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https://www.readbyqxmd.com/read/28215003/improved-electromagnetic-tracking-for-catheter-path-reconstruction-with-application-in-high-dose-rate-brachytherapy
#1
Elodie Lugez, Hossein Sadjadi, Chandra P Joshi, Selim G Akl, Gabor Fichtinger
PURPOSE: Electromagnetic (EM) catheter tracking has recently been introduced in order to enable prompt and uncomplicated reconstruction of catheter paths in various clinical interventions. However, EM tracking is prone to measurement errors which can compromise the outcome of the procedure. Minimizing catheter tracking errors is therefore paramount to improve the path reconstruction accuracy. METHODS: An extended Kalman filter (EKF) was employed to combine the nonlinear kinematic model of an EM sensor inside the catheter, with both its position and orientation measurements...
February 18, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28214977/braf-mutated-colorectal-cancer-what-is-the-optimal-strategy-for-treatment
#2
REVIEW
Romain Cohen, Pascale Cervera, Magali Svrcek, Anna Pellat, Chantal Dreyer, Aimery de Gramont, Thierry André
The BRAF activating mutation, harbored by approximately 10% of colorectal cancers (CRC), confers dramatic prognosis to advanced diseases. In early-stage setting, the identification of the BRAF mutation does not impact the therapeutic decision. Yet, the BRAF mutation could be considered as a stratification factor in adjuvant trials, because of its prognostic impact after relapse. Moreover, both BRAF mutation and mismatch repair (MMR) statuses should be determined in all CRC to help identify sporadic tumors versus Lynch syndrome-related tumors...
February 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28214236/are-hospital-ed-transfers-less-likely-among-nursing-home-residents-with-do-not-hospitalize-orders
#3
Taeko Nakashima, Yuchi Young, Wan-Hsiang Hsu
OBJECTIVES: This study aims to examine whether an advance directive "Do Not Hospitalize" (DNH) would be effective in reducing hospital/emergency department (ED) transfers. Similar effects in residents with dementia were also examined. DESIGN: Cross-sectional study. SETTING/SUBJECTS: New York State (NYS) nursing home residents (n = 43,024). MEASUREMENTS AND ANALYSIS: The Minimum Data Set 2.0 was used to address the study aims...
February 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28214187/microbiological-analysis-antimicrobial-activity-and-heavy-metals-content-of-jordanian-ma-in-hot-springs-water
#4
Muhamad Ali K Shakhatreh, Jacob H Jacob, Emad I Hussein, Majed M Masadeh, Safwan M Obeidat, Abdul-Salam F Juhmani, Mutaz A Abd Al-Razaq
Ma'in hot springs are known as sites of balneotherapy. However, little is known about their microbiology and chemistry. In this study, we aim at evaluating the antimicrobial activity of Ma'in hot-springs water (MHSW), studying its microbiology, and determining its physicochemical properties including the heavy metals content. Therefore, water samples were collected from Ma'in hot springs and tested for antimicrobial activity using agar diffusion method. Water was then cultivated on nutrient agar to isolate and identify the dominant bacteria by chemical and molecular methods...
February 14, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28213817/breakthrough-cancer-pain-and-rational-drug-use
#5
Juan Manuel Núñez Olarte
Recent data indicate that there are large disparities in the use of opioid analgesics to control breakthrough cancer pain (BTcP) in Europe and worldwide. While it is clear that affordability is a key factor, it is certainly not the only one, and other factors, such as cultural differences and overall awareness, are undoubtedly responsible. More work remains to be done to overcome barriers in the use of these medications when warranted. When prescribing a medication for BTcP, it must be considered that its time profile is different from chronic persistent pain...
