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Salah S Al-Zaiti, Ziad Faramand, Mohammad O Alrawashdeh, Susan M Sereika, Christian Martin-Gill, Clifton Callaway
BACKGROUND: Many of the clinical risk scores routinely used for chest pain assessment have not been validated in patients at high risk for acute coronary syndrome (ACS). We performed an independent comparison of HEART, TIMI, GRACE, FRISC, and PURSUIT scores for identifying chest pain due to ACS and for predicting 30-day death or re-infarction in patients arriving through Emergency Medical Services (EMS). METHODS AND RESULTS: We enrolled consecutive EMS patients evaluated for chest pain at three emergency departments...
June 8, 2018: American Journal of Emergency Medicine
Yu Zhang, Deng Chen, Da Xu, Ge Tan, Ling Liu
PURPOSE: To explore the applicability of the epidemiology-based mortality score in status epilepticus (EMSE) and the status epilepticus severity score (STESS) in predicting hospital mortality in patients with status epilepticus (SE) in western China. Furthermore, we sought to compare the abilities of the two scales to predict mortality from convulsive status epilepticus (CSE) and non-convulsive status epilepticus (NCSE). METHOD: Patients with epilepsy (n = 253) were recruited from the West China Hospital of Sichuan University from January 2012 to January 2016...
May 25, 2018: Seizure: the Journal of the British Epilepsy Association
Jolande A Zijlstra, Rudolph W Koster, Marieke T Blom, Freddy K Lippert, Leif Svensson, Johan Herlitz, Jo Kramer-Johansen, Mattias Ringh, Mårten Rosenqvist, Thea Palsgaard Møller, Hanno L Tan, Stefanie G Beesems, Michiel Hulleman, Andreas Claesson, Fredrik Folke, Theresa Mariero Olasveengen, Mads Wissenberg, Carolina Malta Hansen, Soren Viereck, Jacob Hollenberg
BACKGROUND: In the last decade, there has been a rapid increase in the dissemination of automated external defibrillators (AEDs) for prehospital defibrillation of out-of-hospital cardiac arrest patients. The aim of this study was to study the association between different defibrillation strategies on survival rates over time in Copenhagen, Stockholm, Western Sweden and Amsterdam, and the hypothesis was that non-EMS defibrillation increased over time and was associated with increased survival...
June 14, 2018: Heart: Official Journal of the British Cardiac Society
Olga Theou, Emma Squires, Kayla Mallery, Jacques S Lee, Sherri Fay, Judah Goldstein, Joshua J Armstrong, Kenneth Rockwood
BACKGROUND: The ability of acute care providers to cope with the influx of frail older patients is increasingly stressed, and changes need to be made to improve care provided to older adults. Our purpose was to conduct a scoping review to map and synthesize the literature addressing frailty in the acute care setting in order to understand how to tackle this challenge. We also aimed to highlight the current gaps in frailty research. METHODS: This scoping review included original research articles with acutely-ill Emergency Medical Services (EMS) or hospitalized older patients who were identified as frail by the authors...
June 11, 2018: BMC Geriatrics
Sheng Zhang, Jungen Zhang, Meixia Zhang, Genlong Zhong, Zhicai Chen, Longting Lin, Min Lou
Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) can improve clinical outcome in eligible patients with acute ischemic stroke (AIS). However, its efficacy is strongly time-dependent. This study was aimed to examine whether prehospital notification by emergency medical service (EMS) providers could reduce onset to needle time (ONT) and improve neurological outcome in AIS patients who received IVT. We prospectively collected the consecutive clinical and time data of AIS patients who received IVT during one year after the initiation of prehospital notification procedure (PNP)...
June 2018: Aging and Disease
Takumi Ohdate, Fumihiko Omura, Haruyo Hatanaka, Yan Zhou, Masami Takagi, Tetsuya Goshima, Takeshi Akao, Eiichiro Ono
For maltose fermentation, budding yeast Saccharomyces cerevisiae operates a mechanism that involves transporters (MALT), maltases (MALS) and regulators (MALR) collectively known as MAL genes. However, functional relevance of MAL genes during sake brewing process remains largely elusive, since sake yeast is cultured under glucose-rich condition achieved by the co-culture partner Aspergillus spp.. Here we isolated an ethyl methane sulfonate (EMS)-mutagenized sake yeast strain exhibiting enhanced maltose fermentation compared to the parental strain...
