keyword
https://read.qxmd.com/read/38545091/effect-of-human-milk-based-fortification-in-extremely-preterm-infants-fed-exclusively-with-breast-milk-a-randomised-controlled-trial
#1
JOURNAL ARTICLE
Georg Bach Jensen, Magnus Domellöf, Fredrik Ahlsson, Anders Elfvin, Lars Navér, Thomas Abrahamsson
BACKGROUND: Mortality and severe morbidity remain high in extremely preterm infants. Human milk-based nutrient fortifiers may prevent serious complications and death. We aimed to investigate whether supplementation with human milk-based fortifier (HMBF), as compared to bovine milk-based fortifier (BMBF), reduced the incidence of the composite outcome of necrotising enterocolitis (NEC), sepsis, and mortality in extremely preterm infants exclusively fed human milk. METHODS: In this multicentre, randomised controlled trial at 24 neonatal units in Sweden, extremely preterm infants born between gestational week 22 + 0 and 27 + 6 fed exclusively human breast milk (mother's own and/or donor milk), were randomly assigned (1:1) to receive targeted fortification with either HMBF or BMBF...
February 2024: EClinicalMedicine
https://read.qxmd.com/read/38535886/stop-in-time-how-to-reduce-unnecessary-antibiotics-in-newborns-with-late-onset-sepsis-in-neonatal-intensive-care
#2
REVIEW
Domenico Umberto De Rose, Maria Paola Ronchetti, Alessandra Santisi, Paola Bernaschi, Ludovica Martini, Ottavia Porzio, Andrea Dotta, Cinzia Auriti
The fear of missing sepsis episodes in neonates frequently leads to indiscriminate use of antibiotics, and prescription program optimization is suggested for reducing this inappropriate usage. While different authors have studied how to reduce antibiotic overprescription in the case of early onset sepsis episodes, with different approaches being available, less is known about late-onset sepsis episodes. Biomarkers (such as C-reactive protein, procalcitonin, interleukin-6 and 8, and presepsin) can play a crucial role in the prompt diagnosis of late-onset sepsis, but their role in antimicrobial stewardship should be further studied, given that different factors can influence their levels and newborns can be subjected to prolonged therapy if their levels are expected to return to zero...
March 19, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535883/sustaining-the-continued-effectiveness-of-an-antimicrobial-stewardship-program-in-preterm-infants
#3
JOURNAL ARTICLE
Tommaso Zini, Francesca Miselli, Chiara D'Esposito, Lucia Fidanza, Riccardo Cuoghi Costantini, Lucia Corso, Sofia Mazzotti, Cecilia Rossi, Eugenio Spaggiari, Katia Rossi, Licia Lugli, Luca Bedetti, Alberto Berardi
BACKGROUND: There are wide variations in antibiotic use in neonatal intensive care units (NICUs). Limited data are available on antimicrobial stewardship (AS) programs and long-term maintenance of AS interventions in preterm very-low-birth-weight (VLBW) infants. METHODS: We extended a single-centre observational study carried out in an Italian NICU. Three periods were compared: I. "baseline" (2011-2012), II. "intervention" (2016-2017), and III. "maintenance" (2020-2021)...
March 7, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535612/fungemia-by-wickerhamomyces-anomalus-a-narrative-review
#4
REVIEW
Petros Ioannou, Stella Baliou, Diamantis P Kofteridis
Wickerhamomyces anomalus has been previously classified as Hansenula anomala , Pichia anomala , and Candida pelliculosa and was recently reclassified in the genus Wickerhamomyces after phylogenetic analysis of its genetic sequence. An increasing number of reports of human infections by W. anomalus have emerged, suggesting that this microorganism is an emerging pathogen. The present review aimed to provide data on the epidemiology, antifungal resistance, clinical characteristics, treatment, and outcomes of fungemia by W...
March 21, 2024: Pathogens
https://read.qxmd.com/read/38535577/-staphylococcus-capitis-central-line-associated-bloodstream-infections-in-the-neonatal-intensive-care-unit-a-single-center-four-year-experience-in-central-line-management-during-sepsis-treatment
#5
JOURNAL ARTICLE
Anna Sala, Valentina Pivetti, Alessandra Vittorini, Claudia Viggiano, Francesca Castoldi, Valentina Fabiano, Gianluca Lista, Francesco Cavigioli
Coagulase-negative staphylococci (CoNS) are reportedly responsible for 50-60% of bloodstream infections in very preterm (<1500 g) infants in neonatal intensive care units (NICUs). Staphylococcus capitis is an increasingly prevalent pathogen in the neonatal setting, frequently causing central-line-associated bloodstream infections (CLABSIs) that can be difficult to eradicate. Central venous catheter (CVC) removal versus in situ treatment with CoNS CLABSIs is a controversial treatment strategy with no clear consensus...
