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radiation vena cava syndrome

Vahid Mohammad Karimi, Amir Anushiravani, Mohammad Hossein Dabbaghmanesh, Massood Hosseinzadeh, Ali Reza Rasekhi, Mahmoud Zamirian, Amir Anushiravani
The Budd-Chiari syndrome (BCS) is a rare disorder caused by the obstruction of the hepatic veins or the inferior vena cava (IVC) at the suprahepatic level. This syndrome is developed by either hepatic vein thrombosis or mechanical venous obstruction and leads to centrilobular hepatic congestion with the subsequent development of fibrosis and cirrhosis. Intracardiac tumors have been rarely reported as a cause of the BCS. These tumors usually originate from the atrial septum. Very rarely, they arise either from the junction of the IVC and the right atrium or from the Eustachian valve...
July 6, 2016: Journal of Tehran Heart Center
Xiangzheng Liu, Shijie Zhang, Jian Li
Patients with thoracic malignant tumors often suffered from superior vena cava syndrome (SVCS), featured by high morbidity and mortality. Traditionally treated with palliative approaches, SVCS has been widely studied and novel therapeutic approaches have been investigated, focusing on drug therapy, interventional therapy, radiation therapy, surgery and proton therapy. In this manuscript, the progress of therapeutic approaches for SVCS is summarized.
November 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Viviane B L Torres, Juliana Vassalo, Ulysses V A Silva, Pedro Caruso, André P Torelly, Eliezer Silva, José M M Teles, Marcos Knibel, Ederlon Rezende, José J S Netto, Claudio Piras, Luciano C P Azevedo, Fernando A Bozza, Nelson Spector, Jorge I F Salluh, Marcio Soares
INTRODUCTION: Cancer patients are at risk for severe complications related to the underlying malignancy or its treatment and, therefore, usually require admission to intensive care units (ICU). Here, we evaluated the clinical characteristics and outcomes in this subgroup of patients. MATERIALS AND METHODS: Secondary analysis of two prospective cohorts of cancer patients admitted to ICUs. We used multivariable logistic regression to identify variables associated with hospital mortality...
2016: PloS One
Kaustav Talapatra, Soumadip Panda, Sandeep Goyle, Kallol Bhadra, Rajesh Mistry
Superior vena cava syndrome is referred to as a constellation of symptoms and signs caused by obstruction of superior vena cava. It can occur due to both benign and malignant causes with the latter being the predominant. There is a paradigm shift in the approach to manage this condition. It is no longer considered a medical emergency and histological diagnosis is necessary before treatment. This article reviews the causes, symptoms, pathophysiology, and overall management policy which have changed over decades...
April 2016: Journal of Cancer Research and Therapeutics
Nicholas Marinus Batt, Dean Malik, Miranda Harvie, Hemant Sheth
A 40-year-old woman with antiphospholipid syndrome presented with a 5-day history of right upper quadrant (RUQ) pain, radiating posteriorly, associated with fever and vomiting. She was admitted 1-week prior with an upper respiratory infection and erythema multiforme. Clinical assessment revealed sepsis with RUQ tenderness and positive Murphy's sign. Laboratory results showed raised inflammatory markers, along with renal and liver impairment. CT showed bilateral adrenal infarction and inferior vena cava thrombus...
July 20, 2016: BMJ Case Reports
A M Morales-Codina, J A Martín-Benlloch, M Corbellas Aparicio
INTRODUCTION: To describe a single case, the fourth ever reported, of pleomorphic liposarcoma of the spine and to undertake a review of the literature. PRESENTATION OF CASE: A 60 year old male patient had a bilateral lumbosciatica over a 3 month period. Imaging tests revealed a tumor mass in L1-L3 and a fracture in L2. Also, he had a mural thrombus both in the inferior vena cava and the left renal vein. The biopsy revealed a well-differentiated liposarcoma. En bloc resection of the lesion and stabilization was carried out...
2016: International Journal of Surgery Case Reports
Christopher Straka, James Ying, Feng-Ming Kong, Christopher D Willey, Joseph Kaminski, D W Nathan Kim
Superior vena cava syndrome (SVCS) is a relatively common sequela of mediastinal malignancies and may cause significant patient distress. SVCS is a medical emergency if associated with laryngeal or cerebral edema. The etiologies and management of SVCS have evolved over time. Non-malignant SVCS is typically caused by infectious etiologies or by thrombus in the superior vena cava and can be managed with antibiotics or anti-coagulation therapy, respectively. Radiation therapy (RT) has long been a mainstay of treatment of malignant SVCS...
