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https://www.readbyqxmd.com/read/28725547/spatial-working-memory-in-neurofibromatosis-1-altered-neural-activity-and-functional-connectivity
#1
Amira F A Ibrahim, Caroline A Montojo, Kristen M Haut, Katherine H Karlsgodt, Laura Hansen, Eliza Congdon, Tena Rosser, Robert M Bilder, Alcino J Silva, Carrie E Bearden
BACKGROUND: Neurofibromatosis Type 1 (NF1) is a genetic disorder that disrupts central nervous system development and neuronal function. Cognitively, NF1 is characterized by difficulties with executive control and visuospatial abilities. Little is known about the neural substrates underlying these deficits. The current study utilized Blood-Oxygen-Level-Dependent (BOLD) functional MRI (fMRI) to explore the neural correlates of spatial working memory (WM) deficits in patients with NF1. METHODS: BOLD images were acquired from 23 adults with NF1 (age M = 32...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28724331/randomized-double-blinded-pilot-clinical-study-of-the-antidiabetic-activity-of-balanites-aegyptiaca-and-uplc-esi-ms-ms-identification-of-its-metabolites
#2
Hend Rashad, Fateheya M Metwally, Shahira M Ezzat, Maha M Salama, Adel Hasheesh, Amira Abdel Motaal
CONTEXT: Balanites aegyptiaca Del. (Zygophyllaceae) fruits are traditionally known for the treatment of hyperglycaemia. Several in vitro and in vivo studies proposed some mechanisms of action. However, clinical trials in human beings were never reported to date. OBJECTIVES: To investigate the antidiabetic efficacy of the 70% ethanol extract of the pericarps of B. aegyptiaca (BE) within a nutritional intervention in elderly people. MATERIALS AND METHODS: Ultra-performance electrospray ionization-mass spectroscopy (UPLC-ESI-MS/MS) analysis was used for metabolic profiling of BE which was incorporated in hard gelatine capsules (400 mg/day) and tested on 30 type 2 diabetes (T2D) Egyptian patients for 8 weeks...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28720172/comparative-validation-of-the-determination-of-sofosbuvir-in-pharmaceuticals-by-several-inexpensive-ecofriendly-chromatographic-electrophoretic-and-spectrophotometric-methods
#3
Amira F El-Yazbi
Sofosbuvir (SOFO) was approved by the U.S. Food and Drug Administration in 2013 for the treatment of hepatitis C virus infection with enhanced antiviral potency compared with earlier analogs. Notwithstanding, all current editions of the pharmacopeias still do not present any analytical methods for the quantification of SOFO. Thus, rapid, simple, and ecofriendly methods for the routine analysis of commercial formulations of SOFO are desirable. In this study, five accurate methods for the determination of SOFO in pharmaceutical tablets were developed and validated...
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28719307/first-report-on-natural-infection-of-phlebotomus-sergenti-with-leishmania-tropica-in-a-classical-focus-of-leishmania-major-in-tunisia
#4
Kaouther Jaouadi, Jihene Bettaieb, Amira Bennour, Sadok Salem, Mohamed Ridha Rjeibi, Sana Chaabane, Rihab Yazidi, Neila Khabouchi, Adel Gharbi, Afif Ben Salah
In Tunisia, chronic cutaneous leishmaniasis due to Leishmania tropica is an important health problem. Its spreading has not been fully elucidated. Information on sandfly vectors, as well as their associated Leishmania species, is of paramount importance since vector dispersion is one of the major factors responsible for pathogen dissemination. Ninety-seven unfed females belonging to the genera Sergentomyia and Phlebotomus were collected between June and August 2015 using sticky paper traps. Polymerase chain reaction-restriction fragment length polymorphism analysis of the internal transcribed spacer 1and sequencing were used for Leishmania detection and identification...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28717366/interrelationship-between-climatic-ecologic-social-and-cultural-determinants-affecting-dengue-emergence-and-transmission-in-puerto-rico-and-their-implications-for-zika-response
#5
REVIEW
Angela Matysiak, Amira Roess
OBJECTIVE: The global resurgence of dengue has been attributed to rapid population growth, urban expansion, increased air travel, globalization, and climate change. Dengue is now endemic in Puerto Rico. Puerto Rico is at risk for Zika, another emerging arbovirus. The interrelationship between climatic, ecological, social, and cultural factors that affect dengue and other arboviruses' transmission is understudied. DESIGN: The objective of this systematic review is to examine the interrelationship between climatic, ecological, social, and cultural factors on dengue transmission in Puerto Rico and to draw lessons for Zika response...
