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https://www.readbyqxmd.com/read/29243406/the-national-burden-of-influenza-associated-severe-acute-respiratory-illness-hospitalization-in-zambia-2011-2014
#1
Andros Theo, Stefano Tempia, Adam L Cohen, Paul Simusika, Edward Chentulo, Chikama Mukwangole Chikamukwa, Mwaka Monze
BACKGROUND: Estimates of influenza-associated hospitalization are limited in low- and middle-income countries, especially in Africa. OBJECTIVE: To estimate the national number of influenza-associated severe acute respiratory illness (SARI) hospitalization in Zambia. METHODS: We conducted active prospective hospital-based surveillance for SARI at the University Teaching Hospital (UTH) situated in Lusaka Province during 2011-2014. Upper respiratory tract samples were tested for influenza virus using a reverse transcriptase polymerase chain reaction assay...
December 15, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29214969/pedaling-toward-revelation-my-summer-with-flannery-o-connor
#2
Ben Saxton
This section features original work on pathographies-i.e., (auto)biographical accounts of disease, illness, and disability-that provide narrative inquiry relating to the personal, existential, psychological, social, cultural, spiritual, political, and moral meanings of individual experience. Editors are: Nathan Carlin and Therese Jones. For submissions, contact Nathan Carlin at: Nathan.Carlin@uth.tmc.edu.
January 2018: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/29206167/scrnaseqdb-a-database-for-rna-seq-based-gene-expression-profiles-in-human-single-cells
#3
Yuan Cao, Junjie Zhu, Peilin Jia, Zhongming Zhao
Single-cell RNA sequencing (scRNA-Seq) is rapidly becoming a powerful tool for high-throughput transcriptomic analysis of cell states and dynamics at the single cell level. Both the number and quality of scRNA-Seq datasets have dramatically increased recently. A database that can comprehensively collect, curate, and compare expression features of scRNA-Seq data in humans has not yet been built. Here, we present scRNASeqDB, a database that includes almost all the currently available human single cell transcriptome datasets (n = 38) covering 200 human cell lines or cell types and 13,440 samples...
December 5, 2017: Genes
https://www.readbyqxmd.com/read/28991428/discovery-of-a-selective-allosteric-inhibitor-targeting-macrodomain-2-of-polyadenosine-diphosphate-ribose-polymerase-14
#4
Marion Schuller, Kerstin Riedel, Ian Gibbs-Seymour, Kristin Uth, Christian Sieg, André P Gehring, Ivan Ahel, Franz Bracher, Benedikt M Kessler, Jonathan M Elkins, Stefan Knapp
Macrodomains are conserved protein interaction modules that can be found in all domains of life including in certain viruses. Macrodomains mediate recognition of sequence motifs harboring adenosine diphosphate ribose (ADPR) modifications, thereby regulating a variety of cellular processes. Due to their role in cancer or viral pathogenesis, macrodomains have emerged as potential therapeutic targets, but the unavailability of small molecule inhibitors has hampered target validation studies so far. Here, we describe an efficient screening strategy for identification of small molecule inhibitors that displace ADPR from macrodomains...
November 17, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28813986/evaluation-of-the-myo-armband-for-the-classification-of-hand-motions
#5
I Mendez, B W Hansen, C M Grabow, E J L Smedegaard, N B Skogberg, X J Uth, A Bruhn, B Geng, E N Kamavuako
Pattern recognition-based control systems have been widely investigated in prostheses and virtual reality environments to improve amputees' quality of life. Most of these systems use surface electromyography (EMG) to detect user movement intentions. The Myo armband (MYB) is a wireless wearable device, developed by Thalmic Labs, which enables EMG recordings with a limited bandwidth (<100Hz). The aim of this study was to compare MYB's narrow bandwidth with a conventional EMG acquisition system (CONV) that captures the full EMG spectrum to assess its suitability for pattern recognition control...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28510717/fast-population-growth-in-physogastry-reproduction-of-luciaphorus-perniciosus-acari-pygmephoridae-at-different-temperatures
#6
Prapassorn Bussaman, Chirayu Sa-Uth, Angsumarn Chandrapatya, Remzi Atlihan, Ayhan Gökçe, Pavel Saska, Hsin Chi
Luciaphorus perniciosus Rack is one of the most serious pests of several cultivated mushroom species including Ganoderma lucidum (Fr.), Flammulina velutipes Karst., Auricularia polytricha (Mont.) Saac., Lentinus polychrous Lev., and Lentinus squarrosulus (Mont.) Singer in Thailand. Adult female Lu. perniciosus produce offspring inside their physogastric hysterosomas, with all embryos developing through to the adult stage while remaining in the abdomen. Once the abdomen ruptures, the female parent dies and the offspring consisting of mostly fertilized female adults along with a few male adults continue to emerge from the cadaver of the mother for a period of several days...
