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Platelet Aggregation

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https://www.readbyqxmd.com/read/28926782/enterprise-stent-in-recanalizing-non-acute-atherosclerotic-intracranial-internal-carotid-artery-occlusion
#1
Xiaofei Wang, Zhigang Wang, Yong Ji, Xuan Ding, Yizheng Zang, Chengwei Wang
OBJECTIVE: To investigate the safety and effectiveness of recanalization in non-acute occlusion of intracranial internal carotid arteries using the flexible Enterprise self-expanding stent. PATIENTS AND METHODS: From June 2014 to June 2016, 12 consecutive patients with non-acute occlusion of intracranial internal carotid arteries received endovascular recanalization with Enterprise stenting. All patients received medication for anti-platelet aggregation therapy before and after the operation...
June 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28926321/evaluation-of-platelet-activation-during-storage-in-leukocyte-depleted-platelet-concentrates
#2
Miodrag Vucic, Zoran Stanojkovic, Ana Antic, Jelana Vucic, Voja Pavlovic
Structural and functional changes in platelets during storage can lead to the loss of platelet reactivity and response. Our aim was to evaluate leukocyte-depleted platelet concentrates, obtained by in-line filtration on storage days 0, 3 and 5. In non-filtered platelet concentrates (NF-PC) group, 180 whole blood units were collected with quadruple blood bags and then compared to another group of 180 whole blood units (leukocyte-depleted platelet concentrates [LD-PC]), collected in Imuflex Whole Blood Filter Saving Platelets (WB-SP) bags with an integrated leukoreduction filter, with regard to the platelet quality and characteristics...
September 19, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28925467/effects-of-rosuvastatin-on-pentraxin-3-level-and-platelet-aggregation-rate-in-elderly-patients-with-acute-myocardial-infarction-undergoing-elective-interventional-therapy-a-double-blind-controlled-study
#3
Y-H Li, L-H Wang, Q Li, D-W Yu, Y-S Gai, S-X Cai, F Tian, H-Y Zhou
OBJECTIVE: To investigate clinical effects of rosuvastatin on blood lipid levels, hemorheological profiles, vascular endothelial function, pentraxin 3 (PTX-3) level, the number of granule membrane glycoprotein (GMP-140) molecules and platelet aggregation rate in elderly patients with acute myocardial infarction (AMI) undergoing elective percutaneous coronary intervention (PCI). PATIENTS AND METHODS: Total of 120 elderly patients admitted with AMI undergoing elective PCI from July 2014 to January 2016 were selected...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28923554/increased-platelet%C3%A2-alpha2b-adrenergic-receptor-gene-expression-in-well-controlled-hypertensives-the-effect-of-arterial-stiffness
#4
Maria E Marketou, Joanna E Kontaraki, John A Papadakis, George E Vrentzos, Alexandros Patrianakos, Konstantinos Fragkiadakis, Panagiotis Tsiverdis, Dimitris Lempidakis, Gregory Chlouverakis, Panos E Vardas, Fragiskos I Parthenakis
Catecholamines play a major role in atherothrombotic mechanisms in essential hypertension. Alpha2B-adrenergic receptors (α2B-ARs) are implicated in the pathophysiology of platelet aggregation. In this study, we evaluated platelet α2B-AR gene expression levels in patients with well-controlled essential hypertension compared with normal individuals and investigated their association with increased arterial stiffness. Fifty-nine patients with well-controlled essential hypertension (34 men, mean age 65 ± 9 years) and 26 normotensives (19 men, mean age 64 ± 8 years) were included in the study...
August 26, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28922391/impedance-biosensor-for-real-time-monitoring-and-prediction-of-thrombotic-individual-profile-in-flowing-blood
#5
Denise De Zanet, Monica Battiston, Elisabetta Lombardi, Ruben Specogna, Francesco Trevisan, Luigi De Marco, Antonio Affanni, Mario Mazzucato
A new biosensor for the real-time analysis of thrombus formation is reported. The fast and accurate monitoring of the individual thrombotic risk represents a challenge in cardiovascular diagnostics and in treatment of hemostatic diseases. Thrombus volume, as representative index of the related thrombotic status, is usually estimated with confocal microscope at the end of each in vitro experiment, without providing a useful behavioral information of the biological sample such as platelets adhesion and aggregation in flowing blood...
