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https://www.readbyqxmd.com/read/28905447/assessment-of-the-quality-of-neonatal-care-in-the-solomon-islands
#1
Shidan Tosif, Titus Nasi, Amy Gray, Nahad Sadr-Azodi, Divi Ogaoga, Trevor Duke
AIM: To identify strengths and obstacles for improving the quality of newborn care in the Solomon Islands. Improving the quality of newborn care is a priority in the Sustainable Development Goals and the Action Plan for Healthy Newborns in the Western Pacific. The neonatal mortality rate in the Solomon Islands, a lower-middle-income country, has improved slower than overall child mortality. In 2013, neonatal mortality (13.2/1000) constituted 44% of under-5 deaths (30.1/1000). METHODS: A cross-sectional study of newborn care in five provincial hospitals using a World Health Organization assessment tool for hospital quality of care...
September 14, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28901786/effect-of-gestational-age-on-the-epidemiology-of-late-onset-sepsis-in-neonatal-intensive-care-units-a-review
#2
Elsa de Palma Afonso, Stijn Blot
Neonatal sepsis is a major cause of morbidity and mortality. Late-onset sepsis affects a significant percentage of infants admitted to the neonatal intensive care unit (NICU). Most affected newborns are preterm or low birth weight, but late-onset sepsis also affects late preterm and term infants. Understanding how gestational age affects the epidemiology of late-onset sepsis can be of use when defining strategies for its prevention and clinical management in NICU. Areas covered: Available evidence suggests the incidence and mortality of late-onset sepsis is higher in preterm and VLBW infants, but pathogen distribution and risk exposure is similar across all infants admitted to NICU...
September 13, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28901344/-who-gloss-a-global-study-to-promote-the-reduction-of-preventable-maternal-and-neonatal-deaths-related-to-sepsis
#3
Paola D'Aloja, Ilaria Lega, Alice Maraschini, Serena Donati
The study aims to promote the reduction of preventable maternal and neonatal deaths related to sepsis worldwide. To achieve this goal, the study will test new WHO criteria for early identification of maternal sepsis across both low and high resource settings, describe and analyze the frequency and outcomes of suspected or confirmed maternal sepsis for mothers and infants. Additionally, in the European participating countries, the study will describe the patterns of anti-microbial usage amongst women with suspected maternal sepsis, explore migration status amongst women with possible severe maternal infection and describe any variations in their management...
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28895706/-neonatal-renal-abscess-a-diagnostic-and-therapeutic-challenge-a-clinical-case
#4
Sebastián Argañaraz Gonçalves, Enrique Casanueva, Silvia Filipis, Carla Gandini, M Vanesa Rodríguez, Adriana Santiago, Aída Vázquez, Roberto Vagni
Renal abscess is a rare disease in newborn, but severe consequences can occur: sepsis with high mortality, renal scar formation and risk of chronic renal failure. A neonate with unilateral renal abscess due to Staphylococcus aureus is reported, with septicemia, with no other suppurative focus, nor with urinary malformation, with good clinical evolution with intravenous antibiotics and without surgical treatment, but with renal scars sequel. From this case, the strategies of diagnosis, treatment and followup of the renal abscess in a neonate are analyzed, emphasizing the early diagnosis to avoid renal scars...
October 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28895695/bronchopulmonary-dysplasia-incidence-and-risk-factors
#5
Pablo H Brener Dik, Yeimy M Niño Gualdron, María F Galletti, Carolina M Cribioli, Gonzalo L Mariani
INTRODUCTION: Bronchopulmonary dysplasia is the most common chronic pulmonary sequela among very low birth weight infants. The objective of this study was to estimate its incidence in our Neonatal Unit over the past 5 years and analyze associated risk factors. POPULATION AND METHODS: An observational and analytical study was conducted in a retrospective cohort, using data obtained from a prospective database of infants born at Hospital Italiano de Buenos Aires with a birth weight of less than 1500 grams between January 2010 and December 2014...
