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https://www.readbyqxmd.com/read/29783184/postoperative-outcomes-in-patients-with-a-do-not-resuscitate-dnr-order-undergoing-elective-procedures
#1
Ethan Y Brovman, Elisa C Walsh, Brittany N Burton, Christine E Kuo, Charlotta Lindvall, Rodney A Gabriel, Richard D Urman
STUDY OBJECTIVE: Do-not-resuscitate (DNR) status has been shown to be an independent risk factor for mortality in the post-operative period. Patients with DNR orders often undergo elective surgeries to alleviate symptoms and improve quality of life, but there are limited data on outcomes for informed decision making. DESIGN: Retrospective cohort study. SETTING: A multi-institutional setting including operating room, postoperative recovery area, inpatient wards, and the intensive care unit...
May 18, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29782536/fungal-type-carbohydrate-binding-modules-from-the-coccolithophore-emiliania-huxleyi-show-binding-affinity-to-cellulose-and-chitin
#2
Bart J M Rooijakkers, Martina S Ikonen, Markus B Linder
Six fungal-type cellulose binding domains were found in the genome of the coccolithophore Emiliania huxleyi and cloned and expressed in Escherichia coli. Sequence comparison indicate high similarity to fungal cellulose binding domains, raising the question of why these domains exist in coccolithophores. The proteins were tested for binding with cellulose and chitin as ligands, which resulted in the identification of two functional carbohydrate binding modules: EHUX2 and EHUX4. Compared to benchmark fungal cellulose binding domain Cel7A-CBM1 from Trichoderma reesei, these proteins showed slightly lower binding to birch and bacterial cellulose, but were more efficient chitin binders...
2018: PloS One
https://www.readbyqxmd.com/read/29782061/improving-self-management-for-persons-with-parkinson-s-disease-through-education-focusing-on-management-of-daily-life-patients-and-relatives-experience-of-the-swedish-national-parkinson-school
#3
Carina Hellqvist, Nil Dizdar, Peter Hagell, Carina Berterö, Märta Sund Levander
AIMS AND OBJECTIVE: The two folded aim of this study was firstly to identify and describe experiences valuable for managing daily life after participation in the NPS self-management intervention. The second part was to explore the applicability of the Self- and family management framework by Grey and colleagues for persons with Parkinson's Disease and their relatives. BACKGROUND: The impact of PD is evident on the lives of both patients and relatives. The National Parkinson School (NPS) is a Swedish self-management program designed for patients and relatives, aiming at teaching strategies helpful for the ability of self-management, in order to promote life satisfaction...
May 21, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29781939/order-effects-of-resistance-and-stretching-exercises-on-heart-rate-variability-and-blood-pressure-in-healthy-adults
#4
Gleisson da Silva Araujo, David G Behm, Estêvão Rios Monteiro, Aline Gomes Ferreira de Melo Fiuza, Thiago Matassoli Gomes, Jefferson Macedo Vianna, Michel Silva Reis, Jefferson da Silva Novaes
da Silva Araujo, G, Behm, DG, Monteiro, ER, de Melo Fiuza, AGF, Gomes, TM, Vianna, JM, Reis, MS, and da Silva Novaes, J. Order effects of resistance and stretching exercises on heart rate variability and blood pressure in healthy adults. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to compare the acute effect of different combinations and order of resistance exercise (RE) and stretching exercise (SE) on heart rate variability, systolic blood pressure (SBP), and diastolic blood pressure (DBP)...
May 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29781779/comparisons-of-false-negative-rates-from-a-trend-test-alone-and-from-a-trend-test-jointly-with-a-control-high-groups-pairwise-test-in-the-determination-of-the-carcinogenicity-of-new-drugs
#5
Karl K Lin, Mohammad A Rahman
Interest has been expressed in using a joint test procedure that requires that the results of both a trend test and a pairwise comparison test between the control and the high groups be statistically significant simultaneously at the levels of significance recommended in the FDA 2001 draft guidance for industry document for the separate tests in order for the drug effect on the development of an individual tumor type to be considered as statistically significant. Results of our simulation studies show that there is a serious consequence of large inflations of the false negative rate through large decreases of false positive rate in the use of the above joint test procedure in the final interpretation of the carcinogenicity potential of a new drug if the levels of significance recommended for separate tests are used...
