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https://www.readbyqxmd.com/read/29444403/plant-villin-headpiece-domain-demonstrates-a-novel-surface-charge-pattern-and-high-affinity-for-f-actin
#1
Heather L Miears, David R Gruber, Nicholas M Horvath, John M Antos, Jeff Young, Johann P Sigurjonsson, Maya L Klem, Erin A Rosenkranz, Mark Okon, Christopher James McKnight, Liliya Vugmeyster, Serge L Smirnov
Plants utilize multiple isoforms of villin, an F-actin regulating protein with an N-terminal gelsolin-like core and a distinct C-terminal headpiece domain. Unlike their vertebrate homologs, plant villins have a much longer linker polypeptide connecting the core and headpiece. Moreover, the linker-headpiece connection region in plant villins lack sequence homology to the vertebrate villin sequences. It is unknown to what extent the plant villin headpiece structure and function resemble those of the well-studied vertebrate counterparts...
February 14, 2018: Biochemistry
https://www.readbyqxmd.com/read/29444366/is-atopic-dermatitis-associated-with-obesity-a-systematic-review-of-observational-studies
#2
REVIEW
Zarqa Ali, Charlotte Suppli Ulrik, Tove Agner, Simon Francis Thomsen
Obesity has been associated with atopic dermatitis (AD), however the results have been conflicting. Our aim was to provide an update on current knowledge from observational studies addressing the possible association between obesity and AD. Systematic literature review was performed by identifying studies addressing a possible link between AD and overweight/obesity from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)-guidelines...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29444287/mosquitoes-of-northwestern-uganda
#3
J-P Mutebi, M B Crabtree, R C Kading, A M Powers, J P Ledermann, E C Mossel, N Zeidner, J J Lutwama, B R Miller
Despite evidence of arbovirus activity in northwestern Uganda (West Nile Sub-region), there is very limited information on the mosquito fauna of this region. The only published study reported 52 mosquito species in northwestern Uganda but this study took place in 1950 and the information has not been updated for more than 60 yr. In January and June 2011, CO2 baited-light traps were used to collect 49,231 mosquitoes from four different locations, Paraa (9,487), Chobe (20,025), Sunguru (759), and Rhino Camp (18,960)...
February 12, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29444280/prevalence-of-dementia-in-mainland-china-hong-kong-and-taiwan-an-updated-systematic-review-and-meta-analysis
#4
Yu-Tzu Wu, Gemma-Claire Ali, Maëlenn Guerchet, A Matthew Prina, Kit Yee Chan, Martin Prince, Carol Brayne
Background: There are several existing systematic reviews of prevalence of dementia for mainland China, Hong Kong and Taiwan, but several studies have been newly reported. The aim of this study is to update prevalence data in this region and test for variation across geographical areas and time periods using the new dataset. Methods: Twenty prevalence studies identified from World Alzheimer Report 2015 (January 2011-March 2015) and an updated search (March 2015-February 2017) were added to the original dataset (N = 76)...
February 12, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29444217/reply-updated-frequency-analysis-of-spinocerebellar-ataxia-in-china
#5
Marie Coutelier, Alexis Brice, Giovanni Stevanin, Alexandra Durr
No abstract text is available yet for this article.
February 12, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29444203/updated-frequency-analysis-of-spinocerebellar-ataxia-in-china
#6
Zhao Chen, Puzhi Wang, Chunrong Wang, Yun Peng, Xiaocan Hou, Xin Zhou, Tianjiao Li, Huirong Peng, Rong Qiu, Kun Xia, Jorge Sequeiros, Beisha Tang, Hong Jiang
No abstract text is available yet for this article.