2017: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28717322/th1-th2-balance-and-humoral-immune-response-to-potential-antigens-as-early-diagnostic-method-of-equine-strongylus-nematode-infection
#6
Faten A M Abo-Aziza, Seham H M Hendawy, Amira H El Namaky, Heba M Ashry
AIM: The aim of this study was to investigate the early diagnosis of strongyle infection based on early changes in Th1 and Th2 cytokines beside the diagnostic accuracy values and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting profiles using prepared strongyles antigens. MATERIALS AND METHODS: A total of 73 donkeys had a mean age of 4-32 years old were parasitologically examined for strongyle infection. The early changes in Th1 and Th2 cytokines were determined, and the diagnostic accuracy values and SDS-PAGE and western blotting profiles were performed using prepared strongyles antigens; crude somatic Strongylusvulgaris (CSS), excretory-secretory S...
June 2017: Veterinary World
https://www.readbyqxmd.com/read/28714105/spinal-cord-imaging-using-averaged-magnetization-inversion-recovery-acquisitions
#7
Matthias Weigel, Oliver Bieri
PURPOSE: To establish a novel approach for fast high-resolution spinal cord (SC) imaging using averaged magnetization inversion recovery acquisitions (AMIRA). METHODS: The AMIRA concept is based on an inversion recovery (IR) prepared, segmented, and time-limited cine balanced steady state free precession sequence. Typically, for the fastest SC imaging without any signal averaging, eight consecutive images in time with an in-plane resolution of 0.67 × 0.67 mm(2) and 6 mm to 8 mm slice thickness are acquired in 51 s...
July 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28714040/perspectives-of-pharmacy-staff-on-dispensing-subtherapeutic-doses-of-antibiotics-a-theory-informed-qualitative-study
#8
Mohamed Ezzat Khamis Amin, Amira Amine, Mohammad Shoukry Newegy
Background Injudicious dispensing of antibiotics in subtherapeutic doses is common in many developing countries. In Egypt, as in many developing countries, a few pills of common cold products are offered under the name cold group (CG). A cold group may contain one or more pills of antibiotics. A pharmacy client may obtain subtherapeutic doses of antibiotics upon direct request or as part of a CG. Objective To examine factors associated with the unwarranted dispensing of subtherapeutic doses of antibiotics in community pharmacies as part of a CG or upon direct request from patients among community pharmacy staff...
July 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28711639/skin-permeability-enhancement-by-bacillus-subtilis-alkaline-protease-application-to-transdermal-drug-delivery
#9
Mohamed I Nounou, Taha I Zaghloul, Nehal A Ahmed, Amira A Eid, Labiba K El-Khordagui
Enzymes may offer great potentials in topical pharmaceutical applications provided that treatment conditions are controlled for efficacy and safety. In this study, the effect of alkaline protease produced by recombinant Bacillus subtilis cells on the ex-vivo permeability of rabbit ear skin was investigated under different conditions of enzyme activity (5-60 units) and exposure time (15-60min). Data for transepidermal water loss (TEWL) and permeation of a hydrophilic dye, rhodamine B (Rb), indicated biphasic activity-dependent and exposure time-dependent skin permeability...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28691562/mucoadhesive-buccal-tablets-containing-silymarin-eudragit-loaded-nanoparticles-formulation-characterisation-and-ex-vivo-permeation
#10
Amira E El-Nahas, Ahmed N Allam, Amal H El-Kamel
Eudragit-loaded silymarin nanoparticles (SNPs) and their formulation into buccal mucoadhesive tablets were investigated to improve the low bioavailability of silymarin through buccal delivery. Characterisation of SNPs and silymarin buccal tablets (SBTs) containing the optimised NPs were performed. Ex vivo permeability of nominated SBTs were assessed using chicken pouch mucosa compared to SNPs and drug suspension followed by histopathological examination. Selected SNPs had a small size (<150 nm), encapsulation effciency (>77%) with drug release of about 90% after 6 h...
