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https://www.readbyqxmd.com/read/29715428/kinetics-of-huperzine-a-dissociation-from-acetylcholinesterase-via-multiple-unbinding-pathways
#1
Jakub Rydzewski, Rafal Jakubowski, Wieslaw Nowak, Helmut Grubmüller
The dissociation of huperzine A (hupA) from Torpedo californica acetylcholinesterase (TcAChE) was investigated by 4-microsecond unbiased and biased all-atom molecular dynamics (MD) simulations in explicit solvent. We performed our study using memetic sampling (MS) for the determination of reaction pathways (RPs), metadynamics to calculate free energy, and maximum-likelihood estimation (MLE) to recover kinetic rates from unbiased MD simulations. Our simulations suggest that the dissociation of hupA occurs mainly via two RPs: a front-door along the axis of the active-site gorge (pwf) and through a new transient side-door (pws), i...
May 1, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29671616/a-parallel-multiobjective-metaheuristic-for-multiple-sequence-alignment
#2
Álvaro Rubio-Largo, Mauro Castelli, Leonardo Vanneschi, Miguel A Vega-Rodríguez
The alignment among three or more nucleotides/amino acids sequences at the same time is known as multiple sequence alignment (MSA), a nondeterministic polynomial time (NP)-hard optimization problem. The time complexity of finding an optimal alignment raises exponentially when the number of sequences to align increases. In this work, we deal with a multiobjective version of the MSA problem wherein the goal is to simultaneously optimize the accuracy and conservation of the alignment. A parallel version of the hybrid multiobjective memetic metaheuristics for MSA is proposed...
April 19, 2018: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29670551/-the-two-brothers-reconciling-perceptual-cognitive-and-statistical-models-of-musical-evolution
#3
Steven Jan
While the "units, events and dynamics" of memetic evolution have been abstractly theorized (Lynch, 1998), they have not been applied systematically to real corpora in music. Some researchers, convinced of the validity of cultural evolution in more than the metaphorical sense adopted by much musicology, but perhaps skeptical of some or all of the claims of memetics, have attempted statistically based corpus-analysis techniques of music drawn from molecular biology, and these have offered strong evidence in favor of system-level change over time (Savage, 2017)...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29602109/multiple-approaches-to-assess-human-health-risks-from-carcinogenic-and-non-carcinogenic-metals-via-consumption-of-five-fish-species-from-a-large-reservoir-in-turkey
#4
Memet Varol, Muhammet Raşit Sünbül
No abstract text is available yet for this article.
March 27, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29511418/obstetrics-at-decisive-crossroads-regarding-pattern-recognition-of-fetal-heart-rate-decelerations-scientific-principles-and-lessons-from-memetics
#5
REVIEW
Shashikant L Sholapurkar
The survival of cardiotocography (CTG) as a tool for intrapartum fetal monitoring seems threatened somewhat unjustifiably and unwittingly despite the absence of better alternatives. Fetal heart rate (FHR) decelerations are center-stage (most important) in the interpretation of CTG with maximum impact on three-tier classification. The pattern-discrimination of FHR decelerations is inexorably linked to their nomenclature. Unscientific or flawed nomenclature of decelerations can explain the dysfunctional CTG interpretation leading to errors in detection of acidemic fetuses...
April 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29509760/a-memetic-optimization-algorithm-for-multi-constrained-multicast-routing-in-ad-hoc-networks
#6
Rahab M Ramadan, Safa M Gasser, Mohamed S El-Mahallawy, Karim Hammad, Ahmed M El Bakly
A mobile ad hoc network is a conventional self-configuring network where the routing optimization problem-subject to various Quality-of-Service (QoS) constraints-represents a major challenge. Unlike previously proposed solutions, in this paper, we propose a memetic algorithm (MA) employing an adaptive mutation parameter, to solve the multicast routing problem with higher search ability and computational efficiency. The proposed algorithm utilizes an updated scheme, based on statistical analysis, to estimate the best values for all MA parameters and enhance MA performance...
2018: PloS One
https://www.readbyqxmd.com/read/29492082/association-between-body-mass-index-and-activities-of-daily-living-in-homecare-patients
#7
Guzin Zeren Ozturk, Memet Taskın Egici, Mulazim Hussain Bukhari, Dilek Toprak
Objective: Overweight or obesity may cause many chronic illnesses. Furthermore, several studies have shown that high body mass index is associated with mortality and morbidity among the elderly. Therefore, obesity or being overweight could adversely affect the performance of activities of daily living. In this study our aim was to investigate the association between Body Mass Index and Activity of Daily Living in Homecare Patients. Method: The records of 2016 from the homecare unit of Sisli Hamidiye Etfal Training and Research Hospital were retrospectively reviewed...
November 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29492078/smoking-cessation-with-medication-and-behaviour-therapy
#8
Memet Taskin Egici, Guzin Zeren Ozturk, Mulazim Hussain Bukhari, Dilek Toprak
Background and Objective: Smoking Cessation Clinics (SCCs) involve the use of cognitive behavior therapy and effective medications provided by specialists. Our objective was to report socio-demographic data, investigative