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https://www.readbyqxmd.com/read/29231840/autopsy-learning-module-a-tool-for-assessing-self-reflection-and-practice-improvement-competency
#1
Mohammad Saud Khan, William Barnett, Amira Gohara, Jacob Torrison, Christian Coletta, Ragheb Assaly
No abstract text is available yet for this article.
December 11, 2017: International Journal of Medical Education
https://www.readbyqxmd.com/read/29230439/ex-vivo-detection-and-quantification-of-gold-nanoparticles-in-human-seminal-and-follicular-fluids
#2
Dimitrios Bitounis, Jean-Philippe Klein, Lionel Mery, Amira El-Merhie, Valérie Forest, Delphine Boudard, Jérémie Pourchez, Michèle Cottier
Increasing consumption of engineered nanoparticles and occupational exposure to novel, ultrafine airborne particles during the last decades has coincided with deterioration of sperm parameters and delayed fecundity. In order to prevent possible adverse health effects and ensure a sustainable growth for the nanoparticle industry, the ability to investigate the nanosized, mineralogical load of human reproductive systems is becoming a real clinical need. Toward this goal, the current study proposes two methods for the detection and quantification of engineered nanoparticles in human follicular and seminal fluid, developed with the use of well-defined 60 nm Au particles...
December 12, 2017: Analyst
https://www.readbyqxmd.com/read/29227466/morbidity-and-mortality-of-a-cohort-of-peruvian-hiv-infected-children-2003-2012
#3
Amira N Baker, Angela M Bayer, Rolando M Viani, Lenka Kolevic, Myung-Shin Sim, Jaime G Deville
BACKGROUND: Data on pediatric HIV in Peru is limited. The National Institute of Child Health (Instituto Nacional de Salud del Niño: INSN) cares for the most HIV-infected children under age 18 in the country. We describe the outcomes of children seen at INSN's HIV clinic over the 10 years when antiretroviral therapy (ART) and prevention of mother-to-child transmission (PMTCT) interventions became available in 2004. METHODS: We conducted a retrospective review of INSN HIV clinic patients between 2003-2012...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29225690/do-we-need-regional-guidelines-for-breast-cancer-management-in-the-mena-region-mena-breast-cancer-guidelines-project
#4
Reham Fayed, Dina Hamza, Heba Abdallah, Mohamed Kelany, Amira Tahseen, Adel T Aref
Purpose: Breast cancer is the most common cancer among females worldwide in general and in the Middle East and the North African region (MENA region) in particular. Management of breast cancer in the MENA region faces a lot of challenges, which include younger age at presentation, aggressive behaviour, lack of national breast screening programmes and lack of reliable data registries as well as socioeconomic factors. These factors make applying the international guidelines for breast cancer management very challenging...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29224253/phytochemical-composition-and-biological-activities-of-dyssodia-tagetiflora-lag
#5
Ana María García-Bores, Amira Arciniegas-Arciniegas, Alma Reyna Campos, Carlos Céspedes-Acuña, Betsaida Avila-Suárez, Julio Alarcón-Enos, Saul Flores-Maya, Adriana Montserrat Espinosa-González, Alfonso Romo de Vivar-Romo, Carlos Pérez Plasencia, José Guillermo Avila-Acevedo
While plants of the genus Dyssodia are used by man to a certain extent, few phytochemical and pharmacological studies have been performed with species of this genus. D. tagetiflora is an endemic plant of Mexico and has been used as fodder. The aim of this research was to isolate and identify the main bioactive components and evaluate the insecticidal, antioxidant, genotoxic and cytoprotective activities of D. tagetiflora. The isolated substances included an essential oil composed of six monoterpenes, and extracts containing two flavonols, three flavonol-glycosides and four thiophenes...