2017: PloS One
https://www.readbyqxmd.com/read/28921447/structure-pharmacology-and-roles-in-physiology-of-the-p2y12-receptor
#6
Ivar von Kügelgen
P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. The platelet ADP-receptor which has been denominated P2Y12 receptor is an important target in pharmacotherapy. The receptor couples to Gαi2 mediating an inhibition of cyclic AMP accumulation and additional downstream events including the activation of phosphatidylinositol-3-kinase and Rap1b proteins. The nucleoside analogue ticagrelor and active metabolites of the thienopyridine compounds ticlopidine, clopidogrel and prasugrel block P2Y12 receptors and, thereby, inhibit ADP-induced platelet aggregation...
September 12, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28918674/consumption-of-fruitflow-%C3%A2-lowers-blood-pressure-in-pre-hypertensive-males-a-randomised-placebo-controlled-double-blind-cross-over-study
#7
Main Uddin, Dipankar Biswas, Abhik Ghosh, Niamh O'Kennedy, Asim K Duttaroy
In order to investigate whether the angiotensin converting enzyme-inhibitory tomato extract Fruitflow(®) would lower blood pressure after consumption, we conducted a randomised, double-blinded, placebo-controlled human intervention study, involving 12 pre-hypertensive people in a crossover design. Consuming a single dose of 150 mg Fruitflow(®) resulted in a significant reduction in 24-hour average blood pressure as well as average wake-period and sleep-period SBP, compared to placebo. Other parameters related to blood pressure, such as 24-hour average mean arterial pressure, pulse pressure, heart rate, central aortic systolic pressure and radial augmentation index were also reduced...
September 18, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28917976/low-molecular-weight-fucoidan-ameliorates-hindlimb-ischemic-injury-in-type-2-diabetic-rats
#8
Zhiqiang Wang, Tiantian Liu, Xiaoping Chen, Hongjie You, Quanbin Zhang, Jingyi Xue, Yuanyuan Zheng, Dali Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Low molecular weight fucoidan (LMWF), extracted from Laminaria japonica Areschoug, is a traditional Chinese medicine, commonly used to alleviate edema, particularly for feet with numbness and pain. AIM OF THE STUDY: Diabetic mellitus (DM) patients are at high risk of developing peripheral arterial disease (PAD). Individuals with DM and PAD co-morbidity have a much higher risk of critical limb ischemia. LMWF showed several beneficial effects, such as anti-inflammation, anti-thrombosis, and enhancing revascularization...
September 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28915383/force-activatable-biosensor-enables-single-platelet-force-mapping-directly-by-fluorescence-imaging
#9
Yongliang Wang, Dana N LeVine, Margaret Gannon, Yuanchang Zhao, Anwesha Sarkar, Bailey Hoch, Xuefeng Wang
Integrin-transmitted cellular forces are critical for platelet adhesion, activation, aggregation and contraction during hemostasis and thrombosis. Measuring and mapping single platelet forces are desired in both research and clinical applications. Conventional force-to-strain based cell traction force microscopies have low resolution which is not ideal for cellular force mapping in small platelets. To enable platelet force mapping with submicron resolution, we developed a force-activatable biosensor named integrative tension sensor (ITS) which directly converts molecular tensions to fluorescent signals, therefore enabling cellular force mapping directly by fluorescence imaging...
September 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28914792/impact-of-source-and-manufacturing-of-collagen-matrices-on-fibroblast-cell-growth-and-platelet-aggregation
#10
Stefanie Böhm, Christine Strauß, Stefan Stoiber, Cornelia Kasper, Verena Charwat
Collagen is a main component of the extracellular matrix. It is often used in medical applications to support tissue regeneration, hemostasis, or wound healing. Due to different sources of collagen, the properties and performance of available products can vary significantly. In this in vitro study, a comparison of seven different collagen matrices derived from bovine, equine, and porcine sources was performed. As performance indicators, the scaffold function for fibroblasts and platelet aggregation were used...
September 15, 2017: Materials
https://www.readbyqxmd.com/read/28914761/flavonolignans-inhibit-il1-%C3%AE-induced-cross-talk-between-blood-platelets-and-leukocytes
#11
Michal Bijak, Angela Dziedzic, Ewelina Synowiec, Tomasz Sliwinski, Joanna Saluk-Bijak
Interleukin-1 beta (IL-1β)-the most potent pro-inflammatory is responsible for a broad spectrum of immune and inflammatory responses, it induces T-cell and B-cell activation and consequently the synthesis of other pro-inflammatory cytokines (such as IFN-γ and TNF). IL-1β induces the formation of blood platelet-leukocyte aggregates (PLAs), which suggests that IL-1β significantly affects the cross-talk between blood platelets and the immune response system, leading to coronary thrombosis. The aim of our study is to investigate the effect of flavonolignans (silybin, silychristin and silydianin) on the IL-1β-induced interaction between platelets and leukocytes, as well as on the expression and the secretion of pro-inflammatory factors...
