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https://www.readbyqxmd.com/read/29789657/the-cooh-terminal-domain-of-huntingtin-interacts-with-rhogef-kalirin-and-modulates-cell-survival
#1
Hollis McClory, Xiaolong Wang, Ellen Sapp, Leah W Gatune, Maria Iuliano, Chiu-Yi Wu, Gina Nathwani, Kimberly B Kegel-Gleason, Marian DiFiglia, Xueyi Li
Human huntingtin (Htt) contains 3144 amino acids and has an expanded polyglutamine region near the NH2 -terminus in patients with Huntington's disease. While numerous binding partners have been identified to NH2 -terminal Htt, fewer proteins are known to interact with C-terminal domains of Htt. Here we report that kalirin, a Rac1 activator, is a binding partner to C-terminal Htt. Kalirin and Htt co-precipitated from mouse brain endosomes and co-localized at puncta in NRK and immortalized striatal cells and primary cortical neurons...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29751333/head-shape-disparity-impacts-pollutant-accumulation-in-european-eel
#2
Jens De Meyer, Claude Belpaire, Pascal Boeckx, Lieven Bervoets, Adrian Covaci, Govindan Malarvannan, Barbara De Kegel, Dominique Adriaens
Several aspects of the life cycle of the critically endangered European eel (Anguilla anguilla) remain poorly understood. One such aspect is the broad-versus narrow-head dimorphism, and how this impacts their overall performance at different stages of their life cycle. At the yellow eel stage, the phenotypes show a trophic divergence. We investigated whether pollutant accumulation is affected by this disparity. We show that broad-headed eels contained higher concentrations of mercury and several lipophilic organic pollutants, compared to narrow-headed ones, irrespective of their fat content...
May 8, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29737166/effect-of-surface-and-defect-chemistry-on-the-photo-catalytic-properties-of-intentionally-defect-rich-zno-nanorod-arrays
#3
Jan Kegel, Vitaly Z Zubialevich, Michael Schmidt, Ian M Povey, Martyn E Pemble
Due to the abundance of intrinsic defects in zinc oxide (ZnO) the material properties are often governed by same. Knowledge of the defect chemistry has proven to be highly important, especially in terms of the photo-catalytic degradation of pollutants. Given the fact that defect-free materials or structures exhibiting only one type of defect are extremely difficult to produce, it is necessary to evaluate what influence various defects may have when present together in the material. In this study, intentionally defect-rich ZnO nanorod (NR) arrays are grown using a simple low-temperature solution-based growth technique...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29727372/the-effect-of-commonly-performed-exercises-on-the-levator-hiatus-area-and-the-length-and-strength-of-pelvic-floor-muscles-in-postpartum-women
#4
Lauren N Siff, Audra J Hill, Samantha J Walters, Ginny Walters, Mark D Walters
OBJECTIVE: The aim oft his study was to compare the effects of 10 common exercises to traditional pelvic floor muscle (PFM) contractions (Kegel) on levator hiatus (LH) area and PFM length and strength. METHODS: This is a cross-sectional study of 15 healthy postpartum women. Ten exercises were studied. These were common variations of leg, core, and back exercises used in yoga, Pilates, strength training, and physical therapy. Each participant performed all 10 exercises at a single visit in 2 examination settings: transperineal ultrasound and perineometry...
May 2, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29616429/the-different-faces-of-mass-action-in-virus-assembly
#5
Bart van der Holst, Willem K Kegel, Roya Zandi, Paul van der Schoot
The spontaneous encapsulation of genomic and non-genomic polyanions by coat proteins of simple icosahedral viruses is driven, in the first instance, by electrostatic interactions with polycationic RNA binding domains on these proteins. The efficiency with which the polyanions can be encapsulated in vitro, and presumably also in vivo, must in addition be governed by the loss of translational and mixing entropy associated with co-assembly, at least if this co-assembly constitutes a reversible process. These forms of entropy counteract the impact of attractive interactions between the constituents and hence they counteract complexation...
