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https://www.readbyqxmd.com/read/28345099/ultrasensitive-nanoparticle-enhanced-laser-induced-breakdown-spectroscopy-using-a-super-hydrophobic-substrate-coupled-with-magnetic-confinement
#1
Daming Dong, Leizi Jiao, Xiaofan Du, Chunjiang Zhao
In this study, we developed a substrate to enhance the sensitivity of LIBS by 5 orders of magnitude. Using a combination of field enhancement due to the metal nanoparticles in the substrate, the aggregate effect of super-hydrophobic interfaces and magnetic confinement, we performed a quantitative measurement of copper in solution with concentrations on the ppt level. We also demonstrated that the substrate improves quantitative measurements by providing an opportunity for internal standardization.
March 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28340719/application-of-a-rapid-%C3%AE-spe-clean-up-for-multiclass-quantitative-analysis-of-sixteen-new-psychoactive-substances-in-whole-blood-by-lc-ms-ms
#2
Camilla Montesano, Gabriele Vannutelli, Valeria Piccirilli, Manuel Sergi, Dario Compagnone, Roberta Curini
Europe is an important market for illegal drugs, and nowadays a lot of new different psychoactive substances (NPS) are widespread. This work reports the development of a method to determine simultaneously different classes of NPS, as synthetic cannabinoids (SC) and their metabolites, cathinones and phenetylamines, directly on whole blood (WB) without anti-coagulants and using miniaturized solid phase extraction (μ-SPE). In order to demonstrate the feasibility of the method 16 different NPS belonging to the mentioned classes were selected for the analysis...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340430/bilateral-sequential-motor-cortex-stimulation-and-skilled-task-performance-with-non-dominant-hand
#3
Milan B Jelić, Saša R Filipović, Sladjan D Milanović, Vuk B Stevanović, Ljubica Konstantinović
OBJECTIVE: To check whether bilateral sequential stimulation (BSS) of M1 with theta burst stimulation (TBS), using facilitatory protocol over non-dominant M1 followed by inhibitory one over dominant M1, can improve skilled task performance with non-dominant hand more than either of the unilateral stimulations do. Both, direct motor cortex (M1) facilitatory non-invasive brain stimulation (NIBS) and contralateral M1 inhibitory NIBS were shown to improve motor learning. METHODS: Forty right-handed healthy subjects were divided into 4 matched groups which received either ipsilateral facilitatory (intermittent TBS [iTBS] over non-dominant M1), contralateral inhibitory (continuous TBS [cTBS] over dominant M1), bilateral sequential (contralateral cTBS followed by ipsilateral iTBS), or placebo stimulation...
March 6, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28336550/the-effect-of-intravenous-corticotropin-releasing-hormone-administration-on-esophageal-sensitivity-and-motility-in-health
#4
Charlotte Broers, Chloé Melchior, Lukas Van Oudenhove, Tim Vanuytsel, Brecht Van Houtte, Charlotte Scheerens, Nathalie Rommel, Jan F Tack, Ans Pauwels
BACKGROUND: Esophageal hypersensitivity is important in gastro-esophageal reflux disease (GERD) patients refractory to acid-suppressive therapy. Stress affects visceral sensitivity and exacerbates heartburn in GERD. Peripheral CRH is a key mediator of the gut stress response. We hypothesize that CRH increases esophageal sensitivity and alters esophageal motility in health. METHODS: Esophageal sensitivity to thermal, mechanical, electrical and chemical stimuli was assessed in 14 healthy subjects after placebo or CRH (100μg IV)...
March 23, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28328574/the-long-term-reliability-of-static-and-dynamic-quantitative-sensory-testing-in-healthy-individuals
#5
Anna Marcuzzi, Paul J Wrigley, Catherine M Dean, Roger Adams, Julia M Hush
Quantitative sensory tests (QST) have been increasingly used to investigate alterations in somatosensory function in a wide range of painful conditions. The interpretation of these findings is based on the assumption that the measures are stable and reproducible. To date, reliability of QST has been investigated for short test-retest intervals. The aim of this study was to investigate the long-term reliability of a multimodal QST assessment in healthy people, with testing conducted on three occasions over 4-months...
March 21, 2017: Pain
https://www.readbyqxmd.com/read/28319883/the-influence-of-a-depressed-scapular-alignment-on-upper-limb-neural-tissue-mechanosensitivity-and-local-pressure-pain-sensitivity
#6
Patricia Martínez-Merinero, Enriqe Lluch, Tomas Gallezo-Izquierdo, Daniel Pecos-Martín, Gustavo Plaza-Manzano, Susana Nuñez-Nagy, Deborah Falla
BACKGROUND: A depressed scapular alignment could lead to prolonged and repetitive stress or compression of the brachial plexus, resulting in sensitization of neural tissue. However, no study has investigated the influence of alignment of the scapulae on sensitization of upper limb neural tissue in otherwise asymptomatic people. In this case-control study, we investigate the influence of a depressed scapular alignment on mechanosensitivity of the upper limb peripheral nervous system as well as pressure pain thresholds (PPT)...
March 10, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28315769/the-regulation-of-lipid-metabolism-by-a-hypothetical-p-loop-ntpase-and-its-impact-on-fecundity-of-the-brown-planthopper
#7
Rui Pang, Jieqi Qiu, Tengchao Li, Pan Yang, Lei Yue, Yixin Pan, Wenqing Zhang
BACKGROUND: Insect fecundity can be regulated by multiple genes in several important signaling pathways which form an extremely complicated regulatory network. However, there are still many genes that have significant impact on insect fecundity but their action mode are still unknown. METHODS: Quantitative real-time PCR (qRT-PCR), immunofluorescence and western blot were used to study the expression profile of Nl23867 in the brown planthopper, Nilaparvata lugens...
March 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28315052/spatiotemporal-variability-in-salinity-and-hydraulic-relationship-with-salt-intrusion-in-the-tidal-reaches-of-the-minjiang-river-fujian-province-china
#8
Rongrong Xie, Yong Pang, Bingrong Luo, Jiabing Li, Chunshan Wu, Yuyi Zheng, Qiyuan Sun, Peng Zhang, Feifeng Wang
Salinity is one of the most important factors for tidal-affected water bodies including estuaries and tidal river reaches. However, due to the limitations of simultaneous manual monitoring in long-distance areas, studies of estuaries are preferred to tidal reaches. Hence, in this study, we investigated the tidal reach of the Minjiang River and five sets of field observations were used to determine the influence of saltwater intrusion in different seasons. During the dry and wet season with low discharge, the longitudinal salinity profiles showed that a station located about 45 km from the river mouth still suffered from saltwater intrusion especially when the upstream discharge was under 754 m(3) s(-1), where the periodical fluctuation in the salinity remained the same with the water level, but there was a time lag of approximately 4 h compared with the discharge process...
March 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28301687/effect-of-high-frequency-bio-oxidative-ozone-therapy-for-masticatory-muscle-pain-a-double-blind-randomized-clinical-trial
#9
Tamer Celakil, Almina Muric, Bilge Gokcen Roehlig, Gulumser Evlioglu, Haluk Keskin
OBJECTIVES: To evaluate the effect of bio-oxidative ozone application at the points of greatest pain in patients with chronic masticatory muscle pain. METHODS: A total number of 40 (40 women, with a mean age of 31.7) were selected after the diagnosis of myofacial pain dysfunction syndrome according to the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD). The patients were randomly divided into two groups; patients received the ozone therapy at the point of greatest pain, ozone group (n = 20); patients received the sham ozone therapy at the point of greatest pain, placebo group (n = 20)...
March 16, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28295825/effectiveness-of-manual-therapy-versus-surgery-in-pain-processing-due-to-carpal-tunnel-syndrome-a-randomized-clinical-trial
#10
C Fernández-de-Las-Peñas, J Cleland, M Palacios-Ceña, S Fuensalida-Novo, C Alonso-Blanco, J A Pareja, F Alburquerque-Sendín
BACKGROUND: People with carpal tunnel syndrome (CTS) exhibit widespread pressure pain and thermal pain hypersensitivity as a manifestation of central sensitization. The aim of our study was to compare the effectiveness of manual therapy versus surgery for improving pain and nociceptive gain processing in people with CTS. METHODS: The trial was conducted at a local regional Hospital in Madrid, Spain from August 2014 to February 2015. In this randomized parallel-group, blinded, clinical trial, 100 women with CTS were randomly allocated to either manual therapy (n = 50), who received three sessions (once/week) of manual therapies including desensitization manoeuvres of the central nervous system, or surgical intervention (n = 50) group...
