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https://www.readbyqxmd.com/read/27913818/-amyloid-positron-emission-tomography-with-18-%C3%A2-f-florbetaben-in-the-diagnostic-workup-of-dementia-patients
#1
S Schönecker, C Prix, T Raiser, N Ackl, E Wlasich, G Stenglein-Krapf, E Mille, M Brendel, O Sabri, M Patt, H Barthel, P Bartenstein, J Levin, A Rominger, A Danek
BACKGROUND: To this day the definite diagnosis of Alzheimer's disease still relies on post-mortem histopathological detection of neurofibrillary tangles and beta-amyloid deposits. Amyloid positron emission tomography (PET) is a new diagnostic tool that enables the in vivo quantification of pathological beta-amyloid deposits. The aim of the current study was to evaluate to what extent (18)F-florbetaben-PET (FBB-PET) influences the diagnosis of patients with dementia. MATERIAL AND METHODS: Imaging with FBB-PET was performed on 33 patients from our outpatient department for cognitive neurology...
December 2, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27911313/challenges-in-screening-and-recruitment-for-a-neuroimaging-study-in-cognitively-impaired-geriatric-inpatients
#2
Ivayla Apostolova, Catharina Lange, Anna Roberts, Hans Joachim Igel, Anja Mäurer, Stephanie Liese, Melanie Estrella, Vikas Prasad, Elisabeth Stechl, Gernot Lämmler, Elisabeth Steinhagen-Thiessen, Ralph Buchert
BACKGROUND: Neuroimaging-based biomarkers have the potential to improve etiological diagnosis of cognitive impairment in elderly inpatients. However, there is a relative lack of studies on neuroimaging-based biomarkers in hospitalized geriatric patients, as the vast majority of neuroimaging studies in dementia have focused on memory clinic outpatients. An important aspect of study planning is a priori estimation of the rate of screen failures. OBJECTIVE: To report on the rate and causes of screen failures in a prospective study on the utility of neuroimaging (PET, MRI) for the etiological diagnosis of newly manifested cognitive impairment in acutely hospitalized geriatric patients...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911289/the-brain-s-structural-connectome-mediates-the-relationship-between-regional-neuroimaging-biomarkers-in%C3%A2-alzheimer-s-disease
#3
Sneha Pandya, Amy Kuceyeski, Ashish Raj
Alzheimer's disease (AD), one of the most common causes of dementia in adults, is a progressive neurodegenerative disorder exhibiting well-defined neuropathological hallmarks. It is known that disease pathology involves misfolded amyloid-β (Aβ) and tau proteins, and exhibits a relatively stereotyped progression over decades. The relationship between AD neuropathological hallmarks (Aβ, hypometabolism, and tau proteins) and imaging biomarkers (MRI, AV-45/FDG-PET) is not fully understood. In addition, biomarker pathologies are oftentimes discordant, wherein it may show varying levels of abnormality across brain regions...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27903289/changes-in-cerebral-glucose-metabolism-after-3%C3%A2-weeks-of-noninvasive-electrical-stimulation-of-mild-cognitive-impairment-patients
#4
Kyongsik Yun, In-Uk Song, Yong-An Chung
BACKGROUND: Mild cognitive impairment (MCI) is a syndrome that disrupts an individual's cognitive function but preserves activities of daily living. MCI is thought to be a prodromal stage of dementia, which disrupts patients' daily lives and causes severe cognitive dysfunction. Although extensive clinical trials have attempted to slow or stop the MCI to dementia conversion, the results have been largely unsuccessful. The purpose of this study was to determine whether noninvasive electrical stimulation of MCI changes glucose metabolism...
December 1, 2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27879293/living-with-the-animals-animal-or-robotic-companions-for-the-elderly-in-smart-homes
#5
Dirk Preuß, Friederike Legal
Although the use of pet robots in senior living facilities and day-care centres, particularly for individuals suffering from dementia, has been intensively researched, the question of introducing pet robots into domestic settings has been relatively neglected. Ambient assisted living (AAL) offers many interface opportunities for integrating motorised companions. There are diverse medical reasons, as well as arguments from animal ethics, that support the use of pet robots in contrast to living with live animals...