August 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28506272/prevalence-and-clonal-relationship-of-esbl-producing-salmonella-strains-from-humans-and-poultry-in-northeastern-algeria
#7
Samia Djeffal, Sofiane Bakour, Bakir Mamache, Rachid Elgroud, Amir Agabou, Selma Chabou, Sana Hireche, Omar Bouaziz, Kheira Rahal, Jean-Marc Rolain
BACKGROUND: The aims of this study were to investigate Salmonella contamination in broiler chicken farms and slaughterhouses, to assess the antibiotic resistance profile in avian and human Salmonella isolates, and to evaluate the relationship between avian and human Extended Spectrum β-Lactamase (ESBL)-producing isolates. Salmonella was screened in different sample matrices collected at thirty-two chicken farms and five slaughterhouses. The human isolates were recovered from clinical specimens at the University Teaching Hospital of Constantine (UTH)...
May 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28484511/reducing-risks-of-transfusion-transmitted-infections-in-a-resource-limited-hospital-based-blood-bank-the-case-of-the-yaound%C3%A3-university-teaching-hospital-cameroon
#8
C T Tagny, A Ndoumba, S Laperche, E Murphy, D Mbanya
BACKGROUND AND OBJECTIVES: Although interest in assessing risk of TTIs, very few trends in blood safety epidemiological data from resource-limited blood services are reported in the literature. This analysis aims at reporting trends in seroprevalences of TTIs in blood donations in the Yaoundé University Teaching Hospital (UTH) from 2011 to 2015 and to describe reasons for these changes. MATERIALS AND METHODS: All donations of 2015 were tested for HIV 1&2 antibodies and the P24 antigen, HBsAg, HCV antibody and the Treponema pallidum antibody...
August 2016: ISBT Science Series
https://www.readbyqxmd.com/read/28455734/formula-for-predicting-osa-and-the-apnea-hypopnea-index-in-koreans-with-suspected-osa-using-clinical-anthropometric-and-cephalometric-variables
#9
Seon Tae Kim, Kee Hyung Park, Seung-Heon Shin, Ji-Eun Kim, Chi-Un Pae, Kwang-Pil Ko, Hee Young Hwang, Seung-Gul Kang
PURPOSE: This study developed formulas to predict obstructive sleep apnea (OSA) and the Apnea-Hypopnea Index (AHI) in Korean patients with suspected OSA using clinical, anthropometric, and cephalometric variables. METHODS: We evaluated relevant variables in 285 subjects with suspected OSA. These included demographic characteristics, sleep-related symptoms, medical history, clinical scales, anthropometric measurements including facial surface measurements, and cephalometric measurements...
April 29, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28355661/-gene-replacement-therapy-for-inherited-retinal-dystrophies
#10
REVIEW
R Mühlfriedel, V Sothilingam, N Tanimoto, M W Seeliger
Characteristics of inherited retinal dystrophies include deficiencies in light perception and nervous conduction within the retina, leading to reduced vision or even blindness. In this context, the loss of function of photoreceptor-specific genes causes a variety of clinically and aetiologically distinct syndromes - each of them belonging to the group of rare diseases. With a prevalence of 1 in 2500, however, inherited retinal diseases are clinically significant and important - especially since these diseases lead to restrictions of a patient's fitness for work and overall quality of life...