October 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28893488/-clinical-criteria-for-pathogen-bacteria-in-term-newborn-suspected-of-neonatal-sepsis
#6
A Glusko-Charlet, C Fontaine, M Raucy, L Barcat, A Lahana, R Erbani, G Poirie, G Kongolo, M Diouf, A Leke, J Gondry, P Tourneux
BACKGROUND: Neonatal early onset sepsis (EOS) remains an important etiology of neonatal morbidity and mortality. Diagnosis is difficult due to a lack of sensitivity and specificity markers. In France, the management of newborn infants suspected of infection includes the analysis of gastric suction. The objective of the study was to identify early clinical signs in newborn infants with suspected neonatal sepsis to differentiate a likely infection with pathogen bacteria in the gastric suction culture (Streptococcus agalactiae or Escherichia coli) from a possible infection without such pathogen bacteria...
September 8, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28892906/changes-in-haematological-parameters-in-newborns-born-to-preeclamptic-mothers-a-case-control-study-in-a-rural-hospital
#7
Kalavakuru Mouna, Shilpa Manigatta Doddagowda, Krishnappa Junjegowda, Latha Krishnamurthy
INTRODUCTION: Pregnancy is a physiological phenomenon. However, some women develop problems during pregnancy period, which puts both the mother's and the foetus health at risk. Hypertensive disorders of pregnancy are the type of the maternal diseases that can cause the most detrimental effects to the mother and foetus. AIMS: To determine the haematological parameters in neonates born to preeclamptic mothers. MATERIALS AND METHODS: It was a prospective case control study carried out on neonates born to preeclamptic mothers in our institute from March 2016 to November 2016...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891256/composition-and-variation-analysis-of-the-tcr-%C3%AE-chain-cdr3-repertoire-in-neonatal-sepsis
#8
Jinqiao Sun, Bijun Sun, Yanyan Gao, Fusheng He, Lin Yang, Mingbang Wang, Wenhao Zhou
T cell receptor (TCR) diversity is clearly related to protection from infection. However, the characteristics of TCR diversity in neonates are not clear. In this study, we investigated the TCR diversity of neonates with sepsis. Twenty neonates with severe sepsis and 8 matched neonates without infection were enrolled in the study. For the neonates with sepsis, EDTA-anticoagulated blood was collected on day 1 after the diagnosis of sepsis and on day 7 of treatment. For the neonates without infection, blood was collected one time...
September 11, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28891027/short-term-oral-zinc-supplementation-among-babies-with-neonatal-sepsis-for-reducing-mortality-and-improving-outcome-a-double-blind-randomized-controlled-trial
#9
Newton Banupriya, Ballambattu Vishnu Bhat, Bosco Dhas Benet, Christina Catherine, Magadi Gopalakrishna Sridhar, Subhash Chandra Parija
OBJECTIVE: To evaluate the efficacy of short term zinc supplementation on the mortality rate and neurodevelopment outcome in neonates with sepsis at 12 mo corrected age. METHODS: The clinical trial was undertaken in the neonatal intensive care unit of JIPMER during the time period from September 2013 through December 2016. Neonates with clinical manifestations of sepsis who exhibited two positive screening tests (microESR, C- reactive protein, band cell count) were included and randomized into no zinc and zinc group...
September 11, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28890038/improving-the-efficiency-of-auditory-brainstem-responses-in-newborns-using-a-60clicks-s-stimulation-rate
#10
Lourdes Cubero-Rego, Josefina Ricardo-Garcell, María Corsi-Cabrera, Rogelio Cruz-Martínez, Carlos Rebolledo-Fernández, Gloria Otero-Ojeda, Thalía Harmony
Recent evidence suggests that Auditory Brainstem Responses (ABR), in neonates with risk factors for neurological damage, may show auditory brainstem abnormalities, even in patients with normal hearing. To compare the recording and diagnostic accuracy of neonatal Auditory Brainstem Responses (ABR), using 10 and 60clicks/s stimulation rates, two groups of neonates were prospectively studied: 30 healthy full-term neonates, with no peri- or postnatal complications; and 30 high-risk newborns with two or more of the following conditions: hyperbilirubinemia, use of ototoxic drugs, birth weight inferior to 1500g, perinatal sepsis, intraventricular hemorrhage, and/or mechanical ventilation...
