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https://www.readbyqxmd.com/read/27900571/erratum-to-simvastatin-rapidly-and-reversibly-inhibits-insulin-secretion-in-intact-single-islet-cultures
#1
Valentina Scattolini, Camilla Luni, Alessandro Zambon, Silvia Galvanin, Onelia Gagliano, Catalin Dacian Ciubotaru, Angelo Avogaro, Fabio Mammano, Nicola Elvassore, Gian Paolo Fadini
No abstract text is available yet for this article.
November 30, 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/27832439/biosorbent-a-promising-material-for-remediation-of-eutrophic-environments-studies-in-microcosm
#2
Glaucia Pantano, Josilei S Ferreira, Francisco W B Aquino, Edenir R Pereira-Filho, Antonio A Mozeto, Pedro S Fadini
Eutrophication is considered a global environmental problem that causes economic and biodiversity loss. Together with excess phosphorus in some aquatic environments, there is the depletion of phosphate rock deposits, which can directly affect fertilizer production and therefore global food security. Thus, the present work aimed to study a new remediation technique for eutrophic environments that enables the recovery of these environments through phosphorus adsorption in sawdust, creating the possibility to apply the phosphorus-enriched material as an agricultural fertilizer...
November 10, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27830474/simvastatin-rapidly-and-reversibly-inhibits-insulin-secretion-in-intact-single-islet-cultures
#3
Valentina Scattolini, Camilla Luni, Alessandro Zambon, Silvia Galvanin, Onelia Gagliano, Catalin Dacian Ciubotaru, Angelo Avogaro, Fabio Mammano, Nicola Elvassore, Gian Paolo Fadini
INTRODUCTION: Epidemiological studies suggest that statins may promote the development or exacerbation of diabetes, but whether this occurs through inhibition of insulin secretion is unclear. This lack of understanding is partly due to the cellular models used to explore this phenomenon (cell lines or pooled islets), which are non-physiologic and have limited clinical transferability. METHODS: Here, we study the effect of simvastatin on insulin secretion using single-islet cultures, an optimal compromise between biological observability and physiologic fidelity...
December 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/27815289/long-term-prediction-of-cardiovascular-outcomes-by-circulating-cd34-and-cd34-cd133-stem-cells-in-patients-with-type-2-diabetes
#4
Gian Paolo Fadini, Mauro Rigato, Roberta Cappellari, Benedetta Maria Bonora, Angelo Avogaro
OBJECTIVE: Cardiovascular risk varies substantially in the population with diabetes, and biomarkers can improve risk stratification. Circulating stem cells predict future cardiovascular events and death, but data for the population with diabetes are scant. In this study we evaluated the ability of circulating stem cell levels to predict future cardiovascular outcomes and improve risk discrimination in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A cohort of 187 patients with type 2 diabetes was monitored for a median of 6...
November 4, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27696500/the-rs2274911-polymorphism-in-gprc6a-gene-is-associated-with-insulin-resistance-in-normal-weight-and-obese-subjects
#5
Andrea Di Nisio, Maria Santa Rocca, Gian Paolo Fadini, Luca De Toni, Giorgio Marcuzzo, Maria Cristina Marescotti, Marta Sanna, Mario Plebani, Roberto Vettor, Angelo Avogaro, Carlo Foresta
OBJECTIVE: Identification of the novel endocrine role of osteocalcin (OC) and its receptor GPRC6A has given rise to a new branch of research in OC/GPRC6A axis related to glucose metabolism. GPRC6A- and OC-deficient mice share features of the metabolic syndrome, in addition to male infertility. Recently, the polymorphism rs2274911 in GPRC6A was shown to be associated with testicular impairment. We aimed to investigate the role of rs2274911 polymorphism in glucose and lipid metabolism in a cohort of normal weight and obese subjects DESIGN, PATIENTS, SETTINGS: A total of 392 male and females, including 218 obese patients and 174 age-matched normal weight controls, were retrospectively selected...