July 9, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28689522/efficacy-and-toxicity-of-concurrent-chemoradiation-in-inoperable-oral-carcinoma-in-pakistani-population
#11
Abdul Rehman, Zafar Allaudin, Hasan Nisar, Irfan Ullah Khan, Ismat Fatima, Amira Shami, Misbah Masood, Abubaker Shahid
OBJECTIVE: To evaluate the efficacy of concurrent chemoradiation in patients with locally advanced inoperable squamous cell carcinoma of oral cavity in terms of local control and toxicity. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Institute of Nuclear Medicine and Oncology (INMOL), Lahore, from January 2008 to December 2013. METHODOLOGY: Sixty-nine patients with locally advanced inoperable oral cavity cancer, registered in INMOL hospital from January 2008 to December 2013 who fulfilled a pre-defined eligibility criteria, were enrolled in the study...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28680346/association-of-myeloperoxidase-and-the-atherogenic-index-of-plasma-in-children-with-end-stage-renal-disease
#12
Danijela Ristovski-Kornic, Aleksandra Stefanović, Jelena Kotur-Stevuljević, Aleksandra Zeljković, Vesna Spasojević-Kalimanovska, Jelena Vekić, Milica Miljković, Dušan Paripović, Amira Peco-Antić, Zorana Jelić-Ivanović
BACKGROUND: The aim of this study was to explore oxidative stress status, especially the enzyme myeloperoxidase in children with end-stage renal disease. Also, we investigated possible associations between the atherogenic index of plasma and these parameters. METHODS: Lipid status parameters, oxidative stress status parameters, and myeloperoxidase concentration were measured in the sera of 20 children in the last stage of chronic renal disease (ESRD) and 35 healthy children of matching age and sex...
January 2017: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28670852/chemical-composition-antioxidant-properties-%C3%AE-glucosidase-inhibitory-and-antimicrobial-activity-of-essential-oils-from-acacia-mollissima-and-acacia-cyclops-cultivated-in-tunisia
#13
Amira Jelassi, Manel Hassine, Malek Besbes Hlila, Hichem Ben Jannet
The genus Acacia is quite large and can be found in the warm subarid and arid parts but little is known about its chemistry, specially the volatile parts. The volatile oils from fresh flowers of A. mollissima and A. cyclops (growing in Tunisia) obtained by hydrodistillation were analyzed by GC then GC-MS. 18 (94.7% of the total oil composition) and 23 (97.4%) compounds were identified in these oils, respectively. (E,E)-α-Farnesene (51.5%) and (E)-cinnamyl alcohol (10.7%) constituted the major compounds of the flower oil of A...
July 3, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28670261/anaphylaxis-by-antihistamine-containing-bovine-gelatin-the-utility-of-the-basophil-activation-test-in-the-diagnostic-work-up
#14
Eleonora Nucera, Amira Colagiovanni, Simona Mezzacappa, Alessandro Buonomo, Arianna Aruanno, Angela Rizzi, Domenico Schiavino
No abstract text is available yet for this article.
June 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28669668/orosensory-detection-of-bitter-in-fat-taster-healthy-and-obese-participants-genetic-polymorphism-of-cd36-and-tas2r38
#15
Inchirah Karmous, Jiří Plesník, Amira Sayed Khan, Omar Šerý, Abdelmajid Abid, Amani Mankai, Abdellah Aouidet, Naim Akhtar Khan
BACKGROUND & AIMS: We assessed orosensory detection of a long-chain fatty acid, linoleic acid (LA), and a bitter taste marker, 6-n-propylthiouracil (PROP), and correlated lipid-taster subjects with PROP detection and polymorphism in genes encoding bitter and lipid taste receptors, respectively, TAS2R38 and CD36, in normal weight and obese subjects. DESIGN: The normal weight (n = 52, age = 35.3 ± 4.10 years, BMI = 23.22 ± 1.44 kg/m(2)) and obese (n = 52, age = 35...
