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https://www.readbyqxmd.com/read/29772569/evaluation-of-inhaled-procaterol-for-potential-assist-use-in-patients-with-stable-chronic-obstructive-pulmonary-disease
#1
Norio Kodaka, Toru Yamagishi, Kayo Watanabe, Kumiko Kishimoto, Chihiro Nakano, Takeshi Oshio, Kumiko Niitsuma, Nagashige Shimada, Hiroto Matsuse
OBJECTIVES: International guidelines recommend the use of long-acting bronchodilators for the treatment of chronic obstructive pulmonary disease (COPD), but the usefulness of short-acting bronchodilator assist use for stable COPD remains uncertain. The purpose of the present study was to objectively demonstrate the effects of assist use of procaterol, a short-acting -agonist, on the respiratory mechanics of stable COPD patients treated with a long-acting bronchodilator using forced oscillation technique (FOT) and conventional spirometry...
May 17, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29769147/association-of-pulmonary-cardiovascular-and-hematologic-metrics-with-carbon-nanotube-and-nanofiber-exposure-among-u-s-workers-a-cross-sectional-study
#2
Mary K Schubauer-Berigan, Matthew M Dahm, Aaron Erdely, John D Beard, M Eileen Birch, Douglas E Evans, Joseph E Fernback, Robert R Mercer, Stephen J Bertke, Tracy Eye, Marie A de Perio
BACKGROUND: Commercial use of carbon nanotubes and nanofibers (CNT/F) in composites and electronics is increasing; however, little is known about health effects among workers. We conducted a cross-sectional study among 108 workers at 12 U.S. CNT/F facilities. We evaluated chest symptoms or respiratory allergies since starting work with CNT/F, lung function, resting blood pressure (BP), resting heart rate (RHR), and complete blood count (CBC) components. METHODS: We conducted multi-day, full-shift sampling to measure background-corrected elemental carbon (EC) and CNT/F structure count concentrations, and collected induced sputum to measure CNT/F in the respiratory tract...
May 16, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29768509/aging-related-trajectories-of-lung-function-in-the-general-population-the-doetinchem-cohort-study
#3
Sandra H van Oostrom, Peter M Engelfriet, W M Monique Verschuren, Maarten Schipper, Inge M Wouters, Marike Boezen, Henriëtte A Smit, Huib A M Kerstjens, H Susan J Picavet
The objective of this study was to explore trajectories of lung function decline with age in the general population, and to study the effect of sociodemographic and life style related risk factors, in particular smoking and BMI. For this purpose, we used data from the Doetinchem Cohort Study (DCS) of men and women, selected randomly from the general population and aged 20-59 years at inclusion in 1987-1991, and followed until the present. Participants in the DCS are assessed every five years. Spirometry has been performed as part of this assessment from 1994 onwards...
2018: PloS One
https://www.readbyqxmd.com/read/29768414/adipose-derived-mesenchymal-stem-cells-admsc-for-the-treatment-of-secondary-progressive-multiple-sclerosis-a-triple-blinded-placebo-controlled-randomized-phase-i-ii-safety-and-feasibility-study
#4
Oscar Fernández, Guillermo Izquierdo, Victoria Fernández, Laura Leyva, Virginia Reyes, Miguel Guerrero, Antonio León, Carlos Arnaiz, Guillermo Navarro, Maria Dolores Páramo, Antonio De la Cuesta, Bernat Soria, Abdelkrim Hmadcha, David Pozo, Rafael Fernandez-Montesinos, Maria Leal, Itziar Ochotorena, Patricia Gálvez, Maria Angeles Geniz, Francisco Javier Barón, Rosario Mata, Cristina Medina, Carlos Caparrós-Escudero, Ana Cardesa, Natividad Cuende
BACKGROUND: Currently available treatments for secondary progressive multiple sclerosis(SPMS) have limited efficacy and/or safety concerns. Adipose-mesenchymal derived stem cells(AdMSCs) represent a promising option and can be readily obtained using minimally invasive procedures. PATIENTS AND METHODS: In this triple-blind, placebo-controlled study, cell samples were obtained from consenting patients by lipectomy and subsequently expanded. Patients were randomized to a single infusion of placebo, low-dose(1x106cells/kg) or high-dose(4x106cells/kg) autologous AdMSC product and followed for 12 months...
