keyword
MENU ▼
Read by QxMD icon Read
search

pet dementia

keyword
https://www.readbyqxmd.com/read/28938220/metabolic-correlate-of-memory-deficit-awareness-in-dementia-with-lewy-bodies-implication-in-cortical-midline-structure
#1
Tomomichi Iizuka, Masashi Kameyama
The neural substrate of memory-deficit awareness has been studied in mild cognitive impairment and Alzheimer's disease (AD). However, little is known about that in dementia with Lewy bodies (DLB). To determine the neural substrates of memory-deficit awareness in DLB, we investigated the relationship between awareness of memory-deficit and glucose metabolism in DLB. Thirty-four patients with DLB were assessed by (18)F-FDG-PET and dopamine transporter (DAT)-SPECT. The awareness was evaluated using an awareness index that represents the discrepancy between objective and subjective memory scores...
September 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28936941/-diagnostics-in-memory-loss-for-whom-what-and-when
#2
E Richard, E P Moll van Charante
With the advancement of diagnostic tests, the call for an ever-earlier diagnosis of people with memory problems is becoming louder. Diagnostic tests for people with mild cognitive impairment are in fact prognostic tests, complicating the application and interpretation of test results. There is currently insufficient evidence on the incremental diagnostic (or prognostic) value of specific diagnostic tests including MRI, CSF and PET scanning in representative memory clinic populations. Labelling large groups of people who may never develop dementia as having prodromal Alzheimer's disease may be more harmful than a postponed nosological diagnosis in those with mild cognitive impairment...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28934619/distinct-brain-metabolic-patterns-separately-associated-with-cognition-motor-function-and-aging-in-parkinson-s-disease-dementia
#3
Ji Hyun Ko, Audrey Katako, Maram Aljuaid, Andrew L Goertzen, Andrew Borys, Douglas E Hobson, Seok Min Kim, Chong Sik Lee
We explored whether patients with Parkinson's disease dementia (PDD) show a distinct spatial metabolic pattern that characterizes cognitive deficits in addition to motor dysfunction. Eighteen patients with PDD underwent 3 separate positron emission tomography sessions with [(18)F]fluorodeoxyglucose (for glucose metabolism), fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane (for dopamine transporter density) and Pittsburgh compound-B (for beta-amyloid load). We confirmed in PDD versus normal controls, overall hypometabolism in the posterior and prefrontal brain regions accompanied with hypermetabolism in subcortical structures and the cerebellar vermis...
August 31, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28932894/additive-value-of-amyloid-pet-in-routine-cases-of-clinical-dementia-work-up-after-fdg-pet
#4
Matthias Brendel, Jonas Schnabel, Sonja Schönecker, Leonie Wagner, Eva Brendel, Johanna Meyer-Wilmes, Marcus Unterrainer, Andreas Schildan, Marianne Patt, Catharina Prix, Nibal Ackl, Cihan Catak, Oliver Pogarell, Johannes Levin, Adrian Danek, Katharina Buerger, Peter Bartenstein, Henryk Barthel, Osama Sabri, Axel Rominger
PURPOSE: In recent years, several [(18)F]-labeled amyloid-PET tracers have been developed and have obtained clinical approval. Despite their widespread scientific use, studies in routine clinical settings are limited. We therefore investigated the impact of [(18)F]-florbetaben (FBB)-PET on the diagnostic management of patients with suspected dementia that was still unclarified after [(18)F]-fluordeoxyglucose (FDG)-PET. METHODS: All subjects were referred in-house with a suspected dementia syndrome due to neurodegenerative disease...
