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https://www.readbyqxmd.com/read/28217778/a-critical-insight-into-the-development-pipeline-of-microfluidic-immunoassay-devices-for-the-sensitive-quantitation-of-protein-biomarkers-at-the-point-of-care
#1
REVIEW
Ana I Barbosa, Nuno M Reis
The latest clinical procedures for the timely and cost-effective diagnosis of chronic and acute clinical conditions, such as cardiovascular diseases, cancer, chronic respiratory diseases, diabetes or sepsis (i.e. the biggest causes of death worldwide), involve the quantitation of specific protein biomarkers released into the blood stream or other physiological fluids (e.g. urine or saliva). The clinical thresholds are usually in the femtomolar to picolomar range, and consequently the measurement of these protein biomarkers heavily relies on highly sophisticated, bulky and automated equipment in centralised pathology laboratories...
February 20, 2017: Analyst
https://www.readbyqxmd.com/read/28215374/collaboration-with-deaf-communities-to-conduct-accessible-health-surveillance
#2
Steven L Barnett, Kelly A Matthews, Erika J Sutter, Lori A DeWindt, Jacqueline A Pransky, Amanda M O'Hearn, Tamala M David, Robert Q Pollard, Vincent J Samar, Thomas A Pearson
INTRODUCTION: Populations of deaf sign language users experience health disparities unmeasured by current public health surveillance. Population-specific health data are necessary to collaboratively identify health priorities and evaluate interventions. Standardized, reproducible, and language-concordant data collection in sign language is impossible via written or telephone surveys. METHODS: Deaf and hearing researchers, community members, and other stakeholders developed a broad computer-based health survey based on the telephone-administered Behavioral Risk Factor Surveillance System...
March 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28215341/dissection-and-characterization-of-microtubule-bundles-in-the-mitotic-spindle-using-femtosecond-laser-ablation
#3
R Buđa, K Vukušić, I M Tolić
The mitotic spindle is a highly organized and dynamic structure required for segregation of the genetic material into two daughter cells. Although most of the individual players involved in building the spindle have been characterized in vitro, a general understanding of how all of the spindle players act together in vivo is still missing. Hence, in recent years, experiments have focused on introducing mechanical perturbations of the spindle on a micron scale, thereby providing insight into its function and organization, as well as into forces acting in the spindle...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28214925/missed-opportunities-in-neonatal-deaths-in-rwanda-applying-the-three-delays-model-in-a-cross-sectional-analysis-of-neonatal-death
#4
Efua Wilmot, Marcel Yotebieng, Alison Norris, Fidele Ngabo
Objective Administered in a timely manner, current evidence-based interventions could reduce neonatal deaths from infections, intrapartum injuries and complications due to prematurity. The three delays model (delay in seeking care, in arriving at a health facility, and in receiving adequate care), which has been applied to understanding maternal deaths, may be useful for understanding neonatal deaths. We assess the main causes of neonatal deaths in Rwanda and their associated delays. Methods Using a cross-sectional study design, we evaluated data from 2012 from 40 facilities in which babies were delivered...
February 18, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28209364/variable-threshold-method-for-determining-the-boundaries-of-imaged-subvisible-particles
#5
R E Cavicchi, Cayla Collett, Srivalli Telikepalli, Zhishang Hu, Michael Carrier, Dean C Ripple
An accurate assessment of particle characteristics and concentrations in pharmaceutical products by flow imaging requires accurate particle sizing and morphological analysis. Analysis of images begins with the definition of particle boundaries. Commonly a single threshold defines the level for a pixel in the image to be included in the detection of particles, but depending on the threshold level, this results in either missing translucent particles or oversizing of less transparent particles due to the halos and gradients in intensity near the particle boundaries...
