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https://www.readbyqxmd.com/read/29456868/-cinnamomum-zeylanicum-bark-essential-oil-induces-cell-wall-remodelling-and-spindle-defects-in-candida-albicans
#1
Zinnat Shahina, Amira M El-Ganiny, Jessica Minion, Malcolm Whiteway, Taranum Sultana, Tanya E S Dahms
Background: Cinnamon ( Cinnamomum zeylanicum) bark extract exhibits potent inhibitory activity against Candida albicans but the antifungal mechanisms of this essential oil remain largely unexplored. Results: We analyzed the impact of cinnamon bark oil on C. albicans RSY150, and clinical strains isolated from patients with candidemia and candidiasis. The viability of RSY150 was significantly compromised in a dose dependent manner when exposed to cinnamon bark oil, with extensive cell surface remodelling at sub inhibitory levels (62...
2018: Fungal Biology and Biotechnology
https://www.readbyqxmd.com/read/29456388/analgesic-properties-of-nigella-sativa-and-eucheuma-cottonii-extracts
#2
Amira Zakaria, Mohammad Rohani Jais, Reezal Ishak
Background: This study investigates the analgesic properties of the aqueous extracts of Nigella sativa and Eucheuma cottonii in mice. The analgesic properties of both extracts were evaluated in an experimental model of acetic acid-induced writhing test. Materials and Methods: The mice were divided into four different groups and received the test extracts and the standard drug (aspirin) for 14 days via force-feeding. On day 15, the mice were injected with 5% acetic acid, and the number of abdominal constriction and elongation of hind limb (writhes) were counted for 20 min...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29455611/evaluation-of-foetal-neurological-behaviour-in-hypothyroid-pregnant-females-a-pilot-study
#3
Amira Dieb, Randa Salam, Dina Shaheen, Eman Shaeer
OBJECTIVES: Maternal hypothyroidism is known for its possible deleterious effect on the neurocognitive function of the offspring. The aim of the current study is to investigate if maternal hypothyroidism also affects foetal neurological behaviour. METHODS: Fifty foetuses were examined for abnormal neurological behaviour from 25 euthyroid and 25 hypothyroid age matched pregnant females, between 28 and 38 weeks gestation. The hypothyroid group was further subdivided into controlled (n = 5) and uncontrolled (n = 20) groups...
February 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29452244/does-saline-enema-during-the-first-stage-of-labour-reduce-the-incidence-of-clostridium-difficile-colonization-in-neonates-randomized-controlled-trial
#4
Adel M Nada, Reham A Mohsen, Yosra M Hassan, Amira Sabry, Noha S Soliman
BACKGROUND: Maternal rectal enemas may reduce neonatal bacterial exposure during labour; this may reduce the risk of neonatal colonization with Clostridium difficile. The aim of this study was to determine the effectiveness of a saline enema during the first stage of labour in reducing neonatal colonization with C. difficile. METHODS: The study was conducted in Cairo University Hospital from January 2016 to July 2016. Asymptomatic mothers with uncomplicated vaginal delivery and their neonates without diarrhea were included...
February 13, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29446339/the-rs1527483-but-not-rs3212018-cd36-polymorphism-associates-with-linoleic-acid-detection-and-obesity-in-czech-young-adults
#5
Jiří Plesník, Omar Šerý, Amira S Khan, Peter Bielik, Naim A Khan
Recent evidence has raised the possibility of the existence of a sixth taste modality - that is, taste for fat - which is mediated by lingual CD36 and plays a role in obesity. Consequently, the genetic polymorphism of CD36 has been shown to be associated with altered oro-sensory detection of dietary lipids. In the present study, we investigated the relationship between oro-sensory perception of linoleic acid (LA), two CD36 polymorphisms (rs1527483 and rs3212018), obesity parameters and craving habits for dietary lipids in young Czech adults...
