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https://www.readbyqxmd.com/read/29039759/a-dft-study-of-the-geometrical-spectroscopical-and-reactivity-properties-of-diindolylmethane-phenylboronic-acid-hybrids
#1
Amira Jalil Fragoso-Medina, René Gerardo Escobedo-González, María Inés Nicolás-Vázquez, Gabriel Arturo Arroyo-Razo, María Olivia Noguez-Córdova, René Miranda-Ruvalcaba
The structure of the ortho-, meta- and para- hybrid diindolylmethane-phenylboronic acids and their interactions were optimized with by a quantum chemical method, using density functional theory at the (DFT) level. Thus, infrared bands were assigned based on the scaled theoretical wavenumbers by correlating the respective experimental data of the molecules. In addition, the corresponding ¹H-/(13)C-/(11)B-NMR experimental and theoretical chemical shifts were correlated. The target molecules showed a poor treatment of the OH shifts in the GIAO method due to the absence of explicit solvent effects in these calculations; therefore, they were explicitly considered with acetone molecules...
October 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29039412/intermittent-fasting-promotes-adipose-thermogenesis-and-metabolic-homeostasis-via-vegf-mediated-alternative-activation-of-macrophage
#2
Kyoung-Han Kim, Yun Hye Kim, Joe Eun Son, Ju Hee Lee, Sarah Kim, Min Seon Choe, Joon Ho Moon, Jian Zhong, Kiya Fu, Florine Lenglin, Jeong-Ah Yoo, Philip J Bilan, Amira Klip, Andras Nagy, Jae-Ryong Kim, Jin Gyoon Park, Samer Mi Hussein, Kyung-Oh Doh, Chi-Chung Hui, Hoon-Ki Sung
Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benefits is limited. Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice. IF-induced metabolic benefits require fasting-mediated increases of vascular endothelial growth factor (VEGF) expression in white adipose tissue (WAT)...
October 17, 2017: Cell Research
https://www.readbyqxmd.com/read/29037091/an-anthropometric-survey-of-u-s-preterm-and-full-term-neonates
#3
Susan M Abdel-Rahman, Ian M Paul, Paula Delmore, Laura James, Laura Fearn, Andrew M Atz, Brenda B Poindexter, Amira Al-Uzri, Andrew Lewandowski, Barrie L Harper, P Brian Smith
BACKGROUND: Anthropometric data prove valuable for screening and monitoring various medical conditions. In young infants, however, only weight, length and head circumference are represented in publically accessible databases. AIM: To characterise length and circumferential measures in preterm and full-term infants up to 90 days postnatal age. SUBJECTS AND METHODS: In eight U.S. medical centres, trained raters recorded humeral, ulnar, femoral, tibial, and fibular lengths along with mid-upper arm, mid-thigh, chest, abdominal, and neck circumference...
October 16, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/29033001/the-role-of-micrornas-in-photodynamic-therapy-of-cancer
#4
Sherien M El-Daly, Mohammed L Abba, Amira M Gamal-Eldeen
Photodynamic therapy (PDT) is a non-invasive treatment modality used in the management of both benign and malignant conditions. It involves the administration of a photosensitizing agent followed by local light irradiation, which activates the photosensitizer, resulting in tissue damage. An in-depth understanding of the molecular mechanisms and mediators of PDT is important, not only for appreciating how this treatment modality is effective, but also as an avenue for understanding potential shortfalls and untoward effects that can be managed or improved...
October 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031074/synthesis-antiproliferative-anti-tubulin-activity-and-docking-study-of-new-1-2-4-triazoles-as-potential-combretastatin-analogues
#5
Muhamad Mustafa, Dalia Abdelhamid, ElShimaa M N Abdelhafez, Mahmoud A A Ibrahim, Amira M Gamal-Eldeen, Omar M Aly
Combretastatin A4 (CA4) is a natural product characterized by a powerful inhibition of tubulin polymerization and a potential anticancer activity. However, therapeutic application of CA4 is substantially hindered due to geometric isomerization. In the current study, new cis-restricted Combretastatin A4 analogues containing 1,2,4-triazle in place of the olefinic bond were designed and synthesized. The synthesized compounds were evaluated for their in vitro antiproliferative activity in human hepatocellular carcinoma HepG2 and leukemia HL-60 cell lines using MTT assay...
