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https://www.readbyqxmd.com/read/28918550/advance-care-planning-challenges-at-the-emergency-department-of-a-cancer-care-center
#1
Maria T Cruz-Carreras, Patrick Chaftari, Jayne Viets-Upchurch
INTRODUCTION: Code status discussions form an important part of advance care planning (ACP) as it enables physicians to respect the patient's wishes for end-of-life care. However, in some cases, code status discussions can be challenging causing the physician to go against the patient's wishes and the code of medical ethics. This is especially true in an emergency setting. In this paper, we will discuss three cases of advanced cancer patients, where code status discussions posed challenges to healthcare providers...
September 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28918421/macrophage-activation-syndrome-at-the-onset-of-glucocorticoid-resistant-systemic-lupus-erythematosus-a-case-report
#2
Delia Tulbă, Marius Balea, Cristian Băicuș
INTRODUCTION: Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory state mediated by uncontrolled cytokine storm and haemophagocytosis. Although rarely reported, MAS might occur in systemic lupus erythematosus (SLE), notably as an inaugural manifestation. Glucocorticoids (GCs) are the cornerstone of SLE therapy. However, in some cases high doses of GCs are required to achieve remission (i.e. glucocorticoid-resistance), leading to significant side effects. CASE REPORT: A 28-year-old Romani male was admitted to our hospital for polyarthralgia, polyserositis and fatigability...
September 16, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28918344/accesses-for-alcohol-intoxication-to-the-emergency-department-and-the-risk-of-re-hospitalization-an-observational-retrospective-study
#3
Maurizio Baldassarre, Fabio Caputo, Raimondo Maria Pavarin, Matteo Massimo Bossi, Maria Elena Bonavita, Paolo Caraceni, Alice Grignaschi, Mimosa Balloni, Mario Cavazza, Mauro Bernardi, Marco Domenicali
BACKGROUND: Alcohol use disorders (AUD) are a frequent cause of admission to emergency departments (EDs) for acute alcohol intoxication (AAI). Patients with AUD present a higher risk of readmission to EDs for AAI than the general population, however, the distinction between sporadic AAI and AAI in the context of AUD in the ED setting is difficult. AIMS: To analyze the epidemiological characteristics of patients admitted to EDs because of AAI and to identify factors associated with repeated admissions in order to develop a risk stratification system for patients with AUD based on objective data that can be easily applied in an ED setting...
September 1, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28918193/psychedelic-pleasures-an-affective-understanding-of-the-joys-of-tripping
#4
Frederik Bøhling
BACKGROUND: This paper considers the pleasures of psychedelic drugs and proposes a Deleuzian understanding of drugged pleasures as affects. In spite of a large body of work on psychedelics, not least on their therapeutic potentials, the literature is almost completely devoid of discussions of the recreational practices and pleasures of entheogenic drugs. Yet, most people do not use psychedelics because of their curative powers, but because they are fun and enjoyable ways to alter the experience of reality...
September 13, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28917917/characterization-of-structural-cell-wall-polysaccharides-in-cattail-typha-latifolia-evaluation-as-potential-biofuel-feedstock
#5
Diego Rebaque, Romina Martínez-Rubio, Silvia Fornalé, Penélope García-Angulo, Ana Alonso-Simón, Jesús M Álvarez, David Caparros-Ruiz, José L Acebes, Antonio Encina
Second generation bioethanol produced from lignocellulosic biomass is attracting attention as an alternative energy source. In this study, a detailed knowledge of the composition and structure of common cattail (Typha latifolia L.) cell wall polysaccharides, obtained from stem or leaves, has been conducted using a wide set of techniques to evaluate this species as a potential bioethanol feedstock. Our results showed that common cattail cellulose content was high for plants in the order Poales and was accompanied by a small amount of cross-linked polysaccharides...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917826/potassic-zeolites-from-brazilian-coal-ash-for-use-as-a-fertilizer-in-agriculture
#6
Camila Gomes Flores, Helena Schneider, Nilson Romeu Marcilio, Lizete Ferret, João Carlos Pinto Oliveira
Brazilian coal has an ash content ranging from 30 to 50% by weight. Consequently, its use in coal-fired thermoelectric for power production generates a lot of waste. The construction sector is the largest consumer of coal ash, but it cannot absorb the entire amount generated. Thus, other applications for coal ash should be studied in aim to optimize the use of this industrial waste. This research had as focus to synthesize potassic zeolite from of the coal ash into on potassium fertilizer for the grown wheat plant...
