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radiation therapy bleeding

L Sapienza, C R Leão, B B Silva, D G Castro, R C Fogaroli, C Pellizzon
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Jae Hoon Lee, Jisun Yun, Jung-Won Seo, Go-Eun Bae, Jeong-Won Lee, Sang Wun Kim
Primary malignant melanoma (MM) accounts for 1% of all cancers, and only 3% to 7% of these tumors occur in the female genital tract. Data are limited with respect to the basis for treatment recommendations because of the rarity of MM. The overall prognosis of melanomas of the female genital tract is very poor. Two cases of MM of the female genital tract are presented. The first case is of a 70-year-old female patient who complained of left thigh pain and underwent magnetic resonance imaging that showed cervical cancer with involvement of the vagina, bladder, and parametrium, in addition to multiple bony metastases of the proximal femur, acetabulum, and both iliac bones...
September 2016: Obstetrics & Gynecology Science
Joseph Weiner, David Schwartz, Manuel Martinez, Joseph Safdieh, Ayse Aytaman, David Schreiber
PURPOSE: This study was designed to assess the efficacy and outcomes of argon plasma coagulation (APC) in the management of chronic radiation proctitis after conventionally fractionated, dose-escalated radiation therapy (≥7560 cGy). METHODS AND MATERIALS: We retrospectively reviewed the charts on all patients treated with external beam radiation therapy (minimum dose, 7560 cGy) for histologically confirmed prostate cancer at our institution from 2003 to 2011. Five hundred patients met these criteria; of these, 35 patients (7...
August 1, 2016: Practical Radiation Oncology
Jae Y Lee, Stephanie Daignault-Newton, Gerard Heath, Sarah Scarlett, Martin G Sanda, Peter Chang, Meredith M Regan, Jeff M Michalski, Howard M Sandler, Felix Y Feng, Deborah A Kuban, Anthony L Zietman, Jay P Ciezki, Irving D Kaplan, Catrina Crociani, William P McLaughlin, Constantine A Mantz, Steven E Finkelstein, Simeng Suy, Sean P Collins, Olatz Garin, Montserrat Ferrer, Daniel A Hamstra, Daniel E Spratt
PURPOSE: The new short Expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) patient-reported health-related quality of life (HRQOL) tool has removed the rectal bleeding question from the previous much longer version, EPIC-26. Herein, we assess the impact of losing the dedicated rectal bleeding question in 2 independent prospective multicenter cohorts. METHODS AND MATERIALS: In a prospective multicenter test cohort (n=865), EPIC-26 patient-reported HRQOL data were collected for 2 years after treatment from patients treated with prostate radiation therapy from 2003 to 2011...
August 3, 2016: International Journal of Radiation Oncology, Biology, Physics
Fei Dong, Qian Li, JianJun Wu, MinMing Zhang, GuangQiang Zhang, Bin Li, Kai Jin, Jie Min, WeiRen Liang, Ming Chao
INTRODUCTION: Carotid blowout syndrome (CBS) secondary to radiation therapy is life-threatening and requires emergency treatment. More recently, endovascular treatment has provided an effective way to control CBS-related bleeding. CASE DESCRIPTION: We present a case of CBS with a rupture of the internal carotid artery (ICA) pseudo-aneurysm after Gamma Knife radiation therapy for nasopharyngeal carcinoma (NPC). The patient was a 55-year-old man who was transferred to our hospital with severe repetitive epistaxis...
2016: SpringerPlus
Ben G L Vanneste, Aswin L Hoffmann, Emile N van Lin, Lien Van De Voorde, Michael Pinkawa, Philippe Lambin
BACKGROUND AND PURPOSE: Previous studies confirmed that implantable rectum spacers (IRS) decreased acute gastro-intestinal (GI) toxicity in a significant percentage of prostate cancer patients undergoing intensity modulated radiation therapy (IMRT). We developed decision rules based on clinical risk factors (CRFs) to select those patients who are expected to benefit most from IRS implantation. MATERIALS AND METHODS: For 26 patients dose distributions with (IMRT+IRS) and without (IMRT-IRS) IRS were calculated...
September 16, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Brian D Montgomery, Stephen A Boorjian, Matthew J Ziegelmann, Daniel D Joyce, Brian J Linder
OBJECTIVE: Hemorrhagic cystitis is a challenging clinical entity with limited evidence available to guide treatment. The use of intravesical silver nitrate has been reported, though supporting literature is sparse. Here, we sought to assess outcomes of patients treated with intravesical silver nitrate for refractory hemorrhagic cystitis. MATERIAL AND METHODS: We identified nine patients with refractory hemorrhagic cystitis treated at our institution with intravesical silver nitrate between 2000-2015...