February 18, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28213543/functional-characterization-of-a-28-kb-catabolic-island-from-pseudomonas-sp-m1-involved-in-biotransformation-of-%C3%AE-myrcene-and-related-plant-derived-volatiles
#6
Pedro Soares-Castro, Pedro Montenegro-Silva, Hermann J Heipieper, Pedro M Santos
Pseudomonas sp. M1 is able to mineralize highly hydrophobic and recalcitrant compounds such as benzene, phenol and their methylated/halogenated derivatives, as well as the backbone of several monoterpenes. The ability to use such spectrum of compounds as sole carbon source is, most probably, associated with a genetic background evolved under different environmental constraints. The outstanding performance of M1 strain regarding β-myrcene catabolism was elucidated in this work, with focus on the biocatalytical potential of β-myrcene-associated core-code, comprised in a 28-kb genomic island (GI), predicted to be organized in 8 transcriptional units...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28213475/wheat-landrace-genome-diversity
#7
Luzie U Wingen, Claire West, Michelle Leverington-Waite, Sarah Collier, Simon Orford, Richard Goram, Cai-Yun Yang, Julie King, Alexandra M Allen, Amanda Burridge, Keith J Edwards, Simon Griffiths
Understanding the genomic complexity of bread wheat (Triticum aestivum L.) is a cornerstone in the quest to unravel the processes of domestication and the following adaptation of domesticated wheat to a wide variety of environments across the globe. Additionally, it is of importance for future improvement of the crop, particularly in the light of climate change. Focussing on the adaptation after domestication, a nested association mapping (NAM) panel of 60 segregating bi-parental populations were developed mainly involving landrace accessions from the core set of the Watkins hexaploid wheat collection optimized for genetic diversity (WINGEN et al...
February 17, 2017: Genetics
https://www.readbyqxmd.com/read/28213278/identifying-overarching-excipient-properties-towards-an-in-depth-understanding-of-process-and-product-performance-for-continuous-twin-screw-wet-granulation
#8
N Willecke, A Szepes, M Wunderlich, J P Remon, C Vervaet, T De Beer
The overall objective of this work is to understand how excipient characteristics influence the process and product performance for a continuous twin-screw wet granulation process. The knowledge gained through this study is intended to be used for a Quality by Design (QbD)-based formulation design approach and formulation optimization. A total of 9 preferred fillers and 9 preferred binders were selected for this study. The selected fillers and binders were extensively characterized regarding their physico-chemical and solid state properties using 21 material characterization techniques...
February 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28213013/time-course-of-germination-initiation-of-mycelium-proliferation-and-probability-of-visible-growth-and-detectable-afb1-production-of-an-isolate-of-aspergillus-flavus-on-pistachio-extract-agar
#9
Laila Aldars-García, Vicente Sanchis, Antonio J Ramos, Sonia Marín
The aim of this work was to assess the temporal relationship among quantified germination, mycelial growth and aflatoxin B1 (AFB1) production from colonies coming from single spores, in order to find the best way to predict as accurately as possible the presence of AFB1 at the early stages of contamination. Germination, mycelial growth, probability of growth and probability of AFB1 production of an isolate of Aspergillus flavus were determined at 25 °C and two water activities (0.85 and 0.87) on 3% Pistachio Extract Agar (PEA)...
June 2017: Food Microbiology
https://www.readbyqxmd.com/read/28212589/a-multicenter-initiative-for-critical-congenital-heart-disease-newborn-screening-in-texas-neonatal-intensive-care-units
#10
Alice Gong, Charleta Guillory, Liza Creel, Judith Ellen Livingtson, Tiffany M McKee-Garrett, Regine Fortunov
Objective The objective of this study was to implement a strategy for critical congenital heart disease (CCHD) newborn screening in the neonatal intensive care unit (NICU). Design A NICU-specific curriculum, screening algorithm, slide presentations, and templates of orders, policies, and procedures were developed into a toolkit for training NICU personnel. Screening was conducted on first and second screen pre- and postductal oxygen saturations (SpO2) on newborns admitted or transferred to the NICU. Results We trained 347 NICU personnel in 13 Texas hospitals, representing rural, suburban, and metropolitan settings...