October 1, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27636096/correction-modeling-occupancy-of-hosts-by-mistletoe-seeds-after-accounting-for-imperfect-detectability
#6
Rodrigo F Fadini, Renato Cintra
[This corrects the article DOI: 10.1371/journal.pone.0127004.].
2016: PloS One
https://www.readbyqxmd.com/read/27618501/switching-from-twice-daily-glargine-or-detemir-to-once-daily-degludec-improves-glucose-control-in-type-1-diabetes-an-observational-study
#7
S Galasso, A Facchinetti, B M Bonora, V Mariano, F Boscari, E Cipponeri, A Maran, A Avogaro, G P Fadini, D Bruttomesso
BACKGROUND AND AIMS: Degludec is an ultralong-acting insulin analogue with a flat and reproducible pharmacodynamic profile. As some patients with type 1 diabetes (T1D) fail to achieve 24-h coverage with glargine or detemir despite twice-daily injections, we studied the effect of switching T1D patients from twice-daily glargine or detemir to degludec. METHODS AND RESULTS: In this prospective observational study, T1D patients on twice-daily glargine or detemir were enrolled...
December 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27585943/outbreak-investigation-for-toxigenic-corynebacterium-diphtheriae-wound-infections-in-refugees-from-northeast-africa-and-syria-in-switzerland-and-germany-by-whole-genome-sequencing
#8
D M Meinel, R Kuehl, R Zbinden, V Boskova, C Garzoni, D Fadini, M Dolina, B Blümel, T Weibel, S Tschudin-Sutter, A F Widmer, J A Bielicki, A Dierig, U Heininger, R Konrad, A Berger, V Hinic, D Goldenberger, A Blaich, T Stadler, M Battegay, A Sing, A Egli
Toxigenic Corynebacterium diphtheriae is an important and potentially fatal threat to patients and public health. During the current dramatic influx of refugees into Europe, our objective was to use whole genome sequencing for the characterization of a suspected outbreak of C. diphtheriae wound infections among refugees. After conventional culture, we identified C. diphtheriae using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) and investigated toxigenicity by PCR. Whole genome sequencing was performed on a MiSeq Illumina with >70×coverage, 2×250 bp read length, and mapping against a reference genome...
December 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27551743/subclinical-hypothyroidism-and-metabolic-syndrome-a-common-association-by-chance-or-a-cardiovascular-risk-driver
#9
Benedetta Maria Bonora, Gian Paolo Fadini
The metabolic syndrome (MS) and subclinical hypothyroidism (SCH) are highly prevalent in the general population. Cross-sectional epidemiological data suggest that a mutual association exists between the two, although the cause-effect relationship remains poorly elucidated. As SCH raises cholesterol, blood pressure, and visceral fat, it is easy to understand why it associates with MS. Rather, the reasons whereby MS patients are at higher risk for SCH are less apparent. Some studies have reported that SCH is itself characterized by high cardiovascular risk...
October 2016: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/27514514/continued-efforts-to-translate-diabetes-cardiovascular-outcome-trials-into-clinical-practice
#10
REVIEW
Angelo Avogaro, Gian Paolo Fadini, Giorgio Sesti, Enzo Bonora, Stefano Del Prato
Diabetic patients suffer from a high rate of cardiovascular events and such risk increases with HbA1c. However, lowering HbA1c does not appear to yield the same benefit on macrovascular endpoints, as observed for microvascular endpoints. As the number of glucose-lowering medications increases, clinicians have to consider several open questions in the management of type 2 diabetes, one of which is the cardiovascular risk profile of each regimen. Recent placebo-controlled cardiovascular outcome trials (CVOTs) have responded to some of these questions, but careful interpretation is needed...
2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27492838/task-for-today-complete-the-puzzle-of-circulating-stem-cells-and-the-atherosclerotic-burden
#11
EDITORIAL
Gian Paolo Fadini
No abstract text is available yet for this article.
