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https://www.readbyqxmd.com/read/28240253/proteomic-analysis-of-the-mediator-complex-interactome-in-saccharomyces-cerevisiae
#1
Henriette Uthe, Jens T Vanselow, Andreas Schlosser
Here we present the most comprehensive analysis of the yeast Mediator complex interactome to date. Particularly gentle cell lysis and co-immunopurification conditions allowed us to preserve even transient protein-protein interactions and to comprehensively probe the molecular environment of the Mediator complex in the cell. Metabolic (15)N-labeling thereby enabled stringent discrimination between bona fide interaction partners and nonspecifically captured proteins. Our data indicates a functional role for Mediator beyond transcription initiation...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28222045/validation-of-scaffold-design-optimization-in-bone-tissue-engineering-finite-element-modeling-versus-designed-experiments
#2
Nicholas Uth, Jens Mueller, Byran Smucker, Azizeh-Mitra Yousefi
This study reports the development of biological/synthetic scaffolds for bone tissue engineering (TE) via 3D bioplotting. These scaffolds were composed of poly(L-lactic-co-glycolic acid) (PLGA), type I collagen, and nano-hydroxyapatite (nHA) in an attempt to mimic the extracellular matrix of bone. The solvent used for processing the scaffolds was 1,1,1,3,3,3-hexafluoro-2-propanol. The produced scaffolds were characterized by scanning electron microscopy, microcomputed tomography, thermogravimetric analysis, and unconfined compression test...
February 21, 2017: Biofabrication
https://www.readbyqxmd.com/read/28195643/a-prospective-evaluation-of-clinical-and-genetic-predictors-of-weight-changes-in-breast-cancer-survivors
#3
Maureen Sadim, Yanfei Xu, Katharina Selig, Julie Paulus, Regina Uthe, Surbhi Agarwl, Iram Dubin, Panagiota Oikonomopoulou, Lesya Zaichenko, Silvia Aki McCandlish, Linda Van Horn, Christos Mantzoros, Donna Pauler Ankerst, Virginia G Kaklamani
BACKGROUND: Postdiagnosis weight gain in patients with breast cancer has been associated with increased cancer recurrence and mortality. This study was designed to identify risk factors for weight gain and create a predictive model to identify a high-risk population for targeted interventions. METHODS: The weight of 393 patients with breast cancer from the Northwestern Robert H. Lurie Cancer Center was measured over a 2-year period from diagnosis, with body mass index (BMI) change over 18 months as the primary endpoint...
February 14, 2017: Cancer
https://www.readbyqxmd.com/read/28163932/dyslipidemia-in-patients-with-a-cardiovascular-risk-and-disease-at-the-university-teaching-hospital-of-yaound%C3%A3-cameroon
#4
Vicky Jocelyne Ama Moor, Sylvie Ndongo Amougou, Sebastien Ombotto, Felicien Ntone, Doriane Edna Wouamba, Bernadette Ngo Nonga
Objective. To determine the frequency of lipid abnormalities in patients with a cardiovascular risk and disease at the University Teaching Hospital (UTH) of Yaoundé. Materials and Methods. We conducted a cross-sectional study from 1 March to 31 May 2015 at the UTH of Yaoundé. We included all patients seen in the outpatient department with a diagnosis of a cardiovascular disease or a risk factor for cardiovascular disease. Patients who accepted to participate in the study were asked to answer a questionnaire; after that a blood sample was taken for lipid profile...
2017: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/28124381/broad-spectrum-health-improvements-with-one-year-of-soccer-training-in-inactive-mildly-hypertensive-middle-aged-women
#5
P Krustrup, M-B Skoradal, M B Randers, P Weihe, J Uth, J Mortensen, M Mohr
The study tested the hypothesis that long-term soccer training has positive impact on cardiovascular profile, body composition, bone health, and physical capacity in inactive, pre-menopausal women with mild hypertension. The study applied a randomized controlled design in which physically inactive middle-aged women were separated into a soccer training group (n=19; SOC) and a control group (n=12; CON). SOC performed 128±29 (±SD) one-h small-sided soccer training sessions over one year. Blood pressure, body composition, blood lipid profile, and fitness level were determined pre- and post-intervention...