September 13, 2017: Waste Management
https://www.readbyqxmd.com/read/28917817/mechanistic-insight-into-degradation-of-endocrine-disrupting-chemical-by-hydroxyl-radical-an-experimental-and-theoretical-approach
#7
Ruiyang Xiao, Lingwei Gao, Zongsu Wei, Richard Spinney, Shuang Luo, Donghong Wang, Dionysios D Dionysiou, Chong-Jian Tang, Weichun Yang
Advanced oxidation processes (AOPs) based on formation of free radicals at ambient temperature and pressure are effective for treating endocrine disrupting chemicals (EDCs) in waters. In this study, we systematically investigated the degradation kinetics of bisphenol A (BPA), a representative EDC by hydroxyl radical (OH) with a combination of experimental and theoretical approaches. The second-order rate constant (k) of BPA with OH was experimentally determined to be 7.2 ± 0.34 × 10(9) M(-1) s(-1) at pH 7...
September 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28917198/dissipation-behavior-and-residue-distribution-of-fluazaindolizine-and-its-seven-metabolites-in-tomato-ecosystem-based-on-sax-spe-procedure-using-hplc-qqq-ms-ms-technique
#8
Xiaoxin Chen, Xi Li, Kyongjin Pang, Xueqi Fan, Yecheng Ma, Jiye Hu
Fluazaindolizine suspension concentrate (500gL(-1) SC), as a pre-commercialized product, was firstly investigated under open-field conditions. A sensitive method for simultaneous determination of fluazaindolizine and seven metabolites (IN-QEK31, IN-F4106, IN-A5760, IN-UJV12, IN-UNS90, IN-QZY47 and IN-TMQ01) was established and validated using HPLC-QqQ-MS/MS technique. The LOQs of these pollutants in tomato were 0.01mgkg(-1), and their recoveries were 81.1%-117% with the relative standard deviations (RSDs <11...
August 25, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28917116/thermal-and-photo-induced-degradation-of-perfluorinated-carboxylic-acids-kinetics-and-mechanism
#9
Jiaoqin Liu, Ruijuan Qu, Zunyao Wang, Itza Mendoza-Sanchez, Virender K Sharma
Perfluorinated carboxylic acids (PFCAs) of different carbon chain lengths are chemicals of concern to human health and their removal, using conventional remediation technologies, is challenging. The present paper pursuits thermal and photo-induced degradation of PFCAs (F(CF2)nCOOH, n = 1-9) under various concentrations of four different acids (HNO3, H2SO4, HCl, and H3PO4) covering a range of strong acidic to basic pH. For thermal-induced experiments, the temperature was set at 40 °C, 60 °C, and 80 °C at acid strengths of 0...
September 6, 2017: Water Research
https://www.readbyqxmd.com/read/28917105/optimal-conditions-for-flexible-methane-production-in-a-demand-based-operation-of-biogas-plants
#10
W Laperrière, B Barry, M Torrijos, B Pechiné, N Bernet, J P Steyer
The aim of the presented work was to study the methane production limits and to determine optimal conditions for flexible operation of an anaerobic reactor in order to set up an operational strategy. Punctual overloads were conducted in a laboratory-scale anaerobic reactor with readily biodegradable solid substrates, and the influences of overload intensity, baseload value and substrate used were investigated. A maximal daily value around 1000mL/L of reactor for methane production has been assessed. This value did not evolve significantly during experiment time, and conditioned the persistence of overloads as well as the flexibility margin on the reactor, which ranged from +25% to +140% on daily production...
