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Irinitecan

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https://www.readbyqxmd.com/read/25605173/anti-vegf-therapy-with-bevacizumab-limited-cardiovascular-toxicity
#1
Jing Yu, Xu-Fen Cao, Ye Zheng, Rong-Cheng Zhao, Li-Qiu Yan, Lei Zhao, Jia-Wang Wang
PURPOSE: This analysis was conducted to evaluate cardiovascular toxicity of commonly used anti-VEGF therapeutic agent, bevacizumab, in treating patients with cancer. METHODS: Clinical studies evaluating the efficacy and safety of bevacizumab-based regimens on response and safety for patients with cancer were identified using a predefined search strategy, allowing cardiovascular toxicity and other side effects of treatment to be estimated. RESULTS: In bevacizumab based regimens, 4 clinical studies including 282 patients with advanced cancer (including gliomas, cervical, breast and ovarian cancer) were considered eligible for inclusion...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/22777333/safety-verification-trials-of-mfolfiri-and-sequential-iris-bevacizumab-as-first-or-second-line-therapies-for-metastatic-colorectal-cancer-in-japanese-patients
#2
RANDOMIZED CONTROLLED TRIAL
Shunsuke Kato, Hideaki Andoh, Makio Gamoh, Takuhiro Yamaguchi, Yasuko Murakawa, Hideki Shimodaira, Shin Takahashi, Takahiro Mori, Hisatsugu Ohori, Shun-ichi Maeda, Takao Suzuki, Satoshi Kato, Shoko Akiyama, Yuka Sasaki, Takashi Yoshioka, Chikashi Ishioka
OBJECTIVE: S-1 is effective in sequential combination with irinotecan (IRIS) in treating metastatic colorectal cancer. We conducted a randomized phase II trial of modified leucovorin, fluorouracil and irinotecan (mFOLFIRI) + bevacizumab and sequential IRIS + bevacizumab as first- or second-line therapies. METHODS: Sixty metastatic colorectal cancer patients were randomly assigned to receive mFOLFIRI + bevacizumab or sequential IRIS + bevacizumab (7.5 mg/kg of bevacizumab and 150 mg/m(2) of irinitecan, and 80 mg/m(2)/day of S-1 orally from day 3 until day 16 as a 3-week course)...
2012: Oncology
https://www.readbyqxmd.com/read/18565358/-bevacizumab-irinotecan-an-active-treatment-for-recurrent-high-grade-gliomas-preliminary-results-of-an-anocef-multicenter-study
#3
MULTICENTER STUDY
S Guiu, S Taillibert, O Chinot, L Taillandier, J Honnorat, P Y Dietrich, J-P Maire, J S Guillamo, B Guiu, I Catry-Thomas, F Capelle, A Thiebaut, S Cartalat-Carel, C Deville, P Fumoleau, A Desjardins, K Hoang Xuan, B Chauffert
RATIONALE: Second-line chemotherapy is disappointing in recurrent high-grade gliomas. Dramatic responses in recurrent high-grade gliomas have been reported in a recent monocentric trial with a novel association combining bevacizumab (anti-VEGF monoclonal antibody agent) and irinitecan. OBJECTIVE: To report the experience of the ANOCEF group (French speaking neuro-oncology association) using the bevacizumab-irinotecan combination in recurrent high-grade gliomas. METHODS: Eight centers were involved in this retrospective multicenter study...
June 2008: Revue Neurologique
https://www.readbyqxmd.com/read/18433598/-combined-surgical-and-oncological-management-of-colorectal-liver-metastases
#4
REVIEW
Magnus Bergenfeldt, Benny Vittrup Jensen
Isolated colorectal liver metastases should be referred for multispecialist management at a liver centre. Long-time survival is possible after resection and adjuvant therapy. If unresectable, newer chemotherapy with oxaliplatin, irinitecan, bevacizumab and cetuximab may result in a median survival > 20 months. Selected patients may be down-staged and resected with good long-time survival. Bilateral, multiple and large metastases can also be treated by complex combinations of portal vein embolization/ligature, staged resections and local (radiofrequency) ablation...
April 14, 2008: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/17625370/in-vitro-simulation-study-of-individualized-chemotherapy-in-lung-cancer
#5
Cai Li, Akihiko Gemma, Yuji Minegishi, Kuniko Matsuda, Yoko Seike, Rintaro Noro, Aki Shionoya, Akiko Kawakami, Naoki Ogawa, Shoji Kudoh
The primary aim of this in vitro simulation study was to evaluate the utility of gene expression profile analysis in predicting the effect of varying drug combinations for the treatment of lung cancer. Using 10 human cancer cell lines, we focused our gene expression analysis on a cohort of candidate sensitivity-prediction factors, previously reported using cDNA filter arrays, with a view to predicting the ability of a set of anti-cancer drugs commonly used to treat lung cancer, namely cisplatin, 5-fluorouracil (5FU), SN38, docetaxel, gemcitabine, and vinorelbine...
June 2007: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
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