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Claire Galand, Juan Manuel Leyva-Castillo, Juhan Yoon, Alex Han, Margaret S Lee, Andrew N J McKenzie, Michael Stassen, Michiko K Oyoshi, Fred D Finkelman, Raif S Geha
BACKGROUND: Cutaneous exposure to food allergens predisposes to food allergy, which is commonly associated with atopic dermatitis (AD). Levels of the epithelial cytokine IL-33 are increased in skin lesions and serum of patients with AD. Mast cells (MCs) play a critical role in food-induced anaphylaxis and express the IL-33 receptor ST2. The role of IL-33 in patients with MC-dependent food anaphylaxis is unknown. OBJECTIVE: We sought to determine the role and mechanism of action of IL-33 in patients with food-induced anaphylaxis in a model of IgE-dependent food anaphylaxis elicited by oral challenge of epicutaneously sensitized mice...
November 2016: Journal of Allergy and Clinical Immunology
Gregory Noel, Muhammad Imran Arshad, Aveline Filliol, Valentine Genet, Michel Rauch, Catherine Lucas-Clerc, Agnès Lehuen, Jean-Philippe Girard, Claire Piquet-Pellorce, Michel Samson
The IL-33/ST2 axis plays a protective role in T-cell-mediated hepatitis, but little is known about the functional impact of endogenous IL-33 on liver immunopathology. We used IL-33-deficient mice to investigate the functional effect of endogenous IL-33 in concanavalin A (Con A)-hepatitis. IL-33(-/-) mice displayed more severe Con A liver injury than wild-type (WT) mice, consistent with a hepatoprotective effect of IL-33. The more severe hepatic injury in IL-33(-/-) mice was associated with significantly higher levels of TNF-α and IL-1β and a larger number of NK cells infiltrating the liver...
August 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
Andrea Marzullo, Francesca Ambrosi, Mirjam Inchingolo, Fabio Manca, Fiorella Devito, Domenico Angiletta, Annapaola Zito, Pietro Scicchitano, Marco Matteo Ciccone
BACKGROUND: ST2 (suppression of tumorigenity) has been described as a receptor for the interleukin-33, a member of the IL-1 family of cytokines. It is associated to coronary artery disease, all-causes mortality and cardiovascular mortality. AIMS: The present study was designed to assess the immunohistochemical expression of the ST2 receptor (ST2L/Il-1R) in atherosclerotic plaques of formalin fixed paraffin-embedded internal carotid arteries of patients with and without cerebro-vascular symptoms...
2016: PloS One
D P E Margiotta, L Navarini, M Vadacca, M Lo Vullo, F Pignataro, F Basta, A Afeltra
OBJECTIVE: Primary Sjogren's Syndrome (pSS) is a systemic autoimmune disorder characterized by infiltration of the exocrine glands leading to secretory insufficiency. Despite the progress made in understanding the pathogenesis of the SS, many aspects remain to be clarified. Interleukin-33 (IL33) is a recently discovered cytokine, belonging to IL-1 superfamily. IL33 and its soluble receptor ST2 were implied in a number of immune and in autoimmune diseases pathogenesis. In this work ,we analyzed expression of IL33 and ST2 in Sjogren's syndrome...
April 2016: European Review for Medical and Pharmacological Sciences
Wei-Yu Chen, Ya-Jen Chang, Chia-Hao Su, Tzu-Hsien Tsai, Shang-Der Chen, Chung-Hsi Hsing, Jenq-Lin Yang
Interstitial fibrosis and loss of parenchymal tubular cells are the common outcomes of progressive renal diseases. Pro-inflammatory cytokines have been known contributing to the damage of tubular cells and fibrosis responses after renal injury. Interleukin (IL)-33 is a tissue-derived nucleus alarmin that drives inflammatory responses. The regulation and function of IL-33 in renal injury, however, is not well understood. To investigate the involvement of cytokines in the pathogenesis of renal injury and fibrosis, we performed the mouse renal injury model induced by unilateral urinary obstruction (UUO) and analyze the differentially upregulated genes between the obstructed and the contralateral unobstructed kidneys using RNA sequencing (RNAseq)...