September 2016: Turkish Journal of Urology
Filippo Milano, Fabiola Merriam, Ian Nicoud, Jianqiang Li, Ted A Gooley, Shelly Heimfeld, Suzan Imren, Colleen Delaney
: : The hematopoietic syndrome of acute radiation syndrome (h-ARS) is characterized by severe bone marrow aplasia, resulting in a significant risk for bleeding, infections, and death. To date, clinical management of h-ARS is limited to supportive care dictated by the level of radiation exposure, with a high incidence of mortality in those exposed to high radiation doses. The ideal therapeutic agent would be an immediately available, easily distributable single-agent therapy capable of rapid in vivo hematopoietic reconstitution until recovery of autologous hematopoiesis occurs...
September 13, 2016: Stem Cells Translational Medicine
Joseph Paul Weiner, Andrew Thomas Wong, David Schwartz, Manuel Martinez, Ayse Aytaman, David Schreiber
Pelvic radiation is a commonly utilized treatment for malignancy of the genitourinary and lower gastrointestinal tract. Radiation proctitis and the resultant clinical picture varies from asymptomatic to potentially life threatening. Similarly, treatment options also vary greatly, from medical therapy to surgical intervention. Commonly utilized medical therapy includes sucralfate enemas, antibiotics, 5-aminosalicylic acid derivatives, probiotics, antioxidants, short-chain fatty acids, formalin instillation and fractionated hyperbaric oxygen...
August 21, 2016: World Journal of Gastroenterology: WJG
Zhiming Wang, Li Liang, Yiyi Yu, Yan Wang, Rongyuan Zhuang, Yong Chen, Yuehong Cui, Yuhong Zhou, Tianshu Liu
BACKGROUND: The effect of primary tumour resection (PTR) among metastatic colorectal cancer (mCRC) patients remains controversial. Combination chemotherapy with bevacizumab could improve the clinical outcomes of these patients, which might change the importance of PTR in the multi-disciplinary treatment pattern. METHODS: We performed a non-randomized prospective controlled study of mCRC pts whose performance status (PS) scored ≤2 and who received bevacizumab combination chemotherapy (FOLFOX/XELOX/FOLFIRI) as a first-line therapy...
2016: Cellular Physiology and Biochemistry
Takashi Tachibana, Kazumasa Matsumoto, Shoji Nagi, Masahiro Hagiwara, Kentaro Kobayashi, Hideyasu Tsumura, Kazunari Yoshida, Masatsugu Iwamura
We report two octogenarian patients with primary urethral cancer treated with chemotherapy and external beam radiation therapy. An 85-year-old female presented with perineal bleeding. Magnetic resonance imaging (MRI) showed a locally advanced tumor in the urethra. Biopsy was performed and pathologic findings demonstrated squamous cell carcinoma. After receiving one cycle of a half dose of gemcitabine and nedaplatin, the patient received external beam radiation therapy with gemcitabine and nedaplatin treatment followed by two more cycles of chemotherapy...
July 2016: Hinyokika Kiyo. Acta Urologica Japonica
Lucio Dell'Atti, Papa Stefano, Capparelli Gaetano, Ippolito Carmelo
PURPOSE: To assess the efficacy of a short prophylaxis with tranexamic acid in reducing blood loss during transrectal ultrasound-guided prostate biopsy (TRUSBx) in patients taking oral anti-platelet therapy and to prospectively compare this approach with patients without oral prophylaxis. METHODS: A total of 359 consecutive patients taking chronic low dose aspirin were enrolled in this prospective study. Before TRUSBx all patients were randomly assigned into two groups; a short oral prophylaxis with tranexamic acid 500 mg orally, taken one hour before the procedure (group A, N:178 ) and those without oral prophylaxis (group B, N:181)...
May 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Lorna A Brudie, Faizan Khan, Michael J Radi, Sarfraz Ahmad
Endometrial serous carcinomas are very clinically aggressive, which constitutes 40% of all deaths and recurrences associated with endometrial cancer. Small-cell carcinoma of the endometrium is relatively rare but aggressive, and often presents a component of endometrioid carcinoma, and is not generally associated with serous carcinoma. Herein, we report a case of 74-year-old African-American female, who presented with intermittent post-menopausal bleeding for > 1-month. She underwent robotic-assisted laparoscopic hysterectomy, bilateral salpingo-oophorectomy, sentinel lymph node mapping, and pelvic-and-aortic lymphadenectomy...
