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https://www.readbyqxmd.com/read/29765554/targeted-nanoparticle-delivery-of-therapeutic-antisense-micrornas-presensitizes-glioblastoma-cells-to-lower-effective-doses-of-temozolomide-in-vitro-and-in-a-mouse-model
#1
Meenakshi Malhotra, Thillai Veerapazham Sekar, Jeyarama S Ananta, Rammohan Devulapally, Rayhaneh Afjei, Husam A Babikir, Ramasamy Paulmurugan, Tarik F Massoud
Temozolomide (TMZ) chemotherapy for glioblastoma (GBM) is generally well tolerated at standard doses but it can cause side effects. GBMs overexpress microRNA-21 and microRNA-10b, two known oncomiRs that promote cancer development, progression and resistance to drug treatment. We hypothesized that systemic injection of antisense microRNAs (antagomiR-21 and antagomiR-10b) encapsulated in cRGD-tagged PEG-PLGA nanoparticles would result in high cellular delivery of intact functional antagomiRs, with consequent efficient therapeutic response and increased sensitivity of GBM cells to lower doses of TMZ...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29752719/hbv-suppresses-zhx2-expression-to-promote-proliferation-of-hcc-through-mir-155-activation
#2
Xiaojia Song, Siyu Tan, Zhuanchang Wu, Leiqi Xu, Zehua Wang, Yong Xu, Tixiao Wang, Chengjiang Gao, Yaoqin Gong, Xiaohong Liang, Lifen Gao, Brett T Spear, Chunhong Ma
Initiation of hepatocellular carcinoma (HCC) by chronic hepatitis B virus (HBV) infection is a complex process that includes both oncogene activation and tumor suppressor inhibition. The HBV X (HBx) protein has an important and complex role in processes leading to HCC. We previously identified the mammalian Zinc fingers and homeoboxes 2 (ZHX2) gene as an HCC-associated tumor suppressor gene. In the present study, we investigated whether the oncogenic properties of HBV and, more specifically, HBx, involved ZHX2 silencing...
May 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29721077/cyclin-d1-mediated-microrna-expression-signature-predicts-breast-cancer-outcome
#3
Guangxue Wang, Michael Gormley, Jing Qiao, Qian Zhao, Min Wang, Gabriele Di Sante, Shengqiong Deng, Lin Dong, Tim Pestell, Xiaoming Ju, Mathew C Casimiro, Sankar Addya, Adam Ertel, Ayden Tozeren, Qinchuan Li, Zuoren Yu, Richard G Pestell
Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly controls the non-coding genome is poorly understood. Methods: Herein, the miRNA signature maintained by endogenous cyclin D1 in human breast cancer cells was defined. In order to determine the clinical significance of the cyclin D1-mediated miRNA signature, we defined a miRNA expression superset from 459 breast cancer samples...
2018: Theranostics
https://www.readbyqxmd.com/read/29643994/grape-seed-procyanidin-extract-against-lung-cancer-the-role-of-microrna-106b-bioavailability-and-bioactivity
#4
Bingye Xue, Qing-Yi Lu, Larry Massie, Clifford Qualls, Jenny T Mao
MiR-106b is an oncomir and a potential target for anti-cancer therapy. We hypothesize that grape seed procyanidin extract (GSE) exerts antineoplastic effects on lung cancer through modulations of miR-106b and its downstream target. We found that GSE significantly down-regulated miR-106b in a variety of lung neoplastic cells and increased cyclin-dependent kinase inhibitor 1A ( CDKN1A ) mRNA and protein (p21) levels. Transfection of miR-106b mimics reversed the up-regulations of CDKN1A mRNA and p21, abrogated the GSE induced anti-proliferative and anti-invasive properties in lung cancer cells...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29568927/mir-185-and-mir-29a-are-similarly-expressed-in-the-bronchoalveolar-lavage-cells-in-ipf-and-lung-cancer-but-common-targets-dnmt1-and-col1a1-show-disease-specific-patterns
#5
Eleni Bibaki, Eliza Tsitoura, Eirini Vasarmidi, George Margaritopoulos, Athina Trachalaki, Chara Koutoulaki, Theodora Georgopoulou, Demetrios A Spandidos, Nikos Tzanakis, Katerina M Antoniou
Idiopathic pulmonary fibrosis (IPF) and lung cancer (LC) constitute two progressively devastating lung diseases with common risk factors including aging and smoking. There is an increasing interest in the investigation of common pathogenic mechanisms between IPF and LC with therapeutic implications. Several oncomirs, microRNAs associated with malignancy, are also linked with IPF. miR‑29a and miR‑185 downregulation is probably involved both in carcinogenesis and fibrogenesis. We have previously observed miR‑29a and miR‑185 downregulation in IPF cells from bronchoalveolar lavage (BAL) and in this study we investigated their expression in LC BAL cells...