January 25, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28061885/diagnostic-yield-of-nontuberculous-mycobacteria-in-patients-booked-for-endoscopy-at-the-university-teaching-hospital-lusaka
#6
Gershom Chongwe, Charles Michelo, Paul Kelly
BACKGROUND: The intestinal carriage of nontuberculous mycobacteria (NTM) is associated with disease, especially in severely immunocompromised individuals. These organisms, although often considered contaminants, have been known to cause various types of illnesses. We aimed to determine the prevalence of and associated factors for NTM among patients booked for colonoscopy at the University Teaching Hospital (UTH) in Lusaka. METHODS: We randomly recruited 97 patients attending routine endoscopy procedures between November 2012 and October 2013 and after consent, administered a structured questionnaire...
January 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28056829/seroprevalence-and-determinants-of-toxoplasmosis-in-pregnant-women-attending-antenatal-clinic-at-the-university-teaching-hospital-lusaka-zambia
#7
Christiana Frimpong, Mpundu Makasa, Lungowe Sitali, Charles Michelo
BACKGROUND: Toxoplasmosis is a neglected zoonotic disease which is prevalent among pregnant women especially in Africa. This study aimed to determine the seroprevalence and determinants of the disease among pregnant women attending antenatal clinic at the University Teaching Hospital (UTH). METHOD: A cross-sectional study was employed where 411 pregnant women attending antenatal clinic at UTH were interviewed using closed ended questionnaires. Their blood was also tested for Toxoplasma gondii IgG and IgM antibodies using the OnSite Toxo IgG/IgM Combo Rapid test cassettes by CTK Biotech, Inc, USA...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28052928/planning-bioinformatics-workflows-using-an-expert-system
#8
Xiaoling Chen, Jeffrey T Chang
MOTIVATION: Bioinformatic analyses are becoming formidably more complex due to the increasing number of steps required to process the data, as well as the proliferation of methods that can be used in each step. To alleviate this difficulty, pipelines are commonly employed. However, pipelines are typically implemented to automate a specific analysis, and thus are difficult to use for exploratory analyses requiring systematic changes to the software or parameters used. RESULTS: To automate the development of pipelines, we have investigated expert systems...
January 3, 2017: Bioinformatics
https://www.readbyqxmd.com/read/27774725/nanoscale-biodegradable-organic-inorganic-hybrids-for-efficient-cell-penetration-and-drug-delivery
#9
Sebastian Hörner, Sascha Knauer, Christina Uth, Marina Jöst, Volker Schmidts, Holm Frauendorf, Christina Marie Thiele, Olga Avrutina, Harald Kolmar
We report a comprehensive study on novel, highly efficient, and biodegradable hybrid molecular transporters. To this end, we designed a series of cell-penetrating, cube-octameric silsesquioxanes (COSS), and investigated cellular uptake by confocal microscopy and flow cytometry. A COSS with dense spatial arrangement of guanidinium groups displayed fast uptake kinetics and cell permeation at nanomolar concentrations in living HeLa cells. Efficient uptake was also observed in bacteria, yeasts, and archaea. The COSS-based carrier was significantly more potent than cell-penetrating peptides (CPPs) and displayed low toxicity...
November 14, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27733502/szgr-2-0-a-one-stop-shop-of-schizophrenia-candidate-genes
#10
Peilin Jia, Guangchun Han, Junfei Zhao, Pinyi Lu, Zhongming Zhao
SZGR 2.0 is a comprehensive resource of candidate variants and genes for schizophrenia, covering genetic, epigenetic, transcriptomic, translational and many other types of evidence. By systematic review and curation of multiple lines of evidence, we included almost all variants and genes that have ever been reported to be associated with schizophrenia. In particular, we collected ∼4200 common variants reported in genome-wide association studies, ∼1000 de novo mutations discovered by large-scale sequencing of family samples, 215 genes spanning rare and replication copy number variations, 99 genes overlapping with linkage regions, 240 differentially expressed genes, 4651 differentially methylated genes and 49 genes as antipsychotic drug targets...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27539197/a-long-journey-to-short-abbreviations-developing-an-open-source-framework-for-clinical-abbreviation-recognition-and-disambiguation-card
#11
Yonghui Wu, Joshua C Denny, S Trent Rosenbloom, Randolph A Miller, Dario A Giuse, Lulu Wang, Carmelo Blanquicett, Ergin Soysal, Jun Xu, Hua Xu
OBJECTIVE: The goal of this study was to develop a practical framework for recognizing and disambiguating clinical abbreviations, thereby improving current clinical natural language processing (NLP) systems' capability to handle abbreviations in clinical narratives. METHODS: We developed an open-source framework for clinical abbreviation recognition and disambiguation (CARD) that leverages our previously developed methods, including: (1) machine learning based approaches to recognize abbreviations from a clinical corpus, (2) clustering-based semiautomated methods to generate possible senses of abbreviations, and (3) profile-based word sense disambiguation methods for clinical abbreviations...
