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ESBL Piperacillin-Tazobactam

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https://www.readbyqxmd.com/read/28148226/trends-in-antimicrobial-resistance-and-empiric-antibiotic-therapy-of-bloodstream-infections-at-a-general-hospital-in-mid-norway-a-prospective-observational-study
#1
Arne Mehl, Bjørn Olav Åsvold, Angela Kümmel, Stian Lydersen, Julie Paulsen, Ingvild Haugan, Erik Solligård, Jan Kristian Damås, Stig Harthug, Tom-Harald Edna
BACKGROUND: The occurrence of bloodstream infection (BSI) and antimicrobial resistance have been increasing in many countries. We studied trends in antimicrobial resistance and empiric antibiotic therapy at a medium-sized general hospital in Mid-Norway. METHODS: Between 2002 and 2013, 1995 prospectively recorded episodes of BSI in 1719 patients aged 16-99 years were included. We analyzed the antimicrobial non-susceptibility according to place of acquisition, site of infection, microbe group, and time period...
February 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28137811/antimicrobial-activity-of-high-proportion-cefepime-tazobactam-wck-4282-when-tested-against-a-large-worldwide-collection-of-gram-negative-organisms-2014
#2
Helio S Sader, Mariana Castanheira, Rodrigo E Mendes, Robert K Flamm, Ronald N Jones
Cefepime-tazobactam (WCK 4282) is currently under clinical development at 2 gram/2 gram q8h dosaging. A total of 7,981 isolates were collected from 146 medical centers (39 countries) in 2014 as a part of SENTRY Antimicrobial Surveillance Program, and were susceptibility tested by a reference broth microdilution method against cefepime-tazobactam (tazobactam at fixed 4 and 8 μg/mL). Isolates were mainly from pneumonia (29.5%) and bloodstream infections (26.9%). Cefepime-tazobactam (fixed 8 μg/mL) and cefepime inhibited 96...
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28124956/-investigation-of-the-frequency-and-distribution-of-beta-lactamase-genes-in-the-clinical-isolates-of-acinetobacter-baumannii-collected-from-different-regions-of-turkey-a-multicenter-study
#3
Fatih Şaban Beriş, Emine Esra Budak, Duygu Gülek, Aytül Uzun, Zeynep Çizmeci, Fırat Zafer Mengeloğlu, Şahin Direkel, Yeliz Çetinkol, Yasemin Ay Altıntop, Meryem Iraz, Tuba Dal, Safiye Umut Say Coşkun, Pervin Özlem Balcı, Tuba Kayman, Ahmet Çalışkan, Yelda Yazıcı, İsmail Tosun, Ayşe Ertürk, Ayşegül Çopur Çiçek
The diversity and distribution of TEM, SHV and CTX-M type of extended-spectrum beta-lactamases (ESBLs) are important for the treatment and control of infections. Determination of ESBL genes in clinical isolates by polymerase chain reaction (PCR) and DNA sequencing can obtain useful data for their molecular epidemiology and risk. The aim of this study was to investigate the frequency of beta-lactamase genes in Acinetobacter baumannii strains isolated from different regions of Turkey. A total of 519 A.baumannii strains collected from hospitals located at 12 different provinces of Turkey (Bolu (n= 67), Tokat (n= 47), Trabzon (n= 25), Ordu (n= 27), Diyarbakır (n= 47), Niğde (n=31), Kayseri (n= 36), Ankara (n= 41), Kirikkale (n= 26), Kahramanmaraş (n= 25), Mersin (n= 40), Istanbul (n= 107)] between 2011-2012 period were included in the study...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28081324/treatment-efficacy-and-superinfection-rates-in-complicated-urinarytract-infections-treated-with-ertapenem-or-piperacillin-tazobactam
#4
Murat Dizbay, Hasan Selçuk Özger, Ömer Karaşahin, Emine Fusun Karaşahin
BACKGROUND/AIM: In this retrospective study, the efficacy of ertapenem and piperacillin tazobactam was compared in the treatment of complicated urinary tract infections (cUTIs). Treatment responses were also evaluated for both antibiotics. MATERIALS AND METHODS: A total of 230 patients were enrolled in the study. Of these, 170 received ertapenem and 60 received piperacillin-tazobactam. RESULTS: In both groups, urine cultures after 48 h were negative for the initial uropathogen...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28069649/antimicrobial-activity-of-ceftazidime-avibactam-when-tested-against-gram-negative-bacteria-isolated-from-patients-hospitalized-with-pneumonia-in-united-states-medical-centers-2011-2015