March 19, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29547527/the-oncogenic-relevance-of-mir-17-92-cluster-and-its-paralogous-mir-106b-25-and-mir-106a-363-clusters-in-brain-tumors
#6
REVIEW
Renata Gruszka, Magdalena Zakrzewska
The fundamental function of ribonucleic acids is to transfer genetic information from DNA to protein during translation process, however, this is not the only way connecting active RNA sequences with essential biological processes. Up until now, many RNA subclasses of different size, structure, and biological function were identified. Among them, there are non-coding single-stranded microRNAs (miRNAs). This subclass comprises RNAs of 19-25 nucleotides in length that modulate the activity of well-defined coding RNAs and play a crucial role in many physiological and pathological processes...
March 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29540187/mir-362-5p-as-a-novel-prognostic-predictor-of-cytogenetically-normal-acute-myeloid-leukemia
#7
Qiu-Ling Ma, Jing-Han Wang, Min Yang, Huan-Ping Wang, Jie Jin
BACKGROUND: MicroRNAs are of special interest in cancer research and hold significant promise as diagnostic and prognostic biomarkers for malignant disease. MiR-362-5p have been found to exert both oncogenic and tumor suppressive effects depending highly on the cellular context. The aim of this study was to determine whether the expression of miR-362-5p can be served as a prognostic factor for patients with cytogentically normal acute myeloid leukemia (CN-AML). METHODS: We enrolled 224 patients with CN-AML and measured the expression of miR-362-5p by quantitative real time PCR analysis...
March 14, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29538313/a-comprehensive-analysis-of-argonaute-clip-data-identifies-novel-conserved-and-species-specific-targets-of-mir-21-in-human-liver-and-hepatocellular-carcinoma
#8
Aaron Balasingam Koenig, Juan Martín Barajas, María Jose Guerrero, Kalpana Ghoshal
MicroRNAs are ~22 nucleotide RNAs that regulate gene expression at the post-transcriptional level by binding messenger RNA transcripts. miR-21 is described as an oncomiR whose steady-state levels are commonly increased in many malignancies, including hepatocellular carcinoma (HCC). Methods known as cross-linking and immunoprecipitation of RNA followed by sequencing (CLIP-seq) have enabled transcriptome-wide identification of miRNA interactomes. In our study, we use a publicly available Argonaute-CLIP dataset (GSE97061), which contains nine HCC cases with matched benign livers, to characterize the miR-21 interactome in HCC...
March 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29529473/in-vivo-short-term-topical-application-of-bay-11-7082-prevents-the-acidic-bile-induced-mrna-and-mirna-oncogenic-phenotypes-in-exposed-murine-hypopharyngeal-mucosa
#9
Clarence T Sasaki, Sotirios G Doukas, Dimitra P Vageli
PURPOSE: Bile-containing gastroesophageal reflux may promote cancer at extraesophageal sites. Acidic bile can accelerate NF-κB activation and molecular events, linked to premalignant changes in murine hypopharyngeal mucosa (HM). We hypothesize that short-term in vivo topical application of NF-κB inhibitor BAY 11-7082 can prevent acidic bile-induced early preneoplastic molecular events, suggesting its potential role in disease prevention. EXPERIMENTAL DESIGN: We topically exposed HM (C57Bl/6j wild-type) to a mixture of bile acids at pH 3...