May 13, 2016: Biochemical and Biophysical Research Communications
Rui Li, Gang Yang, Ruiqi Yang, Xiaoxing Peng, Jing Li
IL33/ST2 axis activates airway eosinophils that exacerbate airway inflammation. The data was obtained from PubMed, EMBASE, Clinical trial, Cochrane Library, Web of science, CNKI and Wanfang database with time restrictions of 1 Jan, 2000 to 15 Feb, 2016. The meta-analysis was performed using Review Manager 5.2 software. After searching, total 15 documents were included into this meta-analysis, involving in 633 asthma patients and 379 healthy people. The meta-analysis results revealed that the serum IL33 or ST2 level was higher in asthma patients compared to that in healthy people...
2015: International Journal of Clinical and Experimental Medicine
X Wang, Y F Zhu, D M Li, Q Qin, Q Wang, F S Muhali, W J Jiang, J A Zhang
Interleukin 33 (IL33) / ST2 pathway and ST2-interlukin18 receptor1-interlukin18 receptor accessory protein (ST2-IL18R1-IL18RAP) gene cluster have been involved in many autoimmune diseases but few report in autoimmune thyroid diseases (AITD). In this study, we investigated whether polymorphisms of IL33, ST2, IL18R1, and IL18RAP are associated with Graves' disease (GD) and Hashimoto's thyroiditis (HT), two major forms of AITD, among a Chinese population. A total of 11 SNPs were explored in a case-control study including 417 patients with GD, 250 HT patients and 301 controls, including rs1929992, rs10975519, rs10208293, rs6543116, rs1041973, rs3732127, rs11465597, rs1035130, rs2293225, rs1035127, rs917997 of IL 33, ST2-IL18R1-IL18RAP gene cluster...
February 2016: International Journal of Immunogenetics
David M Ansell, Matthew J Hardman
No abstract text is available yet for this article.
January 2016: Experimental Dermatology
Farnaz Zahedi Avval, Shadi Shomali, Mohammad Nadri, Reza Boostani, Lida Jarahi, Masoud Youssefi
ST2 is a member of IL-1 receptor family expressed on Th2 cells and regulates Th2 responces. The gene of ST2 encodes soluble ST2 (sST2) and the transmembrane ST2 (ST2L) isoforms through alternative mRNA splicing. The discovery of IL33/ ST2 signaling pathway, has drawn a great scientific attention to this system. sST2 has been shown to be an indacating factor in various infl ammatory conditions. This study aims to evaluate serum sST2 levels in HTLV-1 infected patients. This study included 49 HTLV-1 seropositive cases of which 14 were sympthomatic...
June 2015: Acta Microbiologica et Immunologica Hungarica
Wei-Yu Chen, Jaewoo Hong, Joseph Gannon, Rahul Kakkar, Richard T Lee
Hypertension increases the pressure load on the heart and is associated with a poorly understood chronic systemic inflammatory state. Interleukin 33 (IL-33) binds to membrane-bound ST2 (ST2L) and has antihypertrophic and antifibrotic effects in the myocardium. In contrast, soluble ST2 appears to act as a decoy receptor for IL-33, blocking myocardial and vascular benefits, and is a prognostic biomarker in patients with cardiovascular diseases. Here we report that a highly local intramyocardial IL-33/ST2 conversation regulates the heart's response to pressure overload...
June 9, 2015: Proceedings of the National Academy of Sciences of the United States of America
Dawn K Reichenbach, Vincent Schwarze, Benjamin M Matta, Victor Tkachev, Elisabeth Lieberknecht, Quan Liu, Brent H Koehn, Dietmar Pfeifer, Patricia A Taylor, Gabriele Prinz, Heide Dierbach, Natalie Stickel, Yvonne Beck, Max Warncke, Tobias Junt, Annette Schmitt-Graeff, Susumu Nakae, Marie Follo, Tobias Wertheimer, Lukas Schwab, Jason Devlin, Simon C Watkins, Justus Duyster, James L M Ferrara, Heth R Turnquist, Robert Zeiser, Bruce R Blazar
Interleukin (IL)-33 binding to the receptor suppression of tumorigenicity 2 (ST2) produces pro-inflammatory and anti-inflammatory effects. Increased levels of soluble ST2 (sST2) are a biomarker for steroid-refractory graft-versus-host disease (GVHD) and mortality. However, whether sST2 has a role as an immune modulator or only as a biomarker during GVHD was unclear. We show increased IL-33 production by nonhematopoietic cells in the gastrointestinal (GI) tract in mice post-conditioning and patients during GVHD...