November 22, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27876444/the-functional-neuroanatomy-of-verbal-memory-in-alzheimer-s-disease-18-f-fluoro-2-deoxy-d-glucose-positron-emission-tomography-fdg-pet-correlates-of-recency-and-recognition-memory
#6
Adam M Staffaroni, Rebecca J Melrose, Lorraine P Leskin, Hannah Riskin-Jones, Dylan Harwood, Mark Mandelkern, David L Sultzer
INTRODUCTION: The objective of this study was to distinguish the functional neuroanatomy of verbal learning and recognition in Alzheimer's disease (AD) using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word Learning task. METHOD: In 81 Veterans diagnosed with dementia due to AD, we conducted a cluster-based correlation analysis to assess the relationships between recency and recognition memory scores from the CERAD Word Learning Task and cortical metabolic activity measured using [(18)F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET)...
November 23, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27866729/molecular-imaging-in-the-diagnosis-of-alzheimer-s-disease-and-related-disorders
#7
REVIEW
L Koric, E Guedj, M O Habert, F Semah, P Branger, P Payoux, F Le Jeune
INTRODUCTION: The diagnosis of Alzheimer's disease (AD) and its related disorders rely on clinical criteria. There is, however, a large clinical overlap between the different neurodegenerative diseases affecting cognition and, frequently, there are diagnostic uncertainties with atypical clinical presentations. Current clinical practices can now regularly use positron emission tomography (PET) and single-photon emission computed tomography (SPECT) molecular imaging to help resolve such uncertainties...
November 17, 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27863444/av-1451-tau-and-%C3%AE-amyloid-pet-imaging-in-dementia-with-lewy-bodies
#8
Kejal Kantarci, Val J Lowe, Bradley F Boeve, Matthew L Senjem, Nikki Tosakulwong, Timothy G Lesnick, Anthony J Spychalla, Jeffrey L Gunter, Julie A Fields, Jonathan Graff-Radford, Tanis J Ferman, David T Jones, Melissa E Murray, David S Knopman, Clifford R Jack, Ronald C Petersen
OBJECTIVE: Patients with probable dementia with Lewy bodies often have Alzheimer's disease-related pathology. Our objective was to determine the pattern of positron emission tomography tau tracer AV-1451 uptake in patients with probable dementia with Lewy bodies, compared to Alzheimer's disease, and its relationship to β-amyloid deposition on positron emission tomography. METHODS: Consecutive patients with clinically probable dementia with Lewy bodies (n=19) from the Mayo Clinic Alzheimer's Disease Research Center underwent MRI, AV-1451 and Pittsburgh compound-B positron emission tomography examinations...
November 18, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27861589/role-of-plasma-clusterin-in-alzheimer-s-disease-a-pilot-study-in-a-tertiary-hospital-in-northern-india
#9
Venugopalan Y Vishnu, Manish Modi, Sandeep Sharma, Manju Mohanty, Manoj Kumar Goyal, Vivek Lal, Niranjan Khandelwal, Bhagwant Rai Mittal, Sudesh Prabhakar
OBJECTIVE: To evaluate the role of plasma clusterin in Alzheimer's disease (AD). BACKGROUND: Plasma clusterin is a promising biomarker as various studies have shown it to be associated with AD. But other studies have shown that plasma clusterin levels were not related to Alzheimer's disease or presymptomatic AD. Hence the diagnostic value of plasma clusterin is still not conclusive. METHODS: Neuropsychological assessment, MRI brain, FDG-PET brain and CSF biomarkers of AD were used for establishing the diagnosis of MCI, AD or Vascular dementia...
2016: PloS One
https://www.readbyqxmd.com/read/27844089/-biomarkers-for-dementia-and-other-neurodegenerative-diseases-current-developments
#10
J Wiltfang, P Lewczuk, M Otto
Cerebrospinal fluid-based neurochemical dementia diagnostics (CSF-NDD) support the early and differential diagnosis of dementia, most importantly the diagnosis of early or preclinical Alzheimer's dementia (AD). Meanwhile CSF-NDD are now recommended for improved exclusion and positive diagnostics of AD by the German national neuropsychiatry S3 dementia guidelines ( www.DGPPN.de ). Meta-analyses of independent international multicenter studies have shown that a combined CSF analysis of amyloid-beta 1-42 (Aβ 1-42, decreased), total tau proteins (increased) and phospho-tau proteins (increased) offers a sensitivity and specificity of 80-90 % for the early and differential diagnosis of AD (AD versus all other)...