2016: SpringerPlus
Michael S Binkley, Susan M Hiniker, Aadel Chaudhuri, Peter G Maxim, Maximilian Diehn, Billy W Loo, David Benjamin Shultz
PURPOSE: We determined cumulative dose to critical structures, rates of toxicity, and outcomes following thoracic reirradiation. METHODS AND MATERIALS: We retrospectively reviewed our institutional database for patients treated between 2008 and 2014, who received thoracic reirradiation with overlap of 25% prescribed isodose lines. Patients received courses of hyperfractionated (n=5), hypofractionated (n=5), conventionally fractionated (n=21), or stereotactic ablative radiation therapy (n=51)...
March 15, 2016: International Journal of Radiation Oncology, Biology, Physics
Nicholas G Zaorsky, Talha Shaikh, Elizabeth Handorf, Gary Eastwick, Adam Hesney, Eli D Scher, Ryan T Jones, Timothy N Showalter, Vladimir Avkshtol, Stephanie R Rice, Eric M Horwitz, Joshua E Meyer
PURPOSE: The purposes of this study were to assess the exposure that medical students (MSs) have to radiation oncology (RO) during the course of their medical school career, as evidenced by 2 time points in current medical training (ie, first vs fourth year; MS1s and MS4s, respectively) and to assess the knowledge of MS1s, MS4s, and primary care physicians (PCPs) about the appropriateness of RT in cancer management in comparison with RO attendings. METHODS: We developed and beta tested an electronic survey divided into 3 parts: RO job descriptions, appropriateness of RT, and toxicities of RT...
February 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Nishan Bingham, H James Wallace Iii, Joanne Monterroso, Claire Verschraegen, Brenda L Waters, Christopher J Anker
Radiation therapy (RT) is the standard of care for cases of superior vena cava (SVC) syndrome secondary to metastatic adenopathy. Histologies vary in radiosensitivity and response time, making alternative therapies such as chemotherapy and/or intravenous stenting preferable alternative options for certain diagnoses. Metastatic urothelial carcinoma is a particularly rare cause of SVC syndrome with only 3 cases reported in the literature. Consequently, optimal management remains challenging, particularly in cases of high tumor burden...
2015: Case Reports in Oncological Medicine
Bruce M Bell, Marco Cura, Cathryn J Shaw, Chet R Rees
When performed for Budd-Chiari syndrome (BCS), transjugular intrahepatic portosystemic shunt (TIPS) creation can be technically difficult due to hepatic congestion and asymmetric hypertrophy. We present three female patients with decompensated BCS in whom TIPS were created using a three-dimensional fluoroscopy guidance system. On a dedicated workstation using three-dimensional volumes of computed tomography imaging, a virtual needle path was created by the operator extending from the needle entry point (hepatic vein stump or inferior vena cava) to the target portal vein...
October 2015: Proceedings of the Baylor University Medical Center
Tomoyuki Nakano, Shunsuke Endo
Mediastinal tumor occasionally causes life-threatening symptoms by infection, enlargement, and invasion to intrathoracic organs requiring an emergent treatment, while routine chest computed tomography (CT) can increasingly lead to incidental diagnosis of an asymptomatic mediastinal tumor. Cystic teratoma is one of the mediastinal tumors with lethal symptoms by rupture into the intrathoracic organs and/or cavities. Emergent tumor resection should be recommended when clinical characters suggest the diagnosis...
July 2015: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Michela Maur, Angela Toss, Massimo Dominici, Antonio Frassoldati, Paolo Corradini, Antonio Maiorana, Annalisa Fontana, Pierfranco Conte
BACKGROUND: NUT midline carcinoma (NMC) is a rare, highly lethal malignancy that results from a chromosome translocation and mostly arises in the midline organs. To date, no treatment has been established. Most patients receive combinations of chemotherapy regimens and radiation, and occasionally subsequent resection; nevertheless, patients have an average survival hardly exceeding 7 months. CASE REPORT: A 21-year-old patient was admitted to our division with a large mediastinal mass with lung nodules, multiple vertebral metastases, and massive nodal involvement...