2018: PloS One
https://www.readbyqxmd.com/read/29765005/heart-rate-recovery-physical-activity-level-and-functional-status-in-subjects-with-copd
#5
Andrea A Morita, Laís K O Silva, Gianna W Bisca, Joice M Oliveira, Nidia A Hernandes, Fabio Pitta, Karina C Furlanetto
BACKGROUND: A normal heart rate reflects the balance between the sympathetic and parasympathetic autonomic nervous system. When the difference between heart rate at the end of an exercise test and after 1 min of recovery, known as the 1-min heart rate recovery, is ≤ 12 beats/min, this may indicate an abnormal delay. We sought to compare physical activity patterns and subjects' functional status with COPD with or without delayed 1-min heart rate recovery after the 6-min walk test (6MWT)...
May 15, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29764241/lack-of-respiratory-and-ocular-effects-following-acute-propylene-glycol-exposure-in-healthy-humans
#6
Pamela Dalton, Brianna Soreth, Christopher Maute, Carolyn Novaleski, Marcy Banton
OBJECTIVE: Propylene glycol (PG) is a widely used solvent, chemical intermediate and carrier substance for foods, pharmaceutical and cosmetic products. Professional and occupational exposure to PG aerosol and vapor may occur from theatrical smoke generators and during application of deicing products to airplanes. While PG is considered to have low toxicity, the results of one study suggested that brief (1-min) exposure to PG mist elicited ocular and respiratory effects in humans. Because the high concentrations and brief exposure duration in that study were not representative of most occupational exposures, a controlled experimental exposure study was conducted to clarify or confirm the earlier findings...
May 15, 2018: Inhalation Toxicology
https://www.readbyqxmd.com/read/29757037/the-clinical-implications-of-tests-confirming-copd-in-subjects-hospitalized-with-exacerbations
#7
Chan Yeu Pu, Nancy Quesada, Richard Nunez Lopez, Karmapath Aryal, Aiman Tulaimat
BACKGROUND: The diagnosis of COPD in patients hospitalized for AECOPD can be confirmed by spirometry showing obstruction or radiographs showing emphysema. The evidence for COPD is sometimes absent or contradicts this diagnosis. The inaccurate attribution of the exacerbation to COPD can lead to suboptimal care and worse outcome. OBJECTIVES: We determined if the presence of tests that confirm the diagnosis of COPD has any implications on the course of the hospitalization and readmission rate...
May 14, 2018: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29755755/lung-volumes-identify-an-at-risk-group-in-persons-with-prolonged-secondhand-tobacco-smoke-exposure-but-without-overt-airflow-obstruction
#8
Mehrdad Arjomandi, Siyang Zeng, Jeroen Geerts, Rachel K Stiner, Bruce Bos, Ian van Koeverden, Jason Keene, Brett Elicker, Paul D Blanc, Warren M Gold
Introduction: Exposure to secondhand smoke (SHS) is associated with occult obstructive lung disease as evident by abnormal airflow indices representing small airway disease despite having preserved spirometry (normal forced expiratory volume in 1 s-to-forced vital capacity ratio, FEV1 /FVC). The significance of lung volumes that reflect air trapping in the presence of preserved spirometry is unclear. Methods: To investigate whether lung volumes representing air trapping could determine susceptibility to respiratory morbidity in people with SHS exposure but without spirometric chronic obstructive pulmonary disease, we examined a cohort of 256 subjects with prolonged occupational SHS exposure and preserved spirometry...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29755709/perioperative-management-of-sickle-cell-disease
#9
REVIEW
Kwame Ofori Adjepong, Folashade Otegbeye, Yaw Amoateng Adjepong
Over 30 million people worldwide have sickle cell disease (SCD). Emergent and non-emergent surgical procedures in SCD have been associated with relatively increased risks of peri-operative mortality, vaso-occlusive (painful) crisis, acute chest syndrome, post-operative infections, congestive heart failure, cerebrovascular accident and acute kidney injury. Pre-operative assessment must include a careful review of the patient's known crisis triggers, baseline hematologic profile, usual transfusion requirements, pre-existing organ dysfunction and opioid use...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29755048/school-based-interprofessional-asthma-self-management-education-program-for-middle-school-students-a-feasibility-trial
#10
Ellen B Buckner, Donna J Copeland, Kristina S Miller, Timothy Op Holt
BACKGROUND: Asthma is the most common chronic disease among school-aged children under 18 years of age and is a major cause of morbidity, loss of school days, and increased hospitalizations. Asthma disproportionately affects low-income, minority youth in Alabama. The benefits of improving asthma control and self-management have significance for improving health, preventing disease, and reducing health disparities by addressing social, behavioral, environmental, economic, and medical determinants of health...
