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https://www.readbyqxmd.com/read/29324341/biotin-conjugated-organic-molecules-and-proteins-for-cancer-therapy-a-review
#1
Santanu Maiti, Priyankar Paira
The main transporter for biotin is sodium dependent multivitamin transporter (SMVT), which is overexpressed in various aggressive cancer cell lines such as ovarian (OV 2008, ID8), leukemia (L1210FR), mastocytoma (P815), colon (Colo-26), breast (4T1, JC, MMT06056), renal (RENCA, RD0995), and lung (M109) cancer cell lines. Furthermore, its overexpression was found higher to that of folate receptor. Therefore, biotin demand in the rapidly growing tumors is higher than normal tissues. Several biotin conjugated organic molecules has been reported here for selective delivery of the drug in cancer cell...
January 2, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29324311/corilagin-a-promising-medicinal-herbal-agent
#2
REVIEW
Xuan Li, Yuan Deng, Zhizhong Zheng, Wen Huang, Lianghua Chen, Qingxuan Tong, Yanlin Ming
Corilagin, a gallotannin, is one of the major active components of many ethnopharmacological plants. It was isolated from Caesalpinia coriaria (Jacq.) Willd. (dividivi) by Schmidt in 1951 for the first time. In the past few decades, corilagin was reported to exhibit anti-tumor, anti-inflammatory and hepatoprotective activities, etc. However, little attention was paid to its pharmacological properties due to the complicated and inefficient extract method. In recent years, with the development of extraction technology corilagin was much easier to obtain than before...
January 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29320955/therapeutic-roles-of-statins-in-gynecology-and-obstetrics-the-current-evidence
#3
Burak Zeybek, Maged Costantine, Gokhan S Kilic, Mostafa A Borahay
INTRODUCTION: Statins are a class of drugs, which act by inhibiting the rate-limiting enzyme of cholesterol biosynthesis (3-hydroxy-3-methyl-glutaryl-CoA reductase). The inhibition of mevalonate synthesis leads to subsequent inhibition of downstream products of this pathway, which explains the pleiotropic effects of these agents in addition to their well-known lipid-lowering effects. Accumulating evidence suggests that statins might be beneficial in various obstetric and gynecologic conditions...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29317319/the-molecular-mechanisms-of-action-of-the-endocrine-disrupting-chemical-bisphenol-a-in-the-development-of-cancer
#4
REVIEW
Ayman E Shafei, Maggie M Ramzy, Abdelhares I Hegazy, Ahmed K Husseny, Usama G El-Hadary, Mazen M Taha, Ali A Mosa
The endocrine disrupting chemical (EDC) is an exogenous substance or mixture that alters the function of the endocrine system and consequently causes adverse effects in intact organisms. Bisphenol A (BPA), one of the most common endocrine disrupting chemicals is a carbon-based synthetic compound used in the production of water bottles, cans, and teeth suture materials. It is known to be a xenoestrogen as it interacts with estrogen receptors and acts as agonist or antagonist via estrogen receptor-dependent signaling pathways...
January 6, 2018: Gene
https://www.readbyqxmd.com/read/29313444/poly-adp-ribose-polymerase-inhibitors-in-the-management-of-ovarian-cancer
#5
Maurie Markman
There is considerable interest and enthusiasm within the clinical gynecologic oncology community regarding the potential for poly (ADP-ribose) polymerase inhibitors to play a critically relevant role in the management of epithelial ovarian cancer and particularly (although not exclusively) in the setting of known mutations in the BRCA gene. This review will briefly highlight the biological rational for the use of poly (ADP-ribose) polymerase inhibitors in this malignancy, followed by summary of currently available clinical data supporting the delivery of agents approved by the US Food and Drug Administration for non-investigative use...
January 2018: Women's Health
https://www.readbyqxmd.com/read/29313170/the-two-faces-of-adjuvant-glucocorticoid-treatment-in-ovarian-cancer
#6
REVIEW
Vladimir Djedovic, Yoo-Young Lee, Alexandra Kollara, Taymaa May, Theodore J Brown
Adjuvant glucocorticoid treatment is routinely used in the treatment of ovarian cancer to mitigate the undesirable side effects of chemotherapy, thereby enhancing tolerability to higher cytotoxic drug doses and frequency of treatment cycles. However, in vitro and preclinical in vivo and ex vivo studies indicate that glucocorticoids may spare tumor cells from undergoing cell death through enhanced cell adhesion, promotion of anti-inflammatory signaling, and/or inhibition of apoptotic pathways. The implications of laboratory studies showing potential negative impact on the efficacy of chemotherapy have been long overlooked since clinical investigations have found no apparent survival detriment attributable to adjuvant glucocorticoid use...
January 8, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29303937/when-and-who-should-perform-epithelial-ovarian-cancer-surgery
#7
Cecilia Escayola, Juan Jose Torrent, Gwenaël Ferron, François Quenet, Denis Querleu
Epithelial ovarian cancer is the most common cause of death due to gynecologic malignancies. Most patients will be diagnosed at an advanced stage, and despite progress in both surgical procedures and novel targeted therapies, the overall survival of these patients remains very low. Among prognostic factors, the International Federation of Gynecology and Obstetrics stage and residual tumor after debulking surgery are the most widely reported. The current review aims to highlight the disparities in the treatment of patients with ovarian cancer and the need for postgraduate training programs in order to accredit gynecologic oncologists...