May 21, 2018: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/29781480/polydisperse-emulsion-digital-assay-to-enhance-time-to-detection-and-extend-dynamic-range-in-bacterial-cultures-enabled-by-a-statistical-framework
#6
Samantha A Byrnes, Elizabeth A Phillips, Toan Huynh, Bernhard H Weigl, Kevin P Nichols
Microbiological culture remains the most sensitive method for detecting viable and infectious bacteria, but these methods often require at least 24 hours to visibly identify bacterial growth. Lab-on-a-chip applications have utilized methods to isolate bacteria in picoliter-sized reaction vessels, resulting in digitized signals that offer improved time-to-detection and improved quantification. Although a great improvement, these approaches typically require expensive and specialized equipment, trained laboratory personnel, and maximum addressable volumes that can be orders of magnitude less than needed for clinically relevant limits of detection...
May 21, 2018: Analyst
https://www.readbyqxmd.com/read/29781395/judicialization-2-0-understanding-right-to-health-litigation-in-real-time
#7
João Biehl, Mariana P Socal, Varun Gauri, Debora Diniz, Marcelo Medeiros, Gabriela Rondon, Joseph J Amon
Over the past two decades, debate over the whys, the hows, and the effects of the ever-expanding phenomenon of right-to-health litigation ('judicialization') throughout Latin America have been marked by polarised arguments and limited information. In contrast to claims of judicialization as a positive or negative trend, less attention has been paid to ways to better understand the phenomenon in real time. In this article, we propose a new approach-Judicialization 2.0-that recognises judicialization as an integral part of democratic life...
May 21, 2018: Global Public Health
https://www.readbyqxmd.com/read/29781375/the-effects-of-bilingual-language-proficiency-on-recall-accuracy-and-semantic-clustering-in-free-recall-output-evidence-for-shared-semantic-associations-across-languages
#8
Wendy S Francis, Randolph S Taylor, Marisela Gutiérrez, Mary K Liaño, Diana G Manzanera, Renee M Penalver
Two experiments investigated how well bilinguals utilise long-standing semantic associations to encode and retrieve semantic clusters in verbal episodic memory. In Experiment 1, Spanish-English bilinguals (N = 128) studied and recalled word and picture sets. Word recall was equivalent in L1 and L2, picture recall was better in L1 than in L2, and the picture superiority effect was stronger in L1 than in L2. Semantic clustering in word and picture recall was equivalent in L1 and L2. In Experiment 2, Spanish-English bilinguals (N = 128) and English-speaking monolinguals (N = 128) studied and recalled word sequences that contained semantically related pairs...
May 19, 2018: Memory
https://www.readbyqxmd.com/read/29780431/mathematical-modelling-of-bacterial-meningitis-transmission-dynamics-with-control-measures
#9
Joshua Kiddy K Asamoah, Farai Nyabadza, Baba Seidu, Mehar Chand, Hemen Dutta
Vaccination and treatment are the most effective ways of controlling the transmission of most infectious diseases. While vaccination helps susceptible individuals to build either a long-term immunity or short-term immunity, treatment reduces the number of disease-induced deaths and the number of infectious individuals in a community/nation. In this paper, a nonlinear deterministic model with time-dependent controls has been proposed to describe the dynamics of bacterial meningitis in a population. The model is shown to exhibit a unique globally asymptotically stable disease-free equilibrium ℰ 0 , when the effective reproduction number ℛ VT ≤ 1, and a globally asymptotically stable endemic equilibrium ℰ 1 , when ℛ VT > 1; and it exhibits a transcritical bifurcation at ℛ VT = 1...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29780271/development-and-evaluation-of-the-r-line-model-algorithms-to-account-for-chemical-transformation-in-the-near-road-environment
#10
Alejandro Valencia, Akula Venkatram, David Heist, David Carruthers, Saravanan Arunachalam
With increased urbanization, there is increased mobility leading to higher amount of traffic-related activity on a global scale. Most NOx from combustion sources (about 90-95%) are emitted as NO, which is then readily converted to NO2 in the ambient air, while the remainder is emitted largely as NO2 . Thus, the bulk of ambient NO2 is formed due to secondary production in the atmosphere, and which R-LINE cannot predict given that it can only model the dispersion of primary air pollutants. NO2 concentrations near major roads are appreciably higher than those measured at monitors in existing networks in urban areas, motivating a need to incorporate a mechanism in R-LINE to account for NO2 formation...