September 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29027088/redescription-of-philometra-filiformis-stossich-1896-nematoda-philometridae-a-gonad-infecting-parasite-of-the-common-pandora-pagellus-erythrinus-linnaeus-sparidae-in-the-mediterranean-sea-including-new-taxonomic-features-revealed-by-sem
#6
František Moravec, Nessrine Ghanmi, Amira Chaabane, Lamia Gargouri, Jean-Lou Justine
The insufficiently known nematode species Philometra filiformis (Stossich, 1896) (Philometridae) is redescribed based on light and scanning electron microscopical (SEM) examinations of specimens collected from the ovaries of the type-host, the common pandora Pagellus erythrinus (Linnaeus) (Perciformes, Sparidae), from off the Mediterranean coast of Tunisia. The male of this species was studied with SEM for the first time, which revealed some new, taxonomically important morphological features. The male posterior end has a caudal mound consisting of two lateral parts widely separated dorsally from each other, four pairs of small adanal papillae, a pair of large but moderately developed papillae located posterior to the cloacal aperture and a pair of small phasmids...
October 12, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/29026466/influenza-research-in-the-eastern-mediterranean-region-a-review
#7
REVIEW
Wasiq Khan, Amira S El Rifay, Mamun Malik, Ghazi Kayali
Given the importance of influenza infections in the Eastern Mediterranean Region (EMR), we conducted a comprehensive literature review to analyze the status of influenza research in the region from 2012. Influenza research has gained more momentum recently with the emergence of H5N1 and new virus strains. Research covering epidemiological, veterinary, and basic science aspects is growing. More sequences were being generated per year, not only for diagnostic purposes but also for research. We included gray literature publications in our search and found several graduate student dissertations from Egypt, which were published on an online portal...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29024908/tackling-the-mortality-from-long-term-exposure-to-outdoor-air-pollution-in-megacities-lessons-from-the-greater-cairo-case-study
#8
Ali Wheida, Amira Nasser, Mostafa El Nazer, Agnes Borbon, Gehad A Abo El Ata, Magdy Abdel Wahab, Stephane C Alfaro
OBJECTIVE: The poor outdoor air quality in megacities of the developing world and its impact on health is a matter of concern for both the local populations and the decision-makers. The objective of this work is to quantify the mortality attributable to long-term exposure to PM2.5, NO2, and O3 in Greater Cairo (Egypt). METHODS: We analyze the temporal and spatial variability of the three pollutants concentrations measured at 18 stations of the area. Then, we apply the method recommended by the WHO to estimate the excess mortality...
October 9, 2017: Environmental Research
https://www.readbyqxmd.com/read/29022829/migratory-white-stork-ciconia-ciconia-a-potential-vector-of-the-oxa-48-producing-escherichia-coli-st38-clone-in-algeria
#9
Amira Bouaziz, Lotfi Loucif, Ammar Ayachi, Karima Guehaz, Esma Bendjama, Jean-Marc Rolain
The emergence of carbapenemase-producing Enterobacteriaceae is of great concern to public health worldwide. The aim of this study was to screen for the presence of carbapenemase-producing Enterobacteriaceae in white stork (Ciconia ciconia) migratory bird stools, and to investigate their molecular support on β-lactamase production. In March 2015, 32 fecal samples of white stork were collected in the Commune of El Madher Wilaya de Batna, in eastern Algeria. Samples were subjected to selective isolation of carbapenem-resistant Enterobacteriaceae...
October 12, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29020389/cactus-aorta
#10
Amira Mahrouf, Gilles Soulat, David Lebeaux, Laurence Iserin, Clement Karsenty
No abstract text is available yet for this article.