April 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29512734/mir%C3%A2-3147-serves-as-an-oncomir-in-vulvar-squamous-cell-cancer-via-smad4-suppression
#10
Xiu-Hua Yang, Feng Guo
The incidence of vulvar squamous cell carcinoma (VSCC) has increased annually over the last decade. MicroRNAs (miRNAs/miRs) serve an important role in tumor progression and development. Our previous microarray studies have revealed that miR‑3147 was overexpressed in VSCC. However, its function and underlying mechanism in VSCC remain unknown. In the present study, it was confirmed by reverse transcription‑quantitative polymerase chain reaction that the expression of miR‑3147 was markedly upregulated in VSCC tissues...
May 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29499238/diverse-functions-of-mir-17-92-cluster-micrornas-in-t-helper-cells
#11
Dirk Baumjohann
T helper (Th) cells are critically involved in adaptive immune responses against various pathogens. In contrast, dysregulated T helper cell responses are associated with a variety of diseases, including autoimmunity, allergies, and cancer. Differentiation of naïve CD4+ T cells into effector T helper cell subsets, including Th1, Th2, Th17, Treg, and T follicular helper (Tfh), requires precise dosing of signaling molecules and transcription factors. MicroRNAs (miRNAs), which are small endogenously expressed RNAs that regulate gene expression, play important roles in these processes...
June 1, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29492795/the-coagulome-and-the-oncomir-impact-of-cancer-associated-haemostatic-dysregulation-on-the-risk-of-metastasis
#12
Kate Burbury, Michael P MacManus
Patients with cancer are at high risk of both thromboembolic and haemorrhagic events during the course of their disease. The pathogenesis of haemostatic dysfunction in cancer is complex and involves the interplay of multiple factors. There is growing evidence that interactions between malignancies and the coagulation system are not random but can represent coordinated and clinically-significant adaptations that enhance tumour cell survival, proliferation and metastatic potential. A detailed understanding of the interactions between the haemostatic systems and the pathophysiology of metastasis may not only provide insight into strategies that could potentially reduce the incidence of thrombohaemorrhagic events and complications, but could also help design strategies that are capable of modifying tumour biology, progression and metastatic potential in ways that could enhance anticancer therapies and thereby improve overall survival...
February 28, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29467883/effects-of-yangzheng-sanjie-decoction-containing-serum-mediated-by-microrna-7-on-cell-proliferation-and-apoptosis-in-gastric-cancer
#13
Wanqun Chen, Yaya Yu, Naikun Yang, Jingli Zhu, Ke Li, Ruocun Li, Wenqiao Su, Lina Luo, Ling Hu, Gengxin Chen, Haixia Deng
Gastric cancer (GC) is one of the most common types of cancer and a leading cause of cancer-associated mortality. MicroRNAs (miRNAs/miRs) are demonstrated to function as oncomiRs or tumor-suppressor-miRs in GC. miR-7 has been identified to be a tumor suppressor of GC by targeting epidermal growth factor receptor (EGFR). In our previous study, Yangzheng Sanjie Decoction (YZSJD), a traditional Chinese formula, was identified to be effective in alleviating the symptoms and even postponing turnover of precancerous lesions...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29435930/quantum-language-of-microrna-application-for-new-cancer-therapeutic-targets
#14
Yoichi Robertus Fujii
MicroRNA (miRNA) is the noncoding gene: therefore, the miRNA gene inheritably controls protein gene expression through transcriptional and post-transcriptional levels. Aberrant expression of miRNA genes causes various human diseases, especially cancers. Although cancer is a complex disease, cancer/miRNA implication has yet been grasped from the perspective of miRNA profile in bed side. Since miRNA is the mobile genetic element, the clinical verification of miRNA in microvesicle of blood is too much straggle to predict potential cancer/miRNA associations without bioinformatical computing...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29425228/kshv-oral-shedding-and-plasma-viremia-result-in-significant-changes-in-the-extracellular-tumorigenic-mirna-expression-profile-in-individuals-infected-with-the-malaria-parasite
#15
Minako Ikoma, Soren Gantt, Corey Casper, Yuko Ogata, Qing Zhang, Ryan Basom, Michael R Dyen, Timothy M Rose, Serge Barcy
Kaposi's sarcoma herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS). Both KSHV and HIV infections are endemic in Uganda, where KS is among the most common cancers in HIV-infected individuals. Recent studies examined the use of small RNAs as biomarkers of disease, including microRNAs (miRNAs), with viral and tumor-derived miRNAs being detected in exosomes from individuals with KSHV-associated malignancies. In the current study, the host and viral extracellular mature miRNA expression profiles were analyzed in blood of KS-negative individuals in Uganda, comparing those with or without KSHV detectable from the oropharynx...
