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https://www.readbyqxmd.com/read/28516158/a-management-algorithm-for-mitomycin-c-induced-cystitis
#1
Amy N Luckenbaugh, Rory M Marks, David C Miller, Alon Z Weizer, John T Stoffel, Jeffrey S Montgomery
Background/Objective: A post-bladder tumor resection dose of MMC can reduce non-invasive papillary (pTa) bladder cancer recurrences by up to 40%; this treatment is recommended in both the AUA and EUA non-muscle-invasive bladder cancer guidelines. A common complication of this treatment is eosinophilic cystitis. Symptoms range from mild urinary frequency and urgency to debilitating pain and dysuria. Currently, there is no established treatment algorithm for MMC-induced cystitis. Methods: Members of the Urologic Surgery Quality Collaborative (USQC), a group composed of over 160 private and academic urologists, met to discuss the management of patients with cystitis following MMC therapy...
April 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28514658/cns-macrophages-control-neurovascular-development-via-cd95l
#2
Si Chen, Nathalie Tisch, Marcel Kegel, Rosario Yerbes, Robert Hermann, Hannes Hudalla, Cecilia Zuliani, Gülce Sila Gülcüler, Klara Zwadlo, Jakob von Engelhardt, Carmen Ruiz de Almodóvar, Ana Martin-Villalba
The development of neurons and vessels shares striking anatomical and molecular features, and it is presumably orchestrated by an overlapping repertoire of extracellular signals. CNS macrophages have been implicated in various developmental functions, including the morphogenesis of neurons and vessels. However, whether CNS macrophages can coordinately influence neurovascular development and the identity of the signals involved therein is unclear. Here, we demonstrate that activity of the cell surface receptor CD95 regulates neuronal and vascular morphogenesis in the post-natal brain and retina...
May 16, 2017: Cell Reports
https://www.readbyqxmd.com/read/28507321/pet-imaging-of-dopamine-d2-receptor-internalization-in-schizophrenia
#3
J J Weinstein, E van de Giessen, R J Rosengard, X Xu, N Ojeil, G Brucato, R B Gil, L S Kegeles, M Laruelle, M Slifstein, A Abi-Dargham
Recent genetic, molecular and post-mortem studies suggest impaired dopamine (DA)-D2 receptor (D2R) trafficking in patients with schizophrenia (SZ). Imaging and preclinical studies have shown agonist-induced D2R internalization can be imaged with positron emission tomography (PET) using D2R radiotracers combined with psychostimulant challenge. This is feasible if radiotracer binding is measured when postchallenge DA levels have returned to baseline, following the initial competition phase between DA and radiotracer for binding to D2R...
May 16, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28451671/defect-promoted-photo-electrochemical-performance-enhancement-of-orange-luminescent-zno-nanorod-arrays
#4
Jan Kegel, Fathima Laffir, Ian M Povey, Martyn E Pemble
Intentionally defect-rich zinc oxide (ZnO) nanorod-arrays were grown from solution by carefully adjusting the concentration ratio of the growth-precursors used followed by various post-deposition thermal treatments. Post-deposition rapid thermal annealing (RTA) at moderate temperatures (350 °C-550 °C) and in various atmospheres was applied to vary the defect composition of the grown nanorod-arrays. It is demonstrated that, intense, defect-related orange emission occurs solely upon RTA around 450 °C and is essentially independent of the atmosphere used...
May 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28419800/ph-reversible-encapsulation-of-oppositely-charged-colloids-mediated-by-polyelectrolytes
#5
Yong Guo, Bas G P van Ravensteijn, Chris H J Evers, Willem K Kegel
We report the first example of reversible encapsulation of micron-sized particles by oppositely charged submicron smaller colloids. The reversibility of this encapsulation process is regulated by pH-responsive poly(acrylic acid) (PAA) present in solution. The competitive adsorption between the small colloids and the poly(acrylic acid) on the surface of the large colloids plays a key role in the encapsulation behavior of the system. pH offers an experimental knob to tune the electrostatic interactions between the two oppositely charged particle species via regulation of the charge density of the poly(acrylic acid)...