January 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29301373/potential-anticancer-properties-of-osthol-a-comprehensive-mechanistic-review
#8
REVIEW
Yalda Shokoohinia, Fataneh Jafari, Zeynab Mohammadi, Leili Bazvandi, Leila Hosseinzadeh, Nicholas Chow, Piyali Bhattacharyya, Mohammad Hosein Farzaei, Ammad Ahmad Farooqi, Seyed Mohammad Nabavi, Mükerrem Betül Yerer, Anupam Bishayee
Cancer is caused by uncontrolled cell proliferation which has the potential to occur in different tissues and spread into surrounding and distant tissues. Despite the current advances in the field of anticancer agents, rapidly developing resistance against different chemotherapeutic drugs and significantly higher off-target effects cause millions of deaths every year. Osthol is a natural coumarin isolated from Apiaceaous plants which has demonstrated several pharmacological effects, such as antineoplastic, anti-inflammatory and antioxidant properties...
January 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29300814/body-mass-index-and-20-specific-cancers-re-analyses-of-dose-response-meta-analyses-of-observational-studies
#9
E K Choi, H B Park, K H Lee, J H Park, M Eisenhut, H J van der Vliet, G Kim, J I Shin
Background: Objectives were to provide an overview and understand the strength of evidence and extent of potential biases and validity of claimed associations between Body Mass Index (BMI) and risk of developing cancer. Methods: We performed an umbrella review and comprehensively re-analysed the data of dose-response meta-analyses on associations between BMI and risk of 20-specific cancers (bladder, brain, breast, colonic, rectal, endometrial, gallbladder, gastric, leukemia, liver, lung, melanoma, multiple myeloma, non-Hodgkins lymphoma, oesophagus, ovarian, pancreatic, prostate, renal, thyroid) by adding big data or missed individual studies...
December 28, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29299762/risk-reduction-surgery-rrs-for-tubo-ovarian-cancer-in-an-irish-gynaecological-practice-an-analysis-of-indications-and-outcomes
#10
Claire Thompson, Ciara McCormick, Waseem Kamran, Ciaran O'Riain, Lucy Norris, David Gallagher, Noreen Gleeson
BACKGROUND: High-grade serous carcinoma (HGSC) is the most common tubo-ovarian cancer. The fallopian tube harbours the precursor lesion: serous tubal intraepithelial carcinoma (STIC). Bilateral salpingo-oophorectomy is an effective risk-reducing surgical (RRS) strategy for breast cancer susceptibility gene mutation carriers (BRCAm). The value of RRS in those without defined genetic risk is unknown but these women represent a substantial cohort in prophylactic surgical practice. METHODS: This is a retrospective review of RRS at an Irish university teaching hospital...
January 3, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29299705/a-comparison-of-the-prognosis-between-adenocarcinoma-and-squamous-cell-carcinoma-in-stage-ib-iia-cervical-cancer
#11
Xiuzhen Xie, Kun Song, Baoxia Cui, Jie Jiang, Xingsheng Yang, Beihua Kong
OBJECTIVE: To explore differences in prognosis between adenocarcinoma (AC) and squamous cell carcinoma (SCC) and to explore feasibility of ovarian preservation in stage IB-IIA cervical cancer (CC). MATERIALS AND METHODS: Medical records of 810 patients (682 SCC + 128 AC) with stage IB-IIA CC were reviewed. Clinical and pathological characters of the two groups were compared using the chi-squared test. Kaplan-Meier survival analysis was used in univariate analysis of prognostic factors...
January 3, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29295697/towards-prevention-of-ovarian-cancer
#12
Aus Tariq Ali
Ovarian cancer is the leading cause of death of all gynaecological cancers. To date, there is no reliable, specific screening procedure for detecting ovarian cancer. The risk factors of ovarian cancer include modifiable and non-modifiable factors. The main goal of the ovarian cancer prevention program is to significantly reduce the risk of development of ovarian cancer and other cancers such as breast and/or peritoneal cancer. The application of non-surgical preventive approaches such as oral contraceptives, parity and breastfeeding has been shown to be highly protective against ovarian cancer development...
