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https://www.readbyqxmd.com/read/28327139/association-of-admission-and-patient-characteristics-with-quality-of-discharge-letters-posthoc-analysis-of-a-retrospective-study
#1
Maaike Langelaan, Rebecca J Baines, Martine C de Bruijne, Cordula Wagner
BACKGROUND: A complete, correct and timely discharge letter can communicate important information from the hospital to the general practitioner. The adequacy of the letter may vary with the patient and admission characteristics of the patient. Insight in the association between these characteristics and the presence and quality of the discharge letter will give rise to improvement activities for a better continuity of care after discharge. The objective was to determine the presence, correctness and timeliness of admission information in discharge letters and to determine the association between patient and admission characteristics, including unplanned readmissions and the quality of the discharge letter...
March 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28325876/comprehensive-and-quantitative-mapping-of-rna-protein-interactions-across-a-transcribed-eukaryotic-genome
#2
Richard She, Anupam K Chakravarty, Curtis J Layton, Lauren M Chircus, Johan O L Andreasson, Nandita Damaraju, Peter L McMahon, Jason D Buenrostro, Daniel F Jarosz, William J Greenleaf
RNA-binding proteins (RBPs) control the fate of nearly every transcript in a cell. However, no existing approach for studying these posttranscriptional gene regulators combines transcriptome-wide throughput and biophysical precision. Here, we describe an assay that accomplishes this. Using commonly available hardware, we built a customizable, open-source platform that leverages the inherent throughput of Illumina technology for direct biophysical measurements. We used the platform to quantitatively measure the binding affinity of the prototypical RBP Vts1 for every transcript in the Saccharomyces cerevisiae genome...
March 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28323801/predicting-acute-compartment-syndrome-pacs-the-role-of-continuous-monitoring
#3
Andrew H Schmidt, Michael J Bosse, Katherine P Frey, Robert V OʼToole, Daniel J Stinner, Daniel O Scharfstein, Vadim Zipunnikov, Ellen J MacKenzie
The diagnosis of acute compartment syndrome (ACS) is a common clinical challenge among patients who sustain high-energy orthopaedic trauma, largely because no validated criteria exist to reliably define the presence of the condition. In the absence of validated diagnostic standards, concern for the potential clinical and medicolegal impact of a missed compartment syndrome may result in the potential overuse of fasciotomy in "at-risk" patients. The goal of the Predicting Acute Compartment Syndrome Study was to develop a decision rule for predicting the likelihood of ACS that would reduce unnecessary fasciotomies while guarding against potentially missed ACS...
April 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28323679/the-day-that-went-missing-a-first-person-account-of-transient-global-amnesia
#4
Trip Gabriel
In this vivid first-person case history, political reporter Trip Gabriel describes experiencing a classic episode of transient global amnesia. He was near the average target age of 61. Although no cause has been established for the syndrome, as with many other patients his episode appears to have been triggered by contact with water: He was racing a sailboat. While remaining alert and handling complex sailing maneuvers, he suddenly developed amnesia that left him with no recollection of finishing two races, returning to shore, drinking a beer with his friends, needing help finding his car, and not knowing where he was or where he lived...
March 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28323174/multicenter-investigation-of-an-implantable-cardioverter-defibrillator-algorithm-to-detect-oversensing
#5
Nicolas Welte, Marc Strik, Romain Eschalier, Pierre Mondoly, Pascal Defaye, Antonio Frontera, Philippe Ritter, Michel Haïssaguerre, Sylvain Ploux, Jayanthi Koneru, Kenneth A Ellenbogen, Pierre Bordachar
BACKGROUND: The SecureSense™ RV Lead Noise Discrimination algorithm is designed to detect lead fracture and other types of oversensing in order to decrease inappropriate therapy. OBJECTIVE: We studied the real-life accuracy of the SecureSenseTM algorithm in ICD patients followed by remote-monitoring across multiple centers. METHODS: Across three French centers, we studied 486 patients with a St. Jude Medical device who were followed by remote-monitoring and who had the SecureSense™ algorithm activated...