2018: PloS One
Remle P Crowe, Rebecca E Cash, Alex Christgen, Tina Hilmas, Lee Varner, Amy Vogelsmeier, William S Gilmore, Ashish R Panchal
OBJECTIVE: Evaluating organizational safety culture is critical for high-stress, high-risk professions such as prehospital emergency medical services (EMS). The aim of the study was to evaluate the psychometric properties of a safety culture instrument for EMS, based on the Agency for Healthcare Research and Quality's widely used Surveys on Patient Safety Culture (SOPS). METHODS: The final EMS-adapted instrument consisted of 37 items covering 11 safety culture domains including 10 domains from existing SOPS instruments and one new domain for communication while en route to an emergency call...
June 11, 2018: Journal of Patient Safety
Rob McMickle
I never had the chance to introduce myself to Ms. Jones. She was without a pulse the night she was wheeled into our emergency room by EMS personnel after arresting during dinner with her family. I, a newly-minted medical student, was in the midst of seeing another patient when a monotonic voice over the intercom abruptly interrupted our meeting to announce her pending arrival: "ROSC en route, t-minus five minutes." I left the room to join the rest of the team organizing in the resuscitation bay, confirming their roles in the resuscitation around the gurney and casually going over their plans for the weekend...
June 12, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Ran Qin, Dongdong Zeng, Chengcong Yang, Delara Akhter, Md Alamin, Xiaoli Jin, Chunhai Shi
Panicle architecture and grain size are two important agronomic traits which determine grain yield directly in rice. In the present study, a mutant named ltbsg1 ( longer top branch and shorter grain 1 ) was isolated from the cultivar “Zhenong 34” ( Oryza sativa L. ssp. indica ) by ethyl methane sulfonate (EMS) mutagenesis. The target gene was studied through phenotype observation, genetic analysis, map-based cloning and functional analysis. The histocytological analysis indicated that the elongated top branch and shorter grain of mutant ltbsg1 were caused from the defects of cell elongation...
June 11, 2018: Genes
J A March, M J Kiemeney, J De Guzman, J D Ferguson
INTRODUCTION: Cricothyrotomy may be necessary for airway management when a patient's airway cannot be maintained through standard techniques such as oral airway placement, blind insertion airway device, or endotracheal intubation. Wire-guided cricothyrotomy is one of many techniques used to perform a cricothyrotomy. Although there is some controversy over which cricothyrotomy technique is superior, there is no published data regarding long term retention rates. The purpose of this study is to determine whether ground based paramedics can be taught and are able to retain the skills necessary to successfully perform a wire-guided cricothyrotomy...
May 31, 2018: American Journal of Emergency Medicine
Emma Mc Donnell, David Hevey, Mathew McCauley, Kevin Noel Ducray
BACKGROUND: Early Maladaptive Schema (EMS) are self-beliefs regarding oneself, others and the world, developed in childhood as the result of cumulative negative experiences (Young, 1993). High levels of EMS are present in the opioid using population along with high levels of emotional dysregulation and maladaptive coping alongside traits of resilience. OBJECTIVES: The study explored the associations between EMS in relation to emotional dysregulation, maladaptive coping, adaptive coping and resilience between a clinical group composed of opioid dependent polydrug users attending a facility for opioid substitution treatment (n = 52) and a healthy comparison group (n = 70)...
June 11, 2018: Substance Use & Misuse
Els Pauwels, Eva Dierckx, Katrien Schoevaerts, Els Santens, Hendrik Peuskens, Laurence Claes
Personality features are considered to be important factors in the pathogenesis of both eating disorder (ED) and substance use disorder (SUD). This study investigates similarities and differences between these early maladaptive schemas (EMSs) (a) between female patients with ED (N = 179) or SUD (N = 169) and (b) between ED subtypes of the restrictive (N = 52), bulimic type (N = 127), or SUD. In total, 348 female patients (Mage  = 29.95; SDage  = 8.40) completed the Young Schema Questionnaire. Multivariate analyses of covariance with EMS scales as dependent variables and (a) ED versus SUD and (b) ED subtypes versus SUD as independent variables and age and psychopathology as control variables revealed that ED patients scored significantly higher on Unrelenting Standards, Defectiveness, Social Undesirability, and Failure than did SUD patients...
June 8, 2018: European Eating Disorders Review: the Journal of the Eating Disorders Association
Yalda Hosseinzadeh Ardakani, Hoda Lavasani, Mohammad-Reza Rouini
The stereoselective pharmacokinetic of Tramadol (T) and its main metabolites concerning the influence of CYP2D6 phenotype and gender on the phase I metabolism of this compound was studied after administration of 100 mg single oral dose of racemic T to 24 male and female subjects. The pharmacokinetic parameters were estimated from plasma concentrations of the analytes enantiomers. The metabolic ratio of T enantiomers was used for CYP2D6 phenotype determination. The plasma concentrations of both tramadol enantiomers were considerably higher in Poor metabolizers (PM) than in extensive metabolizers (EM), resulting in 43% and 37% increase in AUC values of (+)-T and (-)-T respectively...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Marko Hoikka, Tom Silfvast, Tero I Ala-Kokko
OBJECTIVES: The prehospital research field has focused on studying patient survival in cardiac arrest, as well as acute coronary syndrome, stroke, and trauma. There is little known about the overall short-term mortality and its predictability in unselected prehospital patients. This study examines whether a prehospital National Early Warning Score (NEWS) predicts 1-day and 30-day mortalities. METHODS: Data from all emergency medical service (EMS) situations were coupled to the mortality data obtained from the Causes of Death Registry during a six-month period in Northern Finland...
