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https://www.readbyqxmd.com/read/28814583/does-use-of-point-of-care-testing-improve-cost-effectiveness-of-the-nhs-health-check-programme-in-the-primary-care-setting-a-cost-minimisation-analysis
#1
Austen El-Osta, Maria Woringer, Elena Pizzo, Talitha Verhoef, Claire Dickie, Melody Z Ni, Jeremy R Huddy, Michael Soljak, George B Hanna, Azeem Majeed
OBJECTIVE: To determine if use of point of care testing (POCT) is less costly than laboratory testing to the National Health Service (NHS) in delivering the NHS Health Check (NHSHC) programme in the primary care setting. DESIGN: Observational study and theoretical mathematical model with microcosting approach. SETTING: We collected data on NHSHC delivered at nine general practices (seven using POCT; two not using POCT). PARTICIPANTS: We recruited nine general practices offering NHSHC and a pathology services laboratory in the same area...
August 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28809926/impact-of-fortified-versus-unfortified-lipid-based-supplements-on-morbidity-and-nutritional-status-a-randomised-double-blind-placebo-controlled-trial-in-ill-gambian-children
#2
Stefan A Unger, Saikou Drammeh, Jahid Hasan, Kabiru Ceesay, Edrisa Sinjanka, Sainey Beyai, Bakary Sonko, Bai Lamin Dondeh, Anthony J Fulford, Sophie E Moore, Andrew M Prentice
BACKGROUND: Multiple micronutrients (MMN) are commonly prescribed in pediatric primary healthcare in sub-Saharan Africa to improve nutritional status and appetite without evidence for their effectiveness or international clinical guidelines. Community-wide MMN supplementation has shown limited and heterogeneous impact on growth and morbidity. Short-term ready-to-use therapeutic foods in acutely sick children in a hospital setting also had limited efficacy regarding subsequent growth. The effectiveness of MMN in improving morbidity or growth in sick children presenting for primary care has not been assessed...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28809897/topology-optimized-metasurfaces-impact-of-initial-geometric-layout
#3
Jianji Yang, Jonathan A Fan
Topology optimization is a powerful iterative inverse design technique in metasurface engineering and can transform an initial layout into a high-performance device. With this method, devices are optimized within a local design phase space, making the identification of suitable initial geometries essential. In this Letter, we examine the impact of initial geometric layout on the performance of large-angle (75 deg) topology-optimized metagrating deflectors. We find that when conventional metasurface designs based on dielectric nanoposts are used as initial layouts for topology optimization, the final devices have efficiencies around 65%...
August 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28809871/-recall-system-for-vaccinations-in-preschool-children-in-a-local-health-unit-in-rome-italy
#4
Aldo Marsico, Cinzia Roscetti, Angelo Fraioli, Chiara Grecuccio, Alessio Cecili, Laura Zaratti, Elisabetta Franco
In Italy, in this period, much attention is dedicated to reach adequate vaccination coverage in children and adolescents. In this study, Vaccination Registry was checked in a Local Health Unit in Rome, Italy, to identify children born in 2007 and 2008 who had not completed the vaccination schedule. Coverage for booster doses of measles, mumps, rubella and for diphtheria, tetanus, pertussis and polio vaccines in the 2213 children was around 70%. A reminder letter was send to parents of the 661 incompletely immunized children and, if they did not reply, a phone call was made when the phone number was available...
May 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28807635/sustained-benefits-of-ranibizumab-with-or-without-laser-in-branch-retinal-vein-occlusion-24-month-results-of-the-brighter-study
#5
Ramin Tadayoni, Sebastian M Waldstein, Francesco Boscia, Heinrich Gerding, Margarita Gekkieva, Elizabeth Barnes, Ayan Das Gupta, Andreas Wenzel, Ian Pearce
PURPOSE: To evaluate the long-term (24-month) efficacy and safety of ranibizumab 0.5 mg administered pro re nata (PRN) with or without laser using an individualized visual acuity (VA) stabilization criteria in patients with visual impairment due to macular edema secondary to branch retinal vein occlusion (BRVO). DESIGN: Phase IIIb, open-label, randomized, active-controlled, 3-arm, multicenter study. PARTICIPANTS: A total of 455 patients. METHODS: Patients were randomized (2:2:1) to ranibizumab 0...
August 11, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28805393/disappearance-of-the-superionic-phase-transition-in-sub-5-nm-silver-iodide-nanoparticles
#6
Takayuki Yamamoto, Hirokazu Kobayashi, Loku Singgappulige Rosantha Kumara, Osami Sakata, Kiyofumi Nitta, Tomoya Uruga, Hiroshi Kitagawa
Bulk silver iodide (AgI) is known to show a phase transition from the poorly conducting β/γ-phases into the superionic conducting α-phase at 147 °C. Its transition temperature decreases with decreasing the size of AgI, and the α-phase exists stably at 37 °C in AgI nanoparticles with a diameter of 6.3 nm. In this Letter, we investigated the atomic configuration, the phase transition behavior, and the ionic conductivity of AgI nanoparticles with a diameter of 3.0 nm. The combination of pair distribution function (PDF) analysis and reverse Monte Carlo (RMC) modeling based on high-energy X-ray diffraction (XRD) revealed for the first time that they formed the β/γ-phases with atomic disorder...