2018: Transportation Research. Part D, Transport and Environment
https://www.readbyqxmd.com/read/29780265/does-focused-and-dedicated-teaching-improve-the-confidence-of-gp-trainees-to-diagnose-and-manage-common-acute-ent-pathologies-in-primary-care
#11
Vikas Acharya, Matthew Haywood, Naomi Kokkinos, Anisha Raithatha, Sinthuja Francis, Rishi Sharma
Background: General practitioners (GPs) are key members of the health care profession who are required to have a considerable breadth of knowledge to manage and treat patients effectively in the community. Their skills and experience varies depending on the medical school they attended and their foundation training and specialist GP training schemes. Exposure to ear, nose, and throat (ENT)-specific pathology is often insufficient due to the lack of formal otolaryngology rotations, minimal relevant teaching opportunities, and inconsistencies in curricula, despite ENT-related pathology presentations being one of the commonest consultations in primary care...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29780175/rapid-identification-of-a-cooling-tower-associated-legionnaires-disease-outbreak-supported-by-polymerase-chain-reaction-testing-of-environmental-samples-new-york-city-2014-2015
#12
Isaac Benowitz, Robert Fitzhenry, Christopher Boyd, Michelle Dickinson, Michael Levy, Ying Lin, Elizabeth Nazarian, Belinda Ostrowsky, Teresa Passaretti, Jennifer Rakeman, Amy Saylors, Elena Shamoonian, Terry-Ann Smith, Sharon Balter
We investigated an outbreak of eight Legionnaires' disease cases among persons living in an urban residential community of 60,000 people. Possible environmental sources included two active cooling towers (air-conditioning units for large buildings) <1 km from patient residences, a market misting system, a community-wide water system used for heating and cooling, and potable water. To support a timely public health response, we used real-time polymerase chain reaction (PCR) to identify Legionella DNA in environmental samples within hours of specimen collection...
April 2018: Journal of Environmental Health
https://www.readbyqxmd.com/read/29779751/can-shared-mechanisms-of-cultural-evolution-illuminate-the-process-of-creativity-within-the-arts-and-the-sciences
#13
Rory Allen, Pamela Heaton
All creative activity brings about change, since it results in the production of something that did not previously exist. The act of creation is itself influenced by changes that have been previously brought about by others, including previous acts of creation. As with any human behavior, creativity has both biological and cultural aspects and is therefore influenced by biological as well as cultural evolution. However, biological evolution operates slowly and over a much longer timescale than cultural evolution, and change occurring within a human lifetime must be driven by cultural and social, rather than biological processes...
2018: Progress in Brain Research
https://www.readbyqxmd.com/read/29779542/improving-data-for-behavioral-health-workforce-planning-development-of-a-minimum-data-set
#14
Angela J Beck, Phillip M Singer, Jessica Buche, Ronald W Manderscheid, Peter Buerhaus
The behavioral health workforce, which encompasses a broad range of professions providing prevention, treatment, and rehabilitation services for mental health conditions and substance use disorders, is in the midst of what is considered by many to be a workforce crisis. The workforce shortage can be attributed to both insufficient numbers and maldistribution of workers, leaving some communities with no behavioral health providers. In addition, demand for behavioral health services has increased more rapidly as a result of federal legislation over the past decade supporting mental health and substance use parity and by healthcare reform...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29779065/digital-technologies-in-the-treatment-of-anxiety-recent-innovations-and-future-directions
#15
REVIEW
Joseph Firth, John Torous, Rebekah Carney, Jill Newby, Theodore D Cosco, Helen Christensen, Jerome Sarris
PURPOSE OF REVIEW: This review aims to provide a comprehensive overview of the efficacy, limitations, and future of e-health treatments for anxiety. Within this, we provide detail on "first-generation" e-health approaches, such as computerized therapies. Additionally, we assess the emergence and early efficacy of newer methods of treatment delivery, including smartphone apps and virtual reality interventions, discussing the potential and pitfalls for each. RECENT FINDINGS: There is now substantial clinical research demonstrating the efficacy of internet-delivered cognitive behavioral therapy in the treatment of anxiety...