February 13, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28209007/cognitive-ability-as-a-determinant-of-socioeconomic-and-oral-health-status-among-adolescent-college-students-of-bengaluru-india
#6
Rekha Rao Karnam, Naganandini Samapth Kumar, Shruthi Eshwar, Shravani Deolia
INTRODUCTION: Levels of oral health and economic status are unequally distributed throughout the population. Inequality has multiple causes and that the effect of Socio Economic Status (SES) and demographic factors, on oral health is mediated through several factors. Association between cognitive ability and oral health had been demonstrated in older age groups but adolescents and younger adults have received relatively little attention in this field. AIM: To establish the role of cognitive ability as a determinant of SES and oral health status among adolescent college students of Benagluru, Karnataka, India...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208443/density-of-states-and-dynamical-crossover-in-a-dense-fluid-revealed-by-exponential-mode-analysis-of-the-velocity-autocorrelation-function
#7
S Bellissima, M Neumann, E Guarini, U Bafile, F Barocchi
Extending a preceding study of the velocity autocorrelation function (VAF) in a simulated Lennard-Jones fluid [Phys. Rev. E 92, 042166 (2015)PLEEE81539-375510.1103/PhysRevE.92.042166] to cover higher-density and lower-temperature states, we show that the recently demonstrated multiexponential expansion method allows for a full account and understanding of the basic dynamical processes encompassed by a fundamental quantity as the VAF. In particular, besides obtaining evidence of a persisting long-time tail, we assign specific and unambiguous physical meanings to groups of exponential modes related to the longitudinal and transverse collective dynamics, respectively...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28198399/discovery-of-the-fe-analogue-of-akimotoite-in-the-shocked-suizhou-l6-chondrite
#8
Luca Bindi, Ming Chen, Xiande Xie
We report the first natural occurrence of the Fe-analogue of akimotoite, ilmenite-structured MgSiO3, a missing phase among the predicted high-pressure polymorphs of Fe-pyroxene, with the composition (Fe(2+)0.48Mg0.37Ca0.04Na0.04Mn(2+)0.03Al0.03Cr(3+)0.01)Σ=1.00Si1.00O3. The new mineral was approved by the International Mineralogical Association (IMA 2016-085) and named hemleyite in honour of Russell J. Hemley. It was discovered in an unmelted portion of the heavily shocked L6 Suizhou chondrite closely associated to olivine, clinoenstatite and Fe-bearing pyroxene with a composition nearly identical to that of hemleyite...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28193186/afghan-migrants-face-more-suboptimal-care-than-natives-a-maternal-near-miss-audit-study-at-university-hospitals-in-tehran-iran
#9
Soheila Mohammadi, Soraya Saleh Gargari, Masoumeh Fallahian, Carina Källestål, Shirin Ziaei, Birgitta Essén
BACKGROUND: Women from low-income settings have higher risk of maternal near miss (MNM) and suboptimal care than natives in high-income countries. Iran is the second largest host country for Afghan refugees in the world. Our aim was to investigate whether care quality for MNM differed between Iranians and Afghans and identify potential preventable attributes of MNM. METHODS: An MNM audit study was conducted from 2012 to 2014 at three university hospitals in Tehran...
February 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28191498/a-prospective-study-of-patient-safety-incidents-in-gastrointestinal-endoscopy
#10
Manmeet Matharoo, Adam Haycock, Nick Sevdalis, Siwan Thomas-Gibson
Background and study aims Medical error occurs frequently with significant morbidity and mortality. This study aime to assess the frequency and type of endoscopy patient safety incidents (PSIs). Patients and methods A prospective observational study of PSIs in routine diagnostic and therapeutic endoscopy was undertaken in a secondary and tertiary care center. Observations were undertaken within the endoscopy suite across pre-procedure, intra-procedure and post-procedure phases of care. Experienced (Consultant-level) and trainee endoscopists from medical, surgical, and nursing specialities were included...
January 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28187782/sputum-dna-sequencing-in-cystic-fibrosis-non-invasive-access-to-the-lung-microbiome-and-to-pathogen-details
#11
Rounak Feigelman, Christian R Kahlert, Florent Baty, Frank Rassouli, Rebekka L Kleiner, Philipp Kohler, Martin H Brutsche, Christian von Mering
BACKGROUND: Cystic fibrosis (CF) is a life-threatening genetic disorder, characterized by chronic microbial lung infections due to abnormally viscous mucus secretions within airways. The clinical management of CF typically involves regular respiratory-tract cultures in order to identify pathogens and to guide treatment. However, culture-based methods can miss atypical or slow-growing microbes. Furthermore, the isolated microbes are often not classified at the strain level due to limited taxonomic resolution...
February 10, 2017: Microbiome
https://www.readbyqxmd.com/read/28186061/the-need-for-electronic-health-records-in-long-term-care
#12
Sukirtha Tharmalingam, Simon Hagens, Sarah English
Long-term care (LTC) settings serve an important proportion of seniors and vulnerable populations that require 24-hour nursing care. Deployment of interoperable electronic health records (iEHRs) to these settings lag. There is little evidence on the availability of patient information from across the continuum of care. To fill this knowledge gap this study examines the prevalence and nature of information gaps experienced in LTC during patient encounters (n=1050). Overall, more than one-third (34%) of all LTC patient encounters were missing at least one item of information that was needed for the encounter...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28185490/medication-governance-preventing-errors-and-promoting-patient-safety
#13
Caroline Kavanagh
This article highlights the significance of medication errors, identifying potential issues and support systems required. Medication errors involve different health professionals and present at various stages of the medication cycle. Focusing on a collaborative approach and the role of the nurse is necessary. Special groups, particularly older adults, are considered where multiple conditions and multiple medications increase the risk of adverse drug reactions. Nurses' accountability and their knowledge of medications are taken into account along with the role of nurse educators...
February 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28185075/paediatric-patient-safety-and-the-need-for-aviation-black-box-thinking-to-learn-from-and-prevent-medication-errors
#14
Chi Huynh, Ian C K Wong, Jo Correa-West, David Terry, Suzanne McCarthy
Since the publication of To Err Is Human: Building a Safer Health System in 1999, there has been much research conducted into the epidemiology, nature and causes of medication errors in children, from prescribing and supply to administration. It is reassuring to see growing evidence of improving medication safety in children; however, based on media reports, it can be seen that serious and fatal medication errors still occur. This critical opinion article examines the problem of medication errors in children and provides recommendations for research, training of healthcare professionals and a culture shift towards dealing with medication errors...
