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radiation spinal cord compression

Arif Hussain, Abdalla Aly, C Daniel Mullins, Yi Qian, Jorge Arellano, Eberechukwu Onukwugha
The purpose of this study was to estimate the risk of developing skeletal-related events (SREs) based on site of metastasis at diagnosis and identify other predictors of developing SREs among metastatic prostate cancer patients. We conducted a retrospective cohort study using linked SEER (Surveillance, Epidemiology, and End Results) and Medicare data and identified men over the age of 65 with incident metastatic prostate cancer diagnosed during 2005-2009. SREs included radiation (RAD), pathological fractures (PF), bone surgery (BS), and spinal cord compression (SCC)...
October 11, 2016: Cancer Medicine
W H Mui, T C Lam, F C S Wong, W K Sze, S Y Tung
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
V H Lee, T W Lam, S C Ng, M H Szeto, K O Lam, T W Leung
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
M M Gestaut, N Thawani, S Kim, V R Gutti, A Morrow, R A Ward, J H Huang, M K Patel
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
J D D Pennington, A U Kishan, A M Chen
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Sean C Martin, Bassam O Dabbous, Elliott E Ridgeon, Shailendra A Magdum, Thomas A D Cadoux-Hudson, Erlick A C Pereira
OBJECTIVES: Anterior cervical discectomy and fusion (ACDF) is a common operative treatment of compressive pathology of the cervical spinal cord, when caused by one or more degenerated intervertebral discs or related osteophytes. In addition to intra-operative radiographs to confirm spinal level before discectomy and implant position after insertion, traditional practice is to obtain post-operative antero-posterior and lateral plain radiographs (XR) before hospital discharge, despite a paucity of evidence supporting their benefit to patient care...
September 22, 2016: British Journal of Neurosurgery
J C Faivre, J F Py, G Vogin, G Martinage, J Salleron, P Royer, N Grandgirard, D Pasquier, S Thureau
Analgesic external beam radiation therapy is a standard of care for patients with uncomplicated painful bone metastases and/or prevention of bone complications. In case of fracture risk, radiation therapy is performed after surgery in a consolidation of an analgesic purpose and stabilizing osteosynthesis. Radiotherapy is mandatory after vertebroplasty or kyphoplasty. Spinal cord compression - the only emergency in radiation therapy - is indicated postoperatively either exclusively for non surgical indication...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Joe H Chang, John H Shin, Yoshiya J Yamada, Addisu Mesfin, Michael G Fehlings, Laurence D Rhines, Arjun Sahgal
STUDY DESIGN: Systematic literature review. OBJECTIVES: To summarize the risks of 3 key complications of stereotactic body radiotherapy (SBRT) for spinal metastases, that is, radiation myelopathy (RM), vertebral compression fracture (VCF), and epidural disease progression, and to discuss strategies for minimizing them. SUMMARY OF BACKGROUND DATA: RM, VCF and epidural disease progression are now recognized as important risks following SBRT for spine metastases...
October 15, 2016: Spine
Avin Yaldo, Lonnie Wen, Augustina Ogbonnaya, Adriana Valderrama, Jonathan Kish, Michael Eaddy, Charles Kreilick, Krishna Tangirala, Katarzyna Shields
PURPOSE: The development of skeletal-related events (SREs) (pathologic fracture, need for surgery and/or radiation to bone, spinal cord compression, and hypercalcemia of malignancy) in metastatic prostate cancer (MPC) is associated with worsened pain and compromised quality of life. Opioids are frequently used throughout the course of SRE treatment. This study describes the treatment patterns and incremental use of opioids in MPC patients diagnosed with SREs. METHODS: PC patients with bone metastases newly diagnosed with an SRE between January 1, 2005, and September 30, 2014, were identified using MarketScan Commercial and Medicare databases...
August 2016: Clinical Therapeutics
Dara Bakar, Joseph E Tanenbaum, Kevin Phan, Vincent J Alentado, Michael P Steinmetz, Edward C Benzel, Thomas E Mroz
OBJECTIVE The aim of this study was to systematically review the literature on reported outcomes following decompression surgery for spinal metastases. METHODS The authors conducted MEDLINE, Scopus, and Web of Science database searches for studies reporting clinical outcomes and complications associated with decompression surgery for metastatic spinal tumors. Both retrospective and prospective studies were included. After meeting inclusion criteria, articles were categorized based on the following reported outcomes: survival, ambulation, surgical technique, neurological function, primary tumor histology, and miscellaneous outcomes...
August 2016: Neurosurgical Focus
Nathan T Zwagerman, Michael M McDowell, Ronald L Hamilton, Edward A Monaco, John C Flickinger, Peter C Gerszten
OBJECTIVE Increased survival time after diagnosis of neoplastic disease has resulted in a gradual increase in spine tumor incidence. Radiosurgery is frequently a viable alternative to operative management in a population with severe medical comorbidities. The authors sought to assess the histopathological consequences of radiosurgery in the subset of patients progressing to operative intervention. METHODS Eighteen patients who underwent radiosurgery for spine tumors between 2008 and 2014 subsequently progressed to surgical treatment...
August 2016: Neurosurgical Focus
Stefan Janssen, Louisa Bolm, Lukas Käsmann, Tobias Bartscht, Dirk Rades
AIM: Spinal cord compression (SCC) from metastatic soft tissue sarcoma is a rare condition. Little is known regarding its optimal treatment. It is not clear whether these patients should receive radiation therapy alone or neurosurgery plus radiation therapy. This study focused on outcomes of patients with SCC from soft tissue sarcoma after radiation therapy alone. PATIENTS AND METHODS: The effect of radiotherapy on pain relief and motor function and overall survival were evaluated in four patients...