March 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28240253/proteomic-analysis-of-the-mediator-complex-interactome-in-saccharomyces-cerevisiae
#11
Henriette Uthe, Jens T Vanselow, Andreas Schlosser
Here we present the most comprehensive analysis of the yeast Mediator complex interactome to date. Particularly gentle cell lysis and co-immunopurification conditions allowed us to preserve even transient protein-protein interactions and to comprehensively probe the molecular environment of the Mediator complex in the cell. Metabolic (15)N-labeling thereby enabled stringent discrimination between bona fide interaction partners and nonspecifically captured proteins. Our data indicates a functional role for Mediator beyond transcription initiation...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28222045/validation-of-scaffold-design-optimization-in-bone-tissue-engineering-finite-element-modeling-versus-designed-experiments
#12
Nicholas Uth, Jens Mueller, Byran Smucker, Azizeh-Mitra Yousefi
This study reports the development of biological/synthetic scaffolds for bone tissue engineering (TE) via 3D bioplotting. These scaffolds were composed of poly(L-lactic-co-glycolic acid) (PLGA), type I collagen, and nano-hydroxyapatite (nHA) in an attempt to mimic the extracellular matrix of bone. The solvent used for processing the scaffolds was 1,1,1,3,3,3-hexafluoro-2-propanol. The produced scaffolds were characterized by scanning electron microscopy, microcomputed tomography, thermogravimetric analysis, and unconfined compression test...
February 21, 2017: Biofabrication
https://www.readbyqxmd.com/read/28195643/a-prospective-evaluation-of-clinical-and-genetic-predictors-of-weight-changes-in-breast-cancer-survivors
#13
Maureen Sadim, Yanfei Xu, Katharina Selig, Julie Paulus, Regina Uthe, Surbhi Agarwl, Iram Dubin, Panagiota Oikonomopoulou, Lesya Zaichenko, Silvia Aki McCandlish, Linda Van Horn, Christos Mantzoros, Donna Pauler Ankerst, Virginia G Kaklamani
BACKGROUND: Postdiagnosis weight gain in patients with breast cancer has been associated with increased cancer recurrence and mortality. This study was designed to identify risk factors for weight gain and create a predictive model to identify a high-risk population for targeted interventions. METHODS: The weight of 393 patients with breast cancer from the Northwestern Robert H. Lurie Cancer Center was measured over a 2-year period from diagnosis, with body mass index (BMI) change over 18 months as the primary endpoint...
February 14, 2017: Cancer
https://www.readbyqxmd.com/read/28163932/dyslipidemia-in-patients-with-a-cardiovascular-risk-and-disease-at-the-university-teaching-hospital-of-yaound%C3%A3-cameroon
#14
Vicky Jocelyne Ama Moor, Sylvie Ndongo Amougou, Sebastien Ombotto, Felicien Ntone, Doriane Edna Wouamba, Bernadette Ngo Nonga
Objective. To determine the frequency of lipid abnormalities in patients with a cardiovascular risk and disease at the University Teaching Hospital (UTH) of Yaoundé. Materials and Methods. We conducted a cross-sectional study from 1 March to 31 May 2015 at the UTH of Yaoundé. We included all patients seen in the outpatient department with a diagnosis of a cardiovascular disease or a risk factor for cardiovascular disease. Patients who accepted to participate in the study were asked to answer a questionnaire; after that a blood sample was taken for lipid profile...
2017: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/28124381/broad-spectrum-health-improvements-with-one-year-of-soccer-training-in-inactive-mildly-hypertensive-middle-aged-women
#15
P Krustrup, M-B Skoradal, M B Randers, P Weihe, J Uth, J Mortensen, M Mohr
The study tested the hypothesis that long-term soccer training has positive impact on cardiovascular profile, body composition, bone health, and physical capacity in inactive, pre-menopausal women with mild hypertension. The study applied a randomized controlled design in which physically inactive middle-aged women were separated into a soccer training group (n=19; SOC) and a control group (n=12; CON). SOC performed 128±29 (±SD) one-h small-sided soccer training sessions over one year. Blood pressure, body composition, blood lipid profile, and fitness level were determined pre- and post-intervention...