June 21, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28669330/the-quality-of-life-and-professional-future-among-tunisian-workers-suffering-from-occupational-asthma
#16
Mohamed Adnene Henchi, Amira Omrane, Charfeddine Amri, Lamia Bouzgarrou, Ines Rassas, Awatef Mahfoudh, Taoufik Khalfallah, Mohamed Akrout
OBJECTIVE: To identify the factors influencing the quality of life and professional future of patients suffering from occupational asthma. METHOD: A cross-sectional study of patients compensated for occupational asthma in Tunisian center, between 2004-2011. The study of quality of life was based on the Asthma Quality of Life Questionnaires (AQLQ). Some related patents were also discussed. RESULTS: One hundred twenty-nine patients were compensated and the mean age was 40...
June 30, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28659939/application-of-nuclear-volume-measurements-to-comprehend-the-cell-cycle-in-root-knot-nematode-induced-giant-cells
#17
José Dijair Antonino de Souza Junior, Olivier Pierre, Roberta R Coelho, Maria F Grossi-de-Sa, Gilbert Engler, Janice de Almeida Engler
Root-knot nematodes induce galls that contain giant-feeding cells harboring multiple enlarged nuclei within the roots of host plants. It is recognized that the cell cycle plays an essential role in the set-up of a peculiar nuclear organization that seemingly steers nematode feeding site induction and development. Functional studies of a large set of cell cycle genes in transgenic lines of the model host Arabidopsis thaliana have contributed to better understand the role of the cell cycle components and their implication in the establishment of functional galls...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28659002/in-vitro-and-in-vivo-antidiabetic-potential-of-extracts-and-a-furostanol-saponin-from-balanites-aegyptiaca
#18
Shahira Mohammed Ezzat, Amira Abdel Motaal, Sally Abdel Wanees El Awdan
CONTEXT: Balanites aegyptiaca Del. (Zygophyllaceae) fruits are well-known antidiabetic drug in Egyptian folk medicine. Nevertheless, its mechanism of action is still unclear. OBJECTIVES: Searching for the possible mechanisms of action of the plant and identification of its bioactive compounds. MATERIALS AND METHODS: A bio-guided protocol based on the evaluation of α-glucosidase (AG) and aldose reductase (AR) inhibitory activities was adopted to isolate the biologically active compounds from the methanol extract (MeEx)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28657191/intended-and-unintended-use-of-cathinone-mixtures
#19
Amira Guirguis, John Martin Corkery, Jacqueline Leslie Stair, Stewart Brian Kirton, Mire Zloh, Fabrizio Schifano
INTRODUCTION: Cathinones are one of the most popular categories of new psychoactive substances (NPS) consumed. Cathinones have different pharmacological activities and receptor selectivity for monoamine transporters based on their chemical structures. They are incorporated into NPS mixtures and used with other NPS or 'traditional' drugs. Cathinone use represents significant health risks to individuals and is a public health burden. METHODS: Evidence of poly-NPS use with cathinones, seizure information, and literature analyses results on NPS mixtures was systematically gathered from online database sources, including Google Scholar, Scopus, Bluelight, and Drugs-Forum...
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28648676/regulation-of-glut4-activity-in-myotubes-by-3-o-methyl-d-glucose
#20
Ofer Shamni, Guy Cohen, Arie Gruzman, Hilal Zaid, Amira Klip, Erol Cerasi, Shlomo Sasson
The rate of glucose influx to skeletal muscles is determined primarily by the number of functional units of glucose transporter-4 (GLUT4) in the myotube plasma membrane. The abundance of GLUT4 in the plasma membrane is tightly regulated by insulin or contractile activity, which employ distinct pathways to translocate GLUT4-rich vesicles from intracellular compartments. Various studies have indicated that GLUT4 intrinsic activity is also regulated by conformational changes and/or interactions with membrane components and intracellular proteins in the vicinity of the plasma membrane...
June 23, 2017: Biochimica et Biophysica Acta
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