September 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28887432/maternal-pregravid-obesity-remodels-the-dna-methylation-landscape-of-cord-blood-monocytes-disrupting-their-inflammatory-program
#11
Suhas Sureshchandra, Randall M Wilson, Maham Rais, Nicole E Marshall, Jonathan Q Purnell, Kent L Thornburg, Ilhem Messaoudi
Prepregnancy maternal obesity is associated with adverse outcomes for the offspring, including increased incidence of neonatal bacterial sepsis and necrotizing enterocolitis. We recently reported that umbilical cord blood (UCB) monocytes from babies born to obese mothers generate a reduced IL-6/TNF-α response to TLR 1/2 and 4 ligands compared to those collected from lean mothers. These observations suggest altered development of the offspring's immune system, which in turn results in dysregulated function...
September 8, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28886185/clinical-features-and-seasonality-of-parechovirus-infection-in-an-asian-subtropical-city-hong-kong
#12
Grace P K Chiang, Zigui Chen, Martin C W Chan, Simon H M Lee, Angela K Kwok, Apple C M Yeung, E Anthony S Nelson, Kam Lun Hon, Ting Fan Leung, Paul K S Chan
BACKGROUND: The epidemiology of human parechovirus (HPeV) in Asia remains obscure. We elucidated the prevalence, seasonality, type distribution and clinical presentation of HPeV among children in Hong Kong. METHODS: A 24-month prospective study to detect HPeV in children ≤36 months hospitalized for acute viral illnesses. RESULTS: 2.3% of the 3911 children examined had HPeV infection, with most (87.5%) concentrated in September-January (autumn-winter)...
2017: PloS One
https://www.readbyqxmd.com/read/28886074/unique-transcriptomic-response-to-sepsis-is-observed-among-patients-of-different-age-groups
#13
Steven L Raymond, María Cecilia López, Henry V Baker, Shawn D Larson, Philip A Efron, Timothy E Sweeney, Purvesh Khatri, Lyle L Moldawer, James L Wynn
Sepsis is a major cause of morbidity and mortality, especially at the extremes of age. To understand the human age-specific transcriptomic response to sepsis, a multi-cohort, pooled analysis was conducted on adults, children, infants, and neonates with and without sepsis. Nine public whole-blood gene expression datasets (636 patients) were employed. Age impacted the transcriptomic host response to sepsis. Gene expression from septic neonates and adults was more dissimilar whereas infants and children were more similar...
2017: PloS One
https://www.readbyqxmd.com/read/28882128/institutional-maternal-and-perinatal-deaths-a-review-of-40-low-and-middle-income-countries
#14
Patricia E Bailey, Wasihun Andualem, Michel Brun, Lynn Freedman, Sourou Gbangbade, Malick Kante, Emily Keyes, Edwin Libamba, Allisyn C Moran, Halima Mouniri, Dahada Ould El Joud, Kavita Singh
BACKGROUND: Understanding the magnitude and clinical causes of maternal and perinatal mortality are basic requirements for positive change. Facility-based information offers a contextualized resource for clinical and organizational quality improvement. We describe the magnitude of institutional maternal mortality, causes of death and cause-specific case fatality rates, as well as stillbirth and pre-discharge neonatal death rates. METHODS: This paper draws on secondary data from 40 low and middle income countries that conducted emergency obstetric and newborn care assessments over the last 10 years...