March 7, 2024: Pathogens
https://read.qxmd.com/read/38534689/daptomycin-use-for-persistent-coagulase-negative-staphylococcal-bacteremia-in-a-neonatal-intensive-care-unit
#6
JOURNAL ARTICLE
Eleni Papachatzi, Despoina Gkentzi, Sotiris Tzifas, Theodore Dassios, Gabriel Dimitriou
During the last two decades, the incidence of late-onset sepsis (LOS) has increased due to improved survival of premature neonates. Persistent bacteremia (PB) in LOS is defined as more than two positive blood cultures obtained on different calendar days during the same infectious episode. Although rare, PB should be treated aggressively to prevent adverse outcomes. Daptomycin, a lipopeptide antibiotic, has been used in neonates with persistent coagulase-negative staphylococci (CoNS) bacteremia with promising results, but studies reporting on the efficacy and safety of the agent are scarce...
March 12, 2024: Antibiotics
https://read.qxmd.com/read/38534685/an-overview-of-antibiotic-therapy-for-early-and-late-onset-neonatal-sepsis-current-strategies-and-future-prospects
#7
REVIEW
Giovanni Boscarino, Rossana Romano, Carlotta Iotti, Francesca Tegoni, Serafina Perrone, Susanna Esposito
Neonatal sepsis is a clinical syndrome mainly associated with a bacterial infection leading to severe clinical manifestations that could be associated with fatal sequalae. According to the time of onset, neonatal sepsis is categorized as early- (EOS) or late-onset sepsis (LOS). Despite blood culture being the gold standard for diagnosis, it has several limitations, and early diagnosis is not immediate. Consequently, most infants who start empirical antimicrobial therapy do not have an underlying infection. Despite stewardship programs partially reduced this negative trend, in neonatology, antibiotic overuse still persists, and it is associated with several relevant problems, the first of which is the increase in antimicrobial resistance (AMR)...
March 10, 2024: Antibiotics
https://read.qxmd.com/read/38533296/retrospective-comparative-analysis-of-neonatal-mortality-and-morbidity-in-preterm-singleton-and-multiple-births-single-center-experience
#8
JOURNAL ARTICLE
Mohammad Alhasoon, Bader Alqahtani, Mohamad Alreefi, Abdulaziz Homedi, Ghadah Alnami, Saif Alsaif, Kamal Ali
Objective. To compare mortality and major neonatal morbidities between singleton preterm infants and preterm infants of multiple gestations born <33 weeks' gestation. Method. Case-control study of preterm multiples and singletons <33 weeks' born at King Abdul-Aziz Medical City Riyadh (KAMC-R) between January 2017 and December 2020. Out-born infants and infants with lethal congenital abnormalities were excluded from the study. Mortality and major neonatal morbidities including bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), sepsis and surgical necrotizing enterocolitis (NEC) were compared between preterm singletons and multiples...
2024: Global Pediatric Health
https://read.qxmd.com/read/38530043/albumin-and-c-reactive-protein-as-diagnostic-markers-for-neonatal-sepsis-a-retrospective-study
#9
JOURNAL ARTICLE
Wei Yin, ChengChao Fang, Xiaoping Fan, YanLin Chen
OBJECTIVE: To assess the applicability of albumin (ALB) and C-reactive protein (CRP) concentrations in the diagnosis of sepsis in neonates on the day of admission, and to help with early identification and intervention in the development of sepsis. METHODS: This retrospective study included all neonates who were admitted to the neonatal intensive care unit from January 2020 to June 2023. We studied 160 full-term neonates, including 80 with sepsis and 80 healthy controls...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38524344/anatomical-outcome-of-laser-treatment-alone-in-aggressive-retinopathy-of-prematurity
#10
JOURNAL ARTICLE
Anamika Dwivedi, Deepak Dwivedi, Sujata Lakhtakia, Chalisgaonkar Charudutt
PURPOSE: The purpose is to study the anatomical outcome of eyes in aggressive retinopathy of prematurity (AROP), treated with laser photocoagulation alone and to evaluate factors affecting outcomes. METHODS: Records of consecutive babies diagnosed with AROP, undergoing laser photocoagulation treatment in rural tertiary care centers from October 2016 to January 2021 were reviewed retrospectively. Anatomical outcome at 6 months follow-up was grouped as good in eyes with complete regression and poor in those who developed retinal detachment (stage IV a, IV b, and V)...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38523318/stenotrophomonas-maltophilia-neonatal-sepsis-a-case-report
#11
JOURNAL ARTICLE
Williams Oluwatosin Adefila, Isaac Osie, Modou Lamin Keita, Baleng Mahama Wutor, Abdulsalam Olawale Yusuf, Ilias Hossain, Minteh Molfa, Ousman Barjo, Rasheed Salaudeen, Grant Mackenzie
BACKGROUND: Stenotrophomonas maltophilia is a gram-negative bacteria known for causing opportunistic and nosocomial infections in humans. S. maltophilia is an emerging pathogen of concern due to it's increasing prevalence, diverse disease spectrum, intrinsic multi-drug resistance and high mortality rates in immunocompromised individuals. S. maltophilia is a rare cause of neonatal sepsis associated with significant morbidity and mortality. The bacterium's multi-drug resistance poses a considerable challenge for treatment, with various mechanisms contributing to its resistance...