August 5, 2016: Circulation Research
https://www.readbyqxmd.com/read/27449370/ion-imprinted-polymer-for-preconcentration-and-determination-of-ultra-trace-cadmium-employing-flow-injection-analysis-with-thermo-spray-flame-furnace-atomic-absorption-spectrometry
#12
Ayla Campos do Lago, Camila Marchioni, Tássia Venga Mendes, Célio Wisniewski, Pedro Sergio Fadini, Pedro Orival Luccas
This work proposes a preconcentration method using an ion imprinted polymer (IIP) for determination of cadmium, in several samples, employing a mini-column filled with the polymer coupled into a flow injection analysis system with detection by thermospray flame furnace atomic absorption spectrometry (FIA-TS-FF-AAS). The polymer was synthesized via bulk using methacrylic acid and vinylimidazole as a functional monomer. For the FIA system initial assessment, the variables: pH, eluent concentration and buffer concentration were studied, employing a 23 full factorial design...
July 22, 2016: Applied Spectroscopy
https://www.readbyqxmd.com/read/27419674/predictors-of-red-blood-cell-transfusion-after-cardiac-surgery-a-prospective-cohort-study
#13
Camila Takao Lopes, Evelise Helena Fadini Reis Brunori, Agueda Maria Ruiz Zimmer Cavalcante, Sue Ann Moorhead, Juliana de Lima Lopes, Alba Lucia Bottura Leite de Barros
OBJECTIVE: To identify predictors of red blood cell transfusion (RBCT) after cardiac surgery. METHOD: A prospective cohort study performed with 323 adults after cardiac surgery, from April to December of 2013. A data collection instrument was constructed by the researchers containing factors associated with excessive bleeding after cardiac surgery, as found in the literature, for investigation in the immediate postoperative period. The relationship between risk factors and the outcome was assessed by univariate analysis and logistic regression...
December 2015: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/27401837/concise-review-perspectives-and-clinical-implications-of-bone-marrow-and-circulating-stem-cell-defects-in-diabetes
#14
Gian Paolo Fadini, Stefano Ciciliot, Mattia Albiero
Diabetes mellitus is a complex systemic disease characterized by severe morbidity and excess mortality. The burden of its multiorgan complications relies on an imbalance between hyperglycemic cell damage and defective endogenous reparative mechanisms. Inflammation and abnormalities in several hematopoietic components are typically found in diabetes. The discovery that diabetes reduces circulating stem/progenitor cells and impairs their function has opened an entire new field of study where diabetology comes into contact with hematology and regenerative medicine...
July 11, 2016: Stem Cells
https://www.readbyqxmd.com/read/27255499/plerixafor-improves-the-endothelial-health-balance-the-effect-of-diabetes-analysed-by-polychromatic-flow-cytometry
#15
Roberta Cappellari, Marianna D'Anna, Angelo Avogaro, Gian Paolo Fadini
BACKGROUND AND AIMS: Diabetes damages the endothelium and reduces the availability of bone marrow (BM)-derived endothelial progenitor cells (EPCs). The mobilization of hematopoietic stem cells (HSCs) and EPCs in response to G-CSF is impaired by diabetes, owing to CXCL12 dysregulation. We have previously shown that the CXCR4/CXCL12 disruptor plerixafor rescues HSC and EPC mobilization in diabetes. We herein explored the effects of plerixafor on HSCs, EPCs, and circulating endothelial cells (CECs) in patients with and without diabetes...