August 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28804813/a-systematic-review-of-the-clinical-applications-and-complications-of-bone-marrow-aspirate-concentrate-in-management-of-bone-defects-and-nonunions
#7
REVIEW
Mohamed A Imam, James Holton, Lukas Ernstbrunner, Wojciech Pepke, Florian Grubhofer, Ali Narvani, Martyn Snow
PURPOSE: Fracture healing encompasses a succession of dynamic multifactorial metabolic events, which ultimately re-establishes the integrity of the biomechanical properties of the bone. Up to 10% of the fractures occurring annually will need additional surgical procedures because of impaired healing. The aim of this article is to review the current literature regarding the use of bone marrow aspirate concentrate (BMAC) and its effectiveness in the management of bone defects. METHODS: We have included all published clinical literature investigating the development, techniques and applications of BMAC...
August 13, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28801117/incidence-and-outcomes-of-infectious-and-noninfectious-endophthalmitis-after-intravitreal-injections-for-age-related-macular-degeneration
#8
Vincent Daien, Vuong Nguyen, Rohan W Essex, Nigel Morlet, Daniel Barthelmes, Mark C Gillies
PURPOSE: To assess the incidence, cumulative rate, and long-term outcomes of infectious and noninfectious endophthalmitis after intravitreal injections (IVTs) of anti-vascular endothelial growth factor (VEGF) agents. DESIGN: Database study, prospectively designed. PARTICIPANTS: Treatment-naïve eyes with neovascular age-related macular degeneration (nAMD) tracked by the Fight Retinal Blindness! (FRB!) registry that commenced anti-VEGF therapy between January 1, 2006, and November 30, 2016...
August 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28800339/perceptual-learning-improves-contrast-sensitivity-visual-acuity-and-foveal-crowding-in-amblyopia
#9
Michele Barollo, Giulio Contemori, Luca Battaglini, Andrea Pavan, Clara Casco
BACKGROUND: Amblyopic observers present abnormal spatial interactions between a low-contrast sinusoidal target and high-contrast collinear flankers. It has been demonstrated that perceptual learning (PL) can modulate these low-level lateral interactions, resulting in improved visual acuity and contrast sensitivity. OBJECTIVE: We measured the extent and duration of generalization effects to various spatial tasks (i.e., visual acuity, Vernier acuity, and foveal crowding) through PL on the target's contrast detection...
August 11, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28797865/increasing-advance-care-planning-completion-at-an-academic-internal-medicine-outpatient-clinic
#10
Ngoc-Phuong Luu, Candace Nigrin, Kimberly Peairs, Sydney M Dy, Melinda Sawyer, Samantha Pitts, Brent Petty
BACKGROUND: We sought to increase advance care planning completion at an academic internal medicine clinic through an electronic health record. MEASURES: Number of eligible patients who completed a form of advance care planning. INTERVENTION: Multidisciplinary team approach with engagement from providers and clinic staff; implemented informational letter and appropriate forms to eligible patients prior to appointment; informational video and provider reminders at time of appointment...
August 7, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28783749/a-yoga-program-for-cognitive-enhancement
#11
Devon Brunner, Amitai Abramovitch, Joseph Etherton
BACKGROUND: Recent studies suggest that yoga practice may improve cognitive functioning. Although preliminary data indicate that yoga improves working memory (WM), high-resolution information about the type of WM subconstructs, namely maintenance and manipulation, is not available. Furthermore, the association between cognitive enhancement and improved mindfulness as a result of yoga practice requires empirical examination. The aim of the present study is to assess the impact of a brief yoga program on WM maintenance, WM manipulation and attentive mindfulness...
2017: PloS One
https://www.readbyqxmd.com/read/28782972/-perplexed-in-the-extreme-the-holt-james-controversy-of-1902
#12
Edward J Vinski
Although William James never again reprised his lectures on psychology for teachers at Harvard, he spent most of the 1890s presenting them throughout the country. For all his complaints about them, this was a fine source of income and he used the opportunity to revise and refine them over the rest of the decade. By the end of the 1890s, he was prepared to put the talks down in book form, and turned to his long-time publisher, Henry Holt. The two men first became acquainted with each other when James agreed to write a volume for Holt's American Science series...
August 2017: History of Psychology
https://www.readbyqxmd.com/read/28780278/season-independent-cognitive-deficits-in-seasonal-affective-disorder-and-their-relation-to-depressive-symptoms
#13
Liv Vadskjær Hjordt, Dea Siggaard Stenbæk, Brice Ozenne, Brenda Mc Mahon, Ida Hageman, Steen Gregers Hasselbalch, Gitte Moos Knudsen
Although cognitive impairments are common in depressed individuals, it is unclear which aspects of cognition are affected and whether they represent state or trait features of depression. We here exploited a naturalistic model, namely the seasonal fluctuations in depressed status in individuals with Seasonal Affective Disorder (SAD), to study depression-related cognition, longitudinally. Twenty-nine medication-free individuals diagnosed with winter-SAD and 30 demographically matched healthy controls with no seasonality symptoms completed the Letter-number Sequencing task (LNS), the Symbol Digit Modalities Test (SDMT) and the Simple Reaction Time (SRT) twice; in summer and in winter...