December 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29218526/glut4-translocation-in-single-muscle-cells-in-culture-epitope-detection-by-immunofluorescence
#6
Javier R Jaldin-Fincati, Philip J Bilan, Amira Klip
GLUT4 is the major glucose transporter in skeletal muscle. GLUT4 cycles to and from the plasma membrane and its exocytic rate is accelerated by insulin and muscle contraction to achieve a new steady state with more GLUT4 proteins at the muscle cell surface. To gain a better understanding of the molecular and cellular mechanisms that govern GLUT4 protein recycling, we developed an in vitro model in which myc-epitope-tagged GLUT4 or GLUT4-GFP is expressed in L6 skeletal muscle cells. The myc-epitope is inserted into an exofacial domain that is accessible to anti-myc antibodies from the outside of non-permeabilized cells, allowing one to count the number of transporters at the cell surface...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29214994/human-liver-segments-role-of-cryptic-liver-lobes-and-vascular-physiology-in-the-development-of-liver-veins-and-left-right-asymmetry
#7
Jill P J M Hikspoors, Mathijs M J P Peeters, Nutmethee Kruepunga, Hayelom K Mekonen, Greet M C Mommen, S Eleonore Köhler, Wouter H Lamers
Couinaud based his well-known subdivision of the liver into (surgical) segments on the branching order of portal veins and the location of hepatic veins. However, both segment boundaries and number remain controversial due to an incomplete understanding of the role of liver lobes and vascular physiology on hepatic venous development. Human embryonic livers (5-10 weeks of development) were visualized with Amira 3D-reconstruction and Cinema 4D-remodeling software. Starting at 5 weeks, the portal and umbilical veins sprouted portal-vein branches that, at 6...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29209235/the-endless-trip-among-the-nps-users-psychopathology-and-psychopharmacology-in-the-hallucinogen-persisting-perception-disorder-a-systematic-review
#8
REVIEW
Laura Orsolini, Gabriele Duccio Papanti, Domenico De Berardis, Amira Guirguis, John Martin Corkery, Fabrizio Schifano
Hallucinogen-persisting perception disorder (HPPD) is a syndrome characterized by prolonged or reoccurring perceptual symptoms, reminiscent of acute hallucinogen effects. HPPD was associated with a broader range of LSD (lysergic acid diethylamide)-like substances, cannabis, methylenedioxymethamphetamine (MDMA), psilocybin, mescaline, and psychostimulants. The recent emergence of novel psychoactive substances (NPS) posed a critical concern regarding the new onset of psychiatric symptoms/syndromes, including cases of HPPD...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29204234/carotid-doppler-ultrasonography-as-a-screening-tool-of-early-atherosclerotic-changes-in-children-and-young-adults-with-%C3%AE-thalassemia-major
#9
Seif El-Din Abaza, Amina Abdel-Salam, Ahmed A Baz, Amira A Mohamed
Purpose: β-thalassemia major (β-TM) patients had an increased incidence of cardiovascular complications secondary to iron overload. They showed early carotid atherosclerosis as showed by increased carotid intima media thickness (CIMT) that may occur early even when significant iron overload is absent. We aimed to test the diagnostic performance of CIMT measurement by Doppler ultrasonography as a structural indicator for premature atherosclerosis in β-TM patients. Methods: Case-control study included 42 β-TM patients (24 males and 18 females) aged from 3 to 30 years and 36 age- and sex-matched healthy controls...
December 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/29202049/the-odyssey-of-linking-to-and-staying-in-hiv-care-among-male-sex-workers-in-peru
#10
Angela M Bayer, Chanelle M Díaz, Marina Chiappe, Amira N Baker, Miguel S Egoavil, José E Pérez-Lu, Pamina M Gorbach, Patricia J García
Background: In Peru, there is little information about the HIV care continuum. Therefore, we conducted a study to describe the HIV care continuum among male sex workers (MSWs) in Lima. Methods: We applied close-ended surveys with 209 MSWs about their engagement in the HIV care continuum and open-ended surveys with 34 MSWs who are people living with HIV (PLHIV) to explore their linkage to and retention in HIV care. Results: Of 209 MSWs, only 71% (n=148) reported a lifetime HIV test and 56% (n=116) of all MSWs received confirmatory HIV test results...