March 18, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28319311/zinc-regulates-chemical-transmitter-storage-in-nanometer-vesicles-and-exocytosis-dynamics-as-measured-by-amperometry
#6
Lin Ren, Masoumeh Dowlatshahi Pour, Soodabeh Majdi, Xianchan Li, Per Malmberg, Andrew G Ewing
We applied electrochemical techniques with nano-tip electrodes to show that micromolar concentrations of zinc not only trigger changes in the dynamics of exocytosis, but also vesicle content in a model cell line. The vesicle catecholamine content in PC12 cells is significantly decreased after 100 μm zinc treatment, but, catecholamine release during exocytosis remains nearly the same. This contrasts with the number of molecules stored in the exocytosis vesicles, which decreases, and we find that the amount of catecholamine released from zinc-treated cells reaches nearly 100 % content expelled...
March 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28316764/the-association-between-oral-hygiene-and-gastric-pathology-in-patients-with-dyspepsia-a-cross-sectional-study-in-southeast-iran
#7
Leili Zahedi, Elham Jafari, Molook Torabi Parizi, Sara Shafieipour, Mehdi Hayat Bakhsh Abbasi, Sodaif Darvish Moghadam, Mohammad Javad Zahedi
BACKGROUND Many studies have reported an association between periodontal infections and some systemic diseases such as respiratory and cardiovascular diseases. Some studies found a direct association between chronic gastritis caused by Helicobacter pylori (HP) infection and poor periodontal health. METHODS In a cross-sectional study from November 2014 to December 2015 in Kerman, the largest province in southeast Iran, patients with dyspepsia who were candidate for diagnostic upper gastrointestinal (GI) endoscopy were included in our study...
January 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28302424/external-validation-of-the-universal-termination-of-resuscitation-rule-for-out-of-hospital-cardiac-arrest-in-british-columbia
#8
Brian Grunau, John Taylor, Frank X Scheuermeyer, Robert Stenstrom, William Dick, Takahisa Kawano, David Barbic, Ian Drennan, Jim Christenson
STUDY OBJECTIVE: The Universal Termination of Resuscitation Rule (TOR Rule) was developed to identify out-of-hospital cardiac arrests eligible for field termination of resuscitation, avoiding futile transportation to the hospital. The validity of the rule in emergency medical services (EMS) systems that do not routinely transport out-of-hospital cardiac arrest patients to the hospital is unknown. We seek to validate the TOR Rule in British Columbia. METHODS: This study included consecutive, nontraumatic, adult, out-of-hospital cardiac arrests treated by EMS in British Columbia from April 2011 to September 2015...
March 14, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28299848/specimen-identification-errors-in-breast-biopsies-age-matters-report-of-two-near-miss-events-and-review-of-the-literature
#9
Gary Tozbikian, Mary L Gemignani, Edi Brogi
The consequences of patient identification errors due to specimen mislabeling can be deleterious. We describe two near-miss events involving mislabeled breast specimens from two patients who sought treatment at our institution. In both cases, microscopic review of the slides identified inconsistencies between the histologic findings and patient age, unveiling specimen identification errors. By correlating the clinical information with the microscopic findings, we identified mistakes that had occurred at the time of specimen accessioning at the original laboratories...
March 16, 2017: Breast Journal
https://www.readbyqxmd.com/read/28298668/unexplained-obstruction-of-an-integrated-cardiotomy-filter-during-cardiopulmonary-bypass
#10
Cory M Alwardt, Donald S Wilson, Octavio E Pajaro
Cardiopulmonary bypass (CPB) is considered relatively safe in most cases, yet is not complication free. We present a case of an integrated cardiotomy filter obstruction during CPB, requiring circuit reconfiguration. Approximately an hour after uneventful initiation of CPB the integrated cardiotomy filter became obstructed over several minutes, requiring circuit reconfiguration using an external cardiotomy filter to maintain functionality. Following reconfiguration, CPB was maintained with a fully functional circuit allowing safe patient support throughout the remainder of CPB...