May 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28319751/spirituality-religiosity-substance-use-and-hiv-testing-among-young-black-men-who-have-sex-with-men
#6
Adam W Carrico, Erik David Storholm, Annesa Flentje, Emily A Arnold, Lance M Pollack, Torsten B Neilands, Gregory M Rebchook, John L Peterson, Agatha Eke, Wayne Johnson, Susan M Kegeles
BACKGROUND: Spirituality and religiosity may serve as both a resource and a barrier to HIV prevention with young black men who have sex with men (YBMSM). We examined indices of spirituality/religiosity as correlates of binge drinking, stimulant use, and recent HIV testing in a sample of YBMSM. METHODS: From 2011-2013, annual venue-based surveys of sexually active YBMSM ages 18-29 were conducted in Dallas and Houston, Texas. Binge drinking and stimulant use were assessed in the past two months...
May 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28279587/learning-to-live-with-hiv-in-the-rural-townships-a-photovoice-study-of-men-who-have-sex-with-men-living-with-hiv-in-mpumalanga-south-africa
#7
Joseph Daniels, Kabelo Maleke, Tim Lane, Helen Struthers, James McIntyre, Susan Kegeles, Alison Moore, Thomas Coates
There is limited understanding about the health and well-being of men who have sex with men (MSM) with HIV infection living in rural African areas. We present the results of an adapted photovoice project with 35 MSM with HIV infection who live in townships in Mpumalanga, South Africa. The project was designed to explore the social factors that influenced HIV care. Twenty-four photo essays were developed by participants in focus group discussions that were audio-recorded and transcribed for analysis. Transcripts and photo essays were coded using a constant comparison approach combining researcher observation notes and reflection on participant-identified themes...
May 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28272895/depletion-induced-encapsulation-by-dumbbell-shaped-patchy-colloids-stabilize-microspheres-against-aggregation
#8
Joost R Wolters, Joanne E Verweij, Guido Avvisati, Marjolein Dijkstra, Willem K Kegel
In this paper, we demonstrate the stabilization of polystyrene microspheres by encapsulating them with dumbbell-shaped colloids with a sticky and a nonsticky lobe. Upon adding a depletant, an effective short ranged attraction is induced between the microspheres and the smaller, smooth lobes of the dumbbells, making those specifically sticky, whereas the interaction with the larger lobes of the dumbbells is considerably less attractive due to their rough surface, which reduces the overlap volume and leaves them nonsticky...
April 4, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28252827/the-effect-of-rehabilitation-exercises-combined-with-direct-vagina-low-voltage-low-frequency-electric-stimulation-on-pelvic-nerve-electrophysiology-and-tissue-function-in-primiparous-women-a-randomised-controlled-trial
#9
Sumian Yang, Wenshu Sang, Jing Feng, Haifeng Zhao, Xian Li, Ping Li, Hongfang Fan, Zengjun Tang, Lina Gao
AIM AND OBJECTIVE: To evaluate the effect of rehabilitation exercises combined with Direct Vagina Low Voltage Low Frequency Electric Stimulation (DES) on pelvic nerve electrophysiology and tissue function after delivery. BACKGROUND: Whether and how DES effects pelvic floor dysfunction (PFD) are not known clearly. DESIGN: This was a randomised, controlled clinical trial. METHODS: The 189 primiparous women 20-35 years old and with an episiotomy or second degree episiotomy tear were divided into three groups: the control group (n=60) received routine postpartum guidance 2 hours postpartum, the training group (n=63) performed rehabilitation exercises (Kegel exercises and pelvic movements) from 2 days postpartum until 3 months postpartum, and the combination group (n=66) received DES 15 times (3 times a week for 30 min at a time) beginning at the sixth week postpartum in addition to performing rehabilitation exercises...
March 2, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28225904/invasive-haemophilus-influenzae-disease-in-the-vaccine-era-in-rio-de-janeiro-brazil
#10
Mari Tuyama, Jessica Corrêa-Antônio, Jessica Schlackman, Jane W Marsh, Maria C Rebelo, Elaine O Cerqueira, Márcio Nehab, Fabíola Kegele, Getúlio F Carmo, Dominique Ca Thielmann, Paulo F Barroso, Lee H Harrison, David E Barroso
BACKGROUND: Haemophilus influenzae (Hi) serotype b (Hib) conjugate vaccine was incorporated into the infant immunisation schedule in Brazil in 1999, where Hib was one of the major etiologic sources of community-acquired bacterial meningitis. OBJECTIVES: The purpose of this study is to describe the molecular epidemiology of invasive Hi disease in Rio de Janeiro state, Brazil, before and after vaccine introduction. METHODS: Surveillance data from 1986 to 2014 were analysed...