February 15, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29445325/biomarkers-of-amyotrophic-lateral-sclerosis-current-status-and-interest-of-oxysterols-and-phytosterols
#6
REVIEW
Anne Vejux, Amira Namsi, Thomas Nury, Thibault Moreau, Gérard Lizard
Amyotrophic lateral sclerosis (ALS) is a non-demyelinating neurodegenerative disease in adults with motor disorders. Two forms exist: a sporadic form (90% of cases) and a family form due to mutations in more than 20 genes including the Superoxide dismutase 1, TAR DNA Binding Protein, Fused in Sarcoma, chromosome 9 open reading frame 72 and VAPB genes. The mechanisms associated with this pathology are beginning to be known: oxidative stress, glutamate excitotoxicity, protein aggregation, reticulum endoplasmic stress, neuroinflammation, alteration of RNA metabolism...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29439058/autoimmune-necrotising-myopathy-and-hmgcr-antibodies
#7
Kushan Karunaratne, Dimitri Amiras, Matthew C Pickering, Monika Hofer, Stuart Viegas
Statins lower serum cholesterol concentrations by inhibiting the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). Muscle side effects are relatively common and include asymptomatic elevation of serum creatine kinase (CK), myalgia, proximal muscle weakness and rhabdomyolysis. More recently, a subset of cases of immune-mediated necrotising myopathy has been found to have antibodies against HMGCR. It is often an aggressive and debilitating myopathy and has a complex pathogenesis characterised by fibre necrosis, usually with minimal associated inflammation...
February 8, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29435949/a-pharmacokinetic-model-for-amiodarone-in-infants-developed-from-an-opportunistic-sampling-trial-and-published-literature-data
#8
Samantha H Dallefeld, Andrew M Atz, Ram Yogev, Janice E Sullivan, Amira Al-Uzri, Susan R Mendley, Matthew Laughon, Christoph P Hornik, Chiara Melloni, Barrie Harper, Andrew Lewandowski, Jeff Mitchell, Huali Wu, Thomas P Green, Michael Cohen-Wolkowiez
Amiodarone is a first-line antiarrhythmic for life-threatening ventricular fibrillation or ventricular tachycardia in children, yet little is known about its pharmacokinetics (PK) in this population. We developed a population PK (PopPK) model using samples collected via an opportunistic study design of children receiving amiodarone per standard of care supplemented by amiodarone PK data from the literature. Both study data and literature data were predominantly from infants < 2 years old, so our analysis was restricted to this group...
February 12, 2018: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/29430087/clinical-evaluation-of-flowable-resin-composite-versus-conventional-resin-composite-in-carious-and-noncarious-lesions-systematic-review-and-meta-analysis
#9
REVIEW
Omar Osama Shaalan, Eman Abou-Auf, Amira Farid El Zoghby
The purpose of this systematic review was to evaluate clinical performance of flowable composite in carious and noncarious lesions. An electronic search was conducted using specific databases (PubMed, Embase, Cochrane Library, and LILACS) through March 2017. Clinical trials for restoration of carious and noncarious lesions were included with no date restrictions; follow-up was 6 months at least and dental restorations were evaluated using the United States Public Health Service criteria. The systematic search generated 908 papers, of which 35 papers were included for full-text review...
November 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29428880/multiple-traumas-and-resilience-among-street-children-in-haiti-psychopathology-of-survival
#10
Jude Mary Cénat, Daniel Derivois, Martine Hébert, Laetitia Mélissande Amédée, Amira Karray
In Haiti, as in several developing countries, the phenomenon of street children has become a major public health issue. These children are often victims of traumas and adverse life events. This article aimed to investigate traumas experienced by street children and their coping and resilience strategies used to deal with adversities in a logic of survival, relying on a mixed method approach. A group of 176 street children, aged 7-18 (n = 21 girls), recruited in Port-au-Prince, completed measures assessing PTSD, social support and resilience...
February 8, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29427474/chemical-composition-and-antimicrobial-activity-of-ageratina-deltoidea
#11
Amira Arciniegas, Ana-L Pérez-Castorena, Mariana Meléndez-Aguirre, José Guillermo Ávila, Ana María García-Bores, José Luis Villaseñor, Alfonso Romo de Vivar
The chemical study of Ageratina deltoidea afforded grandiflorenic acid (1), kaurenoic acid (2) and eight benzylbenzoates (3 - 10), two of them, 3',5'-dimethoxybenzyl 2,3,6-trimethoxybenzoate (5) and 4'-O-β-ᴅ-glucopyranosyloxy-3'-hydroxybenzyl 2,6-dimethoxybenzoate (9), described for the first time. In addition, the new sesquiterpene lactone deltoidin C (13), together with the known 11, and 12, the phenolic compounds: ayanin, 2,6-dimethoxybenzoic acid, methyl 3,4-dihydroxycinnamate, chlorogenic acid, and 3,5-dicaffeoylquinic acid were also isolated...