March 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/28293159/intensified-tuberculosis-case-finding-implementation-of-isoniazid-preventive-therapy-and-associated-factors-among-people-living-with-human-immunodeficiency-virus-at-public-health-facilities-of-harari-region-eastern-ethiopia-a-cross-sectional-study
#11
Ayele Geleto, Degu Abate, Gudina Egata
OBJECTIVE: Globally, the number of people living with human immunodeficiency virus (PLHIV) particularly in sub-Saharan Africa is growing. This has been resulted in increased number of tuberculosis (TB) new cases. To control burden of TB among PLHIV, a number of collaborative TB/HIV activities were recommended. However, data about collaborative TB/HIV services in the study area is scarce. The objective of this study is to assess intensified TB case finding, implementation of isoniazid preventive therapy (IPT) and associated factors among PLHIV...
January 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28292274/significance-of-clinical-and-morphological-prognostic-risk-factors-in-iga-nephropathy-follow-up-study-of-comparison-patient-groups-with-and-without-renoprotection
#12
Živile Riispere, Anne Kuudeberg, Elviira Seppet, Kristin Sepp, Madis Ilmoja, Merike Luman, Külli Kõlvald, Asta Auerbach, Mai Ots-Rosenberg
BACKGROUND: IgA nephropathy (IgAN) is the most frequent glomerulonephritis in many countries including Estonia. There is no specific treatment for IgAN but renoprotection is indicated when proteinuria is >1 g/day. We aimed to assess the clinicopathological correlations of IgAN and to compare the follow-up outcome of the IgAN patients receiving renoprotection with the patients with other antihypertensive regimen treatments. METHODS: A retrospective kidney biopsy cohort study was carried out in consecutive 73 IgAN cases, using the new Oxford classification...
March 14, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28289254/mechanistic-movement-models-to-understand-epidemic-spread
#13
REVIEW
Abdou Moutalab Fofana, Amy Hurford
An overlooked aspect of disease ecology is considering how and why animals come into contact with one and other resulting in disease transmission. Mathematical models of disease spread frequently assume mass-action transmission, justified by stating that susceptible and infectious hosts mix readily, and foregoing any detailed description of host movement. Numerous recent studies have recorded, analysed and modelled animal movement. These movement models describe how animals move with respect to resources, conspecifics and previous movement directions and have been used to understand the conditions for the occurrence and the spread of infectious diseases when hosts perform a type of movement...
May 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28288457/interferon-dependent-induction-of-clr-b-during-mouse-cytomegalovirus-infection-protects-bystander-cells-from-natural-killer-cells-via-nkr-p1b-mediated-inhibition
#14
Christina L Kirkham, Oscar A Aguilar, Tao Yu, Miho Tanaka, Aruz Mesci, Kuan-Lun Chu, Jason H Fine, Karen L Mossman, Rod Bremner, David S J Allan, James R Carlyle
Natural killer (NK) cells are innate lymphocytes that aid in self-nonself discrimination by recognizing cells undergoing pathological alterations. The NKR-P1B inhibitory receptor recognizes Clr-b, a self-encoded marker of cell health downregulated during viral infection. Here, we show that Clr-b loss during mouse cytomegalovirus (MCMV) infection is predicated by a loss of Clr-b (Clec2d) promoter activity and nascent transcripts, driven in part by MCMV ie3 (M122) activity. In contrast, uninfected bystander cells near MCMV-infected fibroblasts reciprocally upregulate Clr-b expression due to paracrine type-I interferon (IFN) signaling...
March 14, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28285983/assessing-misclassification-of-vaccination-status-implications-for-studies-of-the-safety-of-the-childhood-immunization-schedule
#15
Matthew F Daley, Jason M Glanz, Sophia R Newcomer, Michael L Jackson, Holly C Groom, Marlene M Lugg, Huong Q McLean, Nicola P Klein, Eric S Weintraub, Michael M McNeil
BACKGROUND: To address public concern about the safety of the childhood immunization schedule, the Institute of Medicine recommended observational studies comparing adverse health outcomes of fully vaccinated children to children under-vaccinated due to parental choice. Misclassification of vaccination status could bias such studies. OBJECTIVE: To assess risk of misclassification of vaccination status within the Vaccine Safety Datalink (VSD). DESIGN/METHODS: A retrospective cohort study was conducted in three phases...
