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https://www.readbyqxmd.com/read/28222524/a-combination-of-resveratrol-and-curcumin-is-effective-against-aluminum-chloride-induced-neuroinflammation-in-rats
#1
Amira Zaky, Ahmad Bassiouny, Mahitab Farghaly, Bassma M El-Sabaa
BACKGROUND: Experimental studies have demonstrated that aluminum is an environmental toxin that induces neuroinflammation and the development of Alzheimer's disease. OBJECTIVE: In this report, we investigated the beneficial effect of a combination of resveratrol and curcumin to reduce aluminum-induced neuroinflammation. METHOD: We employed both an in vivo model of aluminum-induced neuroinflammation and an in vitro aluminum stimulated cultured PC-12 cells...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28216640/the-ubiquitin-ligase-cullin5-socs2-regulates-ndr1-stk38-stability-and-nf-%C3%AE%C2%BAb-transactivation
#2
Indranil Paul, Tanveer S Batth, Diego Iglesias-Gato, Amna Al-Araimi, Ibrahim Al-Haddabi, Amira Alkharusi, Gunnar Norstedt, Jesper V Olsen, Fahad Zadjali, Amilcar Flores-Morales
SOCS2 is a pleiotropic E3 ligase. Its deficiency is associated with gigantism and organismal lethality upon inflammatory challenge. However, mechanistic understanding of SOCS2 function is dismal due to our unawareness of its protein substrates. We performed a mass spectrometry based proteomic profiling upon SOCS2 depletion and yield quantitative data for ~4200 proteins. Through this screen we identify a novel target of SOCS2, the serine-threonine kinase NDR1. Over-expression of SOCS2 accelerates turnover, while its knockdown stabilizes, endogenous NDR1 protein...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28213070/selective-a2a-receptors-blockade-reduces-degeneration-of-substantia-nigra-dopamine-neurons-in-a-rotenone-induced-rat-model-of-parkinson-s-disease-a-histological-study
#3
Ahmed M Fathalla, Amira M Soliman, Ahmed A Moustafa
Parkinson's disease (PD) is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Adenosine is a neuromodulator that inhibit the release of dopamine via a disinhibitory mechanism. In this study, we investigated the neuroprotective effect of 8-cyclopentyl-1,3-dipropylxanthine and ZM241385 (respectively, A1 and A2A receptors antagonists), on nigrostriatal dopamine neurons degradation reduction in a rotenone-induced PD model using histopathological and immunohistochemical methods...
February 15, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28210020/p300-wave-changes-in-patients-with-parkinson-s-disease
#4
Kristina Tokic, Marina Titlic, Amira Beganovic-Petrovic, Enra Suljic, Rinaldo Romac, Slobodan Silic
INTRODUCTION: Parkinson's disease (PD) is chronic progressive neurodegenerative disease. In patients with Parkinson's disease among other symptoms occur cognitive dysfunctions, which can be shown by P300 wave changes. AIM: The aim of this study was to demonstrate that patients with Parkinson's disease have reduced amplitude and prolonged latency, longer than 300 ± 10 ms. MATERIAL AND METHODS: The study included 21 patient suffering from Parkinson's disease...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28203774/novel-chromatographic-methods-for-simultaneous-quantification-of-fish-and-wheat-germ-oils-mixture-in-pharmaceutical-dosage-forms
#5
Amira F El-Yazbi, Amr El-Hawiet
No abstract text is available yet for this article.
February 16, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28199398/a-segmentation-based-volumetric-approach-to-localize-and-quantify-cerebral-vasospasm-based-on-tomographic-imaging-data
#6
Axel Neulen, Tobias Pantel, Michael Kosterhon, Stefanie Kirschner, Marc A Brockmann, Sven R Kantelhardt, Alf Giese, Serge C Thal
INTRODUCTION: Quantification of cerebral vasospasm after subarachnoid hemorrhage (SAH) is crucial in animal studies as well as clinical routine. We have developed a method for computer-based volumetric assessment of intracranial blood vessels from cross-sectional imaging data. Here we demonstrate the quantification of vasospasm from micro computed tomography (micro-CT) data in a rodent SAH model and the transferability of the volumetric approach to clinical data. METHODS: We obtained rodent data by performing an ex vivo micro-CT of murine brains after sham surgery or SAH by endovascular filament perforation on day 3 post hemorrhage...