November 14, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27836336/medial-temporal-lobe-subregional-morphometry-using-high-resolution-mri-in-alzheimer-s-disease
#11
David A Wolk, Sandhitsu R Das, Susanne G Mueller, Michael W Weiner, Paul A Yushkevich
Autopsy studies of Alzheimer's disease (AD) have found that neurofibrillary tangle (NFT) pathology of the medial temporal lobe (MTL) demonstrates selective topography with relatively stereotyped subregional involvement at early disease stages, prompting interest in more granular measurement of these structures with in vivo magnetic resonance imaging. We applied a novel, automated method for measurement of hippocampal subfields and extrahippocampal MTL cortical regions. The cohort included cognitively normal (CN) adults (n = 86), early mild cognitive impairment (n = 43), late MCI (n = 22), and mild AD (n = 40) patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI)...
September 30, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27834776/genetic-risk-as-a-marker-of-amyloid-%C3%AE-and-tau-burden-in-cerebrospinal-fluid
#12
Nicola Voyle, Hamel Patel, Amos Folarin, Stephen Newhouse, Caroline Johnston, Pieter Jelle Visser, Richard J B Dobson, Steven J Kiddle
BACKGROUND: The search for a biomarker of Alzheimer's disease (AD) pathology (amyloid-β (Aβ) and tau) is ongoing, with the best markers currently being measurements of Aβ and tau in cerebrospinal fluid (CSF) and via positron emission tomography (PET) scanning. These methods are relatively invasive, costly, and often have high screening failure rates. Consequently, research is aiming to elucidate blood biomarkers of Aβ and tau. OBJECTIVE: This study aims to investigate a case/control polygenic risk score (PGRS) as a marker of tau and investigate blood markers of a combined Aβ and tau outcome for the first time...
November 6, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27816409/progressive-increase-in-brain-glucose-metabolism-after-intrathecal-administration-of-autologous-mesenchymal-stromal-cells-in-patients-with-diffuse-axonal-injury
#13
Jesús Vaquero, Mercedes Zurita, Celia Bonilla, Cecilia Fernández, Juan J Rubio, Jorge Mucientes, Begoña Rodriguez, Edelio Blanco, Luis Donis
BACKGROUND AIMS: Cell therapy in neurological disability after traumatic brain injury (TBI) is in its initial clinical stage. We describe our preliminary clinical experience with three patients with diffuse axonal injury (DAI) who were treated with intrathecal administration of autologous mesenchymal stromal cells (MSCs). METHODS: Three patients with established neurological sequelae due to DAI received intrathecally autologous MSCs. The total number of MSCs administered was 60 × 10(6) (one patient), 100 × 10(6) (one patient) and 300 × 10(6) (one patient)...
November 2, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27814297/cross-sectional-and-longitudinal-cognitive-correlates-of-fddnp-pet-and-csf-amyloid-%C3%AE-and-tau-in-parkinson-s-disease1
#14
Mariateresa Buongiorno, Francesca Antonelli, Yaroslau Compta, Yolanda Fernandez, Javier Pavia, Francisco Lomeña, José Ríos, Isabel Ramírez, José Ramón Garía, Marina Soler, Ana Cámara, Manel Fernández, Misericòrdia Basora, Fáima Salazar, Gerard Sanchez-Etayo, Francesc Valldeoriola, Jorge Raúl Barrio, Maria Jose Marti
Tau and amyloid-β (Aβ) aggregates have been suggested to play a role in the development of dementia in Parkinson's disease (PD). Positron emission tomography (PET) with [18F]FDDNP and the determination of cerebrospinal fluid (CSF) levels of these proteins constitute a means to visualize in vivo Aβ and tau brain accumulation. Information about longitudinal changes of these CSF and PET biomarkers in PD with regard to progression to dementia is lacking. We assessed the cross-sectional and longitudinal associations of CSF and PET biomarkers of tau and Aβ with PD-related cognitive dysfunction in 6 healthy-controls (HC), 16 patients with PD without dementia (PDND), and 8 PD with dementia (PDD)...
November 3, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27806705/neuroimaging-in-vascular-cognitive-impairment-a-state-of-the-art-review
#15
REVIEW
Wolf-Dieter Heiss, Gary A Rosenberg, Alexander Thiel, Rok Berlot, Jacques de Reuck
Imaging is critical in the diagnosis and treatment of dementia, particularly in vascular cognitive impairment, due to the visualization of ischemic and hemorrhagic injury of gray and white matter. Magnetic resonance imaging (MRI) and positron emission tomography (PET) provide structural and functional information. Clinical MRI is both generally available and versatile - T2-weighted images show infarcts, FLAIR shows white matter changes and lacunar infarcts, and susceptibility-weighted images reveal microbleeds...