September 12, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29018585/disentangling-age-gender-interactions-associated-with-risks-of-fatal-and-non-fatal-road-traffic-injuries-in-the-sultanate-of-oman
#11
Amira K Al-Aamri, Sabu S Padmadas, Li-Chun Zhang, Abdullah A Al-Maniri
OBJECTIVE: Road traffic injuries (RTIs) are the leading cause of disability-adjusted life years lost in Oman, Saudi Arabia and United Arab Emirates. Injury prevention strategies often overlook the interaction of individual and behavioural risk factors in assessing the severity of RTI outcomes. We conducted a systematic investigation of the underlying interactive effects of age and gender on the severity of fatal and non-fatal RTI outcomes in the Sultanate of Oman. METHODS: We used the Royal Oman Police national database of road traffic crashes for the period 2010-2014...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/28993577/effect-of-biochanin-a-versus-17%C3%AE-estradiol-in-rat-submandibular-salivary-gland
#12
Amira M Elsherbini, Mohammed A R Mohammed, Fatma M Ibrahim
The epigenetic nature of development mandates the observation of the effect of any exogenous substance, especially those with estrogenic activities, during critical phases of development. The submandibular gland (SMG) presents as a great model due to extensive postnatal development, and is known to be regulated and affected by hormones as well as growth factors. Herein, we observed postnatal development following low doses of Biochanin A (BCA) and 17β estradiol (E2) in rats. The pups were randomly divided into four groups: control, BCA, E2, and dimethyl sulfoxide (DMSO), and euthanized at the 6th, 15th, 30th, and 60th postnatal days (PND)...
October 6, 2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28983412/clinical-significance-of-matrilin-3-gene-polymorphism-in-egyptian-patients-with-primary-knee-osteoarthritis
#13
Safia M Diab, Howyda M Kamal, Amira I Mansour, Rasha M Fawzy, Basma S Azab
OBJECTIVE: Osteoarthritis (OA) is a multifactorial, degenerative, and inflammatory disorder of joints causing damage of the articular cartilage, formation of osteophytes, and eburination of the subchondral bone. Matrilin-3 (MATN-3) is a non-collagenous oligomeric extracellular matrix protein (ECM), which is the smallest member of the matrilin family. This study was conducted to identify the potential association and clinical significance of MATN-3 rs8176070 (SNP6) polymorphism in a series of Egyptian patients with primary knee OA...
September 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28979155/role-of-serum-cystatin-c-and-beta-2-microglobulin-as-early-markers-of-renal-dysfunction-in-children-with-beta-thalassemia-major
#14
Ola Galal Behairy, Eman Rateb Abd Almonaem, Neveen Tawfik Abed, Omima M Abdel Haiea, Rasha M Zakaria, Rania I AbdEllaty, Effat H Asr, Amira Ibrahim Mansour, Amira Mn Abdelrahman, Hoda A Elhady
BACKGROUND: Although advancements have been made in the management of thalassemic patients, many unrecognized complications have emerged, such as renal abnormalities. AIM: To measure serum levels of cystatin-C and β-2 microglobulin in children with beta-thalassemia major (β-TM) and investigate their significance as early markers of glomerular and tubular dysfunctions. SUBJECTS AND METHODS: The study was performed on 70 children with (β-TM) and 20 apparently healthy children matched for age and sex as a control group...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28971515/serum-proteomic-assessment-of-the-progression-of-fracture-healing
#15
Amira I Hussein, Christian Mancini, Kyle E Lybrand, Margaret E Cooke, Heather E Matheny, Brenna L Hogue, Paul Tornetta, Louis C Gerstenfeld
A targeted proteomic analysis of murine serum over a 35-day course of fracture healing was carried out to determine if serum proteomic changes could be used to monitor the biological progression of fracture healing. Transverse, closed femoral fractures where generated and stabilized with intramedullary fixation. A single stranded DNA aptamer-based multiplexed proteomic approach was used to assay 1310 proteins. The transcriptomic profiles for genes matching the 1310 proteins were obtained by microarray analysis of callus mRNA...