February 17, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28212409/pathogenic-waterborne-free-living-amoebae-an-update-from-selected-southeast-asian-countries
#11
Mohamad Azlan Abdul Majid, Tooba Mahboob, Brandon G J Mong, Narong Jaturas, Reena Leeba Richard, Tan Tian-Chye, Anusorn Phimphila, Panomphanh Mahaphonh, Kyaw Nyein Aye, Wai Lynn Aung, Joon Chuah, Alan D Ziegler, Atipat Yasiri, Nongyao Sawangjaroen, Yvonne A L Lim, Veeranoot Nissapatorn
Data on the distribution of free-living amoebae is still lacking especially in Southeast Asian region. The aquatic environment revealed a high occurrence of free-living amoebae (FLA) due to its suitable condition and availability of food source, which subsequently causes infection to humans. A total of 94 water samples consisted of both treated and untreated from Laos (31), Myanmar (42), and Singapore (21) were investigated for the presence of pathogenic FLA. Each water sample was filtered and cultured onto non-nutrient agar seeded with live suspension of Escherichia coli and incubated at room temperature...
2017: PloS One
https://www.readbyqxmd.com/read/28212102/prediction-of-patient-controlled-analgesic-consumption-a-multimodel-regression-tree-approach
#12
Yuh-Jyh Hu, Tien-Hsiung Ku, Yu-Hung Yang, Jia-Ying Shen
Several factors contribute to individual variability in postoperative pain; therefore, individuals consume postoperative analgesics at different rates. Although many statistical studies have analyzed postoperative pain and analgesic consumption, most have identified only the correlation and have not subjected the statistical model to further tests in order to evaluate its predictive accuracy. In this study involving 3052 patients, a multistrategy computational approach was developed for analgesic consumption prediction...
February 13, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28211968/verse-guided-parallel-rf-excitations-using-dynamic-field-correction
#13
Mustafa Çavuşoğlu, Ronald Mooiweer, Klaas P Pruessmann, Shaihan J Malik
In parallel RF pulse design, peak RF magnitudes and specific absorption rate levels are critical concerns in the hardware and safety limits. The variable rate selective excitation (VERSE) method is an efficient technique to limit the peak RF power by applying a local-only RF and gradient waveform reshaping while retaining the on-resonance profile. The accuracy of the excitation performed by the VERSEd RF and gradient waveforms strictly depends on the performance of the employed hardware. Any deviation from the nominal gradient fields as a result of frequency dependent system imperfections violates the VERSE condition similarly to off-resonance effects, leading to significant excitation errors and the RF pulse not converging to the targeted peak RF power...
February 17, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28211787/clinical-factors-influencing-the-decision-to-order-red-blood-cell-transfusions-for-a-sample-of-us-dialysis-patients%C3%A2
#14
J Mark Stephens, John P Caloyeras, John Holmen, Victoria A Kumar, Spiros Tzivelekis, Allan Pollock
AIM: To characterize the clinical context for the decision to order red blood cell (RBC) transfusions in dialysis patients. MATERIALS AND METHODS: Retrospective review of medical records from three integrated health systems serving chronic dialysis patients. Subjects were randomly selected from all patients who received at least one transfusion between January 2009 and December 2013. Data abstracted included transfusion setting, prescribing clinician type, patient demographics and hemoglobin (Hb) concentration prior to transfusion, and cataloguing and prioritizing of clinical factors for their contribution to the decision to transfuse...
February 17, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28211686/multipole-moments-in-the-effective-fragment-potential-method
#15
Colleen Bertoni, Lyudmila V Slipchenko, Alston J Misquitta, Mark S Gordon
In the effective fragment potential (EFP) method the Coulomb potential is represented using a set of multipole moments generated by the distributed multipole analysis (DMA) method. Misquitta, Stone, and Fazeli recently developed a basis space-iterated stockholder atom (BS-ISA) method to generate multipole moments. This study assesses the accuracy of the EFP interaction energies using sets of multipole moments generated from the BS-ISA method, and from several versions of the DMA method (such as analytic and numeric grid-based), with varying basis sets...