February 10, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28184240/assessing-the-validity-and-reliability-of-the-malagasy-version-of-oral-impacts-on-daily-performance-oidp-a-cross-sectional-study
#15
Noeline Razanamihaja, Eva Ranivoharilanto
BACKGROUND: Evaluating health needs includes measures of the impact of state of health on the quality of life. This entails evaluating the psychosocial aspects of health. To achieve this, several tools for measuring the quality of life related to oral health have been developed. However, it is vital to evaluate the psychometric properties of these tools so they can be used in a new context and on a new population. The purpose of this study was to evaluate the reliability and validity of the Malagasy version of a questionnaire for studying the impacts of oral-dental health on daily activities (Oral Impacts on Daily Performance), and analyse the interrelations between the scores obtained and the oral health indicators...
2017: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/28183848/long-term-observation-reveals-high-frequency-engraftment-of-human-acute-myeloid-leukemia-in-immunodeficient-mice
#16
Anna M Paczulla, Stephan Dirnhofer, Martina Konantz, Michael Medinger, Helmut R Salih, Kathrin Rothfelder, Dimitrios A Tsakiris, Jakob R Passweg, Pontus Lundberg, Claudia Lengerke
Repopulation of immunodeficient mice remains the primary method to func-tionally assess human acute myeloid leukemia. Published data report en-graftment of ~40-66% of cases, mostly belonging to intermediate or poor risk subtypes. Here we report that extending follow-up beyond the standard analysis end-points of 10 to 16 weeks post-transplantation permitted leukemic engraftment from nearly every xenotransplanted acute myeloid leukemia case (18/19, ~95%). Xenogeneic leukemic cells showed conserved immune phenotypes and genetic signatures when compared to corresponding pre-transplant cells, and were furthermore able to induce leukemia in re-transplantation assays...
February 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28183300/an-investigation-of-stigmatizing-attitudes-towards-people-living-with-hiv-aids-by-doctors-and-nurses-in-vientiane-lao-pdr
#17
Savina Vorasane, Masamine Jimba, Kimiyo Kikuchi, Junko Yasuoka, Keiko Nanishi, Jo Durham, Vanphanom Sychareun
BACKGROUND: Despite global efforts, HIV-related stigma continues to negatively impact the health and well-being of people living with HIV/AIDS. Even in healthcare settings, people with HIV/AIDS experience discrimination. Anecdotal evidence suggests that healthcare professionals in the Lao People's Democratic Republic, a lower-middle income country situated in Southeast Asia, stigmatize HIV/AID patients. The purpose of this study was to assess HIV stigmatizing attitudes within Laotian healthcare service providers and examine some of the factors associated with HIV/AIDS-related stigma among doctors and nurses...
February 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28181186/an-automated-behavioral-measure-of-mind-wandering-during-computerized-reading
#18
Myrthe Faber, Robert Bixler, Sidney K D'Mello
Mind wandering is a ubiquitous phenomenon in which attention shifts from task-related to task-unrelated thoughts. The last decade has witnessed an explosion of interest in mind wandering, but research has been stymied by a lack of objective measures, leading to a near-exclusive reliance on self-reports. We addressed this issue by developing an eye-gaze-based, machine-learned model of mind wandering during computerized reading. Data were collected in a study in which 132 participants reported self-caught mind wandering while reading excerpts from a book on a computer screen...
February 8, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28178011/nursing-student-patient-safety-errors-in-the-practice-domain-a-scoping-review-protocol-of-the-quantitative-and-qualitative-evidence
#19
June Raymond, Christina M Godfrey, Jennifer M Medves, Amanda Ross-White
The objective of this scoping review is to identify the range of patient safety events that includes patient safety errors, harms or near misses that student nurses make while nursing in their clinical placements. The question that will guide this review is: what types of hazards, healthcare-associated harms, patient safety incidents, reportable circumstances, near misses, harmful incidents, no harm incidents and injuries to patients are being made and reported by nursing students during their practice in healthcare facilities?...
February 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28170434/the-internal-cranial-anatomy-of-romundina-stellina-%C3%A3-rvig-1975-vertebrata-placodermi-acanthothoraci-and-the-origin-of-jawed-vertebrates-anatomical-atlas-of-a-primitive-gnathostome
#20
Vincent Dupret, Sophie Sanchez, Daniel Goujet, Per Erik Ahlberg
Placoderms are considered as the first jawed vertebrates and constitute a paraphyletic group in the stem-gnathostome grade. The acanthothoracid placoderms are among the phylogenetically most basal and morphologically primitive gnathostomes, but their neurocranial anatomy is poorly understood. Here we present a near-complete three-dimensional skull of Romundina stellina, a small Early Devonian acanthothoracid from the Canadian Arctic Archipelago, scanned with propagation phase contrast microtomography at a 7...
2017: PloS One
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