May 14, 2015: Blood
J Malcolm, R A Awang, J Oliver-Bell, J P Butcher, L Campbell, A Adrados Planell, D F Lappin, S Y Fukada, C J Nile, F Y Liew, S Culshaw
Cytokines mediate the balance between protective and destructive immunity in periodontitis. We sought to investigate the role of IL-33 in periodontitis. The expression of IL-33 in gingival tissue from healthy controls (n = 10) and patients with chronic periodontitis (n = 17) was investigated. Based on a murine model of periodontal disease, the function of IL-33 was determined first by administration of exogenous IL-33 and second by inhibition of IL-33 signaling using mice deficient in the IL-33 receptor ST2...
July 2015: Journal of Dental Research
Jin-hua Yang, Fang-qin Wu, Qiang Wen, Wen-cai Zhang, Yang-e Wang, Xin Xiong, Yan-wen Su, Long-xian Cheng
This study investigated the relationship between IL-33/ST2 signal pathway gene polymorphisms and myocardial infarction (MI) in Han Chinese. A case-control association analysis was performed on a total of 490 MI patients (MI group) and 929 normal subjects (NC group). Sequenom Mass Array and Taqman genotyping technique were used to analyze the tag single nucleotide polymorphisms (SNPs) in the genes encoding IL-33, ST2, and IL-1RaP (rs11792633, rs1041973 and rs4624606). The results showed that the frequencies of rs4624606 genotypes AA, TT, AT were 0...
February 2015: Journal of Huazhong University of Science and Technology. Medical Sciences
Domingo A Pascual-Figal, James L Januzzi
ST2 is a member of the interleukin 1 receptor family with 2 main isoforms: transmembrane or cellular (ST2L) and soluble or circulating (sST2) forms. ST2 is the receptor of the IL-33, which is an IL-1-like cytokine that can be secreted by living cells in response to cell damage. IL-33 exerts its cellular functions by binding a receptor complex composed of ST2L and IL-1R accessory protein. The IL-33/ST2 system is upregulated in cardiomyocytes and fibroblasts as response to mechanical stimulation or injury. The interaction between IL33 and ST2L has been demonstrated to be cardioprotective: in experimental models, this interaction reduces myocardial fibrosis, prevents cardiomyocyte hypertrophy, reduces apoptosis, and improves myocardial function...
April 2, 2015: American Journal of Cardiology
Dominique Talabot-Ayer, Praxedis Martin, Christian Vesin, Christian Alexander Seemayer, Solenne Vigne, Cem Gabay, Gaby Palmer
IL-33 is a cytokine of the IL-1 family, which signals through the ST2 receptor. Previous studies emphasized a role for IL-33 in shaping innate and adaptive immune responses. IL-33 was also reported to modulate myelopoiesis and myeloid cell activity. In this article, we describe IL-33-overexpressing CMV/IL33 and LysM/IL33 mice, which display an inflammatory phenotype associated with growth retardation and paw swelling. The phenotype of CMV/IL33 mice is dependent on activation of the ST2 receptor and is characterized by extensive neutrophil infiltration into different organs, including the paws...