September 5, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28916964/presence-of-a-3fe-4s-cluster-in-a-psac-variant-as-a-functional-component-of-the-photosystem-i-electron-transfer-chain-in-synechococcus-sp-pcc-7002
#11
Adam A Pérez, Bryan H Ferlez, Amanda M Applegate, Karim Walters, Zhihui He, Gaozhong Shen, John H Golbeck, Donald A Bryant
A site-directed C14G mutation was introduced into the stromal PsaC subunit of Synechococcus sp. strain PCC 7002 in vivo in order to introduce an exchangeable coordination site into the terminal FB [4Fe-4S] cluster of Photosystem I (PSI). Using an engineered PSI-less strain (psaAB deletion), psaC was deleted and replaced with recombinant versions controlled by a strong promoter, and the psaAB deletion was complemented. Modified PSI accumulated at lower levels in this strain and supported slower photoautotrophic growth than wild type...
September 15, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28916788/a-v0-core-neuronal-circuit-for-inspiration
#12
Jinjin Wu, Paolo Capelli, Julien Bouvier, Martyn Goulding, Silvia Arber, Gilles Fortin
Breathing in mammals relies on permanent rhythmic and bilaterally synchronized contractions of inspiratory pump muscles. These motor drives emerge from interactions between critical sets of brainstem neurons whose origins and synaptic ordered organization remain obscure. Here, we show, using a virus-based transsynaptic tracing strategy from the diaphragm muscle in the mouse, that the principal inspiratory premotor neurons share V0 identity with, and are connected by, neurons of the preBötzinger complex that paces inspiration...
September 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28916710/apc-sets-the-wnt-tone-necessary-for-cerebral-cortical-progenitor-development
#13
Naoki Nakagawa, Jingjun Li, Keiko Yabuno-Nakagawa, Tae-Yeon Eom, Martis Cowles, Tavien Mapp, Robin Taylor, E S Anton
Adenomatous polyposis coli (APC) regulates the activity of β-catenin, an integral component of Wnt signaling. However, the selective role of the APC-β-catenin pathway in cerebral cortical development is unknown. Here we genetically dissected the relative contributions of APC-regulated β-catenin signaling in cortical progenitor development, a necessary early step in cerebral cortical formation. Radial progenitor-specific inactivation of the APC-β-catenin pathway indicates that the maintenance of appropriate β-catenin-mediated Wnt tone is necessary for the orderly differentiation of cortical progenitors and the resultant formation of the cerebral cortex...
September 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28916595/normative-data-for-flow-cytometry-immunophenotyping-of-benign-lymph-nodes-sampled-by-surgical-biopsy
#14
Gregory David Scott, Susan K Atwater, Dita A Gratzinger
AIMS: To create clinically relevant normative flow cytometry data for understudied benign lymph nodes and characterise outliers. METHODS: Clinical, histological and flow cytometry data were collected and distributions summarised for 380 benign lymph node excisional biopsies. Outliers for kappa:lambda light chain ratio, CD10:CD19 coexpression, CD5:CD19 coexpression, CD4:CD8 ratios and CD7 loss were summarised for histological pattern, concomitant diseases and follow-up course...
September 15, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28916367/rucaparib-maintenance-treatment-for-recurrent-ovarian-carcinoma-after-response-to-platinum-therapy-ariel3-a-randomised-double-blind-placebo-controlled-phase-3-trial
#15
Robert L Coleman, Amit M Oza, Domenica Lorusso, Carol Aghajanian, Ana Oaknin, Andrew Dean, Nicoletta Colombo, Johanne I Weberpals, Andrew Clamp, Giovanni Scambia, Alexandra Leary, Robert W Holloway, Margarita Amenedo Gancedo, Peter C Fong, Jeffrey C Goh, David M O'Malley, Deborah K Armstrong, Jesus Garcia-Donas, Elizabeth M Swisher, Anne Floquet, Gottfried E Konecny, Iain A McNeish, Clare L Scott, Terri Cameron, Lara Maloney, Jeff Isaacson, Sandra Goble, Caroline Grace, Thomas C Harding, Mitch Raponi, James Sun, Kevin K Lin, Heidi Giordano, Jonathan A Ledermann
BACKGROUND: Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-wide loss of heterozygosity. In this trial we assessed rucaparib versus placebo after response to second-line or later platinum-based chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma. METHODS: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited patients from 87 hospitals and cancer centres across 11 countries...