August 18, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27448579/-obstetric-endometritis-at-the-uth-yalgado-ouedraogo-of-ouagadougou-burkina-faso-about-the-management-of-102-cases
#12
C M R Ouédraogo, A Ouattara, A Sana, A Ouédraogo, D P Kain, E Komboigo, L Sangaré, J Lankoandé
This is a descriptive cross-sectional study over a nine months period conducted at the UTH-Yalgado Ouédraogo from all patients in whom the diagnosis of endometritis at obstetrical been laid. Endo-cervical and vaginal swabs were taken from all these patients. Commensal bacteria and anaerobes were investigated in the laboratory. During the study period, 102 cases of obstetric endometritis were recorded that to say a frequency of 1.4% of admissions. The average age of patients was 25.2 years [17-43]. The childbirth mean was 2...
December 2016: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/27405748/analysis-of-prehospital-transport-use-for-trauma-patients-in-lusaka-zambia
#13
Hani Mowafi, Rae Oranmore-Brown, Kathryn L Hopkins, Emily E White, Yacob F Mulla, Phil Seidenberg
Despite an increasing burden of injuries, prehospital transport systems remain underdeveloped in many low- and middle-income countries. Little information exists on the use of prehospital services for trauma patients in Zambia. METHOD: A prospective, observational study of trauma presentations was undertaken for 6 months in Lusaka, Zambia, to establish the epidemiology and outcomes of injury in the region. In addition to demographics and mechanism of injury, data were collected on prehospital transport as well as inpatient resources utilization...
July 12, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27060820/diagnosis-of-uterine-and-vaginal-disorders-by-different-methodologies-is-affected-by-concentration-of-estradiol-in-plasma-from-lactating-holstein-cows
#14
B F Silper, A M L Madureira, T A Burnett, A C C Fernandes, F M Abreu, D M Veira, J L M Vasconcelos, R L A Cerri
The relationship between plasma estradiol concentration at time of examination and prevalence of uterine disorders, agreement among methods, and associations of diagnosis with pregnancy hazard and milk yield was studied in 268 Holstein cows examined at 30±3 (exam 1) and 44±3 d in milk (DIM; exam 2). Purulent vaginal discharge was sampled using 2 methods: gloved hand and Metricheck (Simcro, Hamilton, New Zealand; PVD; score ≥3). Percentage of polymorphonuclear leukocytes was determined by endometrial cytology (CYTO; exam 1: ≥18%, exam 2: ≥10%); diameter of uterine horns (UTH; >20 mm), diameter of the inner layer of the cervix (CVX; >20...
June 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27042416/comatose-and-noncomatose-adult-diabetic-ketoacidosis-patients-at-the-university-teaching-hospital-zambia-clinical-profiles-risk-factors-and-mortality-outcomes
#15
Mwanja Kakusa, Brown Kamanga, Owen Ngalamika, Soka Nyirenda
BACKGROUND: Diabetic ketoacidosis (DKA) is one of the commonly encountered diabetes mellitus emergencies. AIM: This study aimed at describing the clinical profiles and hospitalization outcomes of DKA patients at the University Teaching Hospital (UTH) in Lusaka, Zambia and to investigate the role of coma on mortality outcome. MATERIALS AND METHODS: This was a cross-sectional analytical study of hospitalized DKA patients at UTH. The data collected included clinical presentation, precipitating factors, laboratory profiles, complications, and hospitalization outcomes...