March 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28283373/dynamics-affecting-the-risk-of-silent-circulation-when-oral-polio-vaccination-is-stopped
#16
J S Koopman, C J Henry, J H Park, M C Eisenberg, E L Ionides, J N Eisenberg
Waning immunity could allow transmission of polioviruses without causing poliomyelitis by promoting silent circulation (SC). Undetected SC when oral polio vaccine (OPV) use is stopped could cause difficult to control epidemics. Little is known about waning. To develop theory about what generates SC, we modeled a range of waning patterns. We varied both OPV and wild polio virus (WPV) transmissibility, the time from beginning vaccination to reaching low polio levels, and the infection to paralysis ratio (IPR)...
March 1, 2017: Epidemics
https://www.readbyqxmd.com/read/28283304/minor-injury-crashes-prevalence-of-driver-related-risk-factors-and-outcome
#17
Jeffrey R Brubacher, Herbert Chan, Elizabeth Purssell, Benjamin J Tuyp, Daniel K Ting, Vahid Mehrnoush
BACKGROUND: The majority of crashes cause "minor" injuries (i.e., treated and released from the emergency department [ED]). Minor injury crashes are poorly studied. OBJECTIVES: This study aims to determine the prevalence of driver-related risk factors and subsequent outcome in drivers involved in minor crashes. METHODS: We interviewed a convenience sample of injured drivers, aged over 17 years, who were treated and released from the ED. Follow-up interviews were conducted 6 months after the crash...
March 7, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28281873/resolving-the-micro-heterogeneity-and-structural-integrity-of-monoclonal-antibodies-by-hybrid-mass-spectrometric-approaches
#18
Yang Yang, Guanbo Wang, Ting Song, Carlito B Lebrilla, Albert J R Heck
For therapeutic monoclonal antibodies (mAbs), detailed analysis of the structural integrity and heterogeneity, which results from multiple types of post-translational modifications (PTMs), is relevant to various processes, including product characterization, storage stability and quality control. Despite the recent rapid development of new bioanalytical techniques, it is still challenging to completely characterize the proteoform profile of a mAb. As a nearly indispensable tool in mAb analysis, mass spectrometry (MS) provides unique structural information at multiple levels...
February 14, 2017: MAbs
https://www.readbyqxmd.com/read/28278592/exploring-associations-between-self-regulatory-mechanisms-and-neuropsychological-functioning-and-driver-behaviour-after-brain-injury
#19
Per-Ola Rike, Hans J Johansen, Pål Ulleberg, Anna Lundqvist, Anne-Kristine Schanke
The objective of this prospective one-year follow-up study was to explore the associations between self-regulatory mechanisms and neuropsychological tests as well as baseline and follow-up ratings of driver behaviour. The participants were a cohort of subjects with stroke and traumatic brain injury (TBI) who were found fit to drive after a multi-disciplinary driver assessment (baseline). Baseline measures included neuropsychological tests and ratings of self-regulatory mechanisms, i.e., executive functions (Behavior Rating Inventory of Executive Function-Adult Version; BRIEF-A) and impulsive personality traits (UPPS Impulsive Behavior Scale)...
April 11, 2016: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28277349/missed-opportunities-for-prevention-of-mother-to-child-transmission-of-human-immunodeficiency-virus
#20
Gwendolyn B Scott, Susan B Brogly, Daniel Muenz, Alice M Stek, Jennifer S Read
OBJECTIVE: To identify missed opportunities for prevention of mother-to-child transmission of human immunodeficiency virus (HIV). METHODS: Data regarding HIV-infected children born between 2002 and 2009 to HIV-infected women enrolled in the U.S. International Maternal Pediatric Adolescent AIDS Clinical Trials prospective cohort study (protocol P1025) were reviewed. The characteristics of the HIV-infected infants and their mothers and the mothers' clinical management are described...
March 6, 2017: Obstetrics and Gynecology
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