keyword
https://read.qxmd.com/read/38527626/infrared-microspectroscopy-to-elucidate-the-underlying-biomolecular-mechanisms-of-flash-radiotherapy
#21
JOURNAL ARTICLE
Immaculada Martínez-Rovira, Pierre Montay-Gruel, Benoît Petit, Ron Leavitt, Roberto González-Vegas, Pascal Froidevaux, Marjorie Juchaux, Yolanda Prezado, Ibraheem Yousef, Marie-Catherine Vozenin
BACKGROUND: FLASH-radiotherapy (FLASH-RT) is an emerging modality that uses ultra-high dose rates of radiation to enable curative doses to the tumor while preserving normal tissue. The biological studies showed the potential of FLASH-RT to revolutionize radiotherapy cancer treatments. However, the complex biological basis of FLASH-RT is not fully known yet. AIM: Within this context, our aim is to get deeper insights into the biomolecular mechanisms underlying FLASH-RT through Fourier Transform Infrared Microspectroscopy (FTIRM)...
March 23, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38526702/osteopontin-promotes-tumor-growth-and-metastasis-and-gpx4-mediated-anti-lipid-peroxidation-in-triple-negative-breast-cancer-by-activating-the-pi3k-akt-mtor-pathway
#22
JOURNAL ARTICLE
Man Guo, Mengyue Liu, Weihan Li, Cao Wang, Lu Zhang, Hao Zhang
PURPOSE: Triple-negative breast cancer (TNBC) features high aggressiveness, metastasis rate, drug resistance as well as poor prognosis. Osteopontin (OPN) is a key protein in the process of osteogenesis and has emerged as a new tumor marker in recent years. METHODS: Cell viability was tested with the CCK-8 kit. Transwell and wound healing were adopted to test cell invasive and migratory abilities. Tumor sphere formation was detected by tumor sphere formation assay...
March 25, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38526625/regulation-of-cancer-progression-by-ck2-an-emerging-therapeutic-target
#23
REVIEW
Shakeel Hussain, Yilei Guo, Yu Huo, Juanjuan Shi, Yongzhong Hou
Casein kinase II (CK2) is an enzyme with pleiotropic kinase activity that catalyzes the phosphorylation of lots of substrates, including STAT3, p53, JAK2, PTEN, RELA, and AKT, leading to the regulation of diabetes, cardiovascular diseases, angiogenesis, and tumor progression. CK2 is observed to have high expression in multiple types of cancer, which is associated with poor prognosis. CK2 holds significant importance in the intricate network of pathways involved in promoting cell proliferation, invasion, migration, apoptosis, and tumor growth by multiple pathways such as JAK2/STAT3, PI3K/AKT, ATF4/p21, and HSP90/Cdc37...
March 25, 2024: Medical Oncology
https://read.qxmd.com/read/38525782/effects-on-quality-of-life-of-a-telemonitoring-platform-amongst-patients-with-cancer-equalite-a-randomized-trial-protocol
#24
JOURNAL ARTICLE
Felipe Martínez, Carla Taramasco, Manuel Espinoza, Johanna Acevedo, Carolina Goic, Bruno Nervi
Cancer, a pervasive global health challenge, necessitates chemotherapy or radiotherapy treatments for many prevalent forms. However, traditional follow-up approaches encounter limitations, exacerbated by the recent COVID-19 pandemic. Consequently, telemonitoring has emerged as a promising solution, although its clinical implementation lacks comprehensive evidence. This report depicts the methodology of a randomized trial which aims to investigate whether leveraging a smartphone app called Contigo for disease monitoring enhances self-reported quality of life among patients with various solid cancers compared to standard care...
March 15, 2024: Methods and Protocols
https://read.qxmd.com/read/38525697/synbiotics-in-oncology-a-scoping-review-protocol-on-their-impact-and-outcomes-in-cancer-care
#25
JOURNAL ARTICLE
Silvia Belloni, Cristina Arrigoni, Maria Helena Ceruso, Chiara Giacon, Arianna Magon, Gianluca Conte, Marco Alfredo Arcidiacono, Rosario Caruso
Symptom management remains challenging in cancer care. Emerging from nutritional science, nutritional metabolomics has seen exponential growth over recent years, aiming to discern the relationship between dietary habits and health consequences. This protocol aims to present the rationale and methodology for conducting a scoping review to summarize the extent of evidence on synbiotics utilization in cancer symptom management among adults. The scoping review will be undertaken in accordance with the Joanna Briggs Institute (JBI) principles and the research process guided by the PRISMA 2020 scoping reviews extension...
