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https://www.readbyqxmd.com/read/28274402/patient-reported-quality-of-life-during-definitive-and-postprostatectomy-image-guided-radiation-therapy-for-prostate-cancer
#1
Kevin Diao, Emily A Lobos, Eda Yirmibesoglu, Ram Basak, Laura H Hendrix, Brittney Barbosa, Seth M Miller, Kevin A Pearlstein, Gregg H Goldin, Andrew Z Wang, Ronald C Chen
PURPOSE: The importance of patient-reported outcomes is well-recognized. Long-term patient-reported symptoms have been described for individuals who completed radiation therapy (RT) for prostate cancer. However, the trajectory of symptom development during the course of treatment has not been well-described in patients receiving modern, image-guided RT. METHODS AND MATERIALS: Quality-of-life data were prospectively collected for 111 prostate cancer patients undergoing RT using the validated Prostate Cancer Symptom Indices, which assessed 5 urinary obstructive/irritative and 6 bowel symptoms...
March 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28247661/-internal-drainage-in-cancer-patients-optimizing-treatment-of-stent-related-symptoms
#2
A G Martov, D V Ergakov, A B Novikov, N G Muzhetskaya, G L Esen'yan
INTRODUCTION: The so-called stent-related symptoms caused mainly by detrusor overactivity due to distal ("cystic") curl of the internal stent are common among patients with this type of drainage. The need for long-term stenting makes the quality of life of cancer patients one of the challenging problems of modern urology. The aim of this study was to optimize treatment of stent-related symptoms in cancer patients with internal long-term stents by complementing the treatment regimen with m-anticholinergic solifenacin...
April 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28247630/-salvage-external-beam-radiation-therapy-for-prostate-cancer-recurrence-after-high-intensity-focused-ultrasound-ablation
#3
R N Fomkin, V M Popkov, T V Shatylko
The article outlines oncological and functional outcomes of salvage external beam radiation therapy after HIFU-ablation in 49 patients. The study determined overall and relapse-free survival, compared the rates of adverse events stratified by CTCAE, erectile function and continence scores assessed by questionnaire survey. Univariate and multivariate analysis of risk factors for failure of salvage radiation therapy after prostate HIFU-ablation were conducted. In univariate analysis the level of prostate-specific antigen (PSA) prior to radiotherapy, the risk group, PSA nadir after radiotherapy, PSA nadir greater than 0...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28237294/automatic-planning-on-hippocampal-avoidance-whole-brain-radiotherapy
#4
Shuo Wang, Dandan Zheng, Chi Zhang, Rongtao Ma, Nathan R Bennion, Yu Lei, Xiaofeng Zhu, Charles A Enke, Sumin Zhou
Mounting evidence suggests that radiation-induced damage to the hippocampus plays a role in neurocognitive decline for patients receiving whole-brain radiotherapy (WBRT). Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) has been proposed to reduce the putative neurocognitive deficits by limiting the dose to the hippocampus. However, urgency of palliation for patients as well as the complexities of the treatment planning may be barriers to protocol enrollment to accumulate further clinical evidence. This warrants expedited quality planning of HA-WBRT...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28225655/mnte-2-pyp-treatment-or-nox4-inhibition-protects-against-radiation-induced-damage-in-mouse-primary-prostate-fibroblasts-by-inhibiting-the-tgf-beta-1-signaling-pathway
#5
Arpita Chatterjee, Elizabeth A Kosmacek, Rebecca E Oberley-Deegan
Prostate cancer patients who undergo radiotherapy frequently suffer from side effects caused by radiation-induced damage to normal tissues adjacent to the tumor. Exposure of these normal cells during radiation treatment can result in tissue fibrosis and cellular senescence, which ultimately leads to postirradiation-related chronic complications including urinary urgency and frequency, erectile dysfunction, urethral stricture and incontinence. Radiation-induced reactive oxygen species (ROS) have been reported as the most potent causative factor for radiation damage to normal tissue...