August 2016: Gynecologic Oncology Reports
Kitty Huang, David D'Souza, Nikhilesh Patil, Vikram Velker, Eric Leung, Larry Stitt, Frances Whiston, Akira Sugimoto, Jacob McGee, Michel Prefontaine
PURPOSE: Limited therapeutic options are available for the treatment of locally recurrent endometrial carcinoma. Our objective was to report an institutional experience using interstitial brachytherapy (IBT) to treat significant recurrent endometrial carcinoma, including previously irradiated disease. METHODS AND MATERIALS: Between December 2004 and September 2012, 40 patients with high-volume locally recurrent endometrial cancer were treated by high-dose-rate IBT (± external beam radiation therapy EBRT)...
September 2016: Brachytherapy
Vishnu Prasad Nelamangala Ramakrishnaiah, Srinivasan Krishnamachari
Chronic haemorrhagic radiation proctitis (CHRP) is a difficult problem faced by the patients following radiation for pelvic malignancy. There is no standard treatment for this condition, but many methods of treatment are available. The aim of this study was to review the literature to see whether there is an improvement in the available evidence in comparison with previously published systematic reviews in treating patients with CHRP. The PubMed/Medline database and Google Scholar search was selectively searched...
July 27, 2016: World Journal of Gastrointestinal Surgery
Manmohan Singh, Deepak Aggarwal, Shashank Sharad Kale
INTRODUCTION: Large brain arteriovenous malformations (AVMs) pose management challenge in neurosurgical practice. Management remains conservative unless these AVMs bleed or present with neurological deficits. For patients who require treatment, options are limited with very high treatment-related morbidity. Gamma knife radiosurgery remains an excellent noninvasive option for such AVMs. METHODS: This is a retrospective study of 74 patients with large AVMs who were treated with gamma knife radiosurgery over 16 years...
August 2016: Neurosurgery
Jean-Louis Habrand, Jean Datchary, Stéphanie Bolle, Anne Beaudré, Ludovic de Marzi, Kévin Beccaria, Dinu Stefan, Jacques Grill, Rémi Dendale
We report an exceptional case of a very late local failure in a 9-year-old boy presenting with a chordoma of the cranio-cervical junction. The child was initially treated with a combination of surgical resection followed by high dose photon-proton radiation therapy. This aggressive therapy allowed a 9-year remission with minimal side-effects. Unfortunately, he subsequently presented with a local failure managed with a second full-dose course of protons. The child died one year later from local bleeding of unclear etiology...
July 2016: Reports of Practical Oncology and Radiotherapy
H N Ismael, J Denbo, S Cox, C H Crane, P Das, S Krishnan, R T Schroff, M Javle, C Conrad, J Vauthey, T Aloia
INTRODUCTION: Patients with unresectable liver tumors who fail initial treatment modalities have a poor prognosis (<1 yr). Although effective, delivery of high dose radiation therapy to these tumors is limited by proximity of radiosensitive bowel. We have previously reported that placement of a biologic mesh spacer (BMS) can effectively displace the bowel allowing for dose-intense radiation to be delivered with low short-term toxicity. The purpose of this study was to assess and report the long-term safety and oncologic outcomes of this cohort...
October 2016: European Journal of Surgical Oncology
Vincenzo Picardi, Francesco Deodato, Alessandra Guido, Lucia Giaccherini, Gabriella Macchia, Leonardo Frazzoni, Andrea Farioli, Dajana Cuicchi, Savino Cilla, Francesco Cellini, A F M Kamal Uddin, Maria Antonietta Gambacorta, Milly Buwenge, Andrea Ardizzoni, Gilberto Poggioli, Vincenzo Valentini, Lorenzo Fuccio, Alessio G Morganti
PURPOSE: The management of patients with symptomatic rectal cancer not amenable to curative treatment may be challenging. The aim of this phase 2 study was to evaluate the efficacy of short-course radiation therapy in patients with obstructing rectal cancer. METHODS AND MATERIALS: Patients who were not candidates for surgical resection because of synchronous metastases, age, and/or comorbidities were considered eligible. The sample size was calculated based on the 2-stage design of Simon...
July 15, 2016: International Journal of Radiation Oncology, Biology, Physics
Erika M Noonan, Timothy W Farrell
This summary of the American Cancer Society Prostate Cancer Survivorship Care Guidelines targets primary care physicians who coordinate care of prostate cancer survivors with subspecialists. Prostate cancer survivors should undergo prostate-specific antigen screening every six to 12 months and digital rectal examination annually. Surveillance of patients who choose watchful waiting for their prostate cancer should be conducted by a subspecialist. Any hematuria or rectal bleeding must be thoroughly evaluated...
May 1, 2016: American Family Physician
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