February 12, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29444144/improved-ggiw-phd-filter-for-maneuvering-non-ellipsoidal-extended-targets-or-group-targets-tracking-based-on-sub-random-matrices
#7
Zhibing Liang, Fuxian Liu, Jiale Gao
For non-ellipsoidal extended targets and group targets tracking (NETT and NGTT), using an ellipsoid to approximate the target extension may not be accurate enough because of the lack of shape and orientation information. In consideration of this, we model a non-ellipsoidal extended target or target group as a combination of multiple ellipsoidal sub-objects, each represented by a random matrix. Based on these models, an improved gamma Gaussian inverse Wishart probability hypothesis density (GGIW-PHD) filter is proposed to estimate the measurement rates, kinematic states, and extension states of the sub-objects for each extended target or target group...
2018: PloS One
https://www.readbyqxmd.com/read/29443999/absolute-distance-measurement-by-multi-heterodyne-interferometry-using-an-electro-optic-triple-comb
#8
Xianyu Zhao, Xinghua Qu, Fumin Zhang, Yuhang Zhao, Guoqing Tang
We experimentally demonstrate a method for absolute distance measurement using a triple-comb-based multi-heterodyne interferometer which has the capacity to simultaneously balance the non-ambiguous range, resolution, update rate, and cost. Three flat-top electro-optic combs generated via cascaded intensity and phase modulators are adopted to form a measurement scheme including rough and fine measurements, and the unknown distance is determined by detecting the phase changes of the consecutive synthetic wavelengths...
February 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29443620/transforming-patient-compliance-research-in-an-era-of-biomedicalization
#9
Karen Lutfey Spencer
The term patient noncompliance emerged in the 1970s as a tool for analyzing why people do not follow medical directives. Despite its early popularity, the term has languished in sociology while flourishing in biomedical arenas. It seems flaccid in a contemporary healthcare context as it overestimates physician authority and is tone-deaf to biomedicalization. I draw from sociological and anthropological traditions, as well as qualitative interviews with terminally ill patients ( N = 26) and their caregivers ( N = 16), to consider facets of a biomedicalized health experience and implications for an updated vision of compliance...
February 1, 2018: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/29442352/guidelines-of-polish-national-societies-diagnostics-and-treatment-of-thyroid-carcinoma-2018-update
#10
Barbara Jarząb, Marek Dedecjus, Dorota Słowińska-Klencka, Andrzej Lewiński, Zbigniew Adamczewski, Ryszard Anielski, Maciej Bagłaj, Agata Bałdys-Waligórska, Marcin Barczyński, Tomasz Bednarczuk, Artur Bossowski, Monika Buziak-Bereza, Ewa Chmielik, Andrzej Cichocki, Agnieszka Czarniecka, Rafał Czepczyński, Janusz Dzięcioł, Tomasz Gawlik, Daria Handkiewicz-Junak, Kornelia Hasse-Lazar, Alicja Hubalewska-Dydejczyk, Krystian Jażdżewski, Beata Jurecka-Lubieniecka, Michał Kalemba, Grzegorz Kamiński, Małgorzata Karbownik-Lewińska, Mariusz Klencki, Beata Kos-Kudła, Agnieszka Kotecka-Blicharz, Aldona Kowalska, Jolanta Krajewska, Aleksandra Kropińska, Aleksandra Kukulska, Emilia Kulik, Andrzej Kułakowski, Krzysztof Kuzdak, Dariusz Lange, Aleksandra Ledwon, Elżbieta Lewandowska-Jabłońska, Katarzyna Łącka, Barbara Michalik, Anna Nasierowska-Guttmejer, Janusz Nauman, Marek Niedziela, Ewa Małecka-Tendera, Małgorzata Oczko-Wojciechowska, Tomasz Olczyk, Ewa Paliczka-Cieślik, Lech Pomorski, Zbigniew Puch, Józef Roskosz, Marek Ruchała, Dagmara Rusinek, Stanisław Sporny, Agata Stanek-Widera, Zoran Stojcev, Aleksandra Syguła, Anhelli Syrenicz, Sylwia Szpak-Ulczok, Tomasz Tomkalski, Zbigniew Wygoda, Jan Włoch, Ewa Zembala-Nożyńska
Significant advances have been made in thyroid can-cer research in recent years, therefore relevant clinical guidelines need to be updated. The current Polish guidelines "Diagnostics and Treatment of Thyroid Carcinoma" have been formulated at the "Thyroid Cancer and Other Malignancies of Endocrine Glands" conference held in Wisła in November 2015 [1].