February 10, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29420778/deletion-of-aspergillus-nidulans-gdp-mannose-transporters-affects-hyphal-morphometry-cell-wall-architecture-spore-surface-character-cell-adhesion-and-biofilm-formation
#12
Ashraf A Kadry, Amira M El-Ganiny, Rasha A Mosbah, Susan G W Kaminskyj
Systemic human fungal infections are increasingly common. Aspergillus species cause most of the airborne fungal infections. Life-threatening invasive aspergillosis was formerly found only in immune-suppressed patients, but recently some strains of A. fumigatus have become primary pathogens. Many fungal cell wall components are absent from mammalian systems, so they are potential drug targets. Cell-wall-targeting drugs such as echinocandins are used clinically, although echinocandin-resistant strains were discovered shortly after their introduction...
October 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29419671/assessment-of-liver-fibrosis-in-egyptian-chronic-hepatitis-b-patients-a-comparative-study-including-5-noninvasive-indexes
#13
Mohammed Tag-Adeen, Maha Zeinelabedin Omar, Fatma Mohamed Abd-Elsalam, Ali Hasaneen, Mohamed Ahmed Mohamed, Hala Mohamed Elfeky, Ebada Mohamed Said, Badawy Abdul-Aziz, Amira Hefney Osman, Enas Sebaey Ahmed, Ghada Sidky Osman, Taghreed Abdul-Samie
Fibrosis assessment in chronic hepatitis B (CHB) is essential for prediction of long-term prognosis and proper treatment decision. This study was conducted to assess predictability of 5 simple noninvasive fibrosis indexes in comparison to liver biopsy in CHB patients.A total of 200 CHB adult Egyptian patients were consecutively included in this study, all were subjected to liver biopsy with staging of fibrosis using METAVIR scoring system. Fibrosis indexes including S-index, red cell distribution width to platelets ratio index (RPR), fibrosis-4 index (Fib-4), AST to platelets ratio index (APRI), and AST/ALT ratio index (AAR) were compared to biopsy result and their predictabilities for the different fibrosis stages were assessed using area under receiver operating characteristic curve (AUROC) analysis...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29415053/the-association-between-glutamine-repeats-in-the-androgen-receptor-gene-and-personality-traits-in-dromedary-camel-camelus-dromedarius
#14
Sherif Ramadan, Amira M Nowier, Yusuke Hori, Miho Inoue-Murayama
Temperament traits such as fearfulness are important as they define an animal's responses to its environment and handling. The increasing automation of daily tasks and growing population limits contact between camels and humans. Such limitations contribute to fear of humans and changes in physical environment. Monoamine oxidase A (MAOA) and androgen receptor (AR) genes are important candidates associated with mammal personality. In our analysis, MAOA exon 15 showed no polymorphism but a novel polymorphism was seen in the camel AR exon 1; 16, 17, 18, and 19 glutamine repeats were detected...
2018: PloS One
https://www.readbyqxmd.com/read/29414027/associations-of-work-stress-with-hair-cortisol-concentrations-initial-findings-from-a-prospective-study
#15
Raphael M Herr, Christian Almer, Adrian Loerbroks, Amira Barrech, Irina Elfantel, Johannes Siegrist, Harald Gündel, Peter Angerer, Jian Li
There is ample evidence supporting the link between stress at the workplace and physical and mental health. One of the pathways potentially mediating those associations may involve the hypothalamic-pituitary-adrenal (HPA) axis, with cortisol as an end product. While theoretically plausible, findings on the association of self-reported work stress with hair cortisol concentrations (HCC) are inconclusive, being potentially biased by omitted pertinent factors. This issue can be addressed, among others, by eliminating time-invariant factors through consideration of variation within persons over time...