April 3, 2018: Journal of Biological Physics
https://www.readbyqxmd.com/read/29601860/urinary-excretion-of-heptanones-heptanoles-and-2-5-heptanedione-after-controlled-acute-exposure-of-volunteers-to-n-heptane
#6
Bernd Rossbach, Peter Kegel, Stephan Letzel
A lack of well-established parameters and assessment values currently impairs biomonitoring of n-heptane exposure. Using controlled inhalation experiments, our study aimed to collect information on the time course of urinary n-heptane metabolite excretion. By analysing associations between external and internal exposure we investigated the suitability of selected metabolites to reflect n-heptane uptake. Twenty healthy, non-smoking males (aged 19-38 years, median 25.5) were exposed for 3hs to 160, 330 and 500 ppm n-heptane, each...
March 27, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29540090/the-effect-of-pelvic-floor-muscle-training-on-incontinence-problems-after-radical-prostatectomy
#7
Aylin Aydın Sayılan, Ayfer Özbaş
The aim of the current study was to determine the effect of pelvic floor muscle exercises (PFME/Kegel) training administered to patients scheduled for robot-assisted radical prostatectomy on postprocedural incontinence problems. This study was a randomized controlled trial. Pelvic floor muscle exercises were applied to the procedure group three times a day for 6 months. No exercises were applied to the control group. Incontinence and quality-of-life assessments of the 60 patients in the experimental and control groups were performed on months 0 (10 days after removal of the urinary catheter), 1, 3, and 6 through face-to-face and telephone interviews...
March 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29489554/evaluation-of-smartphone-pelvic-floor-exercise-applications-using-standardized-scoring-system
#8
Kara Lauren Barnes, Gena Dunivan, Ashley Jaramillo-Huff, Tessa Krantz, Jennifer Thompson, Peter Jeppson
OBJECTIVE: The aim of this study was to identify smartphone Kegel and pelvic floor exercise applications (apps) and identify those with superior functionality, features, and accuracy. METHODS: We identified a complete list of Kegel and pelvic floor exercise applications by searching iTunes and Google Play stores for "pelvic floor," "pelvic floor exercises," "Kegel," and "Kegel exercises." We used a modified APPLICATIONS scoring system to evaluate all identified apps...
February 27, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29388507/long-range-gamma-phase-synchronization-as-a-compensatory-strategy-during-working-memory-in-high-performing-patients-with-schizophrenia
#9
Rachel P So, Lawrence S Kegeles, Xiangling Mao, Dikoma C Shungu, Arielle D Stanford, Chi-Ming A Chen
Working memory deficits in schizophrenia may be associated with impairments in the integration of neural activity across a distributed network of cortical areas. However, evaluation of the contribution of this integration to working memory impairments in patients is severely confounded by behavioral performance. In the present multidimensional-neuroimaging study, measures of neural oscillations at baseline and during a working memory task, baseline gamma-aminobutyric acid (GABA) level in the left dorsolateral prefrontal cortex (DLPFC), and behavioral performance were obtained...
February 1, 2018: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29371052/analytical-performance-of-a-commercial-multiplex-luminex-based-cytokine-panel-in-the-rat
#10
Tim Erkens, Nick Goeminne, Ann Kegels, Martine Byloos, Petra Vinken
INTRODUCTION: Multiplex immunoassays are an important tool in biomarker research during preclinical drug development. However, information regarding analytical performance of commercial multiplex assays for animal species is often limited. To be able to correctly interpret study results, a fit-for-purpose validation approach is recommended. The objective of our study was to provide a realistic example of what level of validation can be expected from this type of assay, using a rat cytokine panel...
