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Gabriela Grimaldi, Andrea Scupola, Maria G Sammarco, Michele Marullo, Maria A Blasi
Purpose: To report the case of a 13-year-old girl with torpedo maculopathy, evaluated with multimodal morpho-functional retinal imaging, including fundus photography, infra-red and blue fundus autofluorescence, swept-source optical coherence tomography (OCT), en face OCT, OCT angiography and microperimetry (MP). Observations: On fundus examination, a torpedo-like hypopigmented lesion was observed temporal to the fovea in the left eye. OCT showed disruption of outer retinal layers and the presence of a subretinal cleft...
June 2018: American Journal of Ophthalmology Case Reports
Sachi R Patel, Stavros N Moysidis, Nicole Koulisis, Philip P Storey, Amir H Kashani, Narsing A Rao, Damien C Rodger
Purpose: To report the clinical presentation, multimodal imaging, and management of a patient with metastatic melanoma who presented with cystoid macular edema (CME). Observations: We report a case of a 71-year-old Caucasian male with metastatic melanoma who presented with bilateral cystoid macular edema after being on treatment with a programmed T cell death ligand 1 inhibitor, MPDL3280, for 1 year. Multimodal imaging techniques, including color fundus photographs, autofluorescence, spectral domain optical coherence tomography (OCT), fluorescein angiography (Spectralis, Heidelberg, Germany), and spectral-domain OCT angiography (Zeiss; California, USA) were performed to evaluate the etiology of his CME and to monitor his response to treatment...
June 2018: American Journal of Ophthalmology Case Reports
Brian W Chou, Peter L Nesper, Lee M Jampol, Rukhsana G Mirza
Purpose: To report optical coherence tomography angiography (OCTA) findings pre- and post-thermal laser therapy of a rare, asymptomatic, unilateral, isolated retinal hemangioblastoma. Observations: A 40-year-old asymptomatic Caucasian man was found to have an isolated, unilateral retinal hemangioblastoma after referral for possible retinal hole. Comparison of OCTAs pre- and post-thermal laser therapy demonstrated a significant reduction of blood flow toward and within the lesion, in addition to contraction of the lesion and constriction of the accompanying feeder vessels...
June 2018: American Journal of Ophthalmology Case Reports
Maria Vittoria Cicinelli, Chiara Giuffrè, Alessandro Rabiolo, Maurizio Battaglia Parodi, Francesco Bandello
A 58-year-old man with bilateral pigmented paravenous retinochoroidal atrophy (PPRCA) associated with macular coloboma in the right eye underwent color fundus photography and fundus autofluorescence with the California ultra-widefield retinal imaging system (Optos, Dunfermline, UK), spectral-domain optical coherence tomography (SD-OCT) (Heidelberg Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany), and en face OCT angiography (OCTA) (AngioPlex, Cirrus HD-OCT 5000; Carl Zeiss Meditec, Dublin, CA)...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Abed Namavari, Fang Zheng, Elie H Motulsky, João R de Oliveira Dias, Giovanni Gregori, Philip J Rosenfeld
Swept-source optical coherence tomography angiography (SS-OCTA) was used to diagnose choroidal neovascularization (CNV) arising from a choroidal nevus. A 61-year-old woman initially presented with submacular hemorrhage. She was diagnosed with neovascular age-related macular degeneration (AMD) and received three injections of bevacizumab (Avastin; Genentech, South San Francisco, CA). At a follow-up visit, SS-OCTA showed that the CNV appeared to arise from an adjacent choroidal nevus. This is the first report of using SS-OCTA to diagnose CNV associated with a choroidal nevus masquerading as neovascular AMD...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Fang Zheng, Elie H Motulsky, João Rafael de Oliveira Dias, Edith Pérez de López, Giovanni Gregori, Philip J Rosenfeld
BACKGROUND AND OBJECTIVE: To demonstrate the advantage of optical coherence tomography angiography (OCTA) for the diagnosis and management of proliferative macular telangiectasia type 2 (MacTel2) masquerading as neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS: This is an observational cases series. Three patients referred with the diagnosis of neovascular AMD were identified in this retrospective study. In addition to color fundus, fluorescein angiography, and spectral-domain OCT (SD-OCT) imaging, SD-OCTA (AngioPlex; Carl Zeiss Meditec, Dublin, CA) was performed...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Casper Steinmann, Martin A Olsson, Ulf Ryde
We have devised a new efficient approach to compute combined quantum mechanical (QM) and molecular mechanical (MM, i.e. QM/MM) ligand-binding relative free energies. Our method employs the reference-potential approach with free-energy perturbation both at the MM level (between the two ligands) and from MM to QM/MM (for each ligand). To ensure that converged results are obtained for the MM→QM/MM perturbations, explicit QM/MM molecular dynamics (MD) simulations are performed with two intermediate mixed states...
