiled 4 genotypes of gastric cancer with data not ready to change treatment strategy yet. A multimodality approach to therapy is the cornerstone of screening, diagnosing, staging, treating and supporting patients with gastric cancer. The evidence-based approach to localized gastric cancer (>cT1b) is to use an either preoperative or postoperative strategy to maximize the benefit of surgery...
December 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29239065/vitamin-d-receptor-rs2228570-polymorphism-and-susceptibility-to-ovarian-cancer-an-updated-meta-analysis
#18
Hongmei Chen, Jin Zhu
AIM: The FokI polymorphism (C>T, rs2228570) of the vitamin D receptor gene is a coding nonsynonymous single nucleotide polymorphism in the translational initiation codon reported to have functional significance. Although the role of rs2228570 in the risk of ovarian cancer has been widely researched, the association is still unclear. We performed an updated meta-analysis to clarify this issue. METHODS: Eligible studies were retrieved from electronic databases for the period 2007-2016...
December 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29239044/pathology-and-genetics-of-phaeochromocytoma-and-paraganglioma
#19
REVIEW
John Turchini, Veronica K Y Cheung, Arthur S Tischler, Ronald R De Krijger, Anthony J Gill
Phaeochromocytoma and paraganglioma (PHEO/PGL) are rare tumours with an estimated annual incidence of 3 per million. Advances in molecular understanding have led to the recognition that at least 30-40% arise in the setting of hereditary disease. Germline mutations in the succinate dehydrogenase genes SDHA, SDHB, SDHC, SDHD and SDHAF2 are the most prevalent of the more than 19 hereditary genetic abnormalities which have been reported. It is therefore recommended that, depending on local resources and availability, at least some degree of genetic testing should be offered to all PHEO/PGL patients, including those with clinically sporadic disease...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29239038/gastroenteropancreatic-neuroendocrine-neoplasms-selected-pathology-review-and-molecular-updates
#20
REVIEW
Siaw M Chai, Ian S Brown, M Priyanthi Kumarasinghe
Gastroenteropancreatic (GEP) neuroendocrine neoplasms can be broadly separated into well- and poorly differentiated categories. Tumours within each category have similarities in morphology and immunophenotype, but vary in grade, behaviour, molecular signature and responses to therapy. The aetiology of these differences is multifactorial. Site of origin, mucosal milieu and hereditary influences are some of the currently known factors. Given these differences, staging and grading systems continue to evolve, and the most recent World Health Organization classification of pancreatic neuroendocrine neoplasms reflects this by introducing a grade 3 neuroendocrine tumour category for morphologically well-differentiated tumours with an elevated Ki-67 proliferation index and/or mitotic count...
January 2018: Histopathology
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