November 3, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27806159/association-of-higher-cortical-amyloid-burden-with-loneliness-in-cognitively-normal-older-adults
#16
Nancy J Donovan, Olivia I Okereke, Patrizia Vannini, Rebecca E Amariglio, Dorene M Rentz, Gad A Marshall, Keith A Johnson, Reisa A Sperling
Importance: Emotional and behavioral symptoms in cognitively normal older people may be direct manifestations of Alzheimer disease (AD) pathophysiology at the preclinical stage, prior to the onset of mild cognitive impairment. Loneliness is a perceived state of social and emotional isolation that has been associated with cognitive and functional decline and an increased risk of incident AD dementia. We hypothesized that loneliness might occur in association with elevated cortical amyloid burden, an in vivo research biomarker of AD...
November 2, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27801611/clinical-and-imaging-characteristics-of-late-onset-mitochondrial-membrane-protein-associated-neurodegeneration-mpan
#17
Ethan Gore, Brian S Appleby, Mark L Cohen, Suzanne D DeBrosse, James B Leverenz, Bruce L Miller, Sandra L Siedlak, Xiongwei Zhu, Alan J Lerner
Young onset dementias present significant diagnostic challenges. We present the case of a 35-year-old Kuwaiti man with social withdrawal, drowsiness, irritability, anxiety, aphasia, memory loss, hypereflexia, and Parkinsonism. Brain MRI showed bilateral symmetric gradient echo hypointensities in the globi pallidi and substantiae nigrae. Left cortical hypometabolism was seen on brain fluorodeoxyglucose positron emission tomography. A cortical brain biopsy revealed a high Lewy body burden. Genetic testing revealed a homozygous p...
October 2016: Neurocase
https://www.readbyqxmd.com/read/27787958/-18-f-av-1451-tau-positron-emission-tomography-in-progressive-supranuclear-palsy
#18
Jennifer L Whitwell, Val J Lowe, Nirubol Tosakulwong, Stephen D Weigand, Matthew L Senjem, Christopher G Schwarz, Anthony J Spychalla, Ronald C Petersen, Clifford R Jack, Keith A Josephs
BACKGROUND: The [(18) F]AV-1451 positron emission tomography ligand allows the in vivo assessment of tau proteins in the brain. It shows strong binding in Alzheimer's dementia, but little is known about how it performs in progressive supranuclear palsy, a primary 4R tauopathy. OBJECTIVES: The objectives of this study were to determine whether [(18) F]AV-1451 uptake can be observed in progressive supranuclear palsy and to characterize the regional distribution when compared with controls and Alzheimer's dementia...
October 27, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27781973/magnetic-resonance-imaging-and-positron-emission-tomography-in-the-diagnosis-of-neurodegenerative-dementias
#19
A Del Sole, S Malaspina, Alberto Magenta Biasina
Neuroimaging, both with magnetic resonance imaging (MRI) and positron emission tomography (PET), has gained a pivotal role in the diagnosis of primary neurodegenerative diseases. These two techniques are used as biomarkers of both pathology and progression of Alzheimer's disease (AD) and to differentiate AD from other neurodegenerative diseases. MRI is able to identify structural changes including patterns of atrophy characterizing neurodegenerative diseases, and to distinguish these from other causes of cognitive impairment, e...
October 26, 2016: Functional Neurology
https://www.readbyqxmd.com/read/27763550/age-and-brain-region-specific-changes-of-glucose-metabolic-disorder-learning-and-memory-dysfunction-in-early-alzheimer-s-disease-assessed-in-app-ps1-transgenic-mice-using-18-f-fdg-pet
#20
Xue-Yuan Li, Wei-Wei Men, Hua Zhu, Jian-Feng Lei, Fu-Xing Zuo, Zhan-Jing Wang, Zhao-Hui Zhu, Xin-Jie Bao, Ren-Zhi Wang
Alzheimer's disease (AD) is a leading cause of dementia worldwide, associated with cognitive deficits and brain glucose metabolic alteration. However, the associations of glucose metabolic changes with cognitive dysfunction are less detailed. Here, we examined the brains of APP/presenilin 1 (PS1) transgenic (Tg) mice aged 2, 3.5, 5 and 8 months using (18)F-labed fluorodeoxyglucose ((18)F-FDG) microPET to assess age- and brain region-specific changes of glucose metabolism. FDG uptake was calculated as a relative standardized uptake value (SUVr)...
October 18, 2016: International Journal of Molecular Sciences
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