March 22, 2024: Nursing Reports
https://read.qxmd.com/read/38525426/role-and-potential-therapeutic-value-of-histone-methyltransferases-in-drug-resistance-mechanisms-in-lung-cancer
#26
REVIEW
Linxiang Zhang, Xueying Zhang, Yan Shi, Yuhan Ni, Jiaojiao Fei, Zhixin Jin, Wenjuan Li, Xiaojing Wang, Nan Wu
Lung cancer, ranking second globally in both incidence and high mortality among common malignant tumors, presents a significant challenge with frequent occurrences of drug resistance despite the continuous emergence of novel therapeutic agents. This exacerbates disease progression, tumor recurrence, and ultimately leads to poor prognosis. Beyond acquired resistance due to genetic mutations, mounting evidence suggests a critical role of epigenetic mechanisms in this process. Numerous studies have indicated abnormal expression of Histone Methyltransferases (HMTs) in lung cancer, with the abnormal activation of certain HMTs closely linked to drug resistance...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38525424/therapeutically-targeting-the-unique-disease-landscape-of-pediatric-high-grade-gliomas
#27
REVIEW
Dasun Fernando, Afsar U Ahmed, Bryan R G Williams
Pediatric high-grade gliomas (pHGG) are a rare yet devastating malignancy of the central nervous system's glial support cells, affecting children, adolescents, and young adults. Tumors of the central nervous system account for the leading cause of pediatric mortality of which high-grade gliomas present a significantly grim prognosis. While the past few decades have seen many pediatric cancers experiencing significant improvements in overall survival, the prospect of survival for patients diagnosed with pHGGs has conversely remained unchanged...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38525423/application-of-three-dimensional-technology-in-video-assisted-thoracoscopic-surgery-sublobectomy
#28
Xinyu Zhang, Di Yang, Linqian Li, Jianing Wang, Si Liang, Peng Li, Zhe Han, Xiaodong Wang, Ke Zhang
BACKGROUND: Due to the widespread use of imaging techniques, the detection rate of early-stage lung cancer has increased. Video-assisted thoracoscopic surgery (VATS) sublobectomy has emerged as a prominent alternative to lobectomy, offering advantages like reduced resection range, better preservation of lung function, and enhanced postoperative quality of life. However, sublobectomy is more intricate than lobectomy, necessitating a higher level of surgical proficiency and anatomical understanding...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38524869/radiomics-signature-of-osteoarthritis-current-status-and-perspective
#29
REVIEW
Tianshu Jiang, Sing-Hin Lau, Jiang Zhang, Lok-Chun Chan, Wei Wang, Ping-Keung Chan, Jing Cai, Chunyi Wen
UNLABELLED: Osteoarthritis (OA) is one of the fast-growing disability-related diseases worldwide, which has significantly affected the quality of patients' lives and brings about substantial socioeconomic burdens in medical expenditure. There is currently no cure for OA once the bone damage is established. Unfortunately, the existing radiological examination is limited to grading the disease's severity and is insufficient to precisely diagnose OA, detect early OA or predict OA progression...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38523897/real-world-prostate-specific-antigen-reduction-and-survival-outcomes-of-metastatic-hormone-sensitive-prostate-cancer-patients-treated-with-apalutamide-an-observational-retrospective-and-multicentre-study
#30
JOURNAL ARTICLE
Alicia López-Abad, Miguel Ramírez Backhaus, Gerardo Server Gómez, Enrique Cao Avellaneda, Cristóbal Moreno Alarcón, Pedro López Cubillana, Pablo Yago Giménez, Pedro de Pablos Rodríguez, María J Juan Fita, Miguel Á Climent Durán, Iris Guardiola Ruiz, Natalia Vidal Crespo, Miriam Artés Artés, Raúl Montoya Chinchilla, Juan Moreno Avilés, Pablo L Guzmán Martínez-Valls, Pedro Á López González
BACKGROUND: Metastatic hormone-sensitive prostate cancer (mHSPC) treatment has changed drastically during the last years with the emergence of androgen receptor-targeted agents (ARTAs). ARTA combined with androgen deprivation therapy has demonstrated better oncological and survival outcomes in these patients. However, the optimal choice among different ARTAs remains uncertain due to their analogous efficacy. OBJECTIVES: The objective of this study was to describe prostate-specific antigen (PSA) response and oncological outcomes of patients with mHSPC treated with apalutamide...