July 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28777721/infinite-von-mises-fisher-mixture-modeling-of-whole-brain-fmri-data
#14
Rasmus E Røge, Kristoffer H Madsen, Mikkel N Schmidt, Morten Mørup
Cluster analysis of functional magnetic resonance imaging (fMRI) data is often performed using gaussian mixture models, but when the time series are standardized such that the data reside on a hypersphere, this modeling assumption is questionable. The consequences of ignoring the underlying spherical manifold are rarely analyzed, in part due to the computational challenges imposed by directional statistics. In this letter, we discuss a Bayesian von Mises-Fisher (vMF) mixture model for data on the unit hypersphere and present an efficient inference procedure based on collapsed Markov chain Monte Carlo sampling...
August 4, 2017: Neural Computation
https://www.readbyqxmd.com/read/28777698/one-tooth-one-time-1t1t-a-straightforward-approach-to-replace-missing-teeth-in-the-posterior-region
#15
France Lambert, Amélie Mainjot
Like all letters, they do not have an abstract.
August 4, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28774229/what-role-for-prism-adaptation-in-the-rehabilitation-of-pure-neglect-dyslexia
#16
Radek Ptak
Prism adaptation (PA) has been successfully applied in the rehabilitation of spatial neglect, with significant transfer to classic neglect tests and activities of daily living. However, well-controlled studies were unable to replicate these findings, and recent reports suggest that PA may affect selectively visuo-motor symptoms. Here, a patient with pure left neglect dyslexia was tested before, immediately after, and 24 h after PA. Despite a significant adaptation aftereffect adaptation had no effect omissions, substitutions and letter-based errors...
August 4, 2017: Neurocase
https://www.readbyqxmd.com/read/28769095/increased-dopamine-release-after-working-memory-updating-training-neurochemical-correlates-of-transfer
#17
Lars Bäckman, Otto Waris, Jarkko Johansson, Micael Andersson, Juha O Rinne, Kati Alakurtti, Anna Soveri, Matti Laine, Lars Nyberg
Previous work demonstrates that working-memory (WM) updating training results in improved performance on a letter-memory criterion task, transfers to an untrained n-back task, and increases striatal dopamine (DA) activity during the criterion task. Here, we sought to replicate and extend these findings by also examining neurochemical correlates of transfer. Four positron emission tomography (PET) scans using the radioligand raclopride were performed. Two of these assessed DAD2 binding (letter memory; n-back) before 5 weeks of updating training, and the same two scans were performed post training...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28767669/incidence-and-progression-of-diabetic-retinopathy-in-sub-saharan-africa-a-five-year-cohort-study
#18
Philip I Burgess, Simon P Harding, Marta García-Fiñana, Nicholas A V Beare, Simon Glover, Danielle B Cohen, Gerald Msukwa, Theresa J Allain
AIMS: To describe the incidence and progression of retinopathy in people with diabetes in Southern Malawi over 5 years. To document visual loss in a setting where laser treatment is not available. METHODS: Subjects from a cohort sampled from a hospital-based, primary-care diabetes clinic in 2007 were traced in 2012. Laser treatment was not available. Modified Wisconsin grading of retinopathy was performed using slit lamp biomicroscopy by a single ophthalmologist in 2007 and using four-field mydriatic fundus photographs at an accredited reading centre in 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28764477/incipient-fault-diagnosis-in-bearings-under-variable-speed-conditions-using-multiresolution-analysis-and-a-weighted-committee-machine
#19
Viet Tra, Jaeyoung Kim, Sheraz Ali Khan, Jong-Myon Kim
Incipient defects in bearings are traditionally diagnosed either by developing discriminative models for features that are extracted from raw acoustic emission (AE) signals, or by detecting peaks at characteristic defect frequencies in the envelope power spectrum of the AE signals. Under variable speed conditions, however, such methods do not yield the best results. This letter proposes a technique for diagnosing incipient bearing defects under variable speed conditions, by extracting features from different sub-bands of the inherently non-stationary AE signal, and then classifying bearing defects using a weighted committee machine, which is an ensemble of support vector machines and artificial neural networks...
July 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28762155/spatial-knowledge-during-skilled-action-sequencing-hierarchical-versus-nonhierarchical-representations
#20
Lawrence P Behmer, Matthew J C Crump
Typists can type 4 to 5 keystrokes per second at around 95% accuracy, yet they appear to have poor declarative knowledge of key locations. Logan and Crump (2011, Psychology of Learning and Motivation, Vol. 54, pp. 1-27) accounted for this paradox by proposing that typing is hierarchically organized into two loops, with an outer loop that transforms sentences into words and passes each word, one at a time, to an inner loop that transforms each word into its constituent keystrokes; however, the nature of the inner loop's spatial knowledge is not well understood...
July 31, 2017: Attention, Perception & Psychophysics
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