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29752708/coexistence-of-chronic-bronchitis-in-chronic-obstructive-lung-disease
#11
Filip Mejza, Paweł Nastałek, Agnieszka Mastalerz-Migas, Zbigniew Doniec, Wojciech Skucha
The incidence of chronic obstructive pulmonary disease (COPD) is on the rise worldwide. Chronic bronchitis is a frequent accompaniment of COPD, which increases the burden of COPD in affected individuals. The aim of this study was to characterize the phenotype of chronic bronchitis in COPD patients. The study was based on the survey data retrospectively retrieved from the Action Health-Lung Cancer Prophylaxis and Health Care Improvement screening program that concerned all the inhabitants, aged over 40, of the Proszowice administrative region situated in the Lesser Poland Voivodeship in southern Poland...
May 12, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29751547/the-relationship-between-diabetes-mellitus-and-respiratory-function-in-patients-eligible-for-coronary-artery-bypass-grafting
#12
Aleksandra Szylińska, Mariusz Listewnik, Żaneta Ciosek, Magdalena Ptak, Anna Mikołajczyk, Wioletta Pawlukowska, Iwona Rotter
Introduction: Spirometry performed prior to surgery provides information on the types of lung disorders in patients. The purpose of this study was to look for a relationship between the prevalence of diabetes and spirometry parameters. Material and Methods: The study was conducted in patients with coronary artery disease who were eligible for an isolated coronary artery bypass graft in 2013. The study group included 367 patients (287 men and 80 women) aged 68.7 ± 8.4 years. They were divided into those with diagnosed diabetes (group I, n = 138, 37...
May 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29748963/body-mass-index-and-cardiorespiratory-fitness-in-persons-with-multiple-sclerosis
#13
E Sebastião, R W Motl
OBJECTIVE: This study examined body fatness and its association with cardiorespiratory fitness (CRF) in persons with multiple sclerosis (pwMS) accounting for disability status. MATERIALS AND METHODS: This study involved a secondary data analysis from a previous study of 62 pwMS. Body fatness was indirect measured as body mass index (BMI), and CRF was measured as peak oxygen consumption from an incremental exercise test with spirometry. Participants were allocated into 3 different groups based on established BMI categories (ie, normal, overweight, and obese), and data were analyzed using SPSS...
May 11, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29748304/tobacco-smoke-exposure-in-early-life-and-adolescence-in-relation-to-lung-function
#14
Jesse D Thacher, Erica S Schultz, Jenny Hallberg, Ulrika Hellberg, Inger Kull, Per Thunqvist, Göran Pershagen, Per M Gustafsson, Erik Melén, Anna Bergström
Maternal smoking during pregnancy is associated with impaired lung function among young children, but less is known about long-term effects and the impact of adolescents' own smoking. We investigated the influence of maternal smoking during pregnancy, secondhand smoke exposure, and adolescent smoking on lung function at age 16 years.The BAMSE birth cohort collected information on participant's tobacco smoke exposure through repeated questionnaires, and measured saliva cotinine concentrations at age 16. Participants performed spirometry and impulse oscillometry (IOS) at age 16 (n=2295)...
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29747982/asthma-over-the-age-of-65-all-s-well-that-ends-well
#15
Alan P Baptist, Paula J Busse
Asthma in older adults (often classified as those 65 years or older) is relatively common, underdiagnosed, and suboptimally treated. It is an important health problem, as the population of the United States continues to age. Unfortunately, asthma morbidity and mortality rates are highest in this age group. Alterations in the innate and adaptive immune responses occur with aging, and contribute to pathophysiologic differences and subsequent treatment challenges. The symptoms of asthma may differ from those in younger populations, and often include fatigue...