March 2024: Prostate International
https://read.qxmd.com/read/38523649/addressing-disparities-in-cancer-clinical-trials-a-roadmap-to-more-equitable-accrual
#31
JOURNAL ARTICLE
Jon A Hoin, Bradley C Carthon, Shantoria J Brown, Lynn M Durham, L Crain Garrot, Sharad A Ghamande, Andrew W Pippas, Brian M Rivers, Cindy T Snyder, Sheryl Gordon Ann Gabram-Mendola
The Georgia Center for Oncology Research and Education (Georgia CORE) and the Georgia Society of Clinical Oncology (GASCO) held a one-day summit exploring opportunities and evidence-based interventions to address disparities in cancer clinical trials. The purpose of the summit was to identify clear and concise recommendations aimed at decreasing clinical trial accrual disparities in Georgia for rural and minority populations. The summit included expert presentations, panel discussions with leaders from provider organizations throughout Georgia, and breakout sessions to allow participants to critically discuss the information presented...
2024: Front Health Serv
https://read.qxmd.com/read/38523467/current-perspectives-on-radiotherapy-in-hepatocellular-carcinoma-management-a-comprehensive-review
#32
JOURNAL ARTICLE
Dowook Kim, Jun-Sang Kim
This review examines the transformative role of external beam radiotherapy (EBRT) in managing hepatocellular carcinoma (HCC), spotlighting the progression from traditional EBRT techniques to advanced modalities like intensity-modulated radiotherapy (RT), stereotactic body RT (SBRT), and innovative particle therapy, including proton beam therapy and carbon ion RT. These advancements have significantly improved the precision and efficacy of RT, marking a paradigm shift in the multimodal management of HCC, particularly in addressing complex cases and enhancing local tumor control...
March 25, 2024: Journal of liver cancer
https://read.qxmd.com/read/38523336/identifying-metrics-and-designing-measurable-outcomes-in-the-electronic-health-record-to-evaluate-pharmacist-intervention-in-an-oral-chemotherapy-program
#33
JOURNAL ARTICLE
Shelby Koppinger, Elizabeth Weil, Nichole Ruffcorn, Erin McGurty, Kevin Creal, Melissa Rhoades
INTRODUCTION: Due to the increased utilization of oral anticancer agents, pharmacist-led oral anticancer programs have emerged to meet the needs of oral anticancer management. Currently, at Froedtert & MCW, there is a lack of established tools to collect metrics which demonstrate the value of a pharmacist-led oral anticancer program. METHODS: The purpose of this project is to establish metrics that reflect the interventions pharmacists are performing, and second, to develop a documentation tool which can reliably extract discrete data on the identified metrics...
March 24, 2024: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/38523303/recurrent-severe-hypocalcemia-following-chemotherapy-regimen-changes-in-advanced-breast-cancer-two-case-reports
#34
JOURNAL ARTICLE
Yurina Yanase, Hiroko Bando, Riko Sato, Tomohei Matsuo, Aya Ueda, Mai Okazaki, Sachie Hashimoto, Akiko Iguchi-Manaka, Hisato Hara
BACKGROUND: As an oncologic emergency related to abnormalities in calcium metabolism, hypercalcemia associated with paraneoplastic syndrome and bone metastases is well known. Meanwhile, the incidence of hypocalcemia is low, except in cases associated with bone-modifying agents used for bone metastases. Hypocalcemia induced by bone-modifying agents typically occurs early after the initial administration, and its incidence can be significantly reduced by preventive administration of calcium and vitamin D3 supplements...
March 25, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38523017/three-and-seven-month-prostate-specific-antigen-levels-as-prognostic-markers-for-overall-survival-in-metastatic-hormone-sensitive-prostate-cancer-results-from-swog-s1216-a-phase-3-randomized-trial-of-androgen-deprivation-plus-orteronel-or-bicalutamide
#35
JOURNAL ARTICLE
Mamta Parikh, Catherine Tangen, Maha H A Hussain, Shilpa Gupta, Sam Callis, Yeonjung Jo, Andrea Harzstark, Channing J Paller, Saby George, Matthew R Zibelman, Heather H Cheng, Benjamin L Maughan, Jingsong Zhang, Russell K Pachynski, Alan H Bryce, Daniel W Lin, David I Quinn, Seth P Lerner, Ian M Thompson, Tanya B Dorff, Primo N Lara, Neeraj Agarwal
BACKGROUND: A robust decrease in prostate-specific antigen (PSA) in response to androgen deprivation therapy (ADT) has been evaluated as a prognostic factor in patients with metastatic hormone-sensitive prostate cancer (mHSPC) since 2006, but the treatment of mHSPC has since evolved to include intensified therapy. OBJECTIVE: We assessed the association of PSA levels at 3 (PSA-3mo) and 7 (PSA-7mo) mo with overall survival (OS) in patients with mHSPC treated with ADT combined with either bicalutamide or orteronel in the S1216 phase 3 clinical trial...