May 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29349582/can-we-evaluate-the-levator-ani-after-kegel-exercise-in-women-with-pelvic-organ-prolapse-by-transperineal-elastography-a-preliminary-study
#11
Meng Xie, Xuyin Zhang, Xiaodan Zhang, Wenping Wang, Keqin Hua
OBJECTIVES: The aim of this study was to evaluate the stiffness variation of the levator ani in patients with stage I/II pelvic organ prolapse (POP) before and after Kegel exercises by transperineal elastography. METHODS: A total of 20 patients who were diagnosed with staged I/II POP underwent conventional transperineal ultrasound and elastography. For each patient, the levator ani was located and evaluated in the state of Valsalva. After Kegel exercises for 12 weeks, transperineal ultrasound and elastography were repeated...
January 18, 2018: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29346965/solute-mediated-interactions-between-active-droplets
#12
Pepijn G Moerman, Henrique W Moyses, Ernest B van der Wee, David G Grier, Alfons van Blaaderen, Willem K Kegel, Jan Groenewold, Jasna Brujic
Concentration gradients play a critical role in embryogenesis, bacterial locomotion, as well as the motility of active particles. Particles develop concentration profiles around them by dissolution, adsorption, or the reactivity of surface species. These gradients change the surface energy of the particles, driving both their self-propulsion and governing their interactions. Here, we uncover a regime in which solute gradients mediate interactions between slowly dissolving droplets without causing autophoresis...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29311665/hippocampal-dysfunction-in-the-pathophysiology-of-schizophrenia-a-selective-review-and-hypothesis-for-early-detection-and-intervention
#13
J A Lieberman, R R Girgis, G Brucato, H Moore, F Provenzano, L Kegeles, D Javitt, J Kantrowitz, M M Wall, C M Corcoran, S A Schobel, S A Small
Scientists have long sought to characterize the pathophysiologic basis of schizophrenia and develop biomarkers that could identify the illness. Extensive postmortem and in vivo neuroimaging research has described the early involvement of the hippocampus in the pathophysiology of schizophrenia. In this context, we have developed a hypothesis that describes the evolution of schizophrenia-from the premorbid through the prodromal stages to syndromal psychosis-and posits dysregulation of glutamate neurotransmission beginning in the CA1 region of the hippocampus as inducing attenuated psychotic symptoms and initiating the transition to syndromal psychosis...
January 9, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29193066/broader-head-stronger-bite-in-vivo-bite-forces-in-european-eel-anguilla-anguilla
#14
J De Meyer, A Herrel, C Belpaire, G Goemans, C Ide, B De Kegel, J Christiaens, D Adriaens
This work examined three different phenotypes of the yellow-eel stage of the European eel Anguilla anguilla, broad-heads, narrow-heads and eels with an intermediate head shape. The aim was to see whether broad-headed A. anguilla, which generally consume harder, larger prey, such as crustaceans and fish, exerted greater bite force than the narrow-headed variant, which mainly consume soft, small prey such as chironomid larvae. It was found that in 99 yellow A. anguilla, in vivo bite force of broad-heads are higher compared with narrow-heads and intermediates...
January 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29189336/history-of-high-motion-sickness-susceptibility-predicts-vestibular-dysfunction-following-sport-recreation-related-concussion
#15
Alicia M Sufrinko, Nathan E Kegel, Anne Mucha, Michael W Collins, Anthony P Kontos
OBJECTIVE: To compare vestibular dysfunction at 1 to 10 and 11 to 20 days following sport/recreation-related concussion (SRC) in athletes with and without history of motion sickness susceptibility. Secondary aims of this study were to investigate differences in neurocognitive performance and affective symptoms in these groups. DESIGN: Cross-sectional. SETTING: Concussion Specialty Clinic. PARTICIPANTS: One hundred twenty-four adolescents and adults (82 males, 42 females) aged 14 to 26 (16...