February 22, 2017: Radiation Research
https://www.readbyqxmd.com/read/28184272/treatment-of-radiation-induced-cystitis-and-vulvodynia-via-a-ganglion-impar-block-using-a-lateral-approach-under-computed-tomography-guidance-a-case-report
#6
Jeong-Eun Lee, Kyung-Hwa Kwak, Seong Wook Hong, Hoon Jung, Seung-Yeon Chung, Jun-Mo Park
Adjuvant radiation therapy (RT) after colorectal cancer surgery can prevent local recurrence, but has several side effects. Precise injection of drugs into the affected areas is complicated by radiation-induced fibrosis of soft or connective tissue. A 48-year-old woman experienced severe intractable perineal pain, dysuria, urinary urgency, and frequent urination after rectal cancer surgery and adjuvant RT, and was diagnosed with radiation-induced cystitis and vulvodynia. Her symptoms persisted despite two fluoroscopy-guided ganglion impar blocks...
February 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28009966/novel-approaches-in-genetic-characterization-and-targeted-therapy-for-brain-metastases
#7
Brandyn A Castro, Ruby Kuang, Priscilla K Brastianos
Metastases to the brain are a common complication of various cancers and are associated with poor prognosis. Management of these patients requires a multidisciplinary approach including whole-brain radiation therapy, stereotactic radiosurgery, surgical resection, chemotherapy, and supportive treatment. Because of recent technological advancements in genomics, our understanding of the genetics of brain metastases is rapidly advancing. This has led to the discovery of many potential genetic therapeutic targets in metastatic brain lesions...
November 2016: Discovery Medicine
https://www.readbyqxmd.com/read/27635624/patient-reported-urinary-bowel-and-sexual-function-after-hypofractionated-intensity-modulated-radiation-therapy-for-prostate-cancer-results-from-a-randomized-trial
#8
Karen E Hoffman, Heath Skinner, Thomas J Pugh, Khinh R Voong, Lawrence B Levy, Seungtaek Choi, Steven J Frank, Andrew K Lee, Usama Mahmood, Sean E McGuire, Pamela J Schlembach, Weiliang Du, Jennifer Johnson, Rajat J Kudchadker, Deborah A Kuban
OBJECTIVES: Hypofractionated prostate radiotherapy may increase biologically effective dose delivered while shortening treatment duration, but information on patient-reported urinary, bowel, and sexual function after dose-escalated hypofractionated radiotherapy is limited. We report patient-reported outcomes (PROs) from a randomized trial comparing hypofractionated and conventional prostate radiotherapy. METHODS: Men with localized prostate cancer were enrolled in a trial that randomized men to either conventionally fractionated intensity-modulated radiation therapy (CIMRT, 75...
September 15, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27496381/chronic-diarrhea-diagnosis-and-management
#9
REVIEW
Lawrence R Schiller, Darrell S Pardi, Joseph H Sellin
Chronic diarrhea is a common problem affecting up to 5% of the population at a given time. Patients vary in their definition of diarrhea, citing loose stool consistency, increased frequency, urgency of bowel movements, or incontinence as key symptoms. Physicians have used increased frequency of defecation or increased stool weight as major criteria and distinguish acute diarrhea, often due to self-limited, acute infections, from chronic diarrhea, which has a broader differential diagnosis, by duration of symptoms; 4 weeks is a frequently used cutoff...
February 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27389021/high-quality-linac-based-stereotactic-body-radiation-therapy-with-flattening-filter-free-beams-and-volumetric-modulated-arc-therapy-for-low-intermediate-risk-prostate-cancer-a-mono-institutional-experience-with-90-patients
#10
G D'Agostino, C Franzese, F De Rose, D Franceschini, T Comito, E Villa, F Alongi, R Liardo, S Tomatis, P Navarria, P Mancosu, G Reggiori, L Cozzi, M Scorsetti
AIMS: The aim of this phase II study was to evaluate the efficacy and toxicity of stereotactic body radiotherapy in patients with low or intermediate risk prostate cancer. MATERIALS AND METHODS: Biopsy-confirmed prostate cancer patients were enrolled, provided that they had the following characteristics: initial prostate-specific antigen (PSA) ≤ 20 ng/ml, Gleason Score < 7, International Prostate Symptom Score < 7. The treatment schedule was 35 Gy in five fractions, delivered with volumetric modulated arcs with flattening filter free beams...
July 4, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27181241/overactive-bladder-and-storage-lower-urinary-tract-symptoms-following-radical-prostatectomy
#11
Gregory W Hosier, Karthik K Tennankore, Jeffrey G Himmelman, Jerzy Gajewski, Ashley R Cox
OBJECTIVE: To describe the rate of overactive bladder (OAB) and storage lower urinary tract symptoms following radical prostatectomy (RP) and determine if subsequent radiation increases the risk of OAB. METHODS: We reviewed all patients who underwent open RP at our tertiary care institution from January 2006 to June 2011. Primary outcomes were the proportion of patients with new OAB and time to development of OAB in those treated with RP alone vs RP plus radiation...