January 18, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29413080/rumination-social-problem-solving-and-suicide-intent-among-egyptians-with-a-recent-suicide-attempt
#16
Amira Y Sharaf, Ola A Lachine, Elaine A Thompson
The more complex influences of social problem-solving abilities and rumination-specifically brooding and reflection-on suicide intent is not well understood. We hypothesized that social problem solving would moderate the association between reflection and suicide intent, and mediate the influence of brooding on suicide intent. A convenience sample (N=186) of individuals hospitalized for recent suicide attempt was interviewed, assessing suicide intent, social problem solving, brooding, reflection and depression...
February 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29401657/long-term-effectiveness-of-stress-management-at-work-effects-of-the-changes-in-perceived-stress-reactivity-on-mental-health-and-sleep-problems-seven-years-later
#17
Raphael M Herr, Amira Barrech, Natalie Riedel, Harald Gündel, Peter Angerer, Jian Li
The reduction of stress reactivity resulting from stress management interventions prevents disorders and improves mental health, however, its long-term sustainability has been little examined. The objective of this study was, therefore, to determine the effectiveness of a stress management intervention, designed to improve stress reactivity, for mental health and sleep problems seven years later, using longitudinal data from 101 male industrial workers. Linear regressions estimated the adjusted effects of the changes in stress reactivity in general as well as in its six subdimensions (work overload, social conflict, social stress, failure at work, and anticipatory and prolonged reactivity) on depression, anxiety, and sleep problems seven years later...
February 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29396050/association-of-interleukin-il-4-variable-number-of-tandem-repeats-vntrs-and-il-4-590-promoter-polymorphisms-with-susceptibility-to-pediatric-autoimmune-hepatitis-type-1
#18
Amira Ibrahim Mansour, Ola Galal Behairy, Eman Rateb Abd Almonaem, Rasha Mahmoud Abd-Rabuh, Inas Abd Elmonem Ahmed
OBJECTIVE: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease mediated by an autoimmune reaction to hepatocytes, the present study aimed to assess the possible associations between interleukin-4 (IL-4) variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms and susceptibility to autoimmune hepatitis type 1 in children. SUBJECTS AND METHODS: The study was performed on 101 children diagnosed with AIH and 104 apparently healthy, age and sex-matched control children, diagnosis of AIH was based on the simplified score for the diagnosis of AIH...
January 26, 2018: Cytokine
https://www.readbyqxmd.com/read/29394365/live-birth-rate-following-frozen-thawed-blastocyst-transfer-is-higher-with-blastocysts-expanded-on-day-5-than-on-day-6
#19
Lucile Ferreux, Mathilde Bourdon, Amira Sallem, Pietro Santulli, Virginie Barraud-Lange, Nathalie Le Foll, Chloé Maignien, Charles Chapron, Dominique de Ziegler, Jean-Philippe Wolf, Khaled Pocate-Cheriet
STUDY QUESTION: The aim of this study was to evaluate the live birth rate (LBR) after frozen-thawed Day 5 (D5) and Day 6 (D6) blastocyst transfers. SUMMARY ANSWER: LBR following frozen-thawed blastocyst transfer is significantly lower with D6 than with D5 blastocyst regardless of embryo quality. WHAT IS KNOWN ALREADY: During fresh embryo transfer cycles, pregnancy rates (PR) are significantly higher when transferring blastocysts expanded on D5 compared with slow developing blastocysts (D6)...
February 2, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29394140/effect-of-sonic-resin-composite-delivery-on-void-formation-assessed-by-micro-computed-tomography
#20
R Hirata, R R Pacheco, E Caceres, M N Janal, M F Romero, M Giannini, P G Coelho, F A Rueggeberg
OBJECTIVES: The aim of this study was to quantify the internal void volume formation in commercially available, resin composites inserted using conventional or sonic insertion methods, and analyzed using three-dimensional (3D) micro-computed tomography (μCT). METHODS AND MATERIALS: Four resin composites were evaluated: one conventional (Herculite, Ultra, Kerr Corporation, Orange, CA, USA), one flowable bulk fill (SureFil SDR Flow, Dentsply International, York, PA, USA), and two packable bulk fill (SonicFill, Kerr Corporation, and Tetric EvoCeram Bulk Fill, Ivoclar Vivadent Inc, Schaan, Liechtenstein)...
February 2, 2018: Operative Dentistry
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