#5
Helio S Sader, Mariana Castanheira, Robert K Flamm
Bacterial isolates were collected from patients hospitalized with pneumonia (PHP), including ventilator-associated (VAP), from 76 USA medical centers in 2011-2015. The Gram-negative organisms (n=11,185; including 1,097 from VAP) were tested for susceptibility against ceftazidime-avibactam and comparators by broth microdilution method. β-lactamase-encoding genes were screened using a microarray based assay on selected isolates. Pseudomonas aeruginosa and Klebsiella spp. were the most common Gram-negatives isolated from PHP and VAP...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28054236/antibiotic-resistance-patterns-of-escherichia-coli-urinary-isolates-and-comparison-with-antibiotic-consumption-data-over-10%C3%A2-years-2005-2014
#6
P J Stapleton, D J Lundon, R McWade, N Scanlon, M M Hannan, F O'Kelly, M Lynch
INTRODUCTION: Escherichia coli is a common cause of urinary tract infections (UTI). Reviews of antibiotic resistance of this organism can inform choice of empiric treatment of UTI and other infections and strategies for combating antimicrobial resistance. We reviewed laboratory and hospital pharmacy records to assess trends in non-susceptibility rates and the effect of antimicrobial stewardship interventions. METHODS: A retrospective observational study of isolates of E...
January 4, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28051952/antimicrobial-susceptibility-of-gram-negative-eskape-pathogens-isolated-from-hospitalized-patients-with-intra-abdominal-and-urinary-tract-infections-in-asia-pacific-countries-smart-2013-2015
#7
James A Karlowsky, Daryl J Hoban, Meredith A Hackel, Sibylle H Lob, Daniel F Sahm
Gram-negative ESKAPE pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) are responsible for increases in antimicrobial-resistant infections worldwide. We determined in vitro susceptibilities to eight parenteral antimicrobial agents using Clinical and Laboratory Standards Institute broth microdilution methodology for Gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal infections (IAIs) (n=3052) and urinary tract infections (UTIs) (n=1088) in 11 Asia-Pacific countries/regions from 2013 to 2015...
January 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27933141/emergence-of-serotype-k1-klebsiella-pneumoniae-st23-strains-co-producing-the-plasmid-mediated-ampc-beta-lactamase-dha-1-and-an-extended-spectrum-beta-lactamase-in-korea
#8
Hae Suk Cheong, Doo Ryeon Chung, Chaeyoeng Lee, So Hyun Kim, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song
BACKGROUND: Serotype K1 Klebsiella pneumoniae has emerged as an important community pathogen causing various infections, including liver abscesses. Although serotype K1 K. pneumoniae community isolates have been reported as susceptible to most classes of antimicrobial agents, a few cases of infection caused by extended-spectrum beta-lactamase (ESBL)-producing serotype K1 K. pneumoniae have recently been reported in Asian countries. We identified three ESBL-producing strains of serotype K1 K...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27876276/piperacillin-tazobactam-as-an-alternative-antibiotic-therapy-to-carbapenems-in-the-treatment-of-urinary-tract-infections-due-to-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-an-in-silico-pharmacokinetic-study
#9
Hélène Guet-Revillet, Elise Tomini, Aurélie Emirian, Olivier Join-Lambert, Hervé Lécuyer, Jean-Ralph Zahar, Vincent Jullien
Piperacillin/tazobactam (TZP) as an alternative treatment to carbapenems for infections involving extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-PE) remains debated. In this study, the probabilities of pharmacodynamic (PD) target attainment with different TZP regimens in ESBL-producing Escherichia coli (ESBL-Ec) and Klebsiella pneumoniae (ESBL-Kp) were evaluated in the context of pyelonephritis. Minimum inhibitory concentrations (MICs) of 144 ESBL-Ec and 111 ESBL-Kp from pyelonephritis were measured, and two previously published population pharmacokinetic models were used to determine by Monte Carlo simulation the probabilities of reaching two PD targets (50%fT>MIC and 100%fT>MIC) with TZP doses of 4 g three times daily and 4...
