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https://www.readbyqxmd.com/read/27774725/nanoscale-biodegradable-organic-inorganic-hybrids-for-efficient-cell-penetration-and-drug-delivery
#1
Sebastian Hörner, Sascha Knauer, Christina Uth, Marina Jöst, Volker Schmidts, Holm Frauendorf, Christina Marie Thiele, Olga Avrutina, Harald Kolmar
We report a comprehensive study on novel, highly efficient, and biodegradable hybrid molecular transporters. To this end, we designed a series of cell-penetrating, cube-octameric silsesquioxanes (COSS), and investigated cellular uptake by confocal microscopy and flow cytometry. A COSS with dense spatial arrangement of guanidinium groups displayed fast uptake kinetics and cell permeation at nanomolar concentrations in living HeLa cells. Efficient uptake was also observed in bacteria, yeasts, and archaea. The COSS-based carrier was significantly more potent than cell-penetrating peptides (CPPs) and displayed low toxicity...
November 14, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27733502/szgr-2-0-a-one-stop-shop-of-schizophrenia-candidate-genes
#2
Peilin Jia, Guangchun Han, Junfei Zhao, Pinyi Lu, Zhongming Zhao
SZGR 2.0 is a comprehensive resource of candidate variants and genes for schizophrenia, covering genetic, epigenetic, transcriptomic, translational and many other types of evidence. By systematic review and curation of multiple lines of evidence, we included almost all variants and genes that have ever been reported to be associated with schizophrenia. In particular, we collected ∼4200 common variants reported in genome-wide association studies, ∼1000 de novo mutations discovered by large-scale sequencing of family samples, 215 genes spanning rare and replication copy number variations, 99 genes overlapping with linkage regions, 240 differentially expressed genes, 4651 differentially methylated genes and 49 genes as antipsychotic drug targets...
October 12, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27539197/a-long-journey-to-short-abbreviations-developing-an-open-source-framework-for-clinical-abbreviation-recognition-and-disambiguation-card
#3
Yonghui Wu, Joshua C Denny, S Trent Rosenbloom, Randolph A Miller, Dario A Giuse, Lulu Wang, Carmelo Blanquicett, Ergin Soysal, Jun Xu, Hua Xu
OBJECTIVE: The goal of this study was to develop a practical framework for recognizing and disambiguating clinical abbreviations, thereby improving current clinical natural language processing (NLP) systems' capability to handle abbreviations in clinical narratives. METHODS: We developed an open-source framework for clinical abbreviation recognition and disambiguation (CARD) that leverages our previously developed methods, including: (1) machine learning based approaches to recognize abbreviations from a clinical corpus, (2) clustering-based semiautomated methods to generate possible senses of abbreviations, and (3) profile-based word sense disambiguation methods for clinical abbreviations...
August 18, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27448579/-obstetric-endometritis-at-the-uth-yalgado-ouedraogo-of-ouagadougou-burkina-faso-about-the-management-of-102-cases
#4
C M R Ouédraogo, A Ouattara, A Sana, A Ouédraogo, D P Kain, E Komboigo, L Sangaré, J Lankoandé
This is a descriptive cross-sectional study over a nine months period conducted at the UTH-Yalgado Ouédraogo from all patients in whom the diagnosis of endometritis at obstetrical been laid. Endo-cervical and vaginal swabs were taken from all these patients. Commensal bacteria and anaerobes were investigated in the laboratory. During the study period, 102 cases of obstetric endometritis were recorded that to say a frequency of 1.4% of admissions. The average age of patients was 25.2 years [17-43]. The childbirth mean was 2...