February 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28211160/optical-characteristics-of-alvarez-variable-power-spectacles
#16
Hema Radhakrishnan, W Neil Charman
PURPOSE: To establish the optical performance of currently available Alvarez variable-power spectacles in relation to their possible utility for ametropes and presbyopes. METHODS: Two commercial designs of variable-power (variable-focus) spectacles were studied: FocusSpecs and Adlens Adjustables. Using focimetry, power and prism at three different power settings were measured across the aperture of the lenses of each design and local optical quality was explored in more detail using interferometry...
February 17, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28211141/potential-relocation-of-climatic-environments-suggests-high-rates-of-climate-displacement-within-the-north-american-protection-network
#17
Enric Batllori, Marc-André Parisien, Sean A Parks, Max A Moritz, Carol Miller
Ongoing climate change may undermine the effectiveness of protected area networks in preserving the set of biotic components and ecological processes they harbor, thereby jeopardizing their conservation capacity into the future. Metrics of climate change, particularly rates and spatial patterns of climatic alteration, can help assess potential threats. Here, we perform a continent-wide climate change vulnerability assessment whereby we compare the baseline climate of the protected area network in North America (Canada, USA, México - NAM) to the projected end-of-century climate (2071-2100)...
February 17, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28211066/how-computational-methods-and-relativistic-effects-influence-the-study-of-chemical-reactions-involving-ru-no-complexes
#18
Renato Pereira Orenha, Régis Tadeu Santiago, Roberto Luiz Andrade Haiduke, Sérgio Emanuel Galembeck
Two treatments of relativistic effects, namely effective core potentials (ECP) and all-electron scalar relativistic effects (DKH2), are used to obtain geometries and chemical reaction energies for a series of ruthenium complexes in B3LYP/def2-TZVP calculations. Specifically, the reaction energies of reduction (A-F), isomerization (G-I), and Cl(-) negative trans influence in relation to NH3 (J-L) are considered. The ECP and DKH2 approaches provided geometric parameters close to experimental data and the same ordering for energy changes of reactions A-L...
February 16, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28211025/participants-shift-response-deadlines-based-on-list-difficulty-during-reading-aloud-megastudies
#19
Michael J Cortese, Maya M Khanna, Robert Kopp, Jonathan B Santo, Kailey S Preston, Tyler Van Zuiden
We tested the list homogeneity effect in reading aloud (e.g., Lupker, Brown, & Colombo, 1997) using a megastudy paradigm. In each of two conditions, we used 25 blocks of 100 trials. In the random condition, words were selected randomly for each block, whereas in the experimental condition, words were blocked by difficulty (e.g., easy words together, etc.), but the order of the blocks was randomized. We predicted that standard factors (e.g., frequency) would be more predictive of reaction times (RTs) in the blocked than in the random condition, because the range of RTs across the experiment would increase in the blocked condition...
February 16, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28210879/theoretical-study-of-the-spectroscopic-and-nonlinear-optical-properties-of-trans-and-cis-4-hydroxyazobenzene
#20
Hai-Peng Li, Ze-Tong Bi, Wen-Yue Fu, Run-Feng Xu, Yi Zhang, Xiao-Peng Shen, Ming-Xue Li, Gang Tang, Kui Han
We investigate the molecular structure, vibrational and electronic absorption spectra, and electronic hyperpolarizabilities of trans and cis isomers of 4-hydroxyazobenzene (HOAB) via density functional theory. Results show that the azo dye exhibits a high third-order nonlinear optical response and good optical transparency. Both the basis set and the functional are important influences on the results obtained when calculating the absorption spectrum and NLO response. We also study the effect of the solvent on the electronic absorption spectrum to assess the ability of the functional to reproduce the experimental spectrum in combination with a suitable solvent model...
March 2017: Journal of Molecular Modeling
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