March 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28295336/neurochemistry-of-neurons-in-the-ventrolateral-medulla-activated-by-hypotension-are-the-same-neurons-activated-by-glucoprivation
#11
Lindsay M Parker, Sheng Le, Travis Wearne, Kate Hardwick, Natasha N Kumar, Katherine J Robinson, Simon McMullan, Ann K Goodchild
Previous studies have demonstrated that a range of stimuli activate neurons, including catecholaminergic neurons, in the ventrolateral medulla. Not all catecholaminergic neurons are activated and other neurochemical content is largely unknown hence whether stimulus specific populations exist is unclear. Here we determine the neurochemistry (using in situ hybridization) of catecholaminergic and non-catecholaminergic neurons which express c-Fos immunoreactivity throughout the rostrocaudal extent of the ventrolateral medulla, in Sprague Dawley rats treated with hydralazine or saline...
March 13, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28294975/reverse-transcription-in-the-saccharomyces-cerevisiae-long-terminal-repeat-retrotransposon-ty3
#12
REVIEW
Jason W Rausch, Jennifer T Miller, Stuart F J Le Grice
Converting the single-stranded retroviral RNA into integration-competent double-stranded DNA is achieved through a multi-step process mediated by the virus-coded reverse transcriptase (RT). With the exception that it is restricted to an intracellular life cycle, replication of the Saccharomyces cerevisiae long terminal repeat (LTR)-retrotransposon Ty3 genome is guided by equivalent events that, while generally similar, show many unique and subtle differences relative to the retroviral counterparts. Until only recently, our knowledge of RT structure and function was guided by a vast body of literature on the human immunodeficiency virus (HIV) enzyme...
March 15, 2017: Viruses
https://www.readbyqxmd.com/read/28294969/a-metabolomic-approach-for-the-discrimination-of-red-ginseng-root-parts-and-targeted-validation
#13
Gyo In, Hyun Kyu Seo, Hee-Won Park, Kyoung Hwa Jang
Ginsenosides are used as existing markers of red ginseng (RG) quality, and ginsenoside ratios are also indicative of the different components of red ginseng. For the analysis and classification of ginsenoside content, red ginseng was separated into three parts, namely, main roots, lateral roots, and fine roots, and each extract was subjected to ultra-performance liquid chromatography quadruple time-of-flight mass spectrometry (UPLC-QToF-MS) with multivariate statistical analysis. Principal component analysis (PCA) showed a clear discrimination between the extracts of main roots and fine roots and suggested discrimination markers (four for the main roots and five for the fine roots)...
March 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28291046/effectiveness-of-different-deep-dry-needling-dosages-in-the-treatment-of-patients-with-cervical-myofascial-pain-a-pilot-rct
#14
Josué Fernández-Carnero, Laura Gilarranz-de-Frutos, Jose Vicente León-Hernández, Daniel Pecos-Martin, Isabel Alguacil-Diego, Tomás Gallego-Izquierdo, Aitor Martín-Pintado-Zugasti
OBJECTIVE: To assess the effectiveness of different dosages of local twitch responses (LTRs) elicited by deep dry needling (DDN) in relation to pain intensity, pressure pain threshold (PPT), cervical range of movement (CROM), and disability degree in cervical myofascial pain patients. DESIGN: A randomized, double-blind clinical trial. PARTICIPANTS: Eighty-four patients (21 males, 63 females; 27.18 ± 10.91 yrs) with cervical pain. INTERVENTIONS: DDN in active myofascial trigger points (MTrPs) in the upper trapezius...
March 14, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28289561/comparison-of-hand-grip-strength-and-upper-limb-pressure-pain-threshold-between-older-adults-with-or-without-non-specific-shoulder-pain
#15
Cesar Calvo Lobo, Carlos Romero Morales, David Rodríguez Sanz, Irene Sanz Corbalán, Eleuterio A Sánchez Romero, Josué Fernández Carnero, Daniel López López
BACKGROUND: There is a high prevalence of non-specific shoulder pain associated with upper limb functional limitations in older adults. The purpose of this study was to determine the minimal clinically important differences (MCID) of grip strength and pressure pain threshold (PPT) in the upper limb between older adults with or without non-specific shoulder pain. METHODS: A case-control study was carried out following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria...