July 23, 2016: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/27405748/analysis-of-prehospital-transport-use-for-trauma-patients-in-lusaka-zambia
#5
Hani Mowafi, Rae Oranmore-Brown, Kathryn L Hopkins, Emily E White, Yacob F Mulla, Phil Seidenberg
: Despite an increasing burden of injuries, prehospital transport systems remain underdeveloped in many low- and middle-income countries. Little information exists on the use of prehospital services for trauma patients in Zambia. METHOD: A prospective, observational study of trauma presentations was undertaken for 6 months in Lusaka, Zambia, to establish the epidemiology and outcomes of injury in the region. In addition to demographics and mechanism of injury, data were collected on prehospital transport as well as inpatient resources utilization...
July 12, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27060820/diagnosis-of-uterine-and-vaginal-disorders-by-different-methodologies-is-affected-by-concentration-of-estradiol-in-plasma-from-lactating-holstein-cows
#6
B F Silper, A M L Madureira, T A Burnett, A C C Fernandes, F M Abreu, D M Veira, J L M Vasconcelos, R L A Cerri
The relationship between plasma estradiol concentration at time of examination and prevalence of uterine disorders, agreement among methods, and associations of diagnosis with pregnancy hazard and milk yield was studied in 268 Holstein cows examined at 30±3 (exam 1) and 44±3 d in milk (DIM; exam 2). Purulent vaginal discharge was sampled using 2 methods: gloved hand and Metricheck (Simcro, Hamilton, New Zealand; PVD; score ≥3). Percentage of polymorphonuclear leukocytes was determined by endometrial cytology (CYTO; exam 1: ≥18%, exam 2: ≥10%); diameter of uterine horns (UTH; >20 mm), diameter of the inner layer of the cervix (CVX; >20...
June 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27042416/comatose-and-noncomatose-adult-diabetic-ketoacidosis-patients-at-the-university-teaching-hospital-zambia-clinical-profiles-risk-factors-and-mortality-outcomes
#7
Mwanja Kakusa, Brown Kamanga, Owen Ngalamika, Soka Nyirenda
BACKGROUND: Diabetic ketoacidosis (DKA) is one of the commonly encountered diabetes mellitus emergencies. AIM: This study aimed at describing the clinical profiles and hospitalization outcomes of DKA patients at the University Teaching Hospital (UTH) in Lusaka, Zambia and to investigate the role of coma on mortality outcome. MATERIALS AND METHODS: This was a cross-sectional analytical study of hospitalized DKA patients at UTH. The data collected included clinical presentation, precipitating factors, laboratory profiles, complications, and hospitalization outcomes...
March 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26620651/football-training-in-men-with-prostate-cancer-undergoing-androgen-deprivation-therapy-activity-profile-and-short-term-skeletal-and-postural-balance-adaptations
#8
RANDOMIZED CONTROLLED TRIAL
Jacob Uth, Therese Hornstrup, Jesper F Christensen, Karl B Christensen, Niklas R Jørgensen, Eva W Helge, Jakob F Schmidt, Klaus Brasso, Jørn W Helge, Markus D Jakobsen, Lars L Andersen, Mikael Rørth, Julie Midtgaard, Peter Krustrup
PURPOSE: To investigate the activity profile of football training and its short-term effects on bone mass, bone turnover markers (BTMs) and postural balance in men with prostate cancer (PCa) undergoing androgen deprivation therapy (ADT). METHODS: This was a randomised 12-week study in which men with PCa undergoing ADT were assigned to a football intervention group [FTG, n = 29, 67 ± 7 (±SD) years] training 2‒3 times per week for 45‒60 min or to a control group (n = 28, 66 ± 5 years)...
March 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/26572756/efficacy-of-recreational-football-on-bone-health-body-composition-and-physical-functioning-in-men-with-prostate-cancer-undergoing-androgen-deprivation-therapy-32-week-follow-up-of-the-fc-prostate-randomised-controlled-trial
#9
J Uth, T Hornstrup, J F Christensen, K B Christensen, N R Jørgensen, J F Schmidt, K Brasso, M D Jakobsen, E Sundstrup, L L Andersen, M Rørth, J Midtgaard, P Krustrup, E W Helge
UNLABELLED: Androgen deprivation therapy (ADT) for prostate cancer (PCa) impairs musculoskeletal health. We evaluated the efficacy of 32-week football training on bone mineral density (BMD) and physical functioning in men undergoing ADT for PCa. Football training improved the femoral shaft and total hip BMD and physical functioning parameters compared to control. INTRODUCTION: ADT is a mainstay in PCa management. Side effects include decreased bone and muscle strength and increased fracture rates...