2017: PloS One
https://www.readbyqxmd.com/read/28196858/the-2016-walter-b-cannon-lecture-deconstructing-metabolic-inflammation-using-cellular-systems
#7
Kenny L Chan, Parastoo Boroumand, Marciane Milanski, Nicolas J Pillon, Philip J Bilan, Amira Klip
Over the past years we have embarked in a systematic analysis of the effect of obesity or fatty acids on circulating monocytes, microvascular endothelial cells, macrophages and skeletal muscle cells. Using cell culture strategies, we have deconstructed complex physiological systems, then reconstructed 'partial equations' to better understand cell-to-cell communication. Through these approaches we identified that in high saturated fat environments, cell-autonomous pro-inflammatory pathways are activated in monocytes and endothelial cells, promoting monocyte adhesion and transmigration...
February 14, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28193423/effect-of-extraction-ph-on-techno-functional-properties-of-crude-extracts-from-wild-cardoon-cynara-cardunculus-l-flowers
#8
Amal Ben Amira, Ines Makhlouf, Raul Flaviu Petrut, Frédéric Francis, Julien Bauwens, Hamadi Attia, Souhail Besbes, Christophe Blecker
In the present paper, techno-functional properties of rennet derived from C. cardunculus, prepared at various pH (from 3 to 6), were investigated. It was found that the extract prepared at pH 3 had the best milk-clotting properties (MCA/PA ratio). It presented also the highest enzyme content, determined by densitometry analysis on 1D and 2D gels electrophoresis. Formation of milk gels produced by the extracts and chymosin was monitored using dynamic rheology and turbiscan. It can be assumed that by lowering rennet pH, milk pH decreases, causing a significant increase of curd firmness and both elastic (G') and viscous (G″) moduli...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28187091/a-new-scoring-tool-to-assess-overall-survival-in-patients-with-intracerebral-metastases-from-gynecological-cancers
#9
Dirk Rades, Stefan Janssen, Amira Bajrovic, Theo Veninga, Dorothea Fischer, Steven E Schild
OBJECTIVE: This study aimed to facilitate individualized treatment strategies for intracerebral metastases from gynecological cancers by creating a specific overall survival (OS) score. METHODS/MATERIALS: Fifty-six patients irradiated for cerebral metastases from gynecological cancers were included. Eleven factors were retrospectively analyzed for OS: age, Eastern Cooperative Oncology Group (ECOG) performance score, cancer type, histology, histologic grading, initial stage, number of lesions, extracerebral metastases, time between cancer diagnosis and brain metastases treatment, recursive partitioning analysis class, and type of treatment...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28183089/nine-year-longitudinal-psychosocial-and-mental-outcomes-of-a-stress-management-intervention-at-work-using-psychotherapeutic-principles
#10
Jian Li, Natalie Riedel, Amira Barrech, Raphael M Herr, Birgit Aust, Kathrin Mörtl, Johannes Siegrist, Harald Gündel, Peter Angerer
No abstract text is available yet for this article.
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28167397/spectroscopic-properties-of-dy-3-doped-zno-for-white-luminescence-applications
#11
Guesmi Amira, Bouzidi Chaker, Elhouichet Habib
Undoped and Dy(3+) (0.25, 0.5, 0.8 and 1.5at.%) doped ZnO were elaborated by solid-state reaction method. The ZnO:Dy(3+) samples were characterized using X-ray diffraction (XRD), Raman spectroscopy, UV-vis diffuse reflectance spectroscopy and photoluminescence (PL). The XRD analysis confirms the wurtzite structure of ZnO. A slight shift to lower angles, of the (101) peak, is seen with Dy(3+) content, indicating the substitution of these ions into the ZnO lattice. Raman study indicates the good crystallinity of all ZnO:Dy(3+) samples and confirms the substitution of Zn(2+) by Dy(3+)...