September 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28914251/clinical-and-radiographic-comparison-of-platelet-rich-fibrin-and-mineral-trioxide-aggregate-as-pulpotomy-agents-in-primary-molars
#12
Surendra Patidar, Namita Kalra, Amit Khatri, Rishi Tyagi
AIM: This study aimed to evaluate and compare the Platelet-rich fibrin (PRF) and Mineral trioxide aggregate (MTA) as a pulpotomy agent in primary molars. MATERIAL AND METHODS: In this study, 50 primary molars from 50 healthy children aged 5-9 years requiring pulpotomy were randomly allocated into two groups. In PRF group, after coronal pulp removal and hemostasis, remaining pulp tissue was covered with PRF preparation. In the MTA group, the pulp stumps were covered with MTA (Pro Root MTA-Root Canal Repair Material, Dentsply International Inc...
October 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28913351/adequate-platelet-function-inhibition-confirmed-by-two-inductive-agents-predicts-lower-recurrence-of-ischemic-stroke-transient-ischemic-attack
#13
Lulu Zhang, Xiaowei Hu, Juehua Zhu, Xiuying Cai, Yan Kong, Hui Wang, Shanshan Diao, Hongru Zhao, Jianhua Jiang, Dapeng Wang, Quanquan Zhang, Yiren Qin, Wei Yue, Qi Fang
BACKGROUND: The correlation between platelet function and recurrent ischemic stroke or TIA remains uncertain. OBJECTIVE: To investigate two inductive agents to detect platelet functions and assess associations with recurrent ischemic stroke/TIA. METHOD: The study included 738 ischemic stroke/TIA patients. On days 0, 3, and 9 after antiplatelet therapy, platelet function tests were determined by maximum aggregation rate (MAR) using a PL-11 platelet function analyzer and phase matching reagents...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28912593/effect-of-palm-based-tocotrienols-and-tocopherol-mixture-supplementation-on-platelet-aggregation-in-subjects-with-metabolic-syndrome-a-randomised-controlled-trial
#14
Yee-Lin Gan, Ju-Yen Fu, Oi-Ming Lai, Boon-How Chew, Kah-Hay Yuen, Kim-Tiu Teng, Kalanithi Nesaretnam, Kanga Rani Selvaduray, Puvaneswari Meganathan
Tocotrienols, the unsaturated form of vitamin E, were reported to modulate platelet aggregation and thrombotic mechanisms in pre-clinical studies. Using a Food and Drug Administration (FDA)-approved cartridge-based measurement system, a randomised, double-blind, crossover and placebo-controlled trial involving 32 metabolic syndrome adults was conducted to investigate the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity. The participants were supplemented with 200 mg (69% tocotrienols and 31% α-tocopherol) twice daily of PTT mixture or placebo capsules for 14 days in a random order...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910282/characterization-of-intravascular-cellular-activation-in-relationship-to-subclinical-atherosclerosis-in-postmenopausal-women
#15
Muthuvel Jayachandran, Vesna D Garovic, Michelle M Mielke, Kent R Bailey, Brian D Lahr, Virginia M Miller
OBJECTIVE: Mechanisms and interactions among intravascular cells contributing to development of subclinical atherosclerosis are poorly understood. In women, both menopausal status and pregnancy history influence progression of atherosclerosis. This study examined activation and interactions among blood elements with subclinical atherosclerosis in menopausal women with known pregnancy histories. METHODS: Carotid intima-media thickness (CIMT), as a marker of subclinical atherosclerosis, was measured using B-mode ultrasound in age- and parity-matched women [40 with and 40 without a history of preeclampsia] 35 years after the index pregnancy...