2017: PeerJ
https://www.readbyqxmd.com/read/28279754/estrogen-receptors-er%C3%AE-and-er%C3%AE-participation-in-hypothalamus-pituitary-adrenal-axis-activation-by-hemorrhagic-stress
#16
Luana Maria Silva Alves, Procópio Cleber Gama de Barcellos Filho, Celso Rodrigues Franci
The sympato-adrenal-system and hypothalamus-pituitary-adrenal (HPA) axis are anatomically and functionally connected with participation of several brain areas that express estrogen receptors (ERα and ERβ). We assessed the neuronal activity of these areas for FOS expression and the action of PPT (ERα agonist) or DPN (ERβ agonist) in HPA axis activity during hemorrhagic stress. Ovariectomized Wistar rats treated with vehicle (DMSO) or ER agonists were catheterized for blood collection. Animals received (control) or not (hemorrhagic) immediate reposition with the same volume of saline...
March 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/28277434/age-interactions-on-pain-sensitization-in-patients-with-severe-knee-osteoarthritis-and-controls
#17
Kristian Kjær Petersen, Lars Arendt-Nielsen, Sara Finocchietti, Rogerio Pessoto Hirata, Ole Simonsen, Mogens Berg Laursen, Thomas Graven-Nielsen
OBJECTIVES: Widespread pressure hyperalgesia, facilitated temporal summation of pain (TSP), and impaired conditioned pain modulation (CPM) have been found in knee osteoarthritis (KOA) patients compared with controls and these parameters have further been suggested to be altered in the elderly. This study investigated the influence of age on pressure hyperalgesia, TSP, and CPM in patients with KOA and controls. METHODS: One-hundred-thirty-three severe KOA patients and 50 age and sex-matched asymptomatic controls were assessed by cuff algometry and handheld pressure algometry...
March 8, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28274698/effects-of-short-term-oxycodone-maintenance-on-experimental-pain-responses-in-physically-dependent-opioid-abusers
#18
Marion A Coe, Paul N Nuzzo, Michelle R Lofwall, Sharon L Walsh
A common clinical problem with opioid analgesics is the loss of analgesic efficacy after repeated dosing; when this occurs, it is not clear what principles should guide providing effective analgesia among opioid-dependent individuals. This within-subject inpatient study aimed to determine if physically dependent opioid abusers (n=11) experience changes in oxycodone-induced analgesia during two oxycodone maintenance (30mg p.o./q.i.d.) phases: Initial Stabilization (Days 1 - 3) and after 6 weeks of Chronic Dosing...
March 5, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28273939/microbial-transformation-of-ginsenoside-rb1-re-and-rg1-and-its-contribution-to-the-improved-anti-inflammatory-activity-of-ginseng
#19
Shanshan Yu, Xiaoli Zhou, Fan Li, Chunchun Xu, Fei Zheng, Jing Li, Huanxi Zhao, Yulin Dai, Shuying Liu, Yan Feng
Microbial transformation of ginsenosides to increase its pharmaceutical effect is gaining increasing attention in recent years. In this study, Cellulosimicrobium sp. TH-20, which was isolated from soil samples on which ginseng grown, exhibited effective ginsenoside-transforming activity. After protopanaxadiol (PPD)-type ginsenoside (Rb1) and protopanaxatriol (PPT)-type ginsenosides (Re and Rg1) were fed to C. sp. TH20, a total of 12 metabolites, including 6 new intermediate metabolites, were identified. Stepwise deglycosylation and dehydrogenation on the feeding precursors have been observed...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28273107/effects-of-ocean-acidification-on-primary-production-in-a-coastal-north-sea-phytoplankton-community
#20
Tim Eberlein, Sylke Wohlrab, Björn Rost, Uwe John, Lennart T Bach, Ulf Riebesell, Dedmer B Van de Waal
We studied the effect of ocean acidification (OA) on a coastal North Sea plankton community in a long-term mesocosm CO2-enrichment experiment (BIOACID II long-term mesocosm study). From March to July 2013, 10 mesocosms of 19 m length with a volume of 47.5 to 55.9 m3 were deployed in the Gullmar Fjord, Sweden. CO2 concentrations were enriched in five mesocosms to reach average CO2 partial pressures (pCO2) of 760 μatm. The remaining five mesocosms were used as control at ambient pCO2 of 380 μatm. Our paper is part of a PLOS collection on this long-term mesocosm experiment...
2017: PloS One
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