2015: American Journal of Case Reports
Zhen-Bo Wang, Fang-Ling Ning, Xiao-Le Wang, Yu-Feng Cheng, Xin-Jun Dong, Chang-Min Liu, Shao-Shui Chen
Approximately 10% of small cell lung cancer (SCLC) cases develop superior vena cava syndrome (SVCS). Many SCLC patients with SVCS have relatively limited disease, requiring curative rather than palliative treatment. Besides chemotherapy, radiotherapy is important for treating SCLC with SVCS. We retrospectively evaluated the influence of radiotherapy dose on the prognosis of 57 patients with SCLC with SVCS treated with concurrent chemoradiotherapy. The mean biological equivalent radiation dose was 71.5 Gy. We administered etoposide/cisplatin as sequential and concurrent chemotherapy...
2015: International Journal of Clinical and Experimental Medicine
Predrag Matić, Goran Vučurević, Srdjan Babić, Slobodan Tanasković, Branko Lozuk, Dragan Sagić, Djordje Radak
INTRODUCTION: Leiomyosarcomas of the inferior vena cava are rare malignant tumors. A limited number of these cases have been described so far. Only few of them have intracardiac propagation and surgery is rarely undertaken for their treatment. CASE OUTLINE: We present a 52-year-old female patient in whom leiomyosarcoma of the inferior vena cava with intracardiac propagation was diagnosed. The patient underwent successful surgical treatment with complete removal of the tumor and direct suture of the inferior vena cava...
January 2015: Srpski Arhiv za Celokupno Lekarstvo
Marcos D Guimaraes, Almir G V Bitencourt, Edson Marchiori, Rubens Chojniak, Jefferson L Gross, Vikas Kundra
Increased incidence world-wide of cancer and increased survival has also resulted in physicians seeing more complications in patients with cancer. In many cases, complications are the first manifestations of the disease. They may be insidious and develop over a period of months, or acute and manifest within minutes to days. Imaging examinations play an essential role in evaluating cancer and its complications. Plain radiography and ultrasonography (US) are generally performed initially in an urgent situation due to their wide availability, low cost, and minimal or no radiation exposure...
April 29, 2014: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Martha-Grace Knuttinen, Jillian Karow, Winnie Mar, Margaret Golden, Karen L Xie
Magnetic resonance angiography (MRA) provides noninvasive visualization of the vascular supply of soft tissue masses and vascular pathology, without harmful radiation. This is important for planning an endovascular intervention, and helps to evaluate the efficiency and effectiveness of the treatment. MRA with conventional extracellular contrast agents relies on accurate contrast bolus timing, limiting the imaging window to first-pass arterial phase. The recently introduced blood pool contrast agent (BPCA), gadofosveset trisodium, reversibly binds to human serum albumin, resulting in increased T1 relaxivity and prolonged intravascular retention time, permitting both first-pass and steady-state phase high-resolution imaging...
2014: Journal of Clinical Imaging Science
Imtiaz Ahmed, Ahitagni Biswas, Sapna Krishnamurthy, Pramod K Julka
Toxic epidermal necrolysis (TEN) is a severe drug induced type IV hypersensitivity syndrome that can be caused by anticonvulsant drugs, especially the aromatic anticonvulsants such as phenytoin. Most patients with brain metastasis receive whole brain radiotherapy along with anti-edema measures and anticonvulsants either as prophylactic or for symptom control; phenytoin being the most commonly used drug. In a subset of patients, cranial irradiation may act as a precipitating factor along with anticonvulsants for the development of TEN...
November 2014: Saudi Medical Journal
T Windisch, J R Fischer, A Vega, S Decker, M Held, T P Graeter
The benefits of surgical therapy of locally advanced non-small cell lung cancer (NSCLC) with infiltration of the superior vena cava (SVC) remains controversial. Here we describe our therapeutic approach and results of our intervention.A retrospective analysis of 22 patients with NSCLC who underwent SVC replacement (n = 17) or reconstruction (n = 5) between 1998 and 2013 was performed. Pneumonectomy was necessary in 16 patients, lobectomy in 8. Preoperative chemotherapy was administered to 3 patients, 16 received postoperative radiation treatment...
January 2015: Pneumologie
Ebru Unsal, Filiz Cimen, Fatma Canbay, Mujgan Guler
Cancer Global Case ReportsSESSION TYPE: Global Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Lung cancer is the leading cause of cancer-related mortality worldwide. Non-small-cell lung cancers are the most frequent type of lung tumors, with two major histological subtypes: adenocarcinomas and squamous cell carcinomas (1). Squamous-cell carcinoma is the most common histological type of lung cancer to cavitate. Multiple cavitary lesions in primary lung cancer are rare, however, multifocal bronchoalveolar cell carcinoma can occasionally have multiple cavitary lesions (2)...
October 1, 2014: Chest
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