January 25, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28061885/diagnostic-yield-of-nontuberculous-mycobacteria-in-patients-booked-for-endoscopy-at-the-university-teaching-hospital-lusaka
#16
Gershom Chongwe, Charles Michelo, Paul Kelly
BACKGROUND: The intestinal carriage of nontuberculous mycobacteria (NTM) is associated with disease, especially in severely immunocompromised individuals. These organisms, although often considered contaminants, have been known to cause various types of illnesses. We aimed to determine the prevalence of and associated factors for NTM among patients booked for colonoscopy at the University Teaching Hospital (UTH) in Lusaka. METHODS: We randomly recruited 97 patients attending routine endoscopy procedures between November 2012 and October 2013 and after consent, administered a structured questionnaire...
January 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28056829/seroprevalence-and-determinants-of-toxoplasmosis-in-pregnant-women-attending-antenatal-clinic-at-the-university-teaching-hospital-lusaka-zambia
#17
Christiana Frimpong, Mpundu Makasa, Lungowe Sitali, Charles Michelo
BACKGROUND: Toxoplasmosis is a neglected zoonotic disease which is prevalent among pregnant women especially in Africa. This study aimed to determine the seroprevalence and determinants of the disease among pregnant women attending antenatal clinic at the University Teaching Hospital (UTH). METHOD: A cross-sectional study was employed where 411 pregnant women attending antenatal clinic at UTH were interviewed using closed ended questionnaires. Their blood was also tested for Toxoplasma gondii IgG and IgM antibodies using the OnSite Toxo IgG/IgM Combo Rapid test cassettes by CTK Biotech, Inc, USA...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28052928/planning-bioinformatics-workflows-using-an-expert-system
#18
Xiaoling Chen, Jeffrey T Chang
Motivation: Bioinformatic analyses are becoming formidably more complex due to the increasing number of steps required to process the data, as well as the proliferation of methods that can be used in each step. To alleviate this difficulty, pipelines are commonly employed. However, pipelines are typically implemented to automate a specific analysis, and thus are difficult to use for exploratory analyses requiring systematic changes to the software or parameters used. Results: To automate the development of pipelines, we have investigated expert systems...
April 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/27774725/nanoscale-biodegradable-organic-inorganic-hybrids-for-efficient-cell-penetration-and-drug-delivery
#19
Sebastian Hörner, Sascha Knauer, Christina Uth, Marina Jöst, Volker Schmidts, Holm Frauendorf, Christina Marie Thiele, Olga Avrutina, Harald Kolmar
We report a comprehensive study on novel, highly efficient, and biodegradable hybrid molecular transporters. To this end, we designed a series of cell-penetrating, cube-octameric silsesquioxanes (COSS), and investigated cellular uptake by confocal microscopy and flow cytometry. A COSS with dense spatial arrangement of guanidinium groups displayed fast uptake kinetics and cell permeation at nanomolar concentrations in living HeLa cells. Efficient uptake was also observed in bacteria, yeasts, and archaea. The COSS-based carrier was significantly more potent than cell-penetrating peptides (CPPs) and displayed low toxicity...
November 14, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27733502/szgr-2-0-a-one-stop-shop-of-schizophrenia-candidate-genes
#20
Peilin Jia, Guangchun Han, Junfei Zhao, Pinyi Lu, Zhongming Zhao
SZGR 2.0 is a comprehensive resource of candidate variants and genes for schizophrenia, covering genetic, epigenetic, transcriptomic, translational and many other types of evidence. By systematic review and curation of multiple lines of evidence, we included almost all variants and genes that have ever been reported to be associated with schizophrenia. In particular, we collected ∼4200 common variants reported in genome-wide association studies, ∼1000 de novo mutations discovered by large-scale sequencing of family samples, 215 genes spanning rare and replication copy number variations, 99 genes overlapping with linkage regions, 240 differentially expressed genes, 4651 differentially methylated genes and 49 genes as antipsychotic drug targets...
January 4, 2017: Nucleic Acids Research
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