2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29442288/updates-of-peripheral-t-cell-lymphomas-based-on-the-2017-who-classification
#11
REVIEW
Parwiz J Siaghani, Joo Y Song
PURPOSE OF REVIEW: This review will describe and update the readers on the recent changes of the 2017 WHO classification in regard to peripheral T cell lymphomas. RECENT FINDINGS: Significant advances in molecular studies have resulted in revisions of the classification as well as introduction of provisional entities (such as breast implant-associated ALCL, nodal PTCL with TFH phenotype). Major advances in molecular and gene expression profiling have expanded our knowledge of T cell lymphomas, including updates in the diagnostic criteria and sub-classification which will facilitate in improving patient care and research...
February 14, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29442174/correction-to-tandem-affinity-purification-of-attert-reveals-putative-interaction-partners-of-plant-telomerase-in-vivo
#12
Jana Majerská, Petra Procházková Schrumpfová, Ladislav Dokládal, Šárka Schořová, Karel Stejskal, Michal Obořil, David Honys, Lucie Kozáková, Pavla Sováková Polanská, Eva Sýkorová
In the published online version, the affiliations were mixed up. Corrected affiliation section is shown below. Also, the update has also been reflected in the author group section above.
February 14, 2018: Protoplasma
https://www.readbyqxmd.com/read/29442154/modified-york-mason-technique-for-repair-of-iatrogenic-recto-urinary-fistula-20%C3%A2-years-of-the-montsouris-experience
#13
Sébastien Bergerat, François Rozet, Eric Barret, José Batista da Costa, Adalberto Castro, Paolo Dell'oglio, Marc Galiano, Alexandre Ingels, Rafael Sanchez Salas, Xavier Cathelineau
PURPOSE: Iatrogenic recto-urinary fistulas are a disastrous complication of therapeutic interventions on the prostate. Many surgical approaches have been described to repair recto-urinary fistulas and no consensus has been reached regarding the better approach. The objective of this study is to present the results of our updated 20-year experience in the surgical management of recto-urinary fistula using a modified York Mason procedure. METHODS: We proceed to a retrospective single-institution review of surgically treated patients for iatrogenic recto-urinary fistulas between 1998 and 2017 by the modified York Mason technique...
February 13, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29442146/-the-new-tremor-classification-of-the-international-parkinson-and-movement-disorder-society-update-on-frequent-tremors
#14
REVIEW
F Gövert, J Becktepe, G Deuschl
Tremor is one of the most frequent movement disorders. The recently published new classification of the Movement Disorder Society separates the clinical description of tremor syndromes as so-called axis 1 symptom constellations from the etiologies of tremor (axis 2). The same tremor syndromes can therefore be combined with different causes and vice versa. The terminology used in this classification is precisely defined and thereby also the necessary language for medical communication. Frequent tremor syndromes, such as enhanced physiologic tremor, dystonic and parkinsonian tremor as well as focal tremors and task and position-specific tremors are discussed with respect to the phenomenology, and current therapy...
February 13, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29441730/potency-of-%C3%AE-9-tetrahydrocannabinol-and-other-cannabinoids-in-cannabis-in-england-in-2016-implications-for-public-health-and-pharmacology
#15
David J Potter, Kathy Hammond, Shaun Tuffnell, Christopher Walker, Marta Di Forti
BACKGROUND: In 2005 and 2008, studies reported that cannabis in England had become dominated by the sinsemilla (unseeded female) form. The average potency (Δ9-tetrahydrocannabinol [THC] content) of this material had doubled over the previous decade. Cannabis resin then circulating contained approximately equal ratios of THC and cannabidiol (CBD), whereas sinsemilla was almost devoid of CBD. Despite raised health concerns regarding sinsemilla use and the development of psychotic disorders, no update on street cannabis potency has been published since 2008...