November 20, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29167877/utility-of-imaging-based-biomarkers-for-glutamate-targeted-drug-development-in-psychotic-disorders-a-randomized-clinical-trial
#16
Daniel C Javitt, Cameron S Carter, John H Krystal, Joshua T Kantrowitz, Ragy R Girgis, Lawrence S Kegeles, John D Ragland, Richard J Maddock, Tyler A Lesh, Costin Tanase, Philip R Corlett, Douglas L Rothman, Graeme Mason, Maolin Qiu, James Robinson, William Z Potter, Marlene Carlson, Melanie M Wall, Tse-Hwei Choo, Jack Grinband, Jeffrey A Lieberman
Importance: Despite strong theoretical rationale and preclinical evidence, several glutamate-targeted treatments for schizophrenia have failed in recent pivotal trials, prompting questions as to target validity, compound inadequacy, or lack of target engagement. A key limitation for glutamate-based treatment development is the lack of functional target-engagement biomarkers for translation between preclinical and early-stage clinical studies. We evaluated the utility of 3 potential biomarkers-ketamine-evoked changes in the functional magnetic imaging (fMRI) blood oxygen level-dependent response (pharmacoBOLD), glutamate proton magnetic resonance spectroscopy (1H MRS), and task-based fMRI-for detecting ketamine-related alterations in brain glutamate...
January 1, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29155803/pet-imaging-of-dopamine-d2-receptor-internalization-in-schizophrenia
#17
J J Weinstein, E van de Giessen, R J Rosengard, X Xu, N Ojeil, G Brucato, R B Gil, L S Kegeles, M Laruelle, M Slifstein, A Abi-Dargham
This corrects the article DOI: 10.1038/mp.2017.107.
July 25, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29077651/exploring-the-relationship-between-body-mass-index-and-positive-symptom-severity-in-persons-at-clinical-high-risk-for-psychosis
#18
Fernando Caravaggio, Gary Brucato, Lawrence S Kegeles, Eugénie Lehembre-Shiah, Leigh Y Arndt, Tiziano Colibazzi, Ragy Girgis
Metabolic health and positive symptom severity has been investigated in schizophrenia, but not in clinical high risk (CHR) patients. We hypothesized that greater body mass index (BMI) in CHR patients would be related to less positive symptoms. We examined this relationship in CHR patients being treated with 1) no psychotropic medications (n = 58), 2) an antipsychotic (n = 14), or 3) an antidepressant without an antipsychotic (n = 10). We found no relationship between BMI and positive symptoms in unmedicated CHR patients, the majority of whom had a narrow BMI range between 20 and 30...
November 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29072016/-clinical-observation-of-heat-sensitive-moxibustion-combined-with-kegel-exercise-therapy-for-female-stress-urinary-incontinence
#19
Dan Hu, Peng Deng, Lin Jiao, Jun Xiong, Ding-Yi Xie, Ri-Xin Chen
OBJECTIVE: To compare the clinical effects of heat-sensitive moxibustion combined with kegel exercise therapy and simple kegel exercise therapy on female stress urinary incontinence. METHODS: Forty-five female patients with stress urinary incontinence were randomly divided into a treatment group (n=23) and a control group (n=22). Kegel exercise therapy was applied in the two groups. Heat-sensitive moxibustion was used at Zhongji (CV 3), Qihai (CV 6), Ciliao (BL 32) and Shen-shu (BL 23) in the treatment group, once a day for the first 10 times, and once every other day until 5 sessions were given, 10 times as one session...
August 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29067248/the-effect-of-text-message-support-on-diabetes-self-management-in-developing-countries-a-randomised-trial
#20
Josefien Van Olmen, Guy Kegels, Catherine Korachais, Jeroen de Man, Kristien Van Acker, Jean Clovis Kalobu, Maurits van Pelt, Grace Marie Ku, Heang Hen, Dominique Kanda, Billy Malombo, Christian Darras, François Schellevis
OBJECTIVE: mHealth interventions have the potential to facilitate self-management. This TEXT4DSM study implemented a mobile phone intervention in existing diabetes programmes in three low- and middle-income countries (Democratic Republic of Congo, Cambodia, and the Philippines). RESEARCH DESIGN AND METHODS: Sub-studies with a similar randomised controlled trial design were conducted in three different countries. Each sub-study included 480 adults with diabetes. Subjects were randomised to receive either routine care or routine care plus text message self-management support...
March 2017: Journal of Clinical & Translational Endocrinology
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