March 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26620651/football-training-in-men-with-prostate-cancer-undergoing-androgen-deprivation-therapy-activity-profile-and-short-term-skeletal-and-postural-balance-adaptations
#16
RANDOMIZED CONTROLLED TRIAL
Jacob Uth, Therese Hornstrup, Jesper F Christensen, Karl B Christensen, Niklas R Jørgensen, Eva W Helge, Jakob F Schmidt, Klaus Brasso, Jørn W Helge, Markus D Jakobsen, Lars L Andersen, Mikael Rørth, Julie Midtgaard, Peter Krustrup
PURPOSE: To investigate the activity profile of football training and its short-term effects on bone mass, bone turnover markers (BTMs) and postural balance in men with prostate cancer (PCa) undergoing androgen deprivation therapy (ADT). METHODS: This was a randomised 12-week study in which men with PCa undergoing ADT were assigned to a football intervention group [FTG, n = 29, 67 ± 7 (±SD) years] training 2‒3 times per week for 45‒60 min or to a control group (n = 28, 66 ± 5 years)...
March 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/26572756/efficacy-of-recreational-football-on-bone-health-body-composition-and-physical-functioning-in-men-with-prostate-cancer-undergoing-androgen-deprivation-therapy-32-week-follow-up-of-the-fc-prostate-randomised-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
J Uth, T Hornstrup, J F Christensen, K B Christensen, N R Jørgensen, J F Schmidt, K Brasso, M D Jakobsen, E Sundstrup, L L Andersen, M Rørth, J Midtgaard, P Krustrup, E W Helge
UNLABELLED: Androgen deprivation therapy (ADT) for prostate cancer (PCa) impairs musculoskeletal health. We evaluated the efficacy of 32-week football training on bone mineral density (BMD) and physical functioning in men undergoing ADT for PCa. Football training improved the femoral shaft and total hip BMD and physical functioning parameters compared to control. INTRODUCTION: ADT is a mainstay in PCa management. Side effects include decreased bone and muscle strength and increased fracture rates...
April 2016: Osteoporosis International
https://www.readbyqxmd.com/read/26515822/primus-improving-pedigree-reconstruction-using-mitochondrial-and-y-haplotypes
#18
Jeffrey Staples, Lynette Ekunwe, Ethan Lange, James G Wilson, Deborah A Nickerson, Jennifer E Below
UNLABELLED: PRIMUS is a pedigree reconstruction algorithm that uses estimates of genome-wide identity by descent to reconstruct pedigrees consistent with observed genetic data. However, when genetic data for individuals within a pedigree are missing, often multiple pedigrees can be reconstructed that fit the data. We report a major expansion of PRIMUS that uses mitochondrial (mtDNA) and non-recombining Y chromosome (NRY) haplotypes to eliminate many pedigree structures that are inconsistent with the genetic data...
February 15, 2016: Bioinformatics
https://www.readbyqxmd.com/read/26509540/-dacryocystitis-in-a-three-week-old-girl
#19
Charlotte Caspara Uth, Pia Ten Voorde, Slaven Boljanovic
Dacryocystocele is a rare disease, which can be difficult to distinguish from haemangioma, dermoid cyst or encephalocele. Proper diagnosis and treatment is important as the risk of complications is high. A newborn baby with dacryocystitis was referred to a department of plastic surgery with a bluish tumour in the medial corner of the eye. The girl was treated with i.v. antibiotics and the dacryocystocele disappeared in 20 days. Knowledge of the disease is important so patients quickly can be treated medically and possibly surgically in order to avoid fatal complications...
October 26, 2015: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/26430465/does-vitamin-d-intake-during-resistance-training-improve-the-skeletal-muscle-hypertrophic-and-strength-response-in-young-and-elderly-men-a-randomized-controlled-trial
#20
Jakob Agergaard, Jeanette Trøstrup, Jacob Uth, Jonas Vestergard Iversen, Anders Boesen, Jesper L Andersen, Peter Schjerling, Henning Langberg
INTRODUCTION: Recent studies have shown that vitamin-D intake can improve skeletal muscle function and strength in frail vitamin-D insufficient individuals. We investigated whether vitamin-D intake can improve the muscular response to resistance training in healthy young and elderly individuals, respectively. METHODS: Healthy untrained young (n = 20, age 20-30) and elderly (n = 20, age 60-75) men were randomized to 16 weeks of daily supplementary intake of either 48 μg of vitamin-D + 800 mg calcium (Vitamin-D-group) or 800 mg calcium (Placebo-group) during a period and at a latitude of low sunlight (December-April, 56°N)...
2015: Nutrition & Metabolism
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