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https://www.readbyqxmd.com/read/29792353/gastroretentive-raft-liquid-delivery-system-as-a-new-approach-to-release-extension-for-carrier-mediated-drug
#1
Samar M Abouelatta, Ahmed A Aboelwafa, Omaima N El-Gazayerly
Gabapentin (GBP), an antiepileptic and anti-neuropathic agent, suffers from short half-life (5-7 h), has narrow absorption window, and is absorbed via carrier-mediated mechanism resulting in frequent dosing, poor compliance, and poor bioavailability (<60%). Moreover, GBP is a freely water-soluble drug, thus it is considered a challenging candidate to be formulated as extended release dosage form. In this study, raft forming systems were investigated as a potential drug delivery system for prolonging gastric residence time of GBP...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29791476/identifying-county-characteristics-associated-with-resident-well-being-a-population-based-study
#2
Brita Roy, Carley Riley, Jeph Herrin, Erica S Spatz, Anita Arora, Kenneth P Kell, John Welsh, Elizabeth Y Rula, Harlan M Krumholz
BACKGROUND: Well-being is a positively-framed, holistic assessment of health and quality of life that is associated with longevity and better health outcomes. We aimed to identify county attributes that are independently associated with a comprehensive, multi-dimensional assessment of individual well-being. METHODS: We performed a cross-sectional study examining associations between 77 pre-specified county attributes and a multi-dimensional assessment of individual US residents' well-being, captured by the Gallup-Sharecare Well-Being Index...
2018: PloS One
https://www.readbyqxmd.com/read/29791470/quality-of-community-basic-medical-service-utilization-in-urban-and-suburban-areas-in-shanghai-from-2009-to-2014
#3
Lijun Guo, Yong Bao, Jun Ma, Shujun Li, Yuyang Cai, Wei Sun, Qiaohong Liu
Urban areas usually display better health care services than rural areas, but data about suburban areas in China are lacking. Hence, this cross-sectional study compared the utilization of community basic medical services in Shanghai urban and suburban areas between 2009 and 2014. These data were used to improve the efficiency of community health service utilization and to provide a reference for solving the main health problems of the residents in urban and suburban areas of Shanghai. Using a two-stage random sampling method, questionnaires were completed by 73 community health service centers that were randomly selected from six districts that were also randomly selected from 17 counties in Shanghai...
2018: PloS One
https://www.readbyqxmd.com/read/29791197/gender-differences-in-psychosocial-determinants-of-self-perceived-health-among-portuguese-older-adults-in-nursing-homes
#4
Violeta Alarcão, Teresa Madeira, Catarina Peixoto-Plácido, Nuno Sousa-Santos, Elisabete Fernandes, Paulo Nicola, Osvaldo Santos, João Gorjão-Clara
OBJECTIVES: Self-perceived health declines with age, varies by gender and is a predictor of mortality, morbidity, physical and psychological functioning. However, gender differences in health and illness perception are complex and not yet fully understood. This study aimed to explore gender-related differences in psychosocial determinants of self-perceived health among older adults living in nursing homes. METHOD: Nationwide face-to-face survey of the Portuguese population aged 65 and over...
May 23, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29790326/-the-quality-of-life-as-perceived-by-older-people-results-of-a-phenomenological-study
#5
Silvia Grosso, Elisa Ambrosi, Carla Benagli, Luigina Mortari, Federica Canzan
INTRODUCTION: Elderly Quality of life (QoL) is vulnerable because of the decline in physical and mental capacity, discharge from work, rupture of the family and isolation. Many QoL Scales are made for adults: there is little research investigating how older people perceive QOL. AIM: This study aims to explore and understand the perceptions that older people have about their QOL. METHOD: A qualitative research hermeneutics-phenomenological was done...
January 2018: Professioni Infermieristiche
https://www.readbyqxmd.com/read/29789799/the-impact-of-a-clinical-asthma-pathway-on-resident-education
#6
Hina J Talib, Yonit Lax, Marina Reznik
Clinical pathways for asthma management decrease hospital cost and length of stay; however little is known about the educational impact of pathways on residents. Pediatric residents at a children's hospital ( N = 114) were invited to complete a 22-item computerized, anonymous survey 6 months before and 6 months after asthma pathway implementation. The survey assessed pathway use and residents (1) pathway knowledge, (2) attitudes and experiences with managing asthma, and (3) perceived educational benefits. Mean pathway knowledge score increased from the case before to the case after implementation [1...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789260/respondent-driven-sampling-in-a-biomonitoring-study-of-refugees-from-burma-in-buffalo-new-york-who-eat-great-lakes-fish
#7
Ming Liu, Molly McCann, Elizabeth Lewis-Michl, Syni-An Hwang
BACKGROUND: Refugees from Burma who consume fish caught from local waterbodies have increased risk of exposure to environmental contaminants. We used respondent driven sampling (RDS) to sample this hard-to-reach population for the first Biomonitoring of Great Lakes Populations program. In the current study, we examined the interview data and assessed the effectiveness of RDS to sample the unique population. METHODS: In 2013, we used RDS to sample 205 Burmese refugees and immigrants residing in Buffalo, New York who consumed fish caught from Great Lakes waters...
