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Maged Alnawaiseh, Larissa Lahme, Viktoria Müller, André Rosentreter, Nicole Eter
PURPOSE: To evaluate the correlation between flow density, as measured by optical coherence tomography angiography (OCTA), and structural and functional parameters in patients with open-angle glaucoma. METHODS: Thirty-four eyes of 34 patients with open-angle glaucoma and 35 eyes of 35 healthy subjects were prospectively included in this study. OCTA was performed using RTVue XR Avanti with AngioVue. The macula was imaged with a 3 × 3 mm scan and the optic nerve head (ONH) with a 4...
January 13, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Jidong Zhao, Shuang Yang, Xin Xie, Xiangdong Li, Yuanhong Liu
Gold(I) complexes bearing sterically demanding phosphine ligands such as tBuXphos catalyze the cascade Rantenstrauch rearrangement/[4+3] cycloaddition of 1-ethynyl-2-propenyl esters. The reaction provides an efficient and straightforward route to bicyclo[3.2.1]octa-3,6-dienes with high regio- and stereoselectivity. The formation of the [4+3] cycloadducts likely proceeds through the cycloaddition of a gold(I) carbenoid/gold-stabilized allyl cation intermediate with cyclopentadiene arised from Rantenstrauch rearrangement...
January 12, 2018: Journal of Organic Chemistry
Lauriane Salinas, Ankita Chaudhary, Kaweh Mansouri
PURPOSE: To present a case of ocular decompression retinopathy (ODR) occurring after uncomplicated deep sclerectomy with Mitomycin C using optical coherence tomography angiography (OCTA). PATIENT AND METHOD: Single case report. RESULTS: A 55-year-old man with traumatic glaucoma in the right eye complained of blurred vision. Visual acuity was 20/25 and intraocular pressure (IOP) was 50▒mm Hg. Deep sclerectomy with Mitomycin C was performed...
January 4, 2018: Journal of Glaucoma
Chaoliang Chen, Victor X D Yang
Recently, parallel high A-line speed and wide field imaging for optical coherence tomography angiography (OCTA) has become more prevalent, resulting in a dramatic increase of data quantity which poses a challenge for real time imaging even for GPU in data processing. In this manuscript, we propose a new OCTA processing technique, Gabor optical coherence tomographic angiography (GOCTA), for label-free human retinal angiography imaging. In spectral domain optical coherence tomography (SDOCT), k-space resampling and Fourier transform (FFT) are required for the entire data set of interference fringes to calculate blood flow information in previous OCTA algorithms, which are computationally intensive...
December 1, 2017: Biomedical Optics Express
Ang Li, Jiang You, Congwu Du, Yingtian Pan
Angiogenesis is recognized as a crucial component of many neurovascular diseases such as stroke, carcinogenesis, and neurotoxicity of abused drug. The ability to track angiogenesis will facilitate a better understanding of disease progression and assessment of therapeutical effects. Optical coherence angiography (OCTA) is a promising tool to assess 3D microvascular networks due to its micron-level resolution, high sensitivity, and relatively large field of view. However, quantitative OCTA image analysis for characterization of microvascular network changes, including accurately tracking the progression of angiogenesis, remains a challenge...
December 1, 2017: Biomedical Optics Express
Phoebe L Mellen, Kareem Sioufi, Jerry A Shields, Carol L Shields
PURPOSE: To report a patient with clinically invisible retinal astrocytic hamartomas (RAHs) detected on optical coherence tomography (OCT) and studied with OCT angiography (OCTA). METHOD: Case report. RESULTS: An 11-year-old healthy girl was evaluated for reduced visual acuity in the right eye. On examination, best-corrected visual acuity was 20/50 in the right eye and 20/20 in the left eye. Fundus examination revealed blunted foveal reflex in the right eye and normal findings in the left eye...
December 28, 2017: Retinal Cases & Brief Reports
Aniruddha Agarwal, Tripti Choudhary, Vishali Gupta
A 66-year-old male patient presented with decreased vision in both eyes following episode of Chikungunya fever. Examination revealed bilateral retinal lesions with stippled pigmentary changes at the level of the choriocapillaris, involving the macula in the left eye. The retinopathy consisted of outer retinal disruption and retinochoroidal flow abnormalities detected using with additional imaging, including spectral-domain optical coherence tomography (OCT), autofluorescence, and OCT angiography (OCTA). The index case report describes unique OCTA findings in both eyes of an elderly male secondary to Chikungunya fever...
