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https://www.readbyqxmd.com/read/29136251/c-ebp%C3%AE-mediates-rna-polymerase-iii-driven-transcription-of-oncomir-138-in-malignant-gliomas
#1
Federica Di Pascale, Srikanth Nama, Manish Muhuri, Shan Quah, Hisyam M Ismail, Xin Hui Derryn Chan, Gopinath M Sundaram, Rajkumar Ramalingam, Brian Burke, Prabha Sampath
MicroRNA-138 (miR-138) is a pro-survival oncomiR for glioma stem cells. In malignant gliomas, dysregulated expression of microRNAs, such as miR-138, promotes Tumour initiation and progression. Here, we identify the ancillary role of the CCAAT/enhancer binding protein β (C/EBPβ) as a transcriptional activator of miR-138. We demonstrate that a short 158 bp DNA sequence encoding the precursor of miR-138-2 is essential and sufficient for transcription of miR-138. This short sequence includes the A-box and B-box elements characteristic of RNA Polymerase III (Pol III) promoters, and is also directly bound by C/EBPβ via an embedded 'C/EBPβ responsive element' (CRE)...
November 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29118908/mir-25-is-upregulated-before-the-occurrence-of-esophageal-squamous-cell-carcinoma
#2
Yaxu Jia, Heng Lu, Cheng Wang, Junjun Wang, Chenyu Zhang, Fangyu Wang, Chunni Zhang
MicroRNAs (miRNAs) are potential biomarkers for cancer detection including esophageal squamous cell carcinoma (ESCC); however, little is known about their expression profile and diagnostic impact in esophageal squamous cell intraepithelial neoplasia, the pathological precancerous lesion of ESCC. In this study, we examined the expression levels of eight miRNAs that were reported to be deregulated in ESCC, including miR-25, let-7a, miR-100, miR-133a, miR-223, miR-375, miR-483-5p and miR-1322, in 30 pairs of esophageal squamous cell neoplasia lesion tissues and corresponding adjacent normal tissues using quantitative real-time PCR (qRT-PCR)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29115464/microrna-222-promotes-tumor-growth-and-confers-radioresistance-in-nasopharyngeal-carcinoma-by-targeting-pten
#3
Wei Wu, Xi Chen, Shilong Yu, Rui Wang, Ruikun Zhao, Chao Du
MicroRNA-222 (miR‑222) has been reported to be involved in the initiation, development and metastasis of tumors, as well as conferring resistance to chemotherapeutic drugs or radiotherapy in various types of cancer. However, the role and the underlying molecular mechanism of miR‑222 specifically in nasopharyngeal carcinoma (NPC) remains unclear. Thus, the biological function and underlying mechanism of in miR‑222 was investigated in NPC tissue specimens and cell lines. miR‑222 was upregulated in NPC tissues and malignant cell lines compared with adjacent normal samples and cell lines...
October 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29104623/microrna-155-regulates-the-proliferation-cell-cycle-apoptosis-and-migration-of-colon-cancer-cells-and-targets-cbl
#4
Hua Yu, Weiling Xu, Fangchao Gong, Baorong Chi, Junyi Chen, Ling Zhou
MicroRNA-155 (miR-155) is a well-studied miR and acts as an oncomiR in numerous cancer types. However, the biological functions of miR-155 in colon cancer as well as its target genes have remained to be fully elucidated. In order to investigate the biological functions of miR-155, MTT, colony formation and wound healing assays, cell cycle analysis and detection of apoptosis were performed. The results demonstrated that miR-155 promoted the proliferation of colon cancer cells and enhanced their colony formation capacity, promoted their cell cycle progression and inhibited apoptosis...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29100393/down-regulation-of-traditional-oncomirs-in-plasma-of-breast-cancer-patients
#5
Dana Jurkovicova, Bozena Smolkova, Monika Magyerkova, Zuzana Sestakova, Viera Horvathova Kajabova, Ludovit Kulcsar, Iveta Zmetakova, Lenka Kalinkova, Tomas Krivulcik, Marian Karaba, Juraj Benca, Tatiana Sedlackova, Gabriel Minarik, Zuzana Cierna, Ludovit Danihel, Michal Mego, Miroslav Chovanec, Ivana Fridrichova
Deregulated expression of microRNAs has the oncogenic or tumor suppressor function in cancer. Since miRNAs in plasma are highly stable, their quantification could contribute to more precise cancer diagnosis, prognosis and therapy prediction. We have quantified expression of seven oncomiRs, namely miR-17/92 cluster (miR-17, miR-18a, miR-19a and miR-20a), miR-21, miR-27a and miR-155, in plasma of 137 breast cancer (BC) patients. We detected down-regulation of six miRNAs in patients with invasive BC compared to controls; however, only miR-20a and miR-27a down-regulations were statistically significant...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29091291/microrna-21-and-dicer-are-dispensable-for-hepatic-stellate-cell-activation-and-the-development-of-liver-fibrosis
#6
Jorge Matias Caviglia, Jun Yan, Myoung-Kuk Jang, Geum-Youn Gwak, Silvia Affo, Lexing Yu, Peter Olinga, Richard A Friedman, Xin Chen, Robert F Schwabe
Fibrosis and cancer represent two major complications of chronic liver disease. MicroRNAs have been implicated in the development of fibrosis and cancer, thus constituting potential therapeutic targets. Here, we investigated the role of miR-21, a microRNA that has been implicated in the development of fibrosis in multiple organs and also been suggested to act as "oncomir". Accordingly, miR-21 was the microRNA that showed the strongest upregulation in activated hepatic stellate cells (HSC) in multiple models of fibrogenesis, with an 8- to 24-fold induction compared to quiescent HSC...