April 30, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29789049/the-impact-of-cholinesterase-inhibitors-with-or-without-memantine-on-antipsychotic-prescribing
#8
Amie Taggart Blaszczyk, Belinda Hong Mang, Hennie Garza, Monica Mathys
Background Alzheimer's disease (AD) medications have been suggested to positively affect behavior, though not universally in all studies. Their impact on antipsychotic use is not well-defined. Methods This cross-sectional, retrospective study evaluated residents with AD on cholinesterase inhibitors, memantine, both, or neither throughout multiple long-term care facilities during July 2014. Patients were included if they: were between 65 and 89 years of age, had a diagnosis of AD, and had a cognitive assessment within three months of the study period...
May 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29788931/the-prevalence-of-substance-use-among-russian-somali-and-kurdish-migrants-in-finland-a-population-based-study
#9
Essi Salama, Solja Niemelä, Jaana Suvisaari, Tiina Laatikainen, Päivikki Koponen, Anu E Castaneda
BACKGROUND: Substance use is a well-known public health problem, but population-based research on migrants' substance use in Europe is limited. Factors related to the cultural background and current life situation might influence substance use among migrants. Here, the prevalence of substance use in Russian, Somali and Kurdish migrants in Finland is reported in comparison with the general population, and the associations between substance use and socio-economic and migration-related background factors among migrants are analysed...
May 22, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29788928/residents-breastfeeding-knowledge-comfort-practices-and-perceptions-results-of-the-breastfeeding-resident-education-study-brest
#10
Elizabeth Esselmont, Katherine Moreau, Mary Aglipay, Catherine M Pound
BACKGROUND: Physicians have a significant impact on new mothers' breastfeeding practices. However, physicians' breastfeeding knowledge is suboptimal. This knowledge deficit could be the result of limited breastfeeding education in residency. This study aimed to explore pediatric residents' breastfeeding knowledge, comfort level, clinical practices, and perceptions. It also investigated the level and type of education residents receive on breastfeeding and their preferences for improving it...
May 22, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29788921/signatures-of-host-specialization-and-a-recent-transposable-element-burst-in-the-dynamic-one-speed-genome-of-the-fungal-barley-powdery-mildew-pathogen
#11
Lamprinos Frantzeskakis, Barbara Kracher, Stefan Kusch, Makoto Yoshikawa-Maekawa, Saskia Bauer, Carsten Pedersen, Pietro D Spanu, Takaki Maekawa, Paul Schulze-Lefert, Ralph Panstruga
BACKGROUND: Powdery mildews are biotrophic pathogenic fungi infecting a number of economically important plants. The grass powdery mildew, Blumeria graminis, has become a model organism to study host specialization of obligate biotrophic fungal pathogens. We resolved the large-scale genomic architecture of B. graminis forma specialis hordei (Bgh) to explore the potential influence of its genome organization on the co-evolutionary process with its host plant, barley (Hordeum vulgare). RESULTS: The near-chromosome level assemblies of the Bgh reference isolate DH14 and one of the most diversified isolates, RACE1, enabled a comparative analysis of these haploid genomes, which are highly enriched with transposable elements (TEs)...
May 22, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29787918/management-of-adsorbent-content-in-waste-motor-oil-regeneration-by-spectrophotometrical-study-and-effective-acidification-in-production-of-nano-porous-clay
#12
Hooman Shabanzade, Amin Salem, Shiva Salem
In the present work the application of novel technique was highlighted for reduction of adsorbent content in recovery process of waste motor oil by effective acidification. The effects of acidification factors such as acid proportions, adsorbent dose, powder/acid ratio and residence time were analyzed on removal of contaminates from waste oil. Acetic, hydrochloric and sulfuric acids were mixed according to the statistical mixture design algorithm to prepare acidification agents. The dry original clay was submitted into the prepared acidic solutions...
May 16, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29787688/intake-and-factors-associated-with-consumption-of-pureed-food-in-long-term-care-an-analysis-of-making-the-most-of-mealtimes-m3-project
#13
Vanessa Vucea, Heather H Keller, Jill M Morrison, Alison M Duncan, Lisa M Duizer, Christina O Lengyel, Susan E Slaughter
Residents living in long term care (LTC) who consume a pureed diet tend to have inadequate intake; understanding factors associated with poor intake in this group of residents is not well established. This study examined the adequacy of nutrient intake among LTC residents consuming a pureed diet and the factors associated with this intake (n = 67). Data was collected as part of a cross-sectional study conducted in 32 LTC homes. Weighed food intake was measured on three non-consecutive days and analyzed using Food Processor software...