January 22, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28160387/hair-loss-at-injection-sites-of-mesotherapy-for-alopecia
#12
Mohamed El-Komy, Akmal Hassan, Amira Tawdy, Mohamed Solimon, Mohamed Abdel Hady
BACKGROUND: The side effects of mesotherapy for treatment of various forms of alopecia are often underreported, while scientific data for its efficacy are severely lacking. OBJECTIVE: To demonstrate the late onset side effects of mesotherapy for alopecia. METHODS: Three patients with androgenetic alopecia showed hair loss after previously uneventful mesotherapy sessions up to 1 year. RESULTS: Clinical, dermoscopic, and histopathological findings suggested an inflammatory scaring process at sites of mesotherapy injections...
February 3, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28152478/cytotoxic-effect-of-ferrimagnetic-glass-ceramic-nanocomposites-on-bone-osteosarcoma-cells
#13
Amira M Gamal-Eldeen, Salwa A M Abdel-Hameed, Sherien M El-Daly, Mona A M Abo-Zeid, Menha M Swellam
This work pointed out the anti-cancer effect of ferrimagnetic glass ceramic nanocomposites (CaO-ZnO-Fe2O3-SiO2), which contain high amount of magnetite (∼60%), crystallite size <100nm, and different nucleating agents on bone cancer Saos-2 cells. The cell viability was inhibited by FH and FW to <50% and <25%, respectively, with/without magnetism, and both also reduced mitochondrial transmembrane potential (ΔYm), with/without magnetism (no influence of magnetism). Histone deacetylase (HDAC) activity was inhibited by FH, FW, and FHPNT, with/without magnetism...
January 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28152034/diplectanids-from-mycteroperca-spp-epinephelidae-in-the-mediterranean-sea-redescriptions-of-six-species-from-material-collected-off-tunisia-and-libya-proposal-for-the-pseudorhabdosynochus-riouxi-group-and-a-taxonomic-key
#14
Amira Chaabane, Lassad Neifar, Jean-Lou Justine
Diplectanid monogeneans are gill parasites that can infect fish in huge numbers and thus become harmful, especially in maricultured fish. It is therefore useful to have taxonomic tools, such as keys, to identify species. The following diplectanid species from groupers of the Mediterranean Sea were studied: five species of Pseudorhabdosynochus Yamaguti, 1958, including P. riouxi (Oliver, 1986) Kritsky & Beverley-Burton, 1986 from the dusky grouper Mycteroperca marginata, P. enitsuji Neifar & Euzet, 2007, P. bouaini Neifar & Euzet, 2007, P...
2017: PloS One
https://www.readbyqxmd.com/read/28151453/anthropometric-cutoff-values-for-predicting-metabolic-syndrome-in-a-saudi-community-from-the-saudi-dm-study
#15
Khalid Al-Rubean, Amira M Youssef, Yousuf AlFarsi, Ahmad H Al-Sharqawi, Nahla Bawazeer, Mohammad T AlOtaibi, Fahd Issa AlRumaih, Muhammad Shoaib Zaidi
BACKGROUND: The prevalence of metabolic syndrome varies widely by ethnicity and by the criteria used in its definition. OBJECTIVE: To identify the optimal cutoff values for waist circumference (WC), waist-to-hip ratio (WHR) and body mass index (BMI) for identifying metabolic syndrome among the Saudi population. DESIGN: Nationwide household cross-sectional population-based survey. SETTING: Thirteen health sectors in Saudi Arabia...