September 12, 2017: Lancet
https://www.readbyqxmd.com/read/28915471/characterization-of-mechanical-properties-of-pericardium-tissue-using-planar-biaxial-tension-and-flexural-deformation
#16
Kyle Murdock, Caitlin Martin, Wei Sun
Flexure is an important mode of deformation for native and bioprosthetic heart valves. However, mechanical characterization of bioprosthetic leaflet materials has been done primarily through planar tensile testing. In this study, an integrated experimental and computational cantilever beam bending test was performed to characterize the flexural properties of glutaraldehyde-treated bovine and porcine pericardium of different thicknesses. A strain-invariant based structural constitutive model was used to model the pericardial mechanical behavior quantified through the bending tests of this study and the planar biaxial tests previously performed...
September 12, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28915255/scrambled-eggs-a-highly-sensitive-molecular-diagnostic-workflow-for-fasciola-species-specific-detection-from-faecal-samples
#17
Nichola Eliza Davies Calvani, Peter Andrew Windsor, Russell David Bush, Jan Šlapeta
BACKGROUND: Fasciolosis, due to Fasciola hepatica and Fasciola gigantica, is a re-emerging zoonotic parasitic disease of worldwide importance. Human and animal infections are commonly diagnosed by the traditional sedimentation and faecal egg-counting technique. However, this technique is time-consuming and prone to sensitivity errors when a large number of samples must be processed or if the operator lacks sufficient experience. Additionally, diagnosis can only be made once the 12-week pre-patent period has passed...
September 15, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28915100/promotion-of-immunizations-for-health-professionals-in-europe-a-qualitative-study-in-seven-european-member-states
#18
Archontoula Dalma, Pania Karnaki, Agoritsa Baka, Vasilios Raftopoulos, Dina Zota, Afroditi Veloudaki, Amanda Garrison, Paloma Ellis Montalban, Zainub Dhanani, Athena Linos
Health Care Workers (HCWs) are a high-risk group for contracting Vaccine-Preventable Diseases who, despite legislation and guidance, remain undervaccinated. In order to understand their barriers and needs, focus groups were formed with 278 physicians, nurses, infection-control personnel, and policy-makers in 7 EU MS. Several implications for the development of promotional initiatives were identified including the need to overcome organizational barriers, to sensitize HCWs about the importance of immunization and to provide specific up-to-date information about vaccinations covering prevalence of diseases, protection years, side effects, administration times, antibody examinations, costs and immunization settings...
September 15, 2017: Hospital Topics
https://www.readbyqxmd.com/read/28915072/parent-driven-campaign-videos-an-analysis-of-the-motivation-and-affect-of-videos-created-by-parents-of-children-with-complex-healthcare-needs
#19
Bernie Carter, Lucy Bray, Paula Keating, Catherine Wilkinson
Caring for a child with complex health care needs places additional stress and time demands on parents. Parents often turn to their peers to share their experiences, gain support, and lobby for change; increasingly this is done through social media. The WellChild #notanurse_but is a parent-driven campaign that states its aim is to "shine a light" on the care parents, who are not nurses, have to undertake for their child with complex health care needs and to raise decision-makers' awareness of the gaps in service provision and support...
September 15, 2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/28915003/the-evolution-of-dna-templated-synthesis-as-a-tool-for-materials-discovery
#20
Rachel K O'Reilly, Andrew J Turberfield, Thomas R Wilks
Precise control over reactivity and molecular structure is a fundamental goal of the chemical sciences. Billions of years of evolution by natural selection have resulted in chemical systems capable of information storage, self-replication, catalysis, capture and production of light, and even cognition. In all these cases, control over molecular structure is required to achieve a particular function: without structural control, function may be impaired, unpredictable, or impossible. The search for molecules with a desired function is often achieved by synthesizing a combinatorial library, which contains many or all possible combinations of a set of chemical building blocks (BBs), and then screening this library to identify "successful" structures...
September 15, 2017: Accounts of Chemical Research
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