May 22, 2018: Journal of Nutrition in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29787290/amalgamation-of-polyphenols-and-probiotics-induce-health-promotion
#14
Arpita Banerjee, Pubali Dhar
The residing microbiome with its vast repertoire of genes provide distinctive properties to the host by which they can degrade and utilise nutrients that otherwise pass the gastro-intestinal tract unchanged. The polyphenols in our diet have selective growth promoting effects which is of utmost importance as the state of good health has been linked to dominance of particular microbial genera. The polyphenols in native form might more skilfully exert anti-oxidative and anti-inflammatory properties but in a living system it is the microbial derivatives of polyphenol that play a key role in determining health outcome...
May 22, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29786768/risk-prediction-score-for-hiv-infection-development-and-internal-validation-with-cross-sectional-data-from-men-who-have-sex-with-men-in-china
#15
Lu Yin, Yuejuan Zhao, Meridith Blevins Peratikos, Liang Song, Xiangjun Zhang, Ruolei Xin, Zheya Sun, Yunan Xu, Li Zhang, Yifei Hu, Chun Hao, Yuhua Ruan, Yiming Shao, Sten H Vermund, Han-Zhu Qian
Receptive anal intercourse, multiple partners, condomless sex, sexually transmitted infections (STIs), and drug/alcohol addiction are familiar factors that correlate with increased human immunodeficiency virus (HIV) risk among men who have sex with men (MSM). To improve estimation to HIV acquisition, we created a composite score using questions from routine survey of 3588 MSM in Beijing, China. The HIV prevalence was 13.4%. A risk scoring tool using penalized maximum likelihood multivariable logistic regression modeling was developed, deploying backward step-down variable selection to obtain a reduced-form model...
May 21, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29786583/incidence-and-risk-factors-of-spina-bifida-in-children
#16
Mariana O Ryznychuk, Mariana I Kryvchanska, Irina V Lastivka, Roman Ye Bulyk
OBJECTIVE: Introduction: The pathogenesis of spina bifida depends on time, region, race and ethnicity. It is found in 4.7 per 10.000 of live born children worldwide. The aim: The incidence in children of Northern Bukovina was analyzed. The spina bifida incidence for 2007-2016 in this region, as well as, compared to some countries according to EUROCAT data was studied. PATIENTS AND METHODS: Materials and methods: A retrospective study to analyze the risk factors for spina bifida was carried out...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29786025/resident-perspectives-on-communication-training-that-utilizes-immersive-virtual-reality
#17
Francis J Real, Dominick DeBlasio, Nicholas J Ollberding, David Davis, Bradley Cruse, Daniel Mclinden, Melissa D Klein
Background: Communication skills can be difficult to teach and assess in busy outpatient settings. These skills are important for effective counseling such as in cases of influenza vaccine hesitancy. It is critical to consider novel educational methods to supplement current strategies aimed at teaching relational skills. Methods: An immersive virtual reality (VR) curriculum on addressing influenza vaccine hesitancy was developed using Kern's six-step approach to curriculum design...
September 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/29785974/railway-noise-annoyance-on-the-railway-track-in-northwest-slovakia
#18
Alzbeta Pultznerova, Panulinova Eva, Daniela Kucharova, Lubica Argalasova
Introduction: This paper describes an assessment of noise caused by railway traffic in a large high-loaded railway track in Northwest Slovakia. Materials and Methods: The measurements of noise levels generated by trains passing through residential neighborhoods were taken. Noise maps were also calculated showing noise pollution generated by the train traffic. In addition, the annoyance level and sleep disturbance of residents affected by railway noise were evaluated by a validated questionnaire on a pilot sample of 107 respondents living near the important railway track...
May 2018: Noise & Health
https://www.readbyqxmd.com/read/29785971/community-noise-exposure-and-annoyance-activity-interference-and-academic-achievement-among-university-students
#19
Rattapon Onchang, Darryl W Hawker
Background: Noise annoyance and effects on academic performance have been investigated for primary and secondary school students but comparatively little work has been conducted with university students who generally spend more time in dormitories or accommodation for their self-study. Objective: To determine, using a socio-acoustic approach involving face-to-face interviews and actual noise measurements, the effect of various community noise sources on student activities in accommodation both inside and outside a university precinct and also relationships with cumulative grade point average (GPA)...
May 2018: Noise & Health
https://www.readbyqxmd.com/read/29785625/exploring-the-association-between-electronic-health-record-use-and-burnout-among-psychiatry-residents-and-faculty-a-pilot-survey-study
#20
Nicholas M Domaney, John Torous, William E Greenberg
OBJECTIVE: Burnout is a phenomenon with profound negative effects on the US healthcare system. Little is known about the relationship between time spent working on electronic health record (EHR) and burnout among psychiatry residents. The purpose of this study is to generate preliminary data on EHR use and burnout among psychiatry residents and faculty. METHODS: In August 2017, psychiatry residents and faculty at an academic medical center were given the Maslach Burnout Inventory (MBI), a standardized measurement tool for burnout, and a survey of factors related to EHR use and potential risk factors for burnout...
May 21, 2018: Academic Psychiatry
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