January 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28150366/correlation-between-umbilical-resistance-index-and-fetal-growth-pilot-study
#16
Mehdi Kehila, Omar Touhami, Rim Ben Hmid, Hassine Saber Abouda, Khlifi Abdeljelil, Amira Ayachi, Mechaal Mourali, Hédi Khairi, Mohamed Badis Chanoufi
AIM: To investigate normal pregnancies to determine whether there is a relationship between umbilical resistance and fetal growth. METHODS: This prospective study was conducted in three academic departments. Third trimester routine prenatal ultrasonography was used to estimate fetal weight and measure umbilical resistance index (RI). After delivery the birthweight was noted, along with the time interval between the ultrasound and the delivery, and then the weekly weight gain was calculated...
February 2, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28138803/effectiveness-and-persistence-of-liraglutide-treatment-among-patients-with-type-2-diabetes-treated-in-primary-care-and-specialist-settings-a-subgroup-analysis-from-the-evidence-study-a-prospective-2-year-follow-up-observational-post-marketing-study
#17
Luc Martinez, Alfred Penfornis, Jean-Francois Gautier, Eveline Eschwège, Guillaume Charpentier, Amira Bouzidi, Pierre Gourdy
INTRODUCTION: The objective of this subgroup analysis is to investigate the effectiveness of liraglutide in people with type 2 diabetes (T2D) treated within the primary care physician (PCP) and specialist care settings. METHODS: EVIDENCE is a prospective, observational study of 3152 adults with T2D recently starting or about to start liraglutide treatment in France. We followed patients in the PCP and specialist settings for 2 years to evaluate the effectiveness of liraglutide in glycemic control and body weight reduction...
January 30, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28135895/neurologic-complications-in-children-with-scorpionism
#18
Khaled Saad, Mohamed A Abd El-Hamed, Mohamed Gamil M Abo-Elela, Ahmed E Ahmed, Khaled A Abdel-Baseer, Mohamed Diab Aboul-Khair, Kotb Abbass Metwalley, Amira A El-Houfey, Gamal M Hasan, Ahmad M El-Shareef
Scorpion envenomation is a life-threatening health problem in tropical and subtropical regions, particularly among children. The aim of this study was to describe the epidemiologic characteristics, clinical profile, and prognosis of neurologic complications among children with scorpionism in Upper Egypt. In this retrospective study, the neurologic complications of scorpionism in 2 university hospitals were analyzed from the points of epidemiologic and clinical picture and outcomes. The neurologic manifestations were found at a high percentage (85%)...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28131490/prediction-of-3-to-5-month-outcomes-from-signs-of-acute-bilirubin-toxicity-in-newborn-infants
#19
Salma Z El Houchi, Iman Iskander, Rasha Gamaleldin, Amira El Shenawy, Iman Seoud, Hazem Abou-Youssef, Richard P Wennberg
OBJECTIVE: To evaluate the ability of the bilirubin-induced neurologic dysfunction (BIND) score to predict residual neurologic and auditory disability and to document the relationship of BIND score to total serum bilirubin (TSB) concentration. STUDY DESIGN: The BIND score (assessing mental status, muscle tone, and cry patterns) was obtained serially at 6- to 8-hour intervals in 220 near-term and full-term infants with severe hyperbilirubinemia. Neurologic and/or auditory outcomes at 3-5 months of age were correlated with the highest calculated BIND score...
January 25, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28119828/monitoring-step-activity-during-task-oriented-circuit-training-in-high-functioning-chronic-stroke-survivors-a-proof-of-concept-feasibility-study
#20
Sofia Straudi, Carlotta Martinuzzi, Andrea Baroni, Maria Grazia Benedetti, Calogero Foti, Amira Sabbagh Charabati, Claudia Pavarelli, Nino Basaglia
OBJECTIVE: To explore the amount of practice and progression during task-oriented circuit training (TOCT) in chronic stroke survivors; to test the use of pedometers and observation-based measures in detecting step activity; to verify the possible correlation between step activity and locomotor function improvements. METHODS: Six community-dwelling chronic stroke survivors underwent 10 TOCT sessions (2 hours/each) over 2 weeks in which they were trained both on a treadmill and on six task-oriented workstations (W1-W6)...
December 2016: Annals of Rehabilitation Medicine
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