Edward N Schmidt, Dimitra Lamprinaki, Kelli A McCord, Maju Joe, Mirat Sojitra, Ayk Waldow, Jasmine Nguyen, John Monyror, Elena N Kitova, Fahima Mozaneh, Xue Yan Guo, Jaesoo Jung, Jhon R Enterina, Gour C Daskhan, Ling Han, Amanda R Krysler, Christopher R Cromwell, Basil P Hubbard, Lori J West, Marianne Kulka, Simonetta Sipione, John S Klassen, Ratmir Derda, Todd L Lowary, Lara K Mahal, Meghan R Riddell, Matthew S Macauley
Immunomodulatory Siglecs are controlled by their glycoprotein and glycolipid ligands. Siglec-glycolipid interactions are often studied outside the context of a lipid bilayer, missing the complex behaviors of glycolipids in a membrane. Through optimizing a liposomal formulation to dissect Siglec-glycolipid interactions, it is shown that Siglec-6 can recognize glycolipids independent of its canonical binding pocket, suggesting that Siglec-6 possesses a secondary binding pocket tailored for recognizing glycolipids in a bilayer...
April 22, 2023: Nature Communications