January 2018: Indian Journal of Ophthalmology
Youda Huang, Dainan Zhang, Yu Yang, Xiangying Zeng, Yong Ran
Polybrominated diphenyl ethers (PBDEs) were investigated by GC-NCI-MS in sediments collected from the Pearl River Delta (PRD) and Guiyu town, South China. The concentrations of ∑39PBDEs and BDE 209 were in the ranges of 0.31-38.9 ng g-1 and 12.2-488 ng g-1 in the PRD, and 2.57-21,207 ng g-1 and 7.02-66,573 ng g-1 in Guiyu, respectively. The levels of PBDEs in Dongjiang River (DJ), Zhujiang River (ZJ), and Beijiang River (BJ), and Guiyu (GY) followed the order: GY > DJ > ZJ > BJ...
December 21, 2017: Environmental Pollution
Kavita V Bhavsar, Yali Jia, Jie Wang, Rachel C Patel, Andreas K Lauer, David Huang, Steven T Bailey
Purpose: The purpose of this study is to analyze early retinal angiomatous proliferation (RAP) utilizing a novel imaging modality, Projection-Resolved Optical Coherence Tomography Angiography (PR-OCTA). Observations: Five months prior to the diagnosis of a RAP lesion, cross-sectional PR-OCTA demonstrated flow in the outer retina contiguous with the deep retinal capillary plexus (DCP) and adjacent to a small pigment epithelial detachment. After development of a clinically visible RAP lesion, cross-sectional PR-OCTA demonstrated the RAP lesion connecting DCP and sub-retinal pigment epithelial neovascularization...
December 2017: American Journal of Ophthalmology Case Reports
Margaret R Strampe, William J Wirostko, Joseph Carroll
Purpose: To present the case of a 37-year-old female with a foveal macrovessel. Observations: The patient had an incidental finding of congenital retinal macrovessel (CRM) in the left eye on optical coherence tomography (OCT). Visual acuity was normal, and slit lamp and dilated fundus examinations were otherwise unremarkable. OCT angiography (OCTA) imaging allowed for visualization of the depth profile of the vessel as well as the foveal avascular zone (FAZ). The FAZ and foveal pit were both smaller in the affected eye compared to the fellow eye...
December 2017: American Journal of Ophthalmology Case Reports
Ananda Kalevar, J Michael Jumper
Purpose: Diffuse unilateral subacute neuroretinitis (DUSN) is often a challenging diagnosis to make. We present a DUSN case with its multimodal imaging to aid in the diagnosis, emphasizing the observations on optical coherence tomography angiography (OCTA). Observations: The evolution of a DUSN case is presented. Fundus photography and OCTA aided in the identification of the nematode. Conclusions and importance: DUSN is a difficult diagnosis to establish...
September 2017: American Journal of Ophthalmology Case Reports
Georgia Kaidonis, Ruwan A Silva, Steven R Sanislo, Theodore Leng
Purpose: To describe the appearance of the superficial and deep retinal capillary plexi in three patients with fovea plana of differing severity using spectral-domain optical coherence tomography angiography (OCTA). Observations: In the first case of grade 1 fovea plana (a patient with 20/25 vision), OCTA showed an orderly branching pattern of vessels from the superficial and deep retinal plexi extending to the center of the fovea. The second case of grade 3 fovea plana (20/30 vision) showed some disruption of the orderly vascular pattern with small caliber vessels from both superficial and deep layers densely covering the fovea center...
June 2017: American Journal of Ophthalmology Case Reports
Amarjot S Kang, R Joel Welch, Kareem Sioufi, Emil Anthony T Say, Jerry A Shields, Carol L Shields
Purpose: To report optical coherence tomography angiography (OCTA) of iris microhemangiomatosis. Observations: A 75-year-old asymptomatic Caucasian man was found to have bilateral pupillary vascular lesions during cataract evaluation. Visual acuity was counting fingers in the right eye (OD) and 20/40 in the left eye (OS) with normal intraocular pressures in both eyes (OU). In each eye there were multifocal, round, dark red, pinpoint vascular tufts at the pupillary margin, randomly distributed and numbering 1 in OD and 7 in OS, each measuring 0...
June 2017: American Journal of Ophthalmology Case Reports
Kiyoung Kim, Eung Suk Kim, Seung-Young Yu
AIM: To evaluate the correlation between inner retinal layer thinning and the foveal microvasculature in type 2 diabetes using optical coherence tomography angiography (OCTA). METHODS: A cross-sectional study involved 155 diabetic eyes. All patients were divided into two groups based on diabetic retinopathy (DR) grade: no DR (NDR, n=80) and mild-to-moderate non-proliferative DR (NPDR, n=75). Foveal avascular zone (FAZ) area, FAZ circularity index, FAZ perimeter, vessel density and perfusion index of parafoveal and perifoveal area were calculated using OCTA...