May 17, 2018: Journal of Chemical Theory and Computation
Benjamin M Oxley, Brandon Mash, Matthias Zeller, Susannah Banziger, Tong Ren
Reported in this contribution are the synthesis and crystal structures of new mono- and bis-phenyl-acetyl-ides based on CoIII (DMC) (DMC is 5,12-dimethyl-1,4,8,11-tetra-aza-cyclo-tetra-deca-ne). Chlorido-(5,12-dimethyl-1,4,8,11-tetra-aza-cyclo-tetra-deca-ne)(phenyl-ethyn-yl)cobalt(III) chloride-aceto-nitrile-methanol (1/1/1), [Co(C8 H5 )Cl(C12 H28 N4 )]Cl·CH3 CN·CH3 OH, 1 , and (5,12-dimethyl-1,4,8,11-tetra-aza-cyclo-tetra-deca-ne)bis-(phenyl-ethyn-yl)cobalt(III) tri-fluoro-methane-sulfonate-di-chloro-methane (2/1), [Co(C8 H5 )2 (C12 H28 N4 )]2 (CF3 SO3 )2 ·CH2 Cl2 , 2 , were prepared under weak-base conditions in satisfactory yields...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Ana Paula Lopes de Melo, Leandro Bresolin, Bianca Barreto Martins, Vanessa Carratu Gervini, Adriano Bof de Oliveira
The reaction in methanol of CuII acetate monohydrate with 5-fluoro-isatin 3-oxime deprotonated with KOH in a 1:2 molar ratio and recrystallization from pyridine yielded the title compound, [Cu(C8 H4 FN2 O2 )2 (C5 H5 N)2 ]. In the centrosymmetric complex, the anionic form of the isatin oxime acts as a κ2 N , O donor, building five-membered metallarings. The CuII cation is sixfold coordinated in a slightly distorted octa-hedral environment by two trans , equatorial, anionic isatin derivatives and two trans pyridine ligands in axial positions...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Tuncer Hökelek, Safiye Özkaya, Hacali Necefoğlu
In the title centrosymmetric complex, [Mn(C10 H11 O2 )2 (C10 H14 N2 O)2 (H2 O)2 ], the MnII cation is located on an inversion centre. The four O atoms form a slightly distorted square-planar arrangement around the MnII cation, and the distorted octa-hedral coordination is completed by two pyridine N atoms at distances of 2.3289 (15) Å. The dihedral angle between the planar carboxyl-ate group and the adjacent benzene ring is 87.73 (16)°, while the benzene and pyridine rings are oriented at a dihedral angle of 43...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Manel Sonni, Imen Jendoubi, Mohamed Faouzi Zid
The title compound, sodium chromium/aluminium molybdenum/aluminium dodeca-oxide, Na0.72 Cr0.48 Al1.74 Mo2.77 O12 , was prepared by solid-state reaction. Its crystal structure is related to NaSICON-type compounds. The framework is built up from M 1O6 ( M 1 = Cr/Al) octa-hedra and M 2O4 ( M 2 = Mo/Al) tetra-hedra inter-connected by corners. The three-dimensional framework contains cavities in which sodium cations are located. Two validation models (BVS and CHARDI) were used to confirm the proposed structural model...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Tyler K Brescia, Kaltrina Mulosmani, Shivani Gulati, Demosthenes Athanasopoulos, Rita K Upmacis
There are few reports that describe crystal structures of compounds containing cobalt complexed to either dimethyl sulfoxide (Me2 SO) or quinoline (C9 H7 N). The title compound, [Co(C2 H6 OS)6 ][CoCl3 (C9 H7 N)]2 , is a cobalt salt in which the metal ion is complexed to both Me2 SO and quinoline. In particular, we observed that anhydrous cobalt(II) chloride reacts with quinoline in Me2 SO to form a salt that is to be formulated as [CoII (Me2 SO)6 ]2+ {[CoII Cl3 quinoline]2 - }. The CoII atom in the cation portion of this mol-ecule lies on a inversion center and is bound to the O atoms of six Me2 SO moieties in an octa-hedral configuration, while the CoII atom in the anion is attached to three chloride ligands and one quinoline moiety in a tetra-hedral arrangement...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Aleksej Jochim, Inke Jess, Christian Näther
The crystal structure of the title salt, (C6 H8 NO)8 [Fe(NCS)4 (C6 H7 NO)2 ][Fe(NCS)5 (C6 H7 NO)]2 [Fe(NCS)6 ], comprises three negatively charged octa-hedral FeIII complexes with different coordination environments in which the FeIII atoms are coordinated by a different number of thio-cyanate anions and 4-meth-oxy-pyridine ligands. Charge balance is achieved by 4-meth-oxy-pyridinium cations. The asymmetric unit consists of three FeIII cations, one of which is located on a centre of inversion, one on a twofold rotation axis and one in a general position, and ten thio-cyanate anions, two 4-meth-oxy-pyridine ligands and 4-meth-oxy-pyridinium cations (one of which is disordered over two sets of sites)...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Dohyun Moon, Keon Sang Ryoo, Jong-Ha Choi