May 19, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29778318/quality-specifications-for-articles-of-botanical-origin-from-the-united-states-pharmacopeia
#16
Cuiying Ma, Hellen Oketch-Rabah, Nam-Cheol Kim, Maria Monagas, Anton Bzhelyansky, Nandakumara Sarma, Gabriel Giancaspro
BACKGROUND: In order to define appropriate quality of botanical dietary supplements, botanical drugs, and herbal medicines, the United States Pharmacopeia (USP) and the Herbal Medicines Compendium (HMC) contain science-based quality standards that include multiple interrelated tests to provide a full quality characterization for each article in terms of its identity, purity, and content. PURPOSE: To provide a comprehensive description of the pharmacopeial tests and requirements for articles of botanical origin in the aforementioned compendia...
April 10, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29778078/an-effective-and-low-cost-carbon-based-clean-up-method-for-pcdd-fs-and-pcbs-analysis-in-food
#17
Kleopatra Kedikoglou, Danae Costopoulou, Irene Vassiliadou, Evangelos Bakeas, Leondios Leondiadis
Sample preparation is of critical importance in dioxin analysis of food and feed samples. It is a complex procedure that includes lipid extraction followed by the application of chromatographic separation techniques, aiming in removing undesirable interferences from the matrix. The separation of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) from polychlorinated biphenyls (PCBs) is achieved by carbon-based materials which should have high fat capacity in order to be suitable for lipid-containing matrices...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29777927/patient-related-determinants-of-antibiotic-use-a-systematic-review
#18
REVIEW
V Zanichelli, G Tebano, I C Gyssens, V Vlahović-Palčevski, A A Monnier, M Stanic Benic, S Harbarth, M Hulscher, C Pulcini, B D Huttner
OBJECTIVES: We aimed to assess patient-related determinants potentially influencing antibiotic use. METHODS: Studies published in MEDLINE until 30/09/2015 were searched. We included: (1) qualitative studies describing patients' self-reported determinants of antibiotic use; (2) quantitative studies on either self-reported or objectively assessed determinants associated with antibiotic use. Whenever possible, reported determinants were categorized as "barriers" or "facilitators" of responsible antibiotic use...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777488/no-need-for-a-urine-culture-in-elderly-hospitalized-patients-with-a-negative-dipstick-test-result
#19
Zvi Shimoni, Vered Hermush, Joseph Glick, Paul Froom
To determine the clinical utility/disutility of canceling urine cultures in elderly patients with a negative dipstick. The cohort included consecutive patients aged ≥ 65 years hospitalized in internal medicine departments with an admission urinalysis and urine culture (January 1, 2014 to December 31, 2016). We calculated the sensitivity of the dipstick (either a trace leukocyte esterase or a positive nitrite test result) to detect patients with bacteriuria, and the decrease in urine cultures resulting from cancelation in patients with a negative dipstick...
May 18, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29777206/the-fair-guiding-principles-for-data-stewardship-fair-enough
#20
REVIEW
Martin Boeckhout, Gerhard A Zielhuis, Annelien L Bredenoord
The FAIR guiding principles for research data stewardship (findability, accessibility, interoperability, and reusability) look set to become a cornerstone of research in the life sciences. A critical appraisal of these principles in light of ongoing discussions and developments about data sharing is in order. The FAIR principles point the way forward for facilitating data sharing more systematically-provided that a number of ethical, methodological, and organisational challenges are addressed as well.
May 17, 2018: European Journal of Human Genetics: EJHG
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