January 15, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
Ana Márquez, Roser Solans, José Hernández-Rodríguez, Maria C Cid, Santos Castañeda, Marc Ramentol, Luis Rodriguez-Rodriguez, Javier Narváez, Ricardo Blanco, Norberto Ortego-Centeno, Oyvind Palm, Andreas P Diamantopoulos, Niko Braun, Frank Moosig, Torsten Witte, Lorenzo Beretta, Claudio Lunardi, Marco A Cimmino, Augusto Vaglio, Carlo Salvarani, Miguel A González-Gay, Javier Martín
INTRODUCTION: Increased expression of IL-33 and its receptor ST2, encoded by the IL1RL1 gene, has been detected in the inflamed arteries of giant cell arteritis (GCA) patients. The aim of the present study was to investigate for the first time the potential influence of the IL33 and IL1RL1 loci on GCA predisposition. METHODS: A total of 1,363 biopsy-proven GCA patients and 3,908 healthy controls from four European cohorts (Spain, Italy, Germany and Norway) were combined in a meta-analysis...
2014: PloS One
Emma Lefrançais, Anais Duval, Emilie Mirey, Stéphane Roga, Eric Espinosa, Corinne Cayrol, Jean-Philippe Girard
Interleukin-33 (IL-33) is an alarmin cytokine from the IL-1 family. IL-33 activates many immune cell types expressing the interleukin 1 receptor-like 1 (IL1RL1) receptor ST2, including group-2 innate lymphoid cells (ILC2s, natural helper cells, nuocytes), the major producers of IL-5 and IL-13 during type-2 innate immune responses and allergic airway inflammation. IL-33 is likely to play a critical role in asthma because the IL33 and ST2/IL1RL1 genes have been reproducibly identified as major susceptibility loci in large-scale genome-wide association studies...
October 28, 2014: Proceedings of the National Academy of Sciences of the United States of America
Mark Barbour, Debbie Allan, Heping Xu, Cheng Pei, Mei Chen, Wanda Niedbala, Sandra Y Fukada, Anne-Galle Besnard, Jose C Alves-Filho, Xiaoguang Tong, John V Forrester, Foo Yew Liew, Hui-Rong Jiang
Interleukin-33 (IL-33) is associated with several important immune-mediated disorders. However, its role in uveitis, an important eye inflammatory disease, is unknown. Here, we investigated the function of IL-33 in the development of experimental autoimmune uveitis (EAU). IL-33 and IL-33 receptor (ST2) were expressed in murine retinal pigment epithelial (RPE) cells in culture, and IL-33 increased the expression of Il33 and Mcp1 mRNA in RPE cells. In situ, IL-33 was highly expressed in the inner nuclear cells of the retina of naïve mice, and its expression was elevated in EAU mice...
November 2014: European Journal of Immunology
Maria F Hughes, Sebastian Appelbaum, Aki S Havulinna, Annika Jagodzinski, Tanja Zeller, Frank Kee, Stefan Blankenberg, Veikko Salomaa
OBJECTIVES: We hypothesised that soluble ST2 (sST2) levels can identify people with elevated risk of subsequent cardiovascular disease (CVD) and add to existing risk prediction algorithms. BACKGROUND: ST2 is a receptor for the inflammatory cytokine IL33. Increased sST2 levels have been associated with heart failure and death in acute myocardial infarction patients and in the general population. METHODS: We measured high-sensitivity sST2 in 8444 men and women (25-74 years) from the FINRISK97 prospective population cohort...
November 2014: Heart: Official Journal of the British Cardiac Society
Jesús Sánchez-Más, Antonio Lax, María Del Carmen Asensio-López, Maria J Fernandez-Del Palacio, Luis Caballero, Giorgia Santarelli, James L Januzzi, Domingo A Pascual-Figal
BACKGROUND: Interleukin (IL)-33 and sST2 are molecules with an opposite pathophysiologic implications in the myocardial response after acute myocardial infarction (AMI). Both may be a target for therapeutic interventions. The kinetics of IL-33 and sST2 expression in infarcted myocardium and their correlation with the ongoing processes of fibrosis, inflammation and apoptosis remains poorly defined. MATERIALS AND METHODS: Fifty Wistar rats underwent left anterior descending coronary artery surgical ligation and were sacrificed at 1, 2, 4, 12 or 24 weeks post-AMI...
July 2014: European Journal of Clinical Investigation
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