March 25, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38521409/early-onset-neonatal-sepsis-effectiveness-of-classification-based-on-ante-and-intrapartum-risk-factors-and-clinical-monitoring
#12
JOURNAL ARTICLE
Laurie Dalut, Anne Brunhes, Sébastien Cambier, Denis Gallot, Karen Coste
INTRODUCTION: In 2017, the French public health authority HAS published new guidelines for the management of newborns at risk of early bacterial neonatal infection. These guidelines were based on ante- and intrapartum risk factors and clinical monitoring. In January 2021, we implemented a new protocol based on these guidelines in our tertiary maternity unit. OBJECTIVES: To assess the impact of the protocol implemented on neonates' antibiotic prescriptions. METHOD: An "old protocol" group comprising newborns hospitalized between July 1, 2020 and December 31, 2020, was compared to a "new protocol" group formed between January 14, 2021 and July 13, 2021...
March 21, 2024: Journal of Gynecology Obstetrics and Human Reproduction
https://read.qxmd.com/read/38519538/development-and-validation-of-a-novel-risk-classification-tool-for-predicting-long-length-of-stay-in-nicu-blood-transfusion-infants
#13
JOURNAL ARTICLE
Nurbiya Arkin, Ting Zhao, Yanqing Yang, Le Wang
Newborns are as the primary recipients of blood transfusions. There is a possibility of an association between blood transfusion and unfavorable outcomes. Such complications not only imperil the lives of newborns but also cause long hospitalization. Our objective is to explore the predictor variables that may lead to extended hospital stays in neonatal intensive care unit (NICU) patients who have undergone blood transfusions and develop a predictive nomogram. A retrospective review of 539 neonates who underwent blood transfusion was conducted using median and interquartile ranges to describe their length of stay (LOS)...
March 22, 2024: Scientific Reports
https://read.qxmd.com/read/38518030/the-evolution-of-sepsis-publications-and-global-productivity-a-bibliometric-analysis-between-1980-and-2020
#14
JOURNAL ARTICLE
Arzu Akdagli Ekici, Alperen Kisa, Semin Önder Turhan
The literature study was conducted by using the Web of Science (WoS) database, employing bibliometric analysis to examine all papers released from 1980 to 2020. The search was performed using the terms "sepsis, septicemia, septic shock" specifically within the titles of the publications. The findings of the literature research revealed a total of 51,725 articles. Out of the total number of publications, 26,896 articles were identified, accounting for 51.9% of the total. The bibliometric study revealed that the United States had the largest number of papers (8693), followed by China (2807), Germany (2299), France (1606), and the United Kingdom (1932)...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38517573/a-decade-of-neonatal-sepsis-in-stockholm-sweden-gram-positive-pathogens-were-four-times-as-common-as-gram-negatives
#15
JOURNAL ARTICLE
Frida Oldendorff, Viveka Nordberg, Christian G Giske, Lars Navér
PURPOSE: To assess Gram-positive bacterial (GPB) bloodstream infection (BSI) in neonates, covering incidence, morbidity, mortality, antimicrobial resistance patterns and biomarkers in Region Stockholm, Sweden between 2006 and 2016. METHODS: A population-based retrospective epidemiological study including infants with GPB-BSI, admitted to the neonatal units at Karolinska University Hospital (KUH). Data were collected from patient records, the Swedish Neonatal Quality Register, the microbiological laboratory at KUH and the Swedish Public Health Agency...