November 1, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29074558/mir-6743-5p-as-a-direct-upstream-regulator-of-grim-19-enhances-proliferation-and-suppresses-apoptosis-in-glioma-cells
#7
Fang Cao, Qiang Zhang, Wei Chen, Feng Zheng, Qishan Ran, Yang He, Yang Gao, Shengtao Yao
Gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) has been recognized as a tumor suppressor protein, which regulates cell growth, apoptosis and migration by signal transducer and activator of transcription 3 (STAT3) signaling pathway and non-STAT3 pathway in glioma cells. Here, we investigated the molecular mechanisms that regulated GRIM-19 expression in glioma cells. By the TargetScan algorithm, four microRNAs (miRNAs), hsa-miR-17-3p, hsa-miR-423-5p, hsa-miR-3184-5p and hsa-miR-6743-5p, were identified with the potential to bind with 3'-untranslated regions (UTR) of GRIM-19...
October 26, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29073933/role-of-tumor-suppressor-p53-and-micro-rna-interplay-in-multiple-myeloma-pathogenesis
#8
REVIEW
Jahangir Abdi, Nasrin Rastgoo, Lihong Li, Wenming Chen, Hong Chang
The molecular mechanisms underlying dysregulated wild type (wt) p53 in multiple myeloma (MM) have been subjects of intense investigation for years. Indeed, correlation of rarely occurring TP53 gene mutations or deletions with adverse clinical outcomes in MM patients is strongly established, while in majority of cases wtp53 seems to be non-functional or dysregulated bearing a high clinical impact. Interestingly, findings from recent investigations show that micro-RNAs (miRNAs) may contribute to suppression of wtp53 in MM, as they are now known to function as key regulatory elements in the p53 network...
October 26, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29050357/oncomir-17-5p-alarm-signal-in-cancer
#9
REVIEW
Madhusudhan Reddy Bobbili, Robert M Mader, Johannes Grillari, Hanna Dellago
Soon after microRNAs entered the stage as novel regulators of gene expression, they were found to regulate -and to be regulated by- the development, progression and aggressiveness of virtually all human types of cancer. Therefore, miRNAs in general harbor a huge potential as diagnostic and prognostic markers as well as potential therapeutic targets in cancer. The miR-17-92 cluster was found to be overexpressed in many human cancers and to promote unrestrained cell growth, and has therefore been termed onco-miR-1...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028907/oncomir-an-online-resource-for-exploring-pan-cancer-microrna-dysregulation
#10
Nathan W Wong, Yuhao Chen, Shuai Chen, Xiaowei Wang
Summary: Dysregulation of microRNAs (miRNAs) is extensively associated with cancer development and progression. miRNAs have been shown to be biomarkers for predicting tumor formation and outcome. However, identification of the relationships between miRNA expression and tumor characteristics can be difficult and time-consuming without appropriate bioinformatics expertise. To address this issue, we present OncomiR, an online resource for exploring miRNA dysregulation in cancer. Using combined miRNA-seq, RNA-seq, and clinical data from The Cancer Genome Atlas, we systematically performed statistical analyses to identify dysregulated miRNAs that are associated with tumor development and progression in most major cancer types...