September 7, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28880259/management-of-asymptomatic-neonates-born-in-the-setting-of-chorioamnionitis-a-safety-comparison-of-the-well-baby-and-intensive-care-setting
#15
D Peterson, S B Hoffman, D El-Metwally, M Martino-Gomez, D R Chinta, C Hughes Driscoll
BACKGROUND: Evaluate the safety of a change in care setting for asymptomatic neonates born to mothers with chorioamnionitis from the neonatal intensive care unit to the well baby nursery.Local problem:The neonatal intensive care unit evaluation and management of babies born to mothers with chorioamionitis often involves separation of the mother-baby dyad and more invasive interventions. METHODS: A single-center pre/post-intervention study of neonates born from January 2011 to November 2016, comparing safety outcomes in the neonatal intensive care unit (pre-intervention) and well baby nursery (post-intervention), following initiation of a triage protocol...
September 7, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28878521/time-to-positivity-and-antibiotic-sensitivity-of-neonatal-blood-cultures
#16
Sarah Magdy Abdelhamid
BACKGROUND: Sepsis is a commonly encountered and potentially life-threatening problem in neonatal intensive care units, blood culture of neonatal sepsis helps in either optimizing treatment or terminating antibiotics. MATERIALS AND METHODS: We determined the causative agent, time to positivity (TTP), and antibiogram of neonatal blood cultures collected in a tertiary care center, to investigate difference between early- and late-onset neonatal sepsis and to establish the time at which a blood culture could safely be considered negative, using the BacT/ALERT(®) 3D 60...
July 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28876403/antimicrobial-drug-related-problems-in-a-neonatal-intensive-care-unit
#17
Bruna Meirelly Nunes, Tatiana Costa Xavier, Rand Randall Martins
Objective: The goal was to determine the main drug-related problems in neonates who were using antimicrobials. Method: This was an observational, prospective and longitudinal study. Drug-related problems were classified according to version 6.2 of the Pharmaceutical Care Network Europe Foundation classification. A descriptive analysis was performed, in which the clinical and therapeutic variables were presented as absolute and relative frequencies or as the mean and standard deviation, as appropriate...
September 4, 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28875885/a-review-of-antenatal-corticosteroid-use-in-premature-neonates-in-a-middle-income-country
#18
A Laher, D E Ballot, T Ramdin, T Chirwa
BACKGROUND: Antenatal corticosteroid (ANS) use in premature neonates has become a standard of practice. However, there is low ANS coverage in low- to middle-income countries (LMICs). Recent studies have questioned the efficacy of ANSs in such countries. OBJECTIVE: To review the use of ANSs in preterm neonates at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), South Africa. METHODS: This was a retrospective observational study of all neonates with a birth weight of 500 - 1 800 g born at CMJAH between 1 January 2013 and 30 June 2016...
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28871366/predictors-of-mortality-in-children-with-pulmonary-atresia-with-intact-ventricular-septum
#19
Stephanie Grant, David Faraoni, James DiNardo, Kirsten Odegard
Pulmonary atresia with intact ventricular septum (PA/IVS) is a rare cardiac congenital lesion characterized by imperforate pulmonary valve, intact ventricular septum, and atrial level shunt. Although different management strategies to establish a source of non-ductal dependent pulmonary blood flow have been described, studies have not assessed the relationship between the therapeutic approach, patient characteristics, and outcomes. The purpose of this study was to identify predictors of mortality for patients with PA/IVS...
September 4, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28870818/-fatal-female-genital-mutilation-in-a-10-year-old-girl
#20
A Sow, G Diagne, Y Keita, O Sow, A Ndiath, A Ouattara, M-L Sarr, A Sylla, C Moreira
Female genital mutilation (FGM) comprises all procedures involving partial or total removal of the external genitalia and/or any other procedures affecting the female genitalia, for cultural or religious reasons or for nontherapeutic purposes in general. FGM is responsible for a number of short-, medium-, and long-term complications that can engage the vital and functional prognosis, especially in African countries. We report on a case in a 10-year-old girl who underwent genital mutilation, a traditional type of total excision during the neonatal period...
September 1, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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