February 14, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29441699/psychosocial-functioning-and-risk-factors-among-siblings-of-children-with-cancer-an-updated-systematic-review
#16
REVIEW
Kristin Long, Vicky Lehmann, Cynthia Gerhardt, Aubrey Carpenter, Anna Marsland, Melissa Alderfer
OBJECTIVES: Siblings' psychosocial adjustment to childhood cancer is poorly understood. This systematic review summarizes findings and limitations of the sibling literature since 2008, provides clinical recommendations, and offers future research directions. METHOD: MEDLINE/Pubmed, CINAHL, and PsycINFO were searched for articles related to siblings, psychosocial functioning, and pediatric cancer. After systematic screening, studies meeting inclusion criteria were rated for scientific merit, and findings were extracted and synthesized...
February 13, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29441607/an-international-urogynecological-association-iuga-international-continence-society-ics-joint-report-on-the-terminology-for-the-assessment-of-sexual-health-of-women-with-pelvic-floor-dysfunction
#17
Rebecca G Rogers, Rachel N Pauls, Ranee Thakar, Melanie Morin, Annette Kuhn, Eckhard Petri, Brigitte Fatton, Kristene Whitmore, Sheryl Kinsberg, Joseph Lee
AIMS: The terminology in current use for sexual function and dysfunction in women with pelvic floor disorders lacks uniformity, which leads to uncertainty, confusion, and unintended ambiguity. The terminology for the sexual health of women with pelvic floor dysfunction needs to be collated in a clinically-based consensus report. METHODS: This report combines the input of members of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA), and the International Continence Society (ICS), assisted at intervals by many external referees...
February 14, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29441601/refrigeration-cryopreservation-and-pathogen-inactivation-an-updated-perspective-on-platelet-storage-conditions
#18
REVIEW
L Waters, M Cameron, M P Padula, D C Marks, L Johnson
Conventional storage of platelet concentrates limits their shelf life to between 5 and 7 days due to the risk of bacterial proliferation and the development of the platelet storage lesion. Cold storage and cryopreservation of platelets may facilitate extension of the shelf life to weeks and years, and may also provide the benefit of being more haemostatically effective than conventionally stored platelets. Further, treatment of platelet concentrates with pathogen inactivation systems reduces bacterial contamination and provides a safeguard against the risk of emerging and re-emerging pathogens...
February 14, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29441583/photoenzymes-and-related-topics-an-update
#19
Lars Olof Björn
Photoenzymes are enzymes that catalyze photochemical reactions. For a long time it was believed that only two types of photoenzymes exist: Light-dependent NADPH:protochlorophyllide oxidoreductase and photolyase. However, other photoenzymes have now been discovered, most recently fatty acid photodecarboxylase. This article is protected by copyright. All rights reserved.
February 13, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29441441/comparison-of-practice-guidelines-brcapro-and-genetic-counselor-estimates-to-identify-germline-brca1-and-brca2-mutations-in-pancreatic-cancer
#20
Robert C Grant, Spring Holter, Ayelet Borgida, Neesha C Dhani, David W Hedley, Jennifer J Knox, Mohammad R Akbari, George Zogopoulos, Steven Gallinger
Germline BRCA1 and BRCA2 (BRCA) mutation carriers with pancreatic ductal adenocarcinoma (PDAC) may benefit from precision therapies and their relatives should undergo tailored cancer prevention. In this study, we compared strategies to identify BRCA carriers with PDAC. Incident cases of PDAC were prospectively recruited for BRCA sequencing. Probands were evaluated using the National Comprehensive Cancer Network (NCCN) and the Ontario Ministry of Health and Long-Term Care (MOHLTC) guidelines. The probability of each proband carrying a mutation was estimated by surveying genetic counselors and using BRCAPRO...
February 13, 2018: Journal of Genetic Counseling
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