2017: PloS One
https://www.readbyqxmd.com/read/28905392/cryopreserved-platelets-demonstrate-reduced-activation-responses-and-impaired-signaling-after-agonist-stimulation
#16
Lauren Waters, Matthew P Padula, Denese C Marks, Lacey Johnson
BACKGROUND: Room temperature-stored (20-24°C) platelets (PLTs) have a shelf life of 5 days, making it logistically challenging to supply remote medical centers with PLT products. Cryopreservation of PLTs in dimethyl sulfoxide (DMSO) and storage at -80°C enables an extended shelf life up to 2 years. Although cryopreserved PLTs have been widely characterized under resting conditions, their ability to undergo agonist-induced activation is yet to be fully explored. STUDY DESIGN AND METHODS: Buffy coat PLTs were cryopreserved at -80°C with 5% to 6% DMSO and sampled before freezing and after thawing...
September 14, 2017: Transfusion
https://www.readbyqxmd.com/read/28904003/preclinical-pharmacology-and-pharmacokinetics-of-inhaled-hexadecyl-treprostinil-c16tr-a-pulmonary-vasodilator-prodrug
#17
Michel R Corboz, Zhili Li, Vladimir Malinin, Adam J Plaunt, Donna M Konicek, Franziska G Leifer, Kuan-Ju Chen, Charles E Laurent, Han Yin, Marzena C Biernat, Dany Salvail, Jianguo Zhuang, Fadi Xu, Aidan Curran, Walter R Perkins, Richard W Chapman
This report describes the preclinical pharmacology and pharmacokinetics (PK) of hexadecyl-treprostinil (C16TR), a prodrug of treprostinil (TRE), formulated in a lipid nanoparticle (LNP) for inhalation as a pulmonary vasodilator. C16TR showed no activity (> 10 µM) in receptor binding and enzyme inhibition assays including binding to EP2, DP1, IP and EP4; TRE potently bound to each of these prostanoid receptors. C16TR had no effect (up to 200 nM) on platelet aggregation induced by adenosine diphosphate (ADP) in rat blood...
September 13, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28901892/the-effect-of-anthocyanin-supplementation-in-modulating-platelet-function-in-sedentary-population-a-randomised-double-blind-placebo-controlled-cross-over-trial
#18
Kiara Thompson, Holly Hosking, Wayne Pederick, Indu Singh, Abishek B Santhakumar
The anti-thrombotic properties of anthocyanin (ACN) supplementation was evaluated in this randomised, double-blind, placebo (PBO) controlled, cross-over design, dietary intervention trial in sedentary population. In all, sixteen participants (three males and thirteen females) consumed ACN (320 mg/d) or PBO capsules for 28 d followed by a 2-week wash-out period. Biomarkers of thrombogenesis and platelet activation induced by ADP; platelet aggregation induced by ADP, collagen and arachidonic acid; biochemical, lipid, inflammatory and coagulation profile were evaluated before and after supplementation...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28899852/identification-of-extant-vertebrate-myxine-glutinosa-vwf-evolutionary-conservation-of-primary-hemostasis
#19
Marianne A Grant, David L Beeler, Katherine C Spokes, Junmei Chen, Harita Dharaneeswaran, Tracey E Sciuto, Ann M Dvorak, Gianluca Interlandi, José A Lopez, William C Aird
Hemostasis in vertebrates involves both a cellular and protein component. Previous studies in jawless vertebrates (cyclostomes) suggest that the protein response, which involves thrombin-catalyzed conversion of a soluble plasma protein, fibrinogen, into a polymeric fibrin clot, is conserved in all vertebrates. However, similar data are lacking for the cellular response, which in gnathostomes, is regulated by von Willebrand factor (VWF), a glycoprotein that mediates the adhesion of platelets to the subendothelial matrix of injured blood vessels...
September 12, 2017: Blood
https://www.readbyqxmd.com/read/28895774/reduced-platelet-activation-and-platelet-aggregation-in-patients-with-alcoholic-liver-cirrhosis
#20
Pernille Just Vinholt, Anne-Mette Hvas, Christian Nielsen, Anna Cecilia Söderström, Ulrik Sprogøe, Annette Dam Fialla, Mads Nybo
Results from previous studies regarding platelet function in liver cirrhosis are discordant. The aim was to investigate platelet activation and platelet aggregation in patients with alcoholic liver cirrhosis. We included 27 patients with alcoholic liver cirrhosis and 22 healthy individuals. A recently established flow cytometric approach was used to measure platelet activation and platelet aggregation independent of sample platelet count. Platelet aggregation was further investigated using light transmission aggregometry (LTA) (for platelet count >100 × 10(9)/L)...
September 12, 2017: Platelets
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