April 2016: Osteoporosis International
https://www.readbyqxmd.com/read/26515822/primus-improving-pedigree-reconstruction-using-mitochondrial-and-y-haplotypes
#10
Jeffrey Staples, Lynette Ekunwe, Ethan Lange, James G Wilson, Deborah A Nickerson, Jennifer E Below
UNLABELLED: PRIMUS is a pedigree reconstruction algorithm that uses estimates of genome-wide identity by descent to reconstruct pedigrees consistent with observed genetic data. However, when genetic data for individuals within a pedigree are missing, often multiple pedigrees can be reconstructed that fit the data. We report a major expansion of PRIMUS that uses mitochondrial (mtDNA) and non-recombining Y chromosome (NRY) haplotypes to eliminate many pedigree structures that are inconsistent with the genetic data...
February 15, 2016: Bioinformatics
https://www.readbyqxmd.com/read/26509540/-dacryocystitis-in-a-three-week-old-girl
#11
Charlotte Caspara Uth, Pia Ten Voorde, Slaven Boljanovic
Dacryocystocele is a rare disease, which can be difficult to distinguish from haemangioma, dermoid cyst or encephalocele. Proper diagnosis and treatment is important as the risk of complications is high. A newborn baby with dacryocystitis was referred to a department of plastic surgery with a bluish tumour in the medial corner of the eye. The girl was treated with i.v. antibiotics and the dacryocystocele disappeared in 20 days. Knowledge of the disease is important so patients quickly can be treated medically and possibly surgically in order to avoid fatal complications...
October 26, 2015: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/26430465/does-vitamin-d-intake-during-resistance-training-improve-the-skeletal-muscle-hypertrophic-and-strength-response-in-young-and-elderly-men-a-randomized-controlled-trial
#12
Jakob Agergaard, Jeanette Trøstrup, Jacob Uth, Jonas Vestergard Iversen, Anders Boesen, Jesper L Andersen, Peter Schjerling, Henning Langberg
INTRODUCTION: Recent studies have shown that vitamin-D intake can improve skeletal muscle function and strength in frail vitamin-D insufficient individuals. We investigated whether vitamin-D intake can improve the muscular response to resistance training in healthy young and elderly individuals, respectively. METHODS: Healthy untrained young (n = 20, age 20-30) and elderly (n = 20, age 60-75) men were randomized to 16 weeks of daily supplementary intake of either 48 μg of vitamin-D + 800 mg calcium (Vitamin-D-group) or 800 mg calcium (Placebo-group) during a period and at a latitude of low sunlight (December-April, 56°N)...
2015: Nutrition & Metabolism
https://www.readbyqxmd.com/read/26380579/contamination-of-health-care-workers-coats-at-the-university-teaching-hospital-in-lusaka-zambia-the-nosocomial-risk
#13
Susan Mwamungule, Henry Mwelwa Chimana, Sydney Malama, Geoffrey Mainda, Geoffrey Kwenda, John Bwalya Muma
BACKGROUND: Health care Associated Infections (HAIs) are a major public health problem in both developed and developing countries. They pose a severe impact in resource-poor settings, where the rate of infection is estimated to be relatively high. Therefore, this study was conducted to establish empirical evidence related to HAIs in Zambia. METHOD: This was a prospective cross-sectional study conducted from October, 2013 to May 2014 at the University Teaching Hospital (UTH) in Lusaka...