July 2016: In Vivo
L E Howard, A M De Hoedt, W J Aronson, C J Kane, C L Amling, M R Cooperberg, M K Terris, C H Divers, A Valderrama, S J Freedland
BACKGROUND: Skeletal-related events (SREs) including pathologic fracture, spinal cord compression, radiation to bone and surgery to bone, are common in men with bone metastatic castration-resistant prostate cancer (mCRPC). Men with mCRPC are at high risk of death. Whether SREs predict mortality is unclear. We tested the association between SREs and overall survival (OS) in a multiethnic cohort with bone mCRPC, controlling for key covariates unavailable in claims data such as bone pain, number of bone metastases and PSA doubling time (PSADT)...
July 5, 2016: Prostate Cancer and Prostatic Diseases
Ahmed Hashmi, Matthias Guckenberger, Ron Kersh, Peter C Gerszten, Frederick Mantel, Inga S Grills, John C Flickinger, John H Shin, Daniel K Fahim, Brian Winey, Kevin Oh, B C John Cho, Daniel Létourneau, Jason Sheehan, Arjun Sahgal
OBJECTIVE This study is a multi-institutional pooled analysis specific to imaging-based local control of spinal metastases in patients previously treated with conventional external beam radiation therapy (cEBRT) and then treated with re-irradiation stereotactic body radiotherapy (SBRT) to the spine as salvage therapy, the largest such study to date. METHODS The authors reviewed cases involving 215 patients with 247 spinal target volumes treated at 7 institutions. Overall survival was calculated on a patient basis, while local control was calculated based on the spinal target volume treated, both using the Kaplan-Meier method...
June 24, 2016: Journal of Neurosurgery. Spine
Dirk Rades, Antonio J Conde-Moreno, Jon Cacicedo, Barbara Šegedin, Volker Rudat, Steven E Schild
AIM: Malignant spinal cord compression (SCC) is treated with radiotherapy (RT). Additional neurosurgery has become more widely used since a trial showed a benefit for selected patients. Although lymphomas were excluded from that trial, neurosurgery is also increasingly being performed in these patients. This study investigated whether neurosurgery is actually required for this group. PATIENTS AND METHODS: Twenty-nine patients receiving RT alone for SCC from vertebral lymphoma were analyzed for motor function, walking ability, in-field recurrence and survival...
June 2016: Anticancer Research
Regina L Toto, Noel S Zuckerbraun, Mioara D Manole
BACKGROUND: Neck pain in the pediatric population has a broad differential diagnosis, ranging from benign to imminently life-threatening causes. Trauma and infection represent the most common etiologies of pediatric neck pain in the pediatric emergency department (PED) setting. Malignancy, though a rare cause of pediatric neck pain, is important to consider in patients with acquired torticollis or focal neurologic signs. CASE REPORT: We describe the case of a previously healthy 12-year-old female who presented to the PED with neck pain radiating down her upper extremities...
August 2016: Journal of Emergency Medicine
Evangelos Terpos, Meletios A Dimopoulos, Lia A Moulopoulos
The novel criteria for the diagnosis of symptomatic multiple myeloma have revealed the value of modern imaging for the management of patients with myeloma. Whole-body low-dose CT (LDCT) has increased sensitivity over conventional radiography for the detection of osteolytic lesions, and several myeloma organizations and institutions have suggested that whole-body LDCT should replace conventional radiography for the work-up of patients with myeloma. MRI is the best imaging method for the depiction of marrow infiltration by myeloma cells...
2016: American Society of Clinical Oncology Educational Book
Terence Verla, Jonathan G Thomas, Vilmos Thomazy, Gregory N Fuller, Aziz Shaibani, Ibrahim Omeis
Radiation therapy continues to play an extremely valuable role in the treatment of malignancy. The effects of radiation therapy on normal tissue can present in a delayed fashion, resulting in localized damage with pseudomalignant transformation, producing a compressive effect on the spinal cord or exiting nerve roots. Infiltration of inflammatory cells and the subsequent fibrotic response can result in the development of an inflammatory pseudotumor (benign tumor-like lesion) with subsequent mass effect. Herein, the authors present a rare case of inflammatory pseudotumor with fulminant cervicothoracic cord compression, developing 7 years after radiation therapy for breast cancer...
May 27, 2016: Journal of Neurosurgery. Spine
Zhangkai J Cheng, Regina M Bromley, Brad Oborn, Martin Carolan, Jeremy T Booth
The metallic fixations used in surgical procedures to support the spine mechani-cally usually consist of high-density materials. Radiation therapy to palliate spinal cord compression can include prophylactic inclusion of potential tumor around the site of such fixation devices. Determination of the correct density and shape of the spine fixation device has a direct effect on the dose calculation of the radiation field. Even with the application of modern computed tomography (CT), under- or overestimation of dose, both immediately next to the device and in the surround-ing tissues, can occur due to inaccuracies in the dose prediction algorithm...
2016: Journal of Applied Clinical Medical Physics
Woo-Kie Min, Ju-Eun Kim
STUDY DESIGN: Retrospective case study. OBJECTIVE: To report on a case with an extensive intradural arachnoid cyst that caused left hemiparesis. SUMMARY OF BACKGROUND DATA: Intradural arachnoid cysts are not common causes of spinal cord compression and myelopathy. Although arachnoid cysts of the spine have been occasionally reported, cases with extensive intradural arachnoid cysts associated with hemiparesis are rarely reported. METHOD: The patient was a 43-year-old woman who had cervical myelopathy symptoms, including radiating pain and left limb hemiparesis with gait disturbance...
June 2016: Journal of Orthopaedics
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