September 20, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28931302/learning-metabolic-brain-networks-in-mci-and-ad-by-robustness-and-leave-one-out-analysis-an-fdg-pet-study
#5
Zhijun Yao, Bin Hu, Xuejiao Chen, Yuanwei Xie, Jürg Gutknecht, Dennis Majoe
This study attempted to better understand the properties associated with the metabolic brain network in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Graph theory was employed to investigate the topological organization of metabolic brain network among 86 patients with MCI, 89 patients with AD, and 97 normal controls (NCs) using 18F fluoro-deoxy-glucose positron emission tomography (FDG-PET) data. The whole brain was divided into 82 areas by Brodmann atlas to construct networks. We found that MCI and AD showed a loss of small-world properties and topological aberrations, and MCI showed an intermediate measurement between NC and AD...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28929833/the-alzheimer-s-disease-metabolic-brain-pattern-in-mild-cognitive-impairment
#6
Sanne K Meles, Marco Pagani, Dario Arnaldi, Fabrizio De Carli, Barbara Dessi, Silvia Morbelli, Gianmario Sambuceti, Cathrine Jonsson, Klaus L Leenders, Flavio Nobili
We investigated the expression of the Alzheimer's disease-related metabolic brain pattern (ADRP) in (18)F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer's disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28922157/longer-term-investigation-of-the-value-of-18f-fdg-pet-and-magnetic-resonance-imaging-for-predicting-the-conversion-of-mild-cognitive-impairment-to-alzheimer-s-disease-a-multicenter-study
#7
Yoshitaka Inui, Kengo Ito, Takashi Kato
BACKGROUND: The value of fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) and magnetic resonance imaging (MRI) for predicting conversion of mild cognitive impairment (MCI) to Alzheimer's disease (AD) in longer-term is unclear. OBJECTIVE: To evaluate longer-term prediction of MCI to AD conversion using 18F-FDG-PET and MRI in a multicenter study. METHODS: One-hundred and fourteen patients with MCI were followed for 5 years...
September 11, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28912300/-18-f-av-1451-binding-in-vivo-mirrors-the-expected-distribution-of-tdp-43-pathology-in-the-semantic-variant-of-primary-progressive-aphasia
#8
W R Bevan-Jones, Thomas E Cope, P Simon Jones, Luca Passamonti, Young T Hong, Tim D Fryer, Robert Arnold, Kieren S J Allinson, Jonathan P Coles, Franklin I Aigbirhio, Karalyn Patterson, John T O'Brien, James B Rowe
INTRODUCTION: Semantic dementia, including the semantic variant of primary progressive aphasia (svPPA), is strongly associated with TAR-DNA binding protein 43 (TDP-43) type C pathology. It provides a useful model in which to test the specificity of in vivo binding of the putative tau ligand [(18)F]AV-1451, which is elevated in frontotemporal lobar degeneration tauopathies. METHODS AND RESULTS: Seven patients (five with svPPA and two with 'right' semantic dementia) and 12 healthy controls underwent positron emission tomography brain imaging with [(18)F]AV-1451...
September 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28912150/-18-f-fdg-pet-in-parkinsonism-differential-diagnosis-and-cognitive-impairment-in-parkinson-s-disease
#9
Philipp T Meyer, Lars Frings, Gerta Rücker, Sabine Hellwig
Accurate differential diagnosis of parkinsonism is of a paramount therapeutic and prognostic importance. In addition, with the development of invasive therapies and novel disease-specific therapies, strategies for patient enrichment in trial populations are of growing importance. Imaging disease-specific patterns of regional glucose metabolism with positron emission tomography and [(18)F]fluoro-2-deoxy-2-D-glucose ((18)F-FDG) allows for a highly accurate distinction between Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) including multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD)...
September 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28906375/correlations-between-clinical-characteristics-and-neuroimaging-in-chinese-patients-with-subtypes-of-frontotemporal-lobe-degeneration
#10
Zhihong Shi, Shuai Liu, Ying Wang, Shuling Liu, Tong Han, Li Cai, Yuying Zhou, Shuo Gao, Yong Ji
The aim of the study was to obtain an overview of the clinical and neuroimaging features of Chinese patients with subtypes of frontotemporal lobe degeneration (FTLD).We evaluated the demographic features, clinical presentation, and lobe atrophy depicted by magnetic resonance imaging (MRI) in 133 patients with FTLD. Two positron emission tomography (PET) scans were performed at baseline: [C]Pittsburgh compound B PET to assess amyloid-β plaque load and [F]fluorodeoxyglucose (FDG) PET to assess glucose metabolism...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28906268/new-pet-markers-for-the-diagnosis-of-dementia
#11
Pierre Payoux, Anne Sophie Salabert
PURPOSE OF REVIEW: To present the new PET markers that could become in the coming years, relevant to advanced clinical approaches to dementia diagnosis, drug trials, and treatment strategies and discuss their advantages and limitations. RECENT FINDINGS: The most advanced new PET tracers are the markers of the amyloid plaques, the τ compounds and the tracers of the translocator protein as markers of neuroinflammation. The main advantages but also the weaknesses of each of these markers are discussed...
September 12, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28900064/-positron-emission-tomography-imaging-of-microglia-in-diagnosis-of-dementia
#12
Miho Shukuri, Hirotaka Onoe
Neuroinflammation which involves microglial activation is believed to be closely associated with the progression of neurodegeneration in Alzheimer's disease. The activation of microglia is receiving rising attention as a diagnostic and therapeutic target; however, it is important to distinguish its state and phenotype of the microglia. Positron emission tomography (PET) is a non-invasive method that can help visualize the changes of molecules associated with microglial activation in neurological disease under in vivo conditions...
September 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28890300/tau-positron-emission-tomography-using-18-f-thk5351-and-cerebral-glucose-hypometabolism-in-alzheimer-s-disease
#13
Jae Myeong Kang, Sang-Yoon Lee, Seongho Seo, Hye Jin Jeong, Sung-Ho Woo, Hyon Lee, Yeong-Bae Lee, Byeong Kil Yeon, Dong Hoon Shin, Kee Hyung Park, Hyejin Kang, Nobuyuki Okamura, Shozo Furumoto, Kazuhiko Yanai, Victor L Villemagne, Joon-Kyung Seong, Duk L Na, Tatsuo Ido, Jaelim Cho, Kyoung-Min Lee, Young Noh
This study aims to evaluate the clinical validity of [(18)F]THK5351 positron emission tomography (PET) for the assessment of disease progression and symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 30 patients with amnestic mild cognitive impairment (aMCI), and 43 controls with normal cognition (NC) were included. All subjects underwent [(18)F]THK5351 PET, 3.0-T magnetic resonance imaging, and detailed neuropsychological tests. Regions of interest and voxel-based statistical analyses were performed...
August 12, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28890043/a-migration-case-of-kii-amyotrophic-lateral-sclerosis-parkinsonism-dementia-complex-with-the-shortest-stay-in-the-endemic-area-and-the-longest-incubation-to-develop-the-disease
#14
Keiichiro Tsunoda, Toru Yamashita, Hitoshi Shimada, Emi Nomura, Yoshiaki Takahashi, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Makoto Higuchi, Tetsuya Suhara, Yasumasa Kokubo, Shigeki Kuzuhara, Koji Abe
Amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) is an endemic disease observed in the Kii peninsula, Guam, and Papua. We report a case of a 76-year old man with ALS/PDC of the Kii peninsula of Japan (Kii ALS/PDC). The patient was born and grew up in the Kii peninsula. He moved out at age three, and developed symptoms 73years later. He showed pyramidal sign, parkinsonian symptoms, and mildly impaired cognitive function. (131)I-metaiodobenzylguanidine myocardial scintigraphy showed decreased cardiac sympathetic nerve function, and dopamine transporter single photon emission computed tomography imaging showed decreased (123)I-N-ω-fluoropropyl-2β-carbomethoxy3β-(4-iodophenyl) nortropane accumulation...
September 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28875790/outdoor-spaces-improve-dementia-care
#15
Jennifer Trueland
Rachel Potter saw many examples of great practice when she visited residential homes as part of her research into their physical environment. But none sticks in her memory quite as much as the giant rabbits, which were kept as pets at one care home.
September 6, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28869474/cortical-metabolic-and-cognitive-correlates-of-disorientation-in-alzheimer-s-disease
#16
Gali H Weissberger, Rebecca J Melrose, Candace M Fanale, Joseph V Veliz, David L Sultzer
Orientation to time, date, and place is commonly utilized in clinical settings to aid in diagnosis, staging, and monitoring of Alzheimer's disease (AD). This study aimed to identify the cerebral metabolic correlates of orientation in patients with AD, and the degree to which regions associated with orientation overlap with memory-related structures. Eighty-five patients with a diagnosis of probable AD underwent fluorodeoxyglucose positron emission tomography (FDG-PET) and neuropsychological testing. Orientation items from the Dementia Rating Scale and recognition performance from the Consortium to Establish a Registry for AD (CERAD) Word List Learning test were correlated with cerebral glucose metabolism...
September 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28869470/the-cerebrospinal-fluid-a%C3%AE-1-42-a%C3%AE-1-40-ratio-improves-concordance-with-amyloid-pet-for-diagnosing-alzheimer-s-disease-in-a-clinical-setting
#17
Ellis Niemantsverdriet, Julie Ottoy, Charisse Somers, Ellen De Roeck, Hanne Struyfs, Femke Soetewey, Jeroen Verhaeghe, Tobi Van den Bossche, Sara Van Mossevelde, Johan Goeman, Peter Paul De Deyn, Peter Mariën, Jan Versijpt, Kristel Sleegers, Christine Van Broeckhoven, Leonie Wyffels, Adrien Albert, Sarah Ceyssens, Sigrid Stroobants, Steven Staelens, Maria Bjerke, Sebastiaan Engelborghs
BACKGROUND: Evidence suggests that the concordance between amyloid-PET and cerebrospinal fluid (CSF) amyloid-β (Aβ) increases when the CSF Aβ1-42/Aβ1-40 ratio is used as compared to CSF Aβ1-42 levels alone. OBJECTIVE: In order to test this hypothesis, we set up a prospective longitudinal study comparing the concordance between different amyloid biomarkers for Alzheimer's disease (AD) in a clinical setting. METHODS: Seventy-eight subjects (AD dementia (n = 17), mild cognitive impairment (MCI, n = 48), and cognitively healthy controls (n = 13)) underwent a [18F]Florbetapir ([18F]AV45) PET scan, [18F]FDG PET scan, MRI scan, and an extensive neuropsychological examination...
September 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28856092/comparison-of-18-f-flutemetamol-and-11-c-pittsburgh-compound-b-in-cognitively-normal-young-cognitively-normal-elderly-and-alzheimer-s-disease-dementia-individuals
#18
Val J Lowe, Emily Lundt, David Knopman, Matthew L Senjem, Jeffrey L Gunter, Christopher G Schwarz, Bradley J Kemp, Clifford R Jack, Ronald C Petersen
BACKGROUND: Understanding the variation in uptake between different amyloid PET tracers is important to appropriately interpret data using different amyloid tracers. Therefore, we compared the uptake differences in [(18)F]Flutemetamol (FMT) and [(11)C]PiB (PiB) PET in the same people. METHODS: Structural MRI, FMT PET and PiB PET were each performed in 30 young cognitively normal (yCN), 31 elderly cognitively normal (eCN) and 21 Alzheimer's disease dementia (AD) participants...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28844070/the-increasing-impact-of-cerebral-amyloid-angiopathy-essential-new-insights-for-clinical-practice
#19
REVIEW
Gargi Banerjee, Roxana Carare, Charlotte Cordonnier, Steven M Greenberg, Julie A Schneider, Eric E Smith, Mark van Buchem, Jeroen van der Grond, Marcel M Verbeek, David J Werring
Cerebral amyloid angiopathy (CAA) has never been more relevant. The last 5 years have seen a rapid increase in publications and research in the field, with the development of new biomarkers for the disease, thanks to advances in MRI, amyloid positron emission tomography and cerebrospinal fluid biomarker analysis. The inadvertent development of CAA-like pathology in patients treated with amyloid-beta immunotherapy for Alzheimer's disease has highlighted the importance of establishing how and why CAA develops; without this information, the use of these treatments may be unnecessarily restricted...
August 26, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28826526/small-molecule-pet-tracers-for-imaging-proteinopathies
#20
REVIEW
Chester A Mathis, Brian J Lopresti, Milos D Ikonomovic, William E Klunk
In this chapter, we provide a review of the challenges and advances in developing successful PET imaging agents for 3 major types of aggregated amyloid proteins: amyloid-beta (Aβ), tau, and alpha-synuclein (α-syn). These 3 amyloids are involved in the pathogenesis of a variety of neurodegenerative diseases, referred to as proteinopathies or proteopathies, that include Alzheimer disease, Lewy body dementias, multiple system atrophy, and frontotemporal dementias, among others. In the Introduction section, we briefly discuss the history of amyloid in neurodegenerative diseases and describe why progress in developing effective imaging agents has been hampered by the failure of crystallography to provide definitive ligand-protein interactions for rational radioligand design efforts...
September 2017: Seminars in Nuclear Medicine
keyword
keyword
94283
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"