August 2016: Urology
https://www.readbyqxmd.com/read/27111831/non-surgical-interventions-for-late-rectal-problems-proctopathy-of-radiotherapy-in-people-who-have-received-radiotherapy-to-the-pelvis
#12
REVIEW
Fleur T van de Wetering, Leen Verleye, H Jervoise N Andreyev, Jane Maher, Joan Vlayen, Bradley R Pieters, Geertjan van Tienhoven, Rob J P M Scholten
BACKGROUND: This is an update of a Cochrane review first published in 2002, and previously updated in 2007. Late radiation rectal problems (proctopathy) include bleeding, pain, faecal urgency, and incontinence and may develop after pelvic radiotherapy treatment for cancer. OBJECTIVES: To assess the effectiveness and safety of non-surgical interventions for managing late radiation proctopathy. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (Issue 11, 2015); MEDLINE (Ovid); EMBASE (Ovid); CANCERCD; Science Citation Index; and CINAHL from inception to November 2015...
April 25, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26797541/outcomes-associated-with-3-treatment-schedules-of-high-dose-rate-brachytherapy-monotherapy-for-favorable-risk-prostate-cancer
#13
Maha Saada Jawad, Joshua T Dilworth, Gary S Gustafson, Hong Ye, Michelle Wallace, Alvaro Martinez, Peter Y Chen, Daniel J Krauss
PURPOSE: We report the outcomes associated with 3 high-dose-rate (HDR) brachytherapy regimens used as monotherapy for favorable-risk prostate cancer. METHODS AND MATERIALS: Four hundred ninety-four patients with stage ≤T2b prostate cancer, Gleason score ≤7, and prostate-specific antigen levels ≤15 ng/mL underwent HDR brachytherapy as monotherapy. Of those, 319 received 38 Gy in 4 fractions, 79 received 24 Gy in 2 fractions, and 96 received 27 Gy in 2 fractions...
March 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26754654/validity-and-reliability-of-a-lithuanian-version-of-low-anterior-resection-syndrome-score
#14
N E Samalavicius, A Dulskas, M Lasinskas, G Smailyte
BACKGROUND: Up to 90 % of patients undergoing low anterior resection complain of increased daily bowel movements, urgency, and a variable degree of incontinence. A symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer has recently been developed and validated. The aim of our study was to adapt the low anterior resection syndrome (LARS) scale questionnaire to the Lithuanian language, and assess its psychometric properties. METHODS: The LARS questionnaire was translated into Lithuanian by the Scientific Advisory Committee of the Medical Outcomes Trust using a standard procedure of double-back translation...
April 2016: Techniques in Coloproctology
https://www.readbyqxmd.com/read/26732640/therapeutic-evaluation-of-biofeedback-therapy-in-the-treatment-of-anterior-resection-syndrome-after-sphincter-saving-surgery-for-rectal-cancer
#15
Zhonglin Liang, Wenjun Ding, Wei Chen, Zhongchuan Wang, Peng Du, Long Cui
BACKGROUND: Anterior resection syndrome (ARS) is common after sphincter-saving surgery for rectal cancer. It includes changes in the frequency and urgency of bowel movements and fecal incontinence. The therapeutic efficacy of biofeedback on ARS is unclear. We sought to evaluate the effectiveness of biofeedback therapy in patients with ARS after anterior resection for rectal cancer and to investigate the associated factors for therapeutic success. PATIENTS AND METHODS: The study was designed as a retrospective review of the data from 61 patients with ARS collected from a prospectively maintained institutional cancer database...
September 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/26554408/prostate-cancer-screening
#16
Elie Mulhem, Nikolaus Fulbright, Norah Duncan
Among American men, prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer-related death. Although prostate-specific antigen (PSA) testing has been used to screen for prostate cancer for more than 25 years, the test has low sensitivity and specificity, and there is no clear evidence for determining what threshold warrants prostate biopsy. Only one of five randomized controlled trials of PSA screening showed an effect on prostate cancer-specific mortality, and the absolute reduction in deaths from prostate cancer was one per 781 men screened after 13 years of follow-up...