January 1, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29290779/opportunistic-salpingectomy-at-benign-gynecological-surgery-for-reducing-ovarian-cancer-risk-a-10-year-single-centre-experience-from-china-and-a-literature-review
#13
Ying Chen, Hui Du, Lewen Bao, Wenxin Liu
Current evidences indicate that the fallopian tube plays a major role in the pathogenesis of epithelial ovarian cancer (EOC). Salpingectomy represents a novel and potentially effective risk-reducing option. In this study, there were 1822 patients diagnosed and treated for EOC or primary peritoneal cancer (PPC) at Department of Gynecologic Oncology, Tianjin Medical University Cancer Institute and Hospital from January 1, 2007 to April 30, 2017. Among them, 198 patients with a history of gynecological surgery because of benign diseases were enrolled to analyze further...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29289266/is-myc-an-important-biomarker-myc-expression-in-immune-disorders-and-cancer
#14
REVIEW
Shivtia Trop-Steinberg, Yehudit Azar
The proto-oncogene Myc serves as a paradigm for understanding the dynamics of transcriptional regulation. Myc protein has been linked to immune dysfunction, cancer development and neoplastic transformation. We review recent research regarding functions of Myc as an important modulator in immune disorders, postallogeneic hematopoietic stem cell transplantation (HSCT) and several cancers. Myc overexpression has been repeatedly linked to immune disorders and specific cancers, such as myasthenia gravis, psoriasis, pemphigus vulgaris, atherosclerosis, long-term allogeneic survival among HSCT patients, (primary) inflammatory breast cancer, (primary) ovarian carcinoma and hematological malignancies: acute myeloid leukemia, chronic myelogenous leukemia, Hodgkin's lymphoma and diffuse large B-cell lymphoma...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29286535/the-changing-landscape-of-lynch-syndrome-due-to-pms2-mutations
#15
REVIEW
J Blount, A Prakash
DNA repair pathways are essential for cellular survival as our DNA is constantly under assault from both exogenous and endogenous DNA damaging agents. Five major mammalian DNA repair pathways exist within a cell to maintain genomic integrity. Of these, the DNA mismatch repair (MMR) pathway is highly conserved among species and is well documented in bacteria. In humans, the importance of MMR is underscored by the discovery that a single mutation in any one of four genes within the MMR pathway (MLH1, MSH2, MSH6 and PMS2) results in Lynch syndrome (LS)...
December 29, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/29286290/ovarian-cancer-screening-lessons-about-effectiveness
#16
EDITORIAL
Edward J Pavlik
Ovarian cancer screening has been described in scientific reports [1-4], as well as in reviews and summaries[...].
December 29, 2017: Diagnostics
https://www.readbyqxmd.com/read/29282716/targeting-dna-repair-the-genome-as-a-potential-biomarker
#17
REVIEW
Ksenija Nesic, Matthew Wakefield, Olga Kondrashova, Clare L Scott, Iain A McNeish
Genomic instability and mutations are fundamental aspects of human malignancies, leading to progressive accumulation of the hallmarks of cancer. For some time, it has been clear that key mutations may be used both as prognostic and predictive biomarkers, the best-known examples being the presence of germline BRCA1 or BRCA2 mutations, which are not only associated with improved prognosis in ovarian cancer, but are also predictive of response to poly(ADP-ribose) polymerase (PARP) inhibitors. Although biomarkers as specific and powerful as these are rare in human malignancies, next generation sequencing and improved bioinformatic analyses are revealing mutational signatures, broader patterns of alterations in the cancer genome that have the power to reveal information about underlying driver mutational processes...
December 27, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29281099/pretty-good-or-pretty-bad-the-ovary-and-chemicals-in-personal-care-products
#18
Zelieann R Craig, Ayelet Ziv-Gal
Personal care products (PCP) contain a myriad of chemicals generally formulated to provide a safe and beneficial use. Nonetheless, an increasing amount of laboratory animal and human studies indicate that some chemicals in PCP are associated with decreased hormone production, diminished ovarian reserve, ovarian cancer, and early pregnancy loss. The ovary is key to female fertility by providing the eggs and sex steroid hormones for fertilization and maintenance of reproductive function, respectively. Thus, understanding how chemicals in PCP affect the ovary will shed some light on their potential effects on female fertility...
December 21, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29278599/meeting-report-from-the-2016-11th-biennial-ovarian-cancer-research-symposium-mechanisms-of-initiation-and-progression-of-ovarian-cancers
#19
Jeremy Chien, Geeta Mehta
OBJECTIVE: The aim of this study was to review the latest research advances on the mechanisms of initiation and progression of ovarian cancer. METHODS: At the 11th Biennial Ovarian Cancer Research Symposium, which was held in Seattle, Washington in September 2016, leaders in ovarian cancer research convened to present and discuss current advances and future directions in ovarian cancer research. RESULTS: One session was dedicated to Mechanisms of Initiation and Progression of Ovarian Cancer, and included a keynote presentation from Dr Ronny Drapkin, MD (University of Pennsylvania), and an invited oral presentation from Laising Yen, PhD (Baylor College of Medicine)...
November 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29278598/research-summaries-the-11th-biennial-rivkin-center-ovarian-cancer-research-symposium
#20
Deborah K Armstrong
In September 2016, the 11th biennial ovarian cancer research symposium was presented by the Rivkin Center for Ovarian Cancer and the American Association for Cancer Research. The 2016 symposium focused on 4 broad areas of research: Mechanisms of Initiation and Progression of Ovarian Cancer, Tumor Microenvironment and Models of Ovarian Cancer, Detection and Prevention of Ovarian Cancer, and Novel Therapeutics for Ovarian Cancer. The presentations and abstracts from each of these areas are reviewed in this supplement to the International Journal of Gynecologic Oncology...
November 2017: International Journal of Gynecological Cancer
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