2018: PloS One
https://www.readbyqxmd.com/read/29386283/modified-cross-linking-ligation-and-sequencing-of-hybrids-qclash-identifies-kaposi-s-sarcoma-associated-herpesvirus-microrna-targets-in-endothelial-cells
#16
Lauren A Gay, Sunantha Sethuraman, Merin Thomas, Peter C Turner, Rolf Renne
Kaposi's sarcoma (KS) tumors are derived from endothelial cells and express Kaposi's sarcoma-associated herpesvirus (KSHV) microRNAs (miRNAs). Although miRNA targets have been identified in B cell lymphoma-derived cells and epithelial cells, little has been done to characterize the KSHV miRNA targetome in endothelial cells. A recent innovation in the identification of miRNA targetomes, cross-linking, ligation, and sequencing of hybrids (CLASH), unambiguously identifies miRNAs and their targets by ligating the two species while both species are still bound within the RNA-induced silencing complex (RISC)...
April 15, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29383182/transcriptomic-analysis-in-pediatric-spinal-ependymoma-reveals-distinct-molecular-signatures
#17
Anbarasu Lourdusamy, Li Z Luo, Lisa Cd Storer, Kenneth J Cohen, Linda Resar, Richard G Grundy
Pediatric spinal ependymomas (SEPN) are important albeit uncommon malignant central nervous system tumors with limited treatment options. Our current knowledge about the underlying biology of these tumors is limited due to their rarity. To begin to elucidate molecular mechanisms that give rise to pediatric SEPN, we compared the transcriptomic landscape of SEPNs to that of intracranial ependymomas using genome-wide mRNA and microRNA (miRNA) expression profiling in primary tumour samples. We found that pediatric SEPNs are characterized by increased expression of genes involved in developmental processes, oxidative phosphorylation, cellular respiration, electron transport chain, and cofactor metabolic process...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29378184/mir-218-and-mir-129-regulate-breast-cancer-progression-by-targeting-lamins
#18
Stephanie Rebecca Setijono, Mikyung Park, Goeun Kim, Yongjo Kim, Kae Won Cho, Su Jung Song
Breast cancer is the most frequently diagnosed life-threatening cancer in women. Triple-negative breast cancer (TNBC) has an aggressive clinical behavior, but the treatment of TNBC remains challenging. MicroRNAs (miRNAs) have emerged as a potential target for the diagnosis, therapy and prognosis of breast cancer. However, the precise role of miRNAs and their targets in breast cancer remain to be elucidated. Here we show that miR-218 is downregulated and miR-129 is upregulated in TNBC samples and their expressions confer prognosis to patients...
February 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29375712/microrna-20a-promotes-proliferation-and-invasion-by-directly-targeting-early-growth-response-2-in-non-small-cell-lung-carcinoma
#19
Lai Wei, Fengming Ran
MicroRNA-20a (miR-20a) serves a notable role in tumor development and progression; it functions differently in different types of malignant tumor, and its role and mechanism in non-small cell lung carcinoma (NSCLC) remains unclear. In the present study, the effects of miR-20a on the proliferation and invasion of NSCLC cells and the underlying mechanisms behind this were investigated. Reverse transcription-quantitative polymerase chain reaction revealed that the expression level of miR-20a was higher in human NSCLC than in normal tissues...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29366836/prognostic-value-of-microrna-155-in-human-carcinomas-an-updated-meta-analysis
#20
REVIEW
Kangkang Liu, Kun Zhao, Lining Wang, Erlin Sun
BACKGROUND: miR-155 functions as an oncomiR or as an oncosuppressor-miR in human cancer. Although miR-155 has been researched in many cancers, its prognostic value is uncertain. METHODS: We performed a literature search in up-to-date electronic databases including PubMed and Embase to obtain as many relevant articles as possible. Combined hazard ratios (HR) of miR-155 for outcome were analyzed. RESULTS: A total of 24 papers researching different cancers were included in this meta-analysis...
April 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
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