January 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27712137/an-update-on-the-management-of-urinary-tract-infections-in-the-era-of-antimicrobial-resistance
#10
Mazen S Bader, Mark Loeb, Annie A Brooks
Urinary tract infections (UTIs) caused by antibiotic-resistant Gram-negative bacteria are a growing concern due to limited therapeutic options. Gram-negative bacteria, specifically Enterobacteriaceae, are common causes of both community-acquired and hospital acquired UTIs. These organisms can acquire genes that encode for multiple antibiotic resistance mechanisms, including extended-spectrum-lactamases (ESBLs), AmpC- β -lactamase, and carbapenemases. The assessment of suspected UTI includes identification of characteristic symptoms or signs, urinalysis, dipstick or microscopic tests, and urine culture if indicated...
October 7, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27693013/proposed-breakpoint-of-piperacillin-tazobactam-against-extended-spectrum-%C3%AE-lactamases-producing-bacteria-in-bacteremia
#11
Naomi Sugimoto, Yuka Yamagishi, Hiroshige Mikamo
The isolation rate of extended-spectrum β-lactamase (ESBL)-producing bacteria have been increasing in Japan. While the efficacy of piperacillin/tazobactam (PIPC/TAZ) for ESBL-producing bacteria is controversial, carbapenems have generally been shown to be effective. The aim of this study was to determine whether the current Clinical and Laboratory Standards Institute susceptibility breakpoint of ≤16/4 μg/mL PIPC/TAZ predicts the clinical usefulness for bacteremia caused by ESBL-producing Enterobacteriaceae...
January 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27610300/antibiotic-susceptibility-pattern-and-analysis-of-plasmid-profiles-of-pseudomonas-aeruginosa-from-human-animal-and-plant-sources
#12
Bamidele Tolulope Odumosu, Olabayo Ajetunmobi, Hannah Dada-Adegbola, Idowu Odutayo
Multidrug resistant organisms (MDROs) constitute a major public health threat globally. Clinical isolates of Pseudomonas aeruginosa remains one of the most studied MDROs however there is paucity of information regarding the susceptibility of its animal and plants isolates to antipseudomonas drug in Nigeria. From a total of 252 samples consisting of plants, animals and clinical samples, 54, 24 and 22 P. aeruginosa were isolated from vegetables, animals and clinical sources respectively. All the isolates were identified by standard biochemical methods...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27584587/the-management-of-multidrug-resistant-enterobacteriaceae
#13
Matteo Bassetti, Maddalena Peghin, Davide Pecori
PURPOSE OF REVIEW: Multidrug-resistant (MDR) Enterobacteriaceae are often related to the production of extended-spectrum b-lactamases (ESBLs) and carbapenemase-producing Enterobacteriaceae (CRE), and represent an increasing global threat. Recommendations for the therapeutic management of MDR-related infections, however, are mainly derived from retrospective and nonrandomized prospective studies. The aim of this review is to discuss the challenges in the treatment of patients with infections because of MDR Enterobacteriaceae and provide an expert opinion while awaiting for more definitive data...
December 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27547110/antimicrobial-susceptibility-of-klebsiella-pneumoniae-and-escherichia-coli-with-extended-spectrum-%C3%AE-lactamase-associated-genes-in-hospital-tengku-ampuan-afzan-kuantan-pahang
#14
Saleh Mahdi Yahya Mohsen, Hairul Aini Hamzah, Mustafa Muhammad Imad Al-Deen, Roesnita Baharudin
BACKGROUND: To assess antimicrobial susceptibility of extended-spectrum β-lactamase- (ESBL-) producing Klebsiella pneumoniae and Escherichia coli isolates from Hospital Tengku Ampuan Afzan (HTAA), as well as to identify ESBL genes. METHODS: Non-duplicate K. pneumoniae and E. coli isolates were recovered from various clinical samples. Isolates were screened for antimicrobial resistance by disc diffusion method. Isolates resistant to oxyimino-cephalosporins were subjected to phenotypic ESBL production...
March 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27530858/faecal-carriage-rate-of-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-hospitalised-patients-and-healthy-asymptomatic-individuals-coming-for-health-check-up
#15
Rachana Babu, Anil Kumar, Shamsul Karim, Sruthi Warrier, Suresh G Nair, Sanjeev K Singh, Raja Biswas
The prevalence of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) in hospitalised and community patients is of significant public health concern. The aim of this study was to estimate the faecal carriage rate of ESBL-PE in hospitalised patients and healthy asymptomatic individuals coming for health check-up. Non-repetitive, consecutive stool samples from 480 adults (260 healthy individuals and 220 hospitalised patients) aged ≥18 years from November 2011 to July 2013 were screened using MacConkey agar supplemented with ceftazidime...