October 15, 2015: American Family Physician
https://www.readbyqxmd.com/read/26530748/long-term-impact-of-endometrial-cancer-diagnosis-and-treatment-on-health-related-quality-of-life-and-cancer-survivorship-results-from-the-randomized-portec-2-trial
#17
RANDOMIZED CONTROLLED TRIAL
Stephanie M de Boer, Remi A Nout, Ina M Jürgenliemk-Schulz, Jan J Jobsen, Ludy C H W Lutgens, Elzbieta M van der Steen-Banasik, Jan Willem M Mens, Annerie Slot, Marika C Stenfert Kroese, Simone Oerlemans, Hein Putter, Karen W Verhoeven-Adema, Hans W Nijman, Carien L Creutzberg
PURPOSE: To evaluate the long-term health-related quality of life (HRQL) after external beam radiation therapy (EBRT) or vaginal brachytherapy (VBT) among PORTEC-2 trial patients, evaluate long-term bowel and bladder symptoms, and assess the impact of cancer on these endometrial cancer (EC) survivors. PATIENTS AND METHODS: In the PORTEC-2 trial, 427 patients with stage I high-intermediate-risk EC were randomly allocated to EBRT or VBT. The 7- and 10-year HRQL questionnaires consisted of EORTC QLQ-C30; subscales for bowel and bladder symptoms; the Impact of Cancer Questionnaire; and 14 questions on comorbidities, walking aids, and incontinence pads...
November 15, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26271398/a-practical-approach-to-the-management-of-radiation-induced-hemorrhagic-cystitis
#18
REVIEW
Xavier Liem, Fred Saad, Guila Delouya
Radiation-induced hemorrhagic cystitis (HC) is a complication of pelvic radiotherapy, mainly for prostate and uterine cancers. In the acute phase, patients feel urinary urgency and bladder pain. This phase is reversible after radiotherapy. In the chronic stage, an irritative syndrome is coupled with hematuria during the 2-10 years following radiotherapy. Cystoscopy shows white and frosted mucosa with telangiectasia. The incidence is estimated at 5 % or less. It is suggested that the radiation oncologist reviews the dosimetry plan to validate that the lesions coincide with significant radiation exposure confirming diagnosis of radiation-induced HC...
September 2015: Drugs
https://www.readbyqxmd.com/read/26068490/systematic-review-of-radiation-therapy-toxicity-reporting-in-randomized-controlled-trials-of-rectal-cancer-a-comparison-of-patient-reported-outcomes-and-clinician-toxicity-reporting
#19
REVIEW
Alexandra Gilbert, Lucy Ziegler, Maisie Martland, Susan Davidson, Fabio Efficace, David Sebag-Montefiore, Galina Velikova
The use of multimodal treatments for rectal cancer has improved cancer-related outcomes but makes monitoring toxicity challenging. Optimizing future radiation therapy regimens requires collection and publication of detailed toxicity data. This review evaluated the quality of toxicity information provided in randomized controlled trials (RCTs) of radiation therapy in rectal cancer and focused on the difference between clinician-reported and patient-reported toxicity. Medline, EMBASE, and the Cochrane Library were searched (January 1995-July 2013) for RCTs reporting late toxicity in patients treated with regimens including preoperative (chemo)radiation therapy...
July 1, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/25811296/potential-role-of-single-nucleotide-polymorphisms-of-xrcc1-xrcc3-and-rad51-in-predicting-acute-toxicity-in-rectal-cancer-patients-treated-with-preoperative-radiochemotherapy
#20
Mattia F Osti, Luca Nicosia, Linda Agolli, Giovanna Gentile, Teresa Falco, Stefano Bracci, Francesco Di Nardo, Giuseppe Minniti, Vitaliana De Sanctis, Maurizio Valeriani, Marianna Maglio, Marina Borro, Maurizio Simmaco, Riccardo M Enrici
OBJECTIVES: To investigate the association between polymorphisms of DNA repair genes and xenobiotic with acute adverse effects in locally advanced rectal cancer patients treated with neoadjuvant radiochemotherapy. METHODS: Sixty-seven patients were analyzed for the current study. Genotypes in DNA repair genes XRCC1 (G28152A), XRCC3 (A4541G), XRCC3 (C18067T), RAD51 (G315C), and GSTP1 (A313G) were determined by pyrosequencing technology. RESULTS: The observed grade ≥3 acute toxicity rates were 23...
March 24, 2015: American Journal of Clinical Oncology
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