January 2017: Journal of HIV and AIDS
https://www.readbyqxmd.com/read/29198708/knockdown-of-laminin-%C3%AE-5-stimulates-intestinal-cell-differentiation
#11
Manon Lepage, Amira Seltana, Marie-Pier Thibault, Éric Tremblay, Jean-François Beaulieu
Interactions between cells and the extracellular matrix regulate a wide range of cell processes such as proliferation and differentiation. Laminins are major components of the basement membrane that actively participate in most biological functions via their interactions with a variety of specific cell receptors. The α5-containing laminins (LAMA5) are one of the three main types of laminins identified at the epithelial basal lamina in the adult intestine. The aim of the present study was to investigate the role of α5-containing laminins on intestinal cell proliferation and differentiation...
November 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29196764/differences-in-trabecular-microarchitecture-and-simplified-boundary-conditions-limit-the-accuracy-of-qct-based-finite-element-models-of-vertebral-failure
#12
Amira I Hussein, Daniel Louzeiro, Ginu U Unnikrishnan, Elise F Morgan
Vertebral fractures are common in the elderly, but efforts to reduce their incidence have been hampered by incomplete understanding of the failure processes that are involved. This study's goal was to elucidate failure processes in the lumbar vertebra and to assess the accuracy of quantitative computed tomography (QCT)-based finite element (FE) simulations of these processes. Following QCT scanning, spine segments (n=27) consisting of L1 with adjacent intervertebral discs and neighboring endplates of T12 and L2 were compressed axially in a stepwise manner...
December 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29193203/nuclear-and-cytoplasmic-features-in-the-diagnosis-of-clark-s-nevi
#13
Manuel Valdebran, Justin Bandino, Amira Elbendary, Abdallah Gad, Sri Krishna Chaitanya Arudra, Sébastien de Feraudy, Dirk M Elston
BACKGROUND: Interpretation of Clark's nevi has generated debate over the years; although criteria has been proposed for grading morphological features of melanocytes, there is still confusion and variability in the assessment of these lesions. METHODS: This is a retrospective observational study conducted on 100 Clark's nevi and 84 melanomas. A single expert dermatopathologist evaluated all blinded and randomized photomicrographs of both the Clark's nevi and melanomas for the presence of 14 cytologic features...
November 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29191023/a-rapidly-activating-pd-precatalyst-for-suzuki-miyaura-and-buchwald-hartwig-couplings-of-aryl-esters
#14
Amira H Dardir, Patrick R Melvin, Ryan M Davis, Nilay Hazari, Megan Mohadjer Beromi
Esters are valuable electrophiles for cross-coupling due to their ubiquity and ease of synthesis. However, harsh conditions are traditionally required for the effective cross-coupling of ester substrates. Utilizing a recently discovered precatalyst, Pd-catalyzed Suzuki-Miyaura and Buchwald-Hartwig reactions involving cleavage of the C(acyl)-O bond of aryl esters that proceed under mild conditions are reported. The Pd(II) precatalyst is highly active because it is reduced to the Pd(0) active species more rapidly than previous precatalysts...
December 1, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29187488/predictive-factors-and-a-survival-score-for-patients-irradiated-for-metastatic-spinal-cord-compression-from-carcinoma-of-the-salivary-glands
#15
Dirk Rades, Amira Bajrovic, Tobias Bartscht
AIM: To our knowledge, this is the first study focusing on metastatic spinal cord compression (MSCC) from carcinoma of the salivary glands. PATIENTS AND METHODS: Nine patients receiving radiation alone were evaluated for improvement of motor deficits, post-radiation gait function and survival. RESULTS: Of nine characteristics (radiation program, age, sex, additional metastases to bone or to other organs, dynamic of motor deficits, pre-radiation gait function, number of vertebrae affected by MSCC, general condition), strong trends were found for associations between improved motor deficits and their dynamic (p=0...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29186459/the-long-term-impact-of-a-change-in-effort-reward-imbalance-on-mental-health-results-from-the-prospective-man-go-study
#16
Amira Barrech, Natalie Riedel, Jian Li, Raphael M Herr, Kathrin Mörtl, Peter Angerer, Harald Gündel
Background: Little is yet known on the long-term effects of stress management interventions (SMIs) in the workplace. The aim this study was to prospectively examine the effect of an improvement of psychosocial working conditions measured by the Effort-Reward (E-R) Imbalance model within 2 years following an SMI, and mental health 7 years later. Methods: The study sample consisted of 97 male industrial workers from southern Germany. Data were collected pre- and post-intervention in 2006 (T1) and 2008 (T2), respectively, as well as in 2015 (T3)...
