Iker Uriarte, Eva Santamaria, Amaya López-Pascual, María J Monte, Josepmaria Argemí, M Ujue Latasa, Elena Adán-Villaescusa, Ainara Irigaray, Jose M Herranz, María Arechederra, Jorge Basualdo, Felipe Lucena, Fernando J Corrales, Fernando Rotellar, Fernando Pardo, Gregory Merlen, Dominique Rainteau, Bruno Sangro, Thierry Tordjmann, Carmen Berasain, Jose J G Marín, Maite G Fernández-Barrena, Ignacio Herrero, Matias A Avila
BACKGROUND AND AIMS: Liver regeneration is essential for the preservation of homeostasis and survival. Bile acids (BAs)-mediated signaling is necessary for liver regeneration, but BAs levels need to be carefully controlled to avoid hepatotoxicity. We studied the early response of the BAs-fibroblast growth factor 19 (FGF19) axis in healthy individuals undergoing hepatectomy for living donor liver transplant. We also evaluated BAs synthesis in mice upon partial hepatectomy (PH) and acute inflammation, focusing on the regulation of cytochrome-7A1 (CYP7A1), a key enzyme in BAs synthesis from cholesterol...
April 19, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease