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https://www.readbyqxmd.com/read/28535285/delayed-hospital-discharges-of-older-patients-a-systematic-review-on-prevalence-and-costs
#1
Filipa Landeiro, Kenny Roberts, Alastair Mcintosh Gray, José Leal
Purpose of the Study: To determine the prevalence of delayed discharges of elderly inpatients and associated costs. Design and Methods: We searched Medline, Embase, Global Health, CAB Abstracts, Econlit, Web of Knowledge, EBSCO - CINAHL, The Cochrane Library, Health Management Information Consortium, and SCIE - Social Care Online for evidence published between 1990 and 2015 on number of days or proportion of delayed discharges for elderly inpatients in acute hospitals...
May 23, 2017: Gerontologist
https://www.readbyqxmd.com/read/28534679/laser-induced-photofragmentation-fluorescence-imaging-of-alkali-compounds-in-flames
#2
Tomas Leffler, Christian Brackmann, Marcus Aldén, Zhongshan Li
Laser-induced photofragmentation fluorescence has been investigated for the imaging of alkali compounds in premixed laminar methane-air flames. An ArF excimer laser, providing pulses of wavelength 193 nm, was used to photodissociate KCl, KOH, and NaCl molecules in the post-flame region and fluorescence from the excited atomic alkali fragment was detected. Fluorescence emission spectra showed distinct lines of the alkali atoms allowing for efficient background filtering. Temperature data from Rayleigh scattering measurements together with simulations of potassium chemistry presented in literature allowed for conclusions on the relative contributions of potassium species KOH and KCl to the detected signal...
June 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28534644/a-spectral-power-analysis-of-driving-behavior-changes-during-the-transition-from-non-distraction-to-distraction
#3
Yuan Wang, Shan Bao, Wenjun Du, Zhirui Ye, James R Sayer
OBJECTIVE: This paper investigated and compared frequency-domain and time-domain characteristics of drivers' behavior before and after the start of distracted driving. METHOD: Data from an existing naturalistic driving study were used. Fast Fourier transform (FFT) was applied for the frequency domain analysis to explore drivers' behavior pattern changes between non-distracted (pre-starting of visual-manual task) and distracted (post-starting of visual-manual task) driving periods...
May 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28534254/the-cost-of-relapse-in-schizophrenia
#4
REVIEW
Mark Pennington, Paul McCrone
INTRODUCTION: Schizophrenia is a chronic and debilitating mental illness characterised by periods of relapse that require resource intensive management. Quantifying the cost of relapse is central to the evaluation of the cost effectiveness of treating schizophrenia. OBJECTIVES: We aimed to undertake a comprehensive search of the available literature on the cost of relapse. METHODS: We performed a search on multiple databases (MEDLINE, Embase, PsycINFO and Health Management Information Consortium) for any study reporting a cost of relapse or data from which such a cost could be calculated...
May 22, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28534090/tooth-loss-and-liver-cancer-incidence-in-a-finnish-cohort
#5
Baiyu Yang, Jessica L Petrick, Christian C Abnet, Barry I Graubard, Gwen Murphy, Stephanie J Weinstein, Satu Männistö, Demetrius Albanes, Katherine A McGlynn
PURPOSE: Periodontal disease, a major cause of tooth loss in adults, may have systemic effects and has been associated with higher risk of several cancer types. However, the associations of periodontal disease or tooth loss with liver cancer have only been examined prospectively in two studies, neither of which had sufficient statistical power. In addition, no studies assessed the potential confounding by viral hepatitis or Helicobacter pylori infection status. METHODS: In this study, we examined the association between tooth loss and primary liver cancer incidence in a prospective cohort of Finnish male smokers (n = 29,096)...
May 22, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28534081/power-of-pedigree-likelihood-analysis-in-extended-pedigrees-to-classify-rare-variants-of-uncertain-significance-in-cancer-risk-genes
#6
Elisabeth A Rosenthal, John Michael O Ranola, Brian H Shirts
Rare and private variants of uncertain significance (VUS) are routinely identified in clinical panel, exome, and genome sequencing. We investigated the power of single family co-segregation analysis to aid classification of VUS. We simulated thousands of pedigrees using demographics in China and the United States, segregating benign and pathogenic variants. Genotypes and phenotypes were simulated using penetrance models for Lynch syndrome and breast/ovarian cancer. We calculated LOD scores adjusted for proband ascertainment (LODadj), to determine power to yield quantitative evidence for, or against, pathogenicity of the VUS...
May 22, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28533738/genetics-of-tinnitus-still-in-its-infancy
#7
REVIEW
Barbara Vona, Indrajit Nanda, Wafaa Shehata-Dieler, Thomas Haaf
Tinnitus is the perception of a phantom sound that affects between 10 and 15% of the general population. Despite this considerable prevalence, treatments for tinnitus are presently lacking. Tinnitus exhibits a diverse array of recognized risk factors and extreme clinical heterogeneity. Furthermore, it can involve an unknown number of auditory and non-auditory networks and molecular pathways. This complex combination has hampered advancements in the field. The identification of specific genetic factors has been at the forefront of several research investigations in the past decade...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28532935/toric-outcomes-computer-assisted-registration-versus-intraoperative-aberrometry
#8
Jonathan D Solomon, John Ladas
PURPOSE: To compare refractive outcomes of intraoperative computer-assisted registration and intraoperative aberrometry for the reduction of cylinder during toric intraocular lens (IOL) placement. SETTING: Bowie Vision Institute, Bowie, Maryland, USA. DESIGN: Prospective randomized case series. METHOD: The patients were divided into 2 groups that had toric IOL implantation after phacoemulsification. The intraoperative computer-assisted registration group (Group 1) had preoperative toric calculations...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28530476/time-trials-versus-time-to-exhaustion-tests-effects-on-critical-power-w-and-oxygen-uptake-kinetics
#9
Bettina Karsten, Jonathan Baker, Fernando Naclerio, Andreas Klose, Antonino Bianco, Alfred Nimmerichter
PURPOSE: To investigate single-day time-to-exhaustion (TTE) and time trial (TT) based laboratory tests values of critical power (CP), Wprime (W') and respective oxygen kinetics responses. METHODS: Twelve cyclists performed a maximal ramp test followed by three TTE and three TT efforts interspersed by a 60-min recovery between efforts. Oxygen uptake was measured during all trials. The mean response time (MRT) was calculated as a description of the overall V̇O2 kinetic response from the onset to 2 min of exercise...
May 22, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28530097/total-particle-number-emissions-from-modern-diesel-natural-gas-and-hybrid-heavy-duty-vehicles-during-on-road-operation
#10
Tianyang Wang, David Christopher Quiros, Arvind Thiruvengadam, Saroj Pradhan, Shaohua Hu, Tao Huai, Eon S Lee, Yifang Zhu
Particle emissions from heavy-duty vehicles (HDVs) have significant environmental and public health impacts. This study measured total particle number emission factors (PNEFs) from six newly-certified HDVs powered by diesel and compressed natural gas totaling over 6,800 miles of on-road operation in California. Distance-, fuel- and work-based PNEFs were calculated for each vehicle. Distance-based PNEFs of vehicles equipped with original equipment manufacturer (OEM) diesel particulate filters (DPFs) in this study have decreased by 355-3200 times compared to a previous retrofit DPF dynamometer study...
May 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28529877/the-dynamics-of-functional-connectivity-in-neocortical-focal-epilepsy
#11
Mangor Pedersen, Amir Omidvarnia, Evan K Curwood, Jennifer M Walz, Genevieve Rayner, Graeme D Jackson
Focal epilepsy is characterised by paroxysmal events, reflecting changes in underlying local brain networks. To capture brain network activity at the maximal temporal resolution of the acquired functional magnetic resonance imaging (fMRI) data, we have previously developed a novel analysis framework called Dynamic Regional Phase Synchrony (DRePS). DRePS measures instantaneous mean phase coherence within neighbourhoods of brain voxels. We use it here to examine how the dynamics of the functional connections of regional brain networks are altered in neocortical focal epilepsy...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28529251/image-quality-and-clinical-usefulness-of-ray-summation-image-reconstructed-from-ct-data-compared-with-digital-radiography
#12
Shogo Suzuki, Katsuhiro Ichikawa, Shigeru Tamaki
Ray-summation (raysum) images reconstructed from computed tomography (CT) volume data resemble digital radiography (DR) images. Therefore, they have a potential to be used instead of DR images.The aim of this study was to compare the physical image quality evaluated by signal-difference-to-noise ratio (SDNR) and clinical usefulness between raysum and DR images. We employed an oval water phantom simulating adult abdomen for image quality measurement. Raysum images were reconstructed from CT volume data using an assumed x-ray quality of 70 keV...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28528599/eeg-beta-2-power-as-surrogate-marker-for-memory-impairment-a-pilot-study
#13
Andreas K Kaiser, Michael Doppelmayr, Bernhard Iglseder
BACKGROUND: Memory deficits are dominant in dementia and are positively correlated with electroencephalographic (EEG) beta power. EEG beta power can predict the progression of Alzheimer´s (AD) as early as at the stage of mild cognitive impairment (MCI) and could possibly be used as surrogate marker for memory impairment. The objective of this study is to analyze the relationship between frontal and parietal EEG beta power and memory-test outcome. Frontal and parietal beta power is analyzed for a resting state and an eyes-closed backward counting condition and related to memory impairment parameters...
May 22, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28527513/enzymatic-biosynthesis-of-novel-neobavaisoflavone-glucosides-via-bacillus-udp-glycosyltransferase
#14
Tao Ma, Yi-Qun Dai, Nan Li, Qiang Huo, Hong-Mei Li, Yu-Xin Zhang, Zheng-Hao Piao, Cheng-Zhu Wu
The present study was designed to perform structural modifications of of neobavaisoflavone (NBIF), using an in vitro enzymatic glycosylation reaction, in order to improve its water-solubility. Two novel glucosides of NBIF were obtained from an enzymatic glycosylation by UDP-glycosyltransferase. The glycosylated products were elucidated by LC-MS, HR-ESI-MS, and NMR analysis. The HPLC peaks were integrated and the concentrations in sample solutions were calculated. The MTT assay was used to detect the cytotoxic activity of compounds in cancer cell lines...
April 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28527351/permutation-entropy-analysis-of-heart-rate-variability-for-the-assessment-of-cardiovascular-autonomic-neuropathy-in-type-1-diabetes-mellitus
#15
Claudia Carricarte Naranjo, Lazaro M Sanchez-Rodriguez, Marta Brown Martínez, Mario Estévez Báez, Andrés Machado García
Heart rate variability (HRV) analysis is a relevant tool for the diagnosis of cardiovascular autonomic neuropathy (CAN). To our knowledge, no previous investigation on CAN has assessed the complexity of HRV from an ordinal perspective. Therefore, the aim of this work is to explore the potential of permutation entropy (PE) analysis of HRV complexity for the assessment of CAN. For this purpose, we performed a short-term PE analysis of HRV in healthy subjects and type 1 diabetes mellitus patients, including patients with CAN...
May 8, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28524924/a-theoretical-study-on-the-mechanistic-highlights-behind-the-br%C3%A3-nsted-acid-dependent-mer-fac-isomerization-of-homoleptic-carbenic-iridium-complexes-for-pholeds
#16
Tobias Setzer, Christian Lennartz, Andreas Dreuw
Recently, a successful Brønsted-acid mediated geometric isomerization of the meridional homoleptic carbenic iridium(iii) complexes tris-(N-phenyl,N-methyl-benzimidazol-2-yl)iridium(iii) (1) and tris-(N-phenyl,N-benzyl-benzimidazol-2-yl)iridium(iii) (2) into their facial form has been reported. In the present work the pronounced acid-dependency of this particular isomerization procedure is revisited and additional mechanistic pathways are taken into account. Moreover, the acid-induced material decomposition is addressed...
May 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28523955/collaborative-cross-mouse-population-for-studying-the-alveolar-bone-changes-and-impaired-glucose-tolerance-comorbidity-after-high-fat-diet-consumption
#17
Aysar Nashef, Hanifa J Abu-Toamih Atamni, Yuval Buchnik, Hatice Hasturk, Alpdogan Kantarci, Danielle Stephens, Ervin I Wiess, Yael Houri-Haddad, Fuad A Iraqi
BACKGROUND: High-fat diet (HFD), body weight (BW) gain and impaired glucose tolerance development were associated with alveolar bone loss in susceptible individuals. This report explores the Collaborative Cross (CC) mouse population for studying the impact of genetic background on the comorbidity of alveolar bone change and glucose tolerance following HFD consumption. METHODS: 78 mice from 19 different CC lines were maintained on rodents chow diet (CH) for 8 weeks, and subsequently, transferred to HFD (42% Fat) for an additional 12 weeks...
May 19, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28523431/the-dsm-5-self-rated-level-1-cross-cutting-symptom-measure-as-a-screening-tool
#18
Leo Bastiaens, James Galus
The DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Measure was developed to aid clinicians with a dimensional assessment of psychopathology; however, this measure resembles a screening tool for several symptomatic domains. The objective of the current study was to examine the basic parameters of sensitivity, specificity, positive and negative predictive power of the measure as a screening tool. One hundred and fifty patients in a correctional community center filled out the measure prior to a psychiatric evaluation, including the Mini International Neuropsychiatric Interview screen...
May 19, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28523153/pleural-pressure-theory-revisited-a-role-for-capillary-equilibrium
#19
Aaron R Casha, Roberto Caruana-Gauci, Alexander Manche, Marilyn Gauci, Stanley Chetcuti, Luca Bertolaccini, Marco Scarci
BACKGROUND: Theories elucidating pleural pressures should explain all observations including the equal and opposite recoil of the chest wall and lungs, the less than expected pleural hydrostatic gradient and its variation at lobar margins, why pleural pressures are negative and how pleural fluid circulation functions. METHODS: A theoretical model describing equilibrium between buoyancy, hydrostatic forces, and capillary forces is proposed. The capillary equilibrium model described depends on control of pleural fluid volume and protein content, powered by an active pleural pump...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28522908/detection-and-characterization-of-murine-colitis-and-carcinogenesis-by-molecularly-targeted-contrast-enhanced-ultrasound
#20
Markus Brückner, Jan Heidemann, Tobias M Nowacki, Friederike Cordes, Jörg Stypmann, Philipp Lenz, Faekah Gohar, Andreas Lügering, Dominik Bettenworth
AIM: To study mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) and vascular endothelial growth factor (VEGF)-targeted contrast enhanced ultrasound (CEUS) for the assessment of murine colitis and carcinogenesis. METHODS: C57BL/6 mice were challenged with 3% dextran sodium-sulfate (DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAdCAM-1-targeted contrast agent was used to detect and quantify MAdCAM-1 expression...
April 28, 2017: World Journal of Gastroenterology: WJG
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