March 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38517437/antibiotic-use-in-late-preterm-and-full-term-newborns
#16
JOURNAL ARTICLE
Johan Gyllensvärd, Marie Studahl, Lars Gustavsson, Elisabet Hentz, Karin Åkesson, Huiqi Li, Mikael Norman, Anders Elfvin
IMPORTANCE: Antibiotic treatment saves lives in newborns with early-onset sepsis (EOS), but unwarranted antibiotic use is associated with resistant bacteria and adverse outcomes later in life. Surveillance is needed to optimize treatment strategies. OBJECTIVE: To describe antibiotic use in association with the incidence and mortality from EOS among late-preterm and full-term newborns. DESIGN, SETTING, AND PARTICIPANTS: The Sweden Neonatal Antibiotic Use study was a nationwide observational study that included all late-preterm and full-term neonates born from January 1, 2012, to December 31, 2020, in neonatal units of all levels...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38517006/compensation-in-neonatal-clinical-trials-a-perspective
#17
JOURNAL ARTICLE
Apoorva Mathur, Dilip Raja, Anju Sinha, Subodh S Gupta, Y K Gupta, Anand S Kawade, Ramesh Poluru
Well conducted clinical trials are the mainstay for generating evidence on preferred treatments. In order to adequately protect the interests of the trial participants, the Central Licensing Authority of India has formulated guidelines to determine the quantum of compensation in cases of regulatory clinical trial related injury or death. However, these guidelines do not address the nuances of trials recruiting children aged under 16 years, within which, neonates are the most vulnerable population. Thus, there is a need for addressing this lacuna in the current guidelines...
March 19, 2024: Indian Pediatrics
https://read.qxmd.com/read/38516005/hybrid-stage-1-palliation-for-hlhs-the-experience-of-a-tertiary-center-in-a-developing-country
#18
JOURNAL ARTICLE
Fouad Bitar, Issam M El-Rassi, Rana Zareef, Yehya Jassar, Jennifer Abboud, Ziad Bulbul, Fadi Bitar, Mariam Arabi
BACKGROUND: Hypoplastic left heart syndrome (HLHS) accounts for 2.6% of congenital heart disease and is an invariably fatal cardiac anomaly if left untreated. Approximately 33,750 babies are born annually with HLHS in developing countries. Unfortunately, the majority will not survive due to the scarcity of resources and the limited availability of surgical management. AIM: To describe and analyze our experience with the hybrid approach in the management of HLHS in a developing country...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38514819/glucose-tolerance-test-with-a-single-abnormal-value-as-a-predictor-of-type-2-diabetes-mellitus-a-multicenter-retrospective-study
#19
JOURNAL ARTICLE
Seon Ui Lee, Subeen Hong, Sae Kyung Choi, Su Mi Kim, Jae Eun Shin, Ki Cheol Kil, Yeon Hee Kim, Jeong Ha Wie, Yun Sung Jo, Hyun Sun Ko
Clinical implication of a single abnormal value (SAV) in the 100 g oral glucose tolerance test during pregnancy has not been established. We aimed to evaluate the risk of postpartum type 2 diabetes mellitus (T2DM) and investigate adverse pregnancy outcomes in women with SAV, using a retrospective database, from seven medical centers of Korea. Based on the Carpenter-Coustan criteria using two-step approach, pregnancy and postpartum outcomes were compared, among normoglycemic, SAV, and gestational diabetes mellitus (GDM) groups...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38514514/predictive-ability-of-amplitude-integrated-electroencephalography-for-adverse-outcomes-in-neonates-with-sepsis-associated-encephalopathy-a-cohort-study
#20
JOURNAL ARTICLE
Priyansh Jain, Shiv Sajan Saini, Jitendra Kumar Sahu, Priyanka Madaan, Venkataseshan Sundaram, Sourabh Dutta
The authors examined the prevalence of abnormal amplitude integrated electroencephalography (aEEG) patterns in neonates diagnosed with sepsis-associated encephalopathy (SAE). They recorded 36626 min of aEEG in 75 study neonates. Encephalopathy was defined by the Brighton Collaboration Neonatal Encephalopathy criteria. Neonates with primary outcome [either non-survivors or survivors with abnormal neurological examination at discharge using Amiel-Tison assessment tool, n = 58, (77%)] were compared with 17 survivors having normal neurological examination at discharge...
March 22, 2024: Indian Journal of Pediatrics
keyword
keyword
94306
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.