March 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28225898/invasive-haemophilus-influenzae-disease-in-the-vaccine-era-in-rio-de-janeiro-brazil
#11
Mari Tuyama, Jessica Corrêa-Antônio, Jessica Schlackman, Jane W Marsh, Maria C Rebelo, Elaine O Cerqueira, Márcio Nehab, Fabíola Kegele, Getúlio F Carmo, Dominique Ca Thielmann, Paulo F Barroso, Lee H Harrison, David E Barroso
BACKGROUND: Haemophilus influenzae (Hi) serotype b (Hib) conjugate vaccine was incorporated into the infant immunisation schedule in Brazil in 1999, where Hib was one of the major etiologic sources of community-acquired bacterial meningitis. OBJECTIVES: The purpose of this study is to describe the molecular epidemiology of invasive Hi disease in Rio de Janeiro state, Brazil, before and after vaccine introduction. METHODS: Surveillance data from 1986 to 2014 were analysed...
February 16, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28195781/an-evaluation-of-mpowerment-on-individual-level-hiv-risk-behavior-testing-and-psychosocial-factors-among-young-msm-of-color-the-monitoring-and-evaluation-of-mp-mem-project
#12
Gene Shelley, Weston Williams, Gary Uhl, Tamoka Hoyte, Adanze Eke, Carolyn Wright, Gregory Rebchook, Lance Pollack, Kelly Bell, Yan Wang, Qi Cheng, Susan M Kegeles
Young men who have sex with men (MSM) of color are at increased risk for HIV infection. Mpowerment (MP) is an intervention designed to reduce risky sexual behavior and increase HIV testing among young MSM ages 18-29. From 2009 to 2012, three community-based organizations with support from the U.S. Centers for Disease Control and Prevention evaluated MP among N = 298 participants. Following a repeated measures design, data from 3- and 6-month follow-ups were compared to baseline. HIV testing and self-efficacy for safer sex increased at both follow-up time points; self-acceptance as an MSM was higher at follow-up 2...
February 2017: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/28129757/identifying-social-and-economic-barriers-to-regular-care-and-treatment-for-black-men-who-have-sex-with-men-and-women-bmsmw-and-who-are-living-with-hiv-a-qualitative-study-from-the-bruthas-cohort
#13
Emily A Arnold, John Weeks, Michael Benjamin, William R Stewart, Lance M Pollack, Susan M Kegeles, Don Operario
BACKGROUND: There is little research regarding the ability of Black men who have sex with men and women (BMSMW) to access and maintain HIV-related health care and treatment adherence. This population, who often insist on secrecy about their same-sex desire, may experience unique barriers to seeking regular care and treatment. METHODS: From March 2011-April 2014, we recruited 396 BMSMW in the San Francisco Bay Area to be enrolled in our randomized controlled trial...
January 28, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28073524/distribution-occurrence-and-biotoxin-composition-of-the-main-shellfish-toxin-producing-microalgae-within-european-waters-a-comparison-of-methods-of-analysis
#14
Sara E McNamee, Linda K Medlin, Jessica Kegel, Gary R McCoy, Robin Raine, Lucia Barra, Maria Valeria Ruggiero, Wiebe H C F Kooistra, Marina Montresor, Johannes Hagstrom, Eva Perez Blanco, Edna Graneli, Francisco Rodríguez, Laura Escalera, Beatriz Reguera, Simon Dittami, Bente Edvardsen, Joe Taylor, Jane M Lewis, Yolanda Pazos, Christopher T Elliott, Katrina Campbell
Harmful algal blooms (HABs) are a natural global phenomena emerging in severity and extent. Incidents have many economic, ecological and human health impacts. Monitoring and providing early warning of toxic HABs are critical for protecting public health. Current monitoring programmes include measuring the number of toxic phytoplankton cells in the water and biotoxin levels in shellfish tissue. As these efforts are demanding and labour intensive, methods which improve the efficiency are essential. This study compares the utilisation of a multitoxin surface plasmon resonance (multitoxin SPR) biosensor with enzyme-linked immunosorbent assay (ELISA) and analytical methods such as high performance liquid chromatography with fluorescence detection (HPLC-FLD) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for toxic HAB monitoring efforts in Europe...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28058466/-malignization-of-vestibular-schwannoma-13%C3%A2-years-after-radiation-therapy
#15
S Simmermacher, D Vordermark, T Kegel, C Strauss
This article presents a case of malignant transformation of vestibular schwannoma 13 years after stereotactic radiation therapy, which lead to an acute life-threatening condition. Although the observation is currently only based on case reports, an increasing number of these support the hypothesis that there is a relevant risk of malignant transformation in the long-term course of previously irradiated vestibular schwannomas. Therefore, long-term MRI follow-up should be considered.