October 3, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28994735/prediction-potential-of-serum-mir-155-and-mir-24-for-relapsing-early-breast-cancer
#11
Petra Bašová, Michal Pešta, Marek Sochor, Tomáš Stopka
Oncogenic microRNAs (oncomiRs) accumulate in serum due to their increased stability and thus serve as biomarkers in breast cancer (BC) pathogenesis. Four oncogenic microRNAs (miR-155, miR-19a, miR-181b, and miR-24) and one tumor suppressor microRNA (let-7a) were shown to differentiate between high- and low-risk early breast cancer (EBC) and reflect the surgical tumor removal and adjuvant therapy. Here we applied the longitudinal multivariate data analyses to stochastically model the serum levels of each of the oncomiRs using the RT-PCR measurements in the EBC patients (N = 133) that were followed up 4 years after diagnosis...
October 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28981115/mir-23a-b-promote-tumor-growth-and-suppress-apoptosis-by-targeting-pdcd4-in-gastric-cancer
#12
Xiuting Hu, Yanbo Wang, Hongwei Liang, Qian Fan, Ruichi Zhu, Jiayi Cui, Weijie Zhang, Ke Zen, Chen-Yu Zhang, Dongxia Hou, Zhen Zhou, Xi Chen
MicroRNAs (miRNAs) are short non-coding RNAs of 21-23 nucleotides that play important roles in virtually all biological pathways in mammals and in other multicellular organisms. miR-23a and miR-23b (miR-23a/b) are critical oncomiRs (miRNAs that are associated with human cancers) of gastric cancer, but their detailed roles in the initiation and progression of gastric cancer remain to be elucidated. In this study, we found that miR-23a/b were consistently upregulated in gastric cancer tissues. We then investigated the molecular mechanisms through which miR-23a/b contribute to gastric cancer and identified programmed cell death 4 (PDCD4) as a direct target gene of miR-23a/b...
October 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28941018/role-of-non-coding-rnas-in-head-and-neck-squamous-cell-carcinoma-a-narrative-review
#13
REVIEW
M K Sannigrahi, Rajni Sharma, Naresh K Panda, Madhu Khullar
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with high recurrence, metastasis, and poor treatment outcome. Recent studies have reported that non-coding RNA (ncRNA) might play critical role in regulating different types of cancer. MicroRNAs (miRs) are short ncRNAs (20-25 nucleotides), responsible for post-transcriptional regulation of gene expression and may have a role in oncogenesis by acting as oncomiRs or tumor-suppressors miRs. Long non-coding RNAs (lncRNAs) are heterogenous group of ncRNAs more than 200 nucleotides long, can act in cis and/or in trans, and, have been also implicated in carcinogenesis...
September 21, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28934477/a-structural-map-of-oncomir-1-at-single-nucleotide-resolution
#14
Saikat Chakraborty, Yamuna Krishnan
The miR-17-92a cluster, also known as 'oncomiR-1', is an RNA transcript that plays a pivotal regulatory role in cellular processes, including the cell cycle, proliferation and apoptosis. Its dysregulation underlies the development of several cancers. Oncomir-1 comprises six constituent miRNAs, each processed with different efficiencies as a function of both developmental time and tissue type. The structural mechanisms that regulate such differential processing are unknown, and this has impeded our understanding of the dysregulation of oncomiR-1 in pathophysiology...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28927253/comparative-aspects-of-microrna-expression-in-canine-and-human-cancer
#15
REVIEW
Kabiru Sahabi, Gayathri Thevi Selvarajah, Rasedee Abdullah, Cheah Yoke Kqueen, Tan Geok Chin
MicroRNAs (miRNAs) are important players in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have been identified, and many are conserved among vertebrates and invertebrates. MicroRNA regulation is the most abundant mode of post-transcriptional gene regulation. MicroRNAs that are involved in the initiation and progression of cancers are termed oncomiRs, several of which have been identified in canine and human cancer. Similarly, several miRNAs have been reported to be down-regulated in cancers of the two species...