August 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27188655/louse-borne-relapsing-fever-report-of-four-cases-in-switzerland-june-december-2015
#16
Michael Osthoff, Adrian Schibli, Davide Fadini, Pietro Lardelli, Daniel Goldenberger
BACKGROUND: Louse-borne relapsing fever (LBRF) is a neglected disease that has been restricted to East Africa for many decades. Several cases in refugees from the Horn of Africa have been recently diagnosed in four European countries. CASE PRESENTATION: We report four additional cases of LBRF in asylum seekers from Somalia and Eritrea who presented with fever shortly after arriving in Switzerland during a seven-month period. Multiple spirochetes were visualized on stained blood films which were identified as Borrelia recurrentis by 16S rRNA gene sequencing...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27073015/levels-of-circulating-progenitor-cells-cardiovascular-outcomes-and-death-a-meta-analysis-of-prospective-observational-studies
#17
Mauro Rigato, Angelo Avogaro, Gian Paolo Fadini
RATIONALE: Circulating progenitor cells (CPCs), including endothelial progenitor cells (EPCs) are biologically related to many aspects of cardiovascular disease, as they promote angiogenesis and vascular repair. OBJECTIVE: We herein aimed to meta-analyze studies reporting the prognostic role of the CPC/EPC measure on cardiovascular outcomes and death. METHODS AND RESULTS: We screened the English-language literature for longitudinal studies reporting the association between baseline CPC/EPC levels, future cardiovascular events, and death...
June 10, 2016: Circulation Research
https://www.readbyqxmd.com/read/26740598/netosis-delays-diabetic-wound-healing-in-mice-and-humans
#18
Gian Paolo Fadini, Lisa Menegazzo, Mauro Rigato, Valentina Scattolini, Nicol Poncina, Andrea Bruttocao, Stefano Ciciliot, Fabio Mammano, Catalin Dacian Ciubotaru, Enrico Brocco, Maria Cristina Marescotti, Roberta Cappellari, Giorgio Arrigoni, Renato Millioni, Saula Vigili de Kreutzenberg, Mattia Albiero, Angelo Avogaro
Upon activation, neutrophils undergo histone citrullination by protein arginine deiminase (PAD)4, exocytosis of chromatin and enzymes as neutrophil extracellular traps (NETs), and death. In diabetes, neutrophils are primed to release NETs and die by NETosis. Although this process is a defense against infection, NETosis can damage tissue. Therefore, we examined the effect of NETosis on the healing of diabetic foot ulcers (DFUs). Using proteomics, we found that NET components were enriched in nonhealing human DFUs...
April 2016: Diabetes
https://www.readbyqxmd.com/read/26719220/a-perspective-on-netosis-in-diabetes-and-cardiometabolic-disorders
#19
REVIEW
G P Fadini, L Menegazzo, V Scattolini, M Gintoli, M Albiero, A Avogaro
AIMS: To review the significance of a new type of neutrophil cell death (NETosis) in diabetes and cardiometabolic diseases. DATA SYNTHESIS: Diabetes and the metabolic syndrome are characterized by activation of the innate immune system. In this framework, neutrophils are front line defences against infections, but can also turn deleterious if abnormally stimulated. NETosis refers to a type of cell death whereby neutrophils release nuclear material and granule enzymes that together form the NETs (neutrophil extracellular traps)...
January 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/26695864/acute-effects-of-linagliptin-on-progenitor-cells-monocyte-phenotypes-and-soluble-mediators-in-type-2-diabetes
#20
RANDOMIZED CONTROLLED TRIAL
Gian Paolo Fadini, Benedetta Maria Bonora, Roberta Cappellari, Lisa Menegazzo, Monica Vedovato, Elisabetta Iori, Maria Cristina Marescotti, Mattia Albiero, Angelo Avogaro
CONTEXT: Circulating cells, including endothelial progenitor cells (EPCs) and monocyte subtypes, are involved in diabetic complications. Modulation of these cells may mediate additional benefits of glucose-lowering medications. OBJECTIVE: We assessed whether the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin acutely modifies EPCs and monocyte subsets in patients with type 2 diabetes. DESIGN: This was a randomized, crossover, placebo-controlled trial...
February 2016: Journal of Clinical Endocrinology and Metabolism
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