December 19, 2017: British Journal of Ophthalmology
Ji Hyung Choi, Hee Kyung Yang, Ji Eun Lee
BACKGROUND: Retinal artery occlusion is extremely rare in the pediatric population and most patients have risk factors. We report a case of a healthy child with segmental optic atrophy, complicated by incidental branch retinal artery occlusion (BRAO). CASE PRESENTATION: A 10-year-old boy who had a history of his mother's gestational diabetes presented with an inferonasal visual field defect in the left eye. His best-corrected visual acuities were 20/20 in both eyes (OU)...
December 19, 2017: BMC Ophthalmology
Victor M Villegas, Jaclyn L Kovach
Optical coherence tomography angiography (OCTA) is a recently established noninvasive technology for evaluation of the retinal and choroidal vasculature. The literature regarding the findings in macular telangiectasia type 2 (MacTel2) is scarce. We report the OCTA findings associated with a subject with MacTel2 and secondary subretinal neovascularization (SNV). The commercially available Cirrus 5000 with AngioPlex (Zeiss, Jena, Germany) was used, without any subsequent image modification or processing. Subretinal neovascularization was detectable with OCTA at the level of the outer retina and choriocapillaris...
2017: Case Reports in Ophthalmological Medicine
Volodymyr M Hiiuk, Diana D Barakhty, Sergiu Shova, Ruslan A Polunin, Il'ya A Gural'skiy
In the title polymeric complex, {[Fe(C12H10N2)2(H2O)4](CH3C6H4SO3)2·2CH3OH} n , the FeII cation, located on an inversion centre, is coordinated by four water mol-ecules in the equatorial positions and two 1,2-bis-(pyridin-4-yl)ethene mol-ecules in the axial positions. This results in a distorted octa-hedral geometry for the [N2O4] coordination polyhedron. The 1,2-bis-(pyridin-4-yl)ethene mol-ecules bridge the FeII cations, forming polymeric chains running along the a-axis direction. Stabilization of the crystal structure is provided by O-H⋯O hydrogen bonds; these are formed by coordinated water mol-ecules as donors towards the O atoms of the methanol mol-ecules and tosyl-ate anions as acceptors of protons, leading to the formation of a three-dimensional supra-molecular network...
December 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Tuncer Hökelek, Elif Özbek, Mustafa Sertçelik, Çiğdem Şahin Yenice, Hacali Necefoğlu
The asymmetric unit of the title complex, [Zn3(C7H5O2)6(C6H4N2)2], contains one half of the complex mol-ecule, i.e. one and a half ZnII cations, three benzoate (Bnz) and one pyridine-3-carbo-nitrile (Cpy) mol-ecule; the Bnz anions act as bidentate ligands through the carboxyl-ate O atoms, while the Cpy ligand acts as a monodentate N(pyridine)-bonding ligand. The complete centrosymmetric trinuclear complex thus comprises a linear array of three ZnII cations. The central ZnII cation shows an octa-hedral coordination and is bridged to each of the terminal ZnII cations by three Bnz anions...
December 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Patrizia Rossi, Eleonora Macedi, Paola Paoli, Luca Giorgi, Mauro Formica, Vieri Fusi
The title compound, [CaCo2(C22H30N4O6)2](ClO4)2·1.36H2O or {Ca[Co(H-2L1)]2}·2ClO4·1.36H2O {where L1 is 4,10-bis-[(3-hy-droxy-4-pyron-2-yl)meth-yl]-1,7-dimethyl-1,4,7,10-tetra-aza-cyclo-dodecane}, is a trinuclear complex whose asymmetric unit comprises a quarter of the {Ca[Co(H-2L1)]2}2+ trinuclear complex, half of a perchlorate ion and 0.34-water mol-ecules. In the neutral [Co(H-2L1)] moiety, the cobalt ion is hexa-coordinated in a trigonal-prismatic fashion by the surrounding N4O2 donor set. A Ca2+ cation holds together two neutral [Co(H-2L1)] moieties and is octa-coordinated in a distorted trigonal-dodeca-hedral fashion by the surrounding O atoms belonging to the deprotonated oxide and carbonyl groups of two [Co(H-2L1)] units...
December 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Youngjin Kang, Ki-Min Park, Jinho Kim
The asymmetric unit of the title compound, [Ir(C17H11F2N2)3]·0.5CH3(CH2)4CH3·0.5CH2Cl2, comprises one IrIII atom, three 2,6-di-fluoro-3-[5-(2-fluoro-phen-yl)pyridin-2-yl]pyridin-4-yl ligands and half each of an n-hexane and a di-chloro-methane solvent mol-ecule located about crystallographic inversion centres. The IrIII atom displays a distorted octa-hedral coordination geometry, having three C,N-chelating 2,6-di-fluoro-3-[5-(2-fluoro-phen-yl)pyridin-2-yl]pyridin-4-yl ligands arranged in a meridional manner...
December 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
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