October 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28971127/integrated-dataset-of-anatomical-morphological-and-architectural-traits-for-plant-species-in-madagascar
#16
Amira Azizan, Emma Guillon, Yves Caraglio, Patrick Langbour, Sébastien Paradis, Pierre Bonnet, Yannick Brohard, Christine Heinz, Nabila Boutahar, Loïc Brancheriau
In this work, we present a dataset, which provides information on the structural diversity of some endemic tropical species in Madagascar. The data were from CIRAD xylotheque (since 1937), and were also collected during various fieldworks (since 1964). The field notes and photographs were provided by French botanists; particularly by Francis Hallé. The dataset covers 250 plant species with anatomical, morphological, and architectural traits indexed from digitized wood slides and fieldwork documents. The digitized wood slides were constituted by the transverse, tangential, and radial sections with three optical magnifications...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/28956451/topical-phenytoin-nanostructured-lipid-carriers-design-and-development
#17
Amira Motawea, Thanaa Borg, Abd El-Gawad H Abd El-Gawad
Phenytoin (PHT) is an antiepileptic drug that was reported to exhibit high wound healing activity. Nevertheless, its limited solubility, bioavailability, and inefficient distribution during topical administration limit its use. Therefore, this study aims to develop, characterize nanostructured lipid carriers (NLCs) and evaluate their potential in topical delivery of PHT to improve the drug entrapment efficiency and sustained release. The NLCs were prepared by hot homogenization followed by ultrasonication method using 2(3) factorial design...
September 28, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28952275/potential-diagnostic-and-prognostic-value-of-lymphocytic-mitochondrial-dna-deletion-in-relation-to-folic-acid-status-in-hcv-related-hepatocellular-carcinoma
#18
Abdel Rahman N Zekri, Hosny Salama, Eman Medhat, Sherif Hamdy, Zeinab K Hassan, Yasser Mabrouk Bakr, Amira Salah El - Din Youssef, Doaa Saleh, Ramy Saeed, Dalia Omran
Objective: We assessed the possibility of using mitochondrial (mt) DNA deletion as a molecular biomarker for disease progression in HCV-related hepatocellular carcinoma (HCC) and to identify its association with folic acid status. Methods: Serum folic acid and lymphocytic mtDNA deletions were assessed in 90 patients; 50 with HCC, 20 with liver cirrhosis (LC), and 20 with chronic hepatitis C (CHC) compared to 10 healthy control subjects. The diagnostic accuracy of mtDNA deletions frequency was evaluated using receiver-operating characteristic (ROC) curve analysis Survival analysis was performed using the Kaplan-Meier method...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28950023/assessment-of-maldi-tof-ms-biotyping-for-borrelia-burgdorferi-sl-detection-in-ixodes-ricinus
#19
Pierre H Boyer, Nathalie Boulanger, Amira Nebbak, Elodie Collin, Benoit Jaulhac, Lionel Almeras
Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has been demonstrated to be useful for tick identification at the species level. More recently, this tool has been successfully applied for the detection of bacterial pathogens directly in tick vectors. The present work has assessed the detection of Borrelia burgdorferi sensu lato in Ixodes ricinus tick vector by MALDI-TOF MS. To this aim, experimental infection model of I. ricinus ticks by B. afzelii was carried out and specimens collected in the field were also included in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28946813/nationwide-french-study-of-ret-variants-detected-from-2003-to-2013-suggests-a-possible-influence-of-polymorphisms-as-modifiers
#20
Maylis Lebeault, Stéphane Pinson, Marine Guillaud-Bataille, Anne-Paule Gimenez-Roqueplo, Alain Carrie, Véronique D Barbu, Pascal Pigny, Stephane Bezieau, Jean Marc Rey, Chantal Delvincourt, Sophie Giraud, Charlotte Veyrat Durebex, Patrick Saulnier, Nathalie Bouzamondo, Marie Chabbert, Julien Blin, Amira Mohamed, PAuline Romanet, Francoise Borson-Chazot, Vincent Rohmer, Anne Barlier, Mirebeau-Prunier Delphine
BACKGROUND: The presence of single nucleotide polymorphisms (SNPs) in the RET (REarranged during Transfection) gene has been investigated with regard to their potential role in the development or progression of medullary thyroid cancer (MTC) or pheochromocytomas (PHEO) in patients with the multiple endocrine neoplasia type 2 (MEN2) syndrome. The aim of this study was to evaluate the spectrum of RET variants in France between 2003 and 2013, and an evaluation of the impact of SNPs on the MEN2 A phenotype...
September 25, 2017: Thyroid: Official Journal of the American Thyroid Association
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