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interleukin33

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https://www.readbyqxmd.com/read/28763061/interleukin33-deficiency-causes-tau-abnormality-and-neurodegeneration-with-alzheimer-like-symptoms-in-aged-mice
#1
C Carlock, J Wu, J Shim, I Moreno-Gonzalez, M R Pitcher, J Hicks, A Suzuki, J Iwata, J Quevado, Y Lou
This corrects the article DOI: 10.1038/tp.2017.142.
August 1, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28675392/interleukin33-deficiency-causes-tau-abnormality-and-neurodegeneration-with-alzheimer-like-symptoms-in-aged-mice
#2
C Carlock, J Wu, J Shim, I Moreno-Gonzalez, M R Pitcher, J Hicks, A Suzuki, J Iwata, J Quevado, Y Lou
Late-onset Alzheimer's disease (AD) remains a medical mystery. Recent studies have linked it to impaired repair of aged neurons. Potential involvement of interleukin33 (IL33) in AD has been reported. Here we show that IL33, which was expressed by up to 75% astrocytes in the aged brains, was critical for repair of aged neurons. Mice lacking Il33 gene (Il33(-/-)) developed AD-like disease after 60-80 weeks, which was characterized by tau abnormality and a heavy loss of neurons/neurites in the cerebral cortex and hippocampus accompanied with cognition/memory impairment...
July 4, 2017: Translational Psychiatry
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