2015: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/26323717/a-hybrid-bayesian-approach-for-genome-wide-association-studies-on-related-individuals
#14
A Yazdani, D B Dunson
MOTIVATION: Both single marker and simultaneous analysis face challenges in GWAS due to the large number of markers genotyped for a small number of subjects. This large p small n problem is particularly challenging when the trait under investigation has low heritability. METHOD: In this article, we propose a two-stage approach that is a hybrid method of single and simultaneous analysis designed to improve genomic prediction of complex traits. In the first stage, we use a Bayesian independent screening method to select the most promising SNPs...
December 15, 2015: Bioinformatics
https://www.readbyqxmd.com/read/26150619/brca-1-2-gene-mutation-and-gastrointestinal-stromal-tumours-a-potential-association
#15
Julie Waisbren, Regina Uthe, Kalliopi Siziopikou, Virginia Kaklamani
Mutations of the BRCA1/2 genes have been described in association with a number of malignancies including cancers of the breast, ovary, prostate and stomach, but have never been described in relation to gastrointestinal stromal tumours (GIST). We describe a patient with a BRCA2 8642del3insC mutation who developed prostate cancer, breast cancer and GIST. GIST has been shown to be associated with a number of malignancies, including some of the common BRCA1/2-related cancers, but it has never been associated with BRCA1/2 gene mutations...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/26130578/integrating-full-spectrum-of-sequence-features-into-predicting-functional-microrna-mrna-interactions
#16
Zixing Wang, Wenlong Xu, Yin Liu
MOTIVATION: MicroRNAs (miRNAs) play important roles in general biological processes and diseases pathogenesis. Identifying miRNA target genes is an essential step to fully understand the regulatory effects of miRNAs. Many computational methods based on the sequence complementary rules and the miRNA and mRNA expression profiles have been developed for this purpose. It is noted that there have been many sequence features of miRNA targets available, including the context features of the target sites, the thermodynamic stability and the accessibility energy for miRNA-mRNA interaction...
November 1, 2015: Bioinformatics
https://www.readbyqxmd.com/read/26123240/correction-combination-of-inverse-electron-demand-diels-alder-reaction-with-highly-efficient-oxime-ligation-expands-the-toolbox-of-site-selective-peptide-conjugations
#17
S Hörner, C Uth, O Avrutina, H Frauendorf, M Wiessler, H Kolmar
Correction for 'Combination of inverse electron-demand Diels-Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations' by S. Hörner, et al., Chem. Commun., 2015, DOI: 10.1039/c5cc03434e.
July 25, 2015: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/26090288/nasal-reconstruction-in-a-child-after-a-dog-bite-9-years-later
#18
Charlotte Caspara Uth, Slaven Boljanovic
An 8-year-old boy had the caudal part of his nose bitten off by a dog. Nasal reconstruction with a forehead flap was performed initially with success, and 9 years later, the reconstructed nose was found to have grown equally in size with the underlining tissue, resulting in a continuous satisfactory cosmetic result.
May 2015: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/26074398/combination-of-inverse-electron-demand-diels-alder-reaction-with-highly-efficient-oxime-ligation-expands-the-toolbox-of-site-selective-peptide-conjugations
#19
S Hörner, C Uth, O Avrutina, H Frauendorf, M Wiessler, H Kolmar
A modular approach combining inverse electron-demand Diels-Alder coupling (DARinv) and oxime ligation expands the toolbox of bioorthogonal peptide chemistry. Applicability of versatile site-specific bifunctional building blocks is demonstrated by generation of defined conjugates comprising linear, cystine-bridged and multi-disulfide functional peptides as well as their conjugation with hybrid silsesquioxane nanoparticles.
July 14, 2015: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/26041377/body-composition-in-prostate-cancer-patients-novel-insights-suggest-diverse-prognostic-roles-of-lean-and-fat-mass
#20
EDITORIAL
Jacob Uth, Jesper Frank Christensen
No abstract text is available yet for this article.
September 2015: Endocrine
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