September 20, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28900085/-expression-of-mir-21-and-its-acat1-armcx1-and-pten-target-genes-in-liver-of-female-rats-treated-with-ddt-and-benzo-a-pyrene
#16
M D Chanyshev, D S Ushakov, L F Gulyaeva
MiR-21 is the most studied cancer-promoting oncomiR, which target numerous tumor suppressor genes associated with proliferation, apoptosis, and invasion. Here we have studied the synthesis of miR-21 and quantified the mRNA and protein levels for miR-21 potential target genes, i.e., Acat1, Armcx1, and Pten, in the livers of female Wistar rats after their treatment with either 1,1-trichloro-2,2-di(4-chlorophenyl)ethane (DDT) or benzo[a]pyrene (BP). The most important finding appears to be the significant decrease in the miR-21 level the day after treatment with DDT with subsequent rebound...
July 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28881794/enhanced-efficacy-of-akt-and-fak-kinase-combined-inhibition-in-squamous-cell-lung-carcinomas-with-stable-reduction-in-pten
#17
Andrea Cavazzoni, Silvia La Monica, Roberta Alfieri, Andrea Ravelli, Nele Van Der Steen, Rocco Sciarrillo, Denise Madeddu, Costanza Anna Maria Lagrasta, Federico Quaini, Mara Bonelli, Claudia Fumarola, Daniele Cretella, Graziana Digiacomo, Marcello Tiseo, Godefridus J Peters, Andrea Ardizzoni, Pier Giorgio Petronini, Elisa Giovannetti
Squamous cell lung carcinoma (SCC) accounts for 30% of patients with NSCLC and to date, no molecular targeted agents are approved for this type of tumor. However, recent studies have revealed several oncogenic mutations in SCC patients, including an alteration of the PI3K/AKT pathway, i.e. PI3K point mutations and amplification, AKT mutations and loss or reduced PTEN expression. Prompted by our observation of a correlation between PTEN loss and FAK phosphorylation in a cohort of patients with stage IV SCC, we evaluated the relevance of PTEN loss in cancer progression as well as the efficacy of a new combined treatment with the pan PI3K inhibitor buparlisip and the FAK inhibitor defactinib...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881718/quercetin-inhibits-cr-vi-induced-malignant-cell-transformation-by-targeting-mir-21-pdcd4-signaling-pathway
#18
Poyil Pratheeshkumar, Young-Ok Son, Sasidharan Padmaja Divya, Lei Wang, Lilia Turcios, Ram Vinod Roy, John Andrew Hitron, Donghern Kim, Jin Dai, Padmaja Asha, Zhuo Zhang, Xianglin Shi
Hexavalent chromium [Cr(VI)] is an important human carcinogen associated with pulmonary diseases and lung cancer. Inhibition of Cr(VI)-induced carcinogenesis by a dietary antioxidant is a novel approach. Quercetin is one of the most abundant dietary flavonoids widely present in many fruits and vegetables, possesses potent antioxidant and anticancer properties. MicroRNA-21 (miR-21) is a key oncomiR significantly elevated in the majority of human cancers that exerts its oncogenic activity by targeting the tumor suppressor gene programmed cell death 4 (PDCD4)...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28831264/microrna-130a-is-an-oncomir-suppressing-the-expression-of-crmp4-in-gastric-cancer
#19
Yiran Zhou, Ruhong Li, Haidong Yu, Ruotian Wang, Zhiqiang Shen
Gastric cancer is one of the most common causes of death worldwide, although its incidence has steadily declined in recent years. There is strong evidence that aberrantly expressed microRNAs (miRNAs) are involved in gastric cancer tumorigenesis. Furthermore, CRMP4 is closely associated with the occurrence and development of gastric cancer, and our predictions suggest that miR-130a, which can promote gastric cancer tumorigenesis, is a potential CRMP4 regulator. In this study, we investigated the expression of CRMP4 and miR-130a in human gastric cancer cell lines by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot (WB) examination and direct interactions between miR-130a and CRMP4 by dual-luciferase reporter assay...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28820056/involvement-of-cd24-in-multiple-cancer-related-pathways-makes-it-an-interesting-new-target-for-cancer-therapy
#20
Shirin Eyvazi, Bahram Kazemi, Siavoush Dastmalchi, Mojgan Bandehpour
CD24 (cluster of differentiation 24) is a small heavy glycosylated protein, which is overexpressed in many cancer and some cancer stem cells and is associated with the development, invasion, and metastasis of cancer cells. The exact role of CD24 in these processes is not fully understood, however, in this article, it has been tried to present collection of cancer-related mechanisms attributed to CD24. Based on the literature, CD24 dis-regulates different signaling pathways in various cancer cells, including; Src kinases, STAT3, EGFR, Wnt/β-catenin and MAPK...
August 18, 2017: Current Cancer Drug Targets
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