June 7, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Wessam El-Baz, Johannes Honold, Lukas Hardi, Peter Tzscheutschler
Modelling and optimization of energy management systems (EMS) require different data types for operation and validation. In this article, a multi-purpose dataset is provided for EMS applications. It includes PV measurement data for the PV generation and prediction algorithms associated with EMS systems. Weather data has also been measured at the same location for the optimization of PV prediction algorithms and other applications such as building model simulations. Moreover, the dataset contains detailed measurements of a seminar room where not only temperatures have been measured, but also user feedback for comfort assessment...
April 2018: Data in Brief
Wolfgang Kemmler, Anja Weissenfels, Sebastian Willert, Mahdieh Shojaa, Simon von Stengel, Andre Filipovic, Heinz Kleinöder, Joshua Berger, Michael Fröhlich
Exercise positively affects most risk factors, diseases and disabling conditions of middle to advanced age, however the majority of middle-aged to older people fall short of the exercise doses recommended for positively affecting cardio-metabolic, musculoskeletal and neurophysiological fitness or disabling conditions. Whole-Body Electromyostimulation (WB-EMS) may be a promising exercise technology for people unable or unmotivated to exercise conventionally. However, until recently there has been a dearth of evidence with respect to WB-EMS-induced effects on health-related outcomes...
2018: Frontiers in Physiology
Ricardo Costa, Joana Luísa Pereira, Maria Ana Santos, Mário Pacheco, Sofia Guilherme
The responses of non-target organisms to pesticide exposure are still poorly explored in what concerns the development of adjustments favouring population success. Owing to the vital role of DNA integrity, it is important to identify genome-maintenance skills and their determinant factors. Thus, the major aims of the present study were: (i) to assess the genotoxicity of the penoxsulam-based herbicide (Viper® ) to the crayfish Procambarus clarkii; (ii) to understand the influence of gender and contamination history in the genotoxic responses following exposure to this herbicide; (iii) to investigate the damage mechanisms involved in putative adjustments shown by P...
June 4, 2018: Ecotoxicology
Eugene Lin, Victoria Calderon, Julie Goins-Whitmore, Vibhav Bansal, Osama Zaidat
Background and purpose: As the fourth mobile stroke unit (MSU) in the nation, and the first 24/7 unit worldwide, we review our initial experience with the Mercy Health MSU and institutional protocols implemented to facilitate rapid treatment of acute stroke patients and field triage for patients suffering other time-sensitive, acute neurologic emergencies in Lucas County, Ohio, and the greater Toledo metropolitan area. Methods: Data was prospectively collected for all patients transported and treated by the MSU during the first 6 months of service...
2018: Frontiers in Neurology
Rosalind Case, Susie Cartledge, Josine Siedenburg, Karen Smith, Lahn Straney, Bill Barger, Judith Finn, Janet E Bray
INTRODUCTION: Understanding regional variation in bystander cardiopulmonary resuscitation (CPR) is important to improving out-of-hospital cardiac arrest (OHCA) survival. In this study we aimed to identify barriers to providing bystander CPR in regions with low rates of bystander CPR and where OHCA was recognised in the emergency call. METHODS: We retrospectively reviewed emergency calls for adults in regions of low bystander CPR in the Australian state of Victoria...
June 1, 2018: Resuscitation
Vincent Michel, Emilie Julio, Thierry Candresse, Julien Cotucheau, Christophe Decorps, Roxane Volpatti, Benoît Moury, Laurent Glais, François Dorlhac de Borne, Véronique Decroocq, Sylvie German-Retana
Potato virus Y is one of the most damaging viruses of tobacco. In particular, aggressive necrotic strains (PVYN ) lead to considerable losses in yield. The main source of resistance against PVY is linked to the va locus. However, va-overcoming PVY isolates inducing necrotic symptoms were observed in several countries. In this context, it is important to find va-independent protection strategies. In a previous study, the phenotyping of 162 tobacco varieties revealed ten accessions that do not carry the va allele and do not exhibit typical PVYN -induced veinal necrosis...
June 4, 2018: Plant Journal: for Cell and Molecular Biology
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