May 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29743778/respiratory-morbidity-among-rice-mill-workers-in-an-urban-area-of-burdwan-district-west-bengal-a-cross-sectional-study
#16
Madhab Ch Rana, Somnath Naskar, Ramaprasad Roy, Dilip Kr Das, Soumya Das
Background: Rice mill workers constitute a special group from the perspective of occupational health. Unprotected dust exposure among them adversely affects their respiratory health, which needs to be evaluated. Adequate evidence is still lacking in many parts of India including West Bengal. Burdwan is one of the main rice-producing districts in the state with abundant rice mills. Aim: The aim of the study was to find out the prevalence and pattern of respiratory morbidity and associated background characteristics of rice mill workers...
January 2018: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29743118/arterial-stiffness-in-adults-with-steady-state-bronchiectasis-association-with-clinical-indices-and-disease-severity
#17
Yong-Hua Gao, Juan-Juan Cui, Ling-Yun Wang, Ke-Qin Yin, Li Wang, Guo-Jun Zhang, Shao-Xia Liu
BACKGROUND: Cardiovascular disease are common co-morbidities in bronchiectasis and contribute substantially to disease burden and mortality. Brachial-ankle pulse wave velocity (baPWV), a measure of arterial stiffness, has a strong predictive value for cardiovascular event. We hypothesized that baPWV would be increased in steady-state bronchiectasis patients, and correlates with the degree of systemic inflammation and disease severity assessed with Bronchiectasis Severity Index and FACED scores...
May 9, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29742906/relationship-of-spirometric-body-plethysmographic-and-diffusing-capacity-parameters-to-emphysema-scores-derived-from-ct-scans
#18
Kathrin Kahnert, Bertram Jobst, Frank Biertz, Jürgen Biederer, Henrik Watz, Rudolf M Huber, Jürgen Behr, Philippe A Grenier, Peter Alter, Claus F Vogelmeier, Hans-Ulrich Kauczor, Rudolf A Jörres
Phenotyping of chronic obstructive pulmonary disease (COPD) with computed tomography (CT) is used to distinguish between emphysema- and airway-dominated type. The phenotype is reflected in correlations with lung function measures. Among these, the relative value of body plethysmography has not been quantified. We addressed this question using CT scans retrospectively collected from clinical routine in a large COPD cohort. Three hundred and thirty five patients with baseline data of the German COPD cohort COPD and Systemic Consequences-Comorbidities Network were included...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29742176/proportion-and-clinical-characteristics-of-non-asthmatic-non-smokers-among-adults-with-airflow-obstruction
#19
Hiroto Takiguchi, Tomoe Takeuchi, Kyoko Niimi, Hiromi Tomomatsu, Katsuyoshi Tomomatsu, Naoki Hayama, Tsuyoshi Oguma, Takuya Aoki, Tetsuya Urano, Satomi Asai, Hayato Miyachi, Koichiro Asano
BACKGROUND AND OBJECTIVES: Chronic obstructive pulmonary disease (COPD) mainly develops after long-term exposure to cigarette or biomass fuel smoke, but also occurs in non-smokers with or without a history of asthma. We investigated the proportion and clinical characteristics of non-smokers among middle-aged to elderly subjects with airflow obstruction. METHODS: We retrospectively analyzed 1,892 subjects aged 40-89 years who underwent routine preoperative spirometry at a tertiary university hospital in Japan...
2018: PloS One
https://www.readbyqxmd.com/read/29740896/gold-assessment-of-copd-severity-in-the-clinical-practice-research-datalink-cprd
#20
Cristina Rebordosa, Estel Plana, Jaume Aguado, Steven Thomas, Esther García-Gil, Susana Perez-Gutthann, Jordi Castellsague
PURPOSE: To evaluate availability of spirometry and symptom data in the Clinical Practice Research Datalink (United Kingdom) to assess COPD severity using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016 definition and comparing it with an algorithm used in other studies. METHODS: This was a descriptive, noninterventional, secondary database cohort study of patients with COPD aged 40 years or older, who initiated treatment with specific COPD medications...
May 8, 2018: Pharmacoepidemiology and Drug Safety
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