January 5, 2017: HNO
https://www.readbyqxmd.com/read/27939961/investigating-the-use-of-a-gammatone-filterbank-for-a-cochlear-implant-coding-strategy
#16
Sonia Tabibi, Andrea Kegel, Wai Kong Lai, Norbert Dillier
BACKGROUND: Contemporary speech processing strategies in cochlear implants (CIs) such as the Advanced Combination Encoder (ACE) use a standard Fast Fourier Transform (FFT) filterbank to extract envelopes. The assignment of the FFT bins to approximate the frequency resolution of the basilar membrane is only partly based on physiology, especially since the bins are distributed linearly below 1000Hz and logarithmically above 1000Hz. NEW METHOD: A Gammatone filterbank which provides a closer approximation to the bandwidths of filters in the human auditory system could replace the standard FFT filterbank in the ACE strategy...
February 1, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27914346/tuning-particle-geometry-of-chemically-anisotropic-dumbbell-shaped-colloids
#17
Bas G P van Ravensteijn, Willem K Kegel
Chemically anisotropic dumbbell-shaped colloids are prepared starting from cross-linked polymer seed particles coated with a chlorinated outer layer. These chlorinated seeds are swollen with monomer. Subsequently, a liquid protrusion is formed on the surface of the seed particle by phase separation between the monomer and the swollen polymer network. Solidification of these liquid lobes by polymerization leads to the desired dumbbell-shaped colloids. The chlorine groups remain confined on the seed lobe of the particles, ensuring chemical anisotropy of the resulting particles...
March 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27913764/ethnic-differences-in-fall-risk-among-community-dwelling-older-people-in-the-netherlands
#18
Fatima El Fakiri, Amber A Kegel, Gea M Schouten, Mary P H Berns
OBJECTIVE: This study measures the prevalence of falls and fear of falling among a population sample aged ≥65 years from different ethnic minorities living in the Netherlands, and examines whether ethnicity contributed to the differences in fall risk. METHOD: We analyzed data from 8,892 Dutch, Moroccan, Turkish, and Surinamese participants. Descriptive statistics and multiple regression analyses were conducted with falls and fear of falling as the dependent variable and ethnicity as the independent variable...
December 2, 2016: Journal of Aging and Health
https://www.readbyqxmd.com/read/27886578/kynurenic-acid-and-psychotic-symptoms-and-personality-traits-in-twins-with-psychiatric-morbidity
#19
Magdalena E Kegel, Viktoria Johansson, Lennart Wetterberg, Maria Bhat, Lilly Schwieler, Tyrone D Cannon, Ina Schuppe-Koistinen, Göran Engberg, Mikael Landén, Christina M Hultman, Sophie Erhardt
Increased cytokines and kynurenic acid (KYNA) levels in cerebrospinal fluid (CSF) have been reported in patients with schizophrenia and bipolar disorder. The aim of the present study was to investigate cytokines and kynurenines in the CSF of twin pairs discordant for schizophrenia or bipolar disorder and to study these CSF markers in relation to psychotic symptoms and personality traits. CSF levels of tryptophan (TRP), KYNA, quinolinic acid (QUIN), interleukin (IL)-6, IL-8 and tumor necrosis factor-alpha (TNF-α) were analyzed in 23 twins with schizophrenia or bipolar disorder, and in their not affected co-twins...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27865171/iron-and-manganese-removal-recent-advances-in-modelling-treatment-efficiency-by-rapid-sand-filtration
#20
D Vries, C Bertelkamp, F Schoonenberg Kegel, B Hofs, J Dusseldorp, J H Bruins, W de Vet, B van den Akker
A model has been developed that takes into account the main characteristics of (submerged) rapid filtration: the water quality parameters of the influent water, notably pH, iron(II) and manganese(II) concentrations, homogeneous oxidation in the supernatant layer, surface sorption and heterogeneous oxidation kinetics in the filter, and filter media adsorption characteristics. Simplifying assumptions are made to enable validation in practice, while maintaining the main mechanisms involved in iron(II) and manganese(II) removal...
February 1, 2017: Water Research
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