September 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27530851/molecular-characterisation-of-extended-spectrum-%C3%AE-lactamase-and-plasmid-ampc-producing-escherichia-coli-strains-isolated-from-broilers-in-b%C3%A3-ja%C3%A3-a-algeria
#16
Mohamed Belmahdi, Sofiane Bakour, Charbel Al Bayssari, Abdelaziz Touati, Jean-Marc Rolain
This study aimed to characterise the molecular support of antibiotic resistance in expanded-spectrum cephalosporin (ESC)-resistant Escherichia coli isolates recovered from healthy broilers in Béjaïa, northeast Algeria. A total of 61 intestinal swabs from slaughtered broilers from four regions in Béjaïa locality, Algeria, were collected between February and April 2014, from which 20 ESC-resistant E. coli strains were isolated. Escherichia coli isolates were identified by classical biochemical and MALDI-TOF methods...
September 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27494134/esbl-detection-comparison-of-a-commercially-available-chromogenic-test-for-third-generation-cephalosporine-resistance-and-automated-susceptibility-testing-in-enterobactericeae
#17
Mohamed Ramadan El-Jade, Marijo Parcina, Ricarda Maria Schmithausen, Christoph Stein, Alina Meilaender, Achim Hoerauf, Ernst Molitor, Isabelle Bekeredjian-Ding
Rapid detection and reporting of third generation cephalosporine resistance (3GC-R) and of extended spectrum betalactamases in Enterobacteriaceae (ESBL-E) is a diagnostic and therapeutic priority to avoid inefficacy of the initial antibiotic regimen. In this study we evaluated a commercially available chromogenic screen for 3GC-R as a predictive and/or confirmatory test for ESBL and AmpC activity in clinical and veterinary Enterobacteriaceae isolates. The test was highly reliable in the prediction of cefotaxime and cefpodoxime resistance, but there was no correlation with ceftazidime and piperacillin/tazobactam minimal inhibitory concentrations...
2016: PloS One
https://www.readbyqxmd.com/read/27343986/antimicrobial-activity-against-a-global-collection-of-skin-and-skin-structure-pathogens-results-from-the-tigecycline-evaluation-and-surveillance-trial-t-e-s-t-2010-2014
#18
Maria Tärnberg, Lennart E Nilsson, Michael J Dowzicky
BACKGROUND: As part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) we report antimicrobial resistance among Gram-positive and Gram-negative isolates collected globally from integumentary sources between 2010 and 2014. METHODS: Minimum inhibitory concentrations and antimicrobial resistance were determined according to Clinical and Laboratory Standards Institute guidelines (US Food and Drug Administration breakpoints against tigecycline). The Cochran-Armitage trend test was used to identify statistically significant changes in resistance...
August 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27316973/in-vitro-potency-of-amikacin-and-comparators-against-e-coli-k-pneumoniae-and-p-aeruginosa-respiratory-and-blood-isolates
#19
Christina A Sutherland, Jamie E Verastegui, David P Nicolau
BACKGROUND: The purpose of this study was to define the potency of amikacin and comparator agents against a collection of blood and respiratory nosocomial isolates implicated in ICU based pulmonary infections gathered from US hospitals. METHODS: Minimum inhibitory concentrations of amikacin, aztreonam, cefepime, ceftazidime, ceftolozane/tazobactam, ceftriaxone, ciprofloxacin, imipenem, meropenem, piperacillin/tazobactam and tobramycin were tested against 2460 Gram-negative isolates...
June 17, 2016: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/27313108/molecular-epidemiology-and-antimicrobial-susceptibility-of-ampc-and-or-extended-spectrum-esbl-%C3%A3-lactamaseproducing-proteus-spp-clinical-isolates-in-zenica-doboj-canton-bosnia-and-herzegovina
#20
Selma Uzunović, Amir Ibrahimagić, Dunja Hodžić, Branka Bedenić
Aim To investigate prevalence, antimicrobial susceptibility, molecular characteristics, and genetic relationship of AmpC- and/or extended spectrum beta lactamase (ESBL)- producing Proteus spp. clinical isolates in Zenica-Doboj Canton, Bosnia and Herzegovina. Methods Antibiotic susceptibility was determined by disc diffusion and broth microdilution methods according to CLSI guidelines. Double-disk synergy test was performed in order to screen for ESBLs, and combined disk test with phenylboronic acid to detect AmpC β -lactamases...
August 1, 2016: Medicinski Glasnik
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