The asymmetric unit of the title compound, Ag[Cr(C11 H14 N2 O8 )]·3H2 O, contains one [Cr(1,3-pdta)]- anion [1,3-pdta is (propane-1,3-diyldi-nitrilo)-tetra-acetate], one Ag+ cation and three water mol-ecules. The Cr3+ ion is coordinated to the four O and two N atoms of the 1,3-pdta ligand, displaying a distorted octa-hedral geometry. The mean Cr-N and Cr-O bond lengths are 2.0727 (17) and 1.9608 (15) Å, respectively. The conformations of the chelate rings were found to be envelope for the glycinates and twist-boat for the six-membered di-amine ( T ) ring...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Eric J Keller, Meghan Porter, Joy E Garrett, Meredith Varie, Haiyan Wang, Karen E Pollok, John J Turchi, Jeffrey M Zaleski, Joseph R Dynlacht
Enediynes are a highly cytotoxic class of compounds. However, metallation of these compounds may modulate their activation, and thus their cytotoxicity. We previously demonstrated that cytotoxicity of two different metalloenediynes, including (Z)-N,N'-bis[1-pyridyl-2-yl-meth-(E)-ylidene]octa-4-ene-2,6-diyne-1,8-diamine] (PyED), is potentiated when the compounds are administered to HeLa cells during hyperthermia treatment at concentrations that are minimally or not cytotoxic at 37°C. In this study, we further characterized the concentration, time and temperature dependence of cytotoxicity of PyED on human U-1 melanoma cells...
May 15, 2018: Radiation Research
Taejin Park, Sun-Joo Jang, Myounghee Han, Sukyoung Ryu, Wang-Yuhl Oh
We demonstrate a novel hybrid-beam scanning-based quantitative optical coherence tomography angiography (OCTA) that provides high-speed wide dynamic range blood flow speed imaging. The hybrid-beam scanning scheme enables multiple OCTA image acquisitions with a wide range of multiple time intervals simultaneously providing wide dynamic range blood flow speed imaging independent of the blood vessel orientation, which was quantified over a speed range of 0.6∼104  mm/s through the blood flow phantom experiments...
May 15, 2018: Optics Letters
Bingyao Tan, Alexander Wong, Kostadinka Bizheva
A novel image processing algorithm based on a modified Bayesian residual transform (MBRT) was developed for the enhancement of morphological and vascular features in optical coherence tomography (OCT) and OCT angiography (OCTA) images. The MBRT algorithm decomposes the original OCT image into multiple residual images, where each image presents information at a unique scale. Scale selective residual adaptation is used subsequently to enhance morphological features of interest, such as blood vessels and tissue layers, and to suppress irrelevant image features such as noise and motion artefacts...
May 1, 2018: Biomedical Optics Express
Myeong Jin Ju, Morgan Heisler, Arman Athwal, Marinko V Sarunic, Yifan Jian
We demonstrate the utility of a novel scanning method for optical coherence tomography angiography (OCTA). Although raster scanning is commonly used for OCTA imaging, a bidirectional approach would lessen the distortion caused by galvanometer-based scanners as sources continue to increase sweep rates. As shown, a unidirectional raster scan approach has a lower effective scanning time than bidirectional approaches; however, a strictly bidirectional approach causes contrast variation along the B-scan direction due to the non-uniform time interval between B-scans...
May 1, 2018: Biomedical Optics Express
Ling Mo, Xiaobo Zheng, Yuxin Sun, Lehuan Yu, Xiaojun Luo, Xiangrong Xu, Xiaoquan Qin, Yongli Gao, Bixian Mai
A broad suite of persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and dichlorodiphenyltrichloroethane (DDT) and its metabolites, were analyzed in pectoral muscle of eight terrestrial passerine bird species from an extensive e-waste recycling site in South China. Concentrations of PCBs, PBDEs, and DDTs in bird samples ranged from 1260-279,000, 121-14,200, and 31-7910ng/g lipid weight, respectively. Insectivorous birds had significantly higher levels of PCBs, PBDEs, and DDTs than those in granivorous birds...
August 15, 2018: Science of the Total Environment
Rana Imani, Satya Prakash, Hojatollah Vali, Shahab Faghihi
The successful application of nucleic acid-based therapy for the treatment of various cancers is largely dependent on a safe and efficient delivery system. A dual-functionalized graphene oxide (GO)-based nanocarrier with the conjugation of aminated-polyethylene glycol (PEG-diamine) and octa-arginine (R8) for the intracellular delivery of nucleic acids is proposed. The functionalized sites are covalently co-conjugated and the PEG : R8 molar ratio is optimized at 10 : 1 to achieve a hydrocolloidally stable size of 252 ± 2...
May 14, 2018: Biomaterials Science
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