March 23, 2024: European Urology Oncology
https://read.qxmd.com/read/38522889/endoscopic-resection-of-residual-rectal-neoplasia-after-definitive-chemoradiotherapy-for-rectal-cancer
#36
REVIEW
Robert Klimkowski, Jakub Krzyzkowiak, Nastazja Dagny Pilonis, Krzysztof Bujko, Michal F Kaminski
The conventional approach to treating locally advanced rectal cancer, commonly defined as cT3 or cT4 primary tumors or with nodal metastases, involves chemoradiation (CRT) followed by surgical resection. There is a growing recognition of the potential for nonsurgical management following CRT or total neoadjuvant therapy (TNT), which allows for organ preservation. "Watch and wait" strategy may be considered if complete clinical response is achieved. In cases when adenoma or superficial cancer is present, a novel approach known as "salvage endoscopic resection of the residual disease" is emerging as a viable nonsurgical option for carefully selected patients...
February 2024: Best Practice & Research. Clinical Gastroenterology
https://read.qxmd.com/read/38522368/finding-value-in-novel-antibiotics-how-can-infectious-diseases-adopt-incremental-cost-effectiveness-to-improve-new-antibiotic-utilization
#37
JOURNAL ARTICLE
Sean R Van Helden, Lucas T Schulz, Megan Wimmer, Victoria L Cancelliere, Warren E Rose
Research and development of innovative antimicrobials is paramount to addressing the antimicrobial resistance threat. Although antimicrobial discovery and development has increased, difficulties have emerged in the pharmaceutical industry after market approval. In this minireview, we summarize clinical trial data on recently approved antibiotics, calculate incremental cost-effectiveness ratio (ICER) values, and explore ways to adapt ICER calculations to the limitations of antimicrobial clinical trial design...
March 8, 2024: Diagnostic Microbiology and Infectious Disease
https://read.qxmd.com/read/38522058/design-and-evaluation-of-a-multiepitope-vaccine-for-pancreatic-cancer-using-immune-dominant-epitopes-derived-from-the-signature-proteome-in-expression-datasets
#38
JOURNAL ARTICLE
Sooram Banesh, Nupoor Patil, Vihadhar Reddy Chethireddy, Arnav Bhukmaria, Prakash Saudagar
Pancreatic cancer is a highly aggressive and often lethal malignancy with limited treatment options. Its late-stage diagnosis and resistance to conventional therapies make it a significant challenge in oncology. Immunotherapy, particularly cancer vaccines, has emerged as a promising avenue for treating pancreatic cancer. Multi-epitope vaccines, designed to target multiple epitopes derived from various antigens associated with pancreatic cancer, have gained attention as potential candidates for improving therapeutic outcomes...
March 24, 2024: Medical Oncology
https://read.qxmd.com/read/38522008/developments-and-future-prospects-of-personalized-medicine-in-head-and-neck-squamous-cell-carcinoma-diagnoses-and-treatments
#39
REVIEW
Shalindu Malshan Jayawickrama, Piyumi Madhushani Ranaweera, Ratupaskatiye Gedara Gunaratnege Roshan Pradeep, Yovanthi Anurangi Jayasinghe, Kalpani Senevirathna, Abdul Jabbar Hilmi, Rajapakse Mudiyanselage Gamini Rajapakse, Kehinde Kazeem Kanmodi, Ruwan Duminda Jayasinghe
BACKGROUND: Precision healthcare has entered a new era because of the developments in personalized medicine, especially in the diagnosis and treatment of head and neck squamous cell carcinoma (HNSCC). This paper explores the dynamic landscape of personalized medicine as applied to HNSCC, encompassing both current developments and future prospects. RECENT FINDINGS: The integration of personalized medicine strategies into HNSCC diagnosis is driven by the utilization of genetic data and biomarkers...
March 2024: Cancer reports
https://read.qxmd.com/read/38521965/emerging-measurements-for-tumor-infiltrating-lymphocytes-in-breast-cancer
#40
JOURNAL ARTICLE
Rongrong Wu, Yoshiya Horimoto, Masanori Oshi, Matthew G K Benesch, Thaer Khoury, Kazuaki Takabe, Takashi Ishikawa
Tumor-infiltrating lymphocytes are a general term for lymphocytes or immune cells infiltrating the tumor microenvironment. Numerous studies have demonstrated tumor-infiltrating lymphocytes to be robust prognostic and predictive biomarkers in breast cancer. Recently, immune checkpoint inhibitors, which directly target tumor-infiltrating lymphocytes, have become part of standard of care treatment for triple-negative breast cancer. Surprisingly, tumor-infiltrating lymphocytes quantified by conventional methods do not predict response to immune checkpoint inhibitors, which highlights the heterogeneity of tumor-infiltrating lymphocytes and the complexity of the immune network in the tumor microenvironment...
March 23, 2024: Japanese Journal of Clinical Oncology
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