December 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29183388/restraint-use-among-selected-hospitalized-elderly-patients-in-cairo-egypt
#17
Amira G Eltaliawi, Mohamed El-Shinawi, Angela Comer, Sarah Hamazah, Jon Mark Hirshon
OBJECTIVE: This study's primary objective was to investigate the prevalence of physical and chemical restraint use in selected elderly hospitalized patients. RESULTS: This study was conducted in April 2014 in four major acute care hospitals. Trained data collectors assessed the use of physical and chemical restraint among all admitted elderly patients. There were 287 elderly patients (median age 64 years, 46% women). 32 patients were restrained. The overall prevalence of restraints was 11...
November 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29181392/long-term-effectiveness-of-a-stress-management-intervention-at-work-a-9-year-follow-up-study-based-on-a-randomized-wait-list-controlled-trial-in-male-managers
#18
Jian Li, Natalie Riedel, Amira Barrech, Raphael M Herr, Birgit Aust, Kathrin Mörtl, Johannes Siegrist, Harald Gündel, Peter Angerer
Objective: Short- and medium-term effectiveness (up to 3 years) of individual level stress management interventions (SMI) at work were demonstrated, yet long-term effectiveness remains unexplored. We therefore aimed to address this research gap. Methods: 94 male middle managers participated in a randomized wait-list controlled trial between 2006 and 2008 and in a post-trial-follow-up survey in 2015. During the first two years, all received an 18-hour psychotherapeutic SMI intervention which was based on the Effort-Reward Imbalance (ERI) model: tackling stressor on mismatch between effort and reward and promoting recovery on overcommitment...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29180808/engagement-of-mhc-class-i-by-the-inhibitory-receptor-lilrb1-suppresses-macrophages-and-is-a-target-of-cancer-immunotherapy
#19
Amira A Barkal, Kipp Weiskopf, Kevin S Kao, Sydney R Gordon, Benyamin Rosental, Ying Y Yiu, Benson M George, Maxim Markovic, Nan G Ring, Jonathan M Tsai, Kelly M McKenna, Po Yi Ho, Robin Z Cheng, James Y Chen, Layla J Barkal, Aaron M Ring, Irving L Weissman, Roy L Maute
Exciting progress in the field of cancer immunotherapy has renewed the urgency of the need for basic studies of immunoregulation in both adaptive cell lineages and innate cell lineages. Here we found a central role for major histocompatibility complex (MHC) class I in controlling the phagocytic function of macrophages. Our results demonstrated that expression of the common MHC class I component β2-microglobulin (β2M) by cancer cells directly protected them from phagocytosis. We further showed that this protection was mediated by the inhibitory receptor LILRB1, whose expression was upregulated on the surface of macrophages, including tumor-associated macrophages...
November 27, 2017: Nature Immunology
https://www.readbyqxmd.com/read/29180261/optimal-choice-of-k-mer-in-composition-vector-method-for-genome-sequence-comparison
#20
Subhram Das, Tamal Deb, Nilanjan Dey, Amira S Ashour, D K Bhattacharya, D N Tibarewala
Several proteins and genes are members of families that share a public evolutionary. In order to outline the evolutionary relationships and to recognize conserved patterns, sequence comparison becomes an emerging process. The current work investigates critically the k-mer role in composition vector method for comparing genome sequences. Generally, composition vector methods using k-mer are applied under choice of different value of k to compare genome sequences. For some values of k, results are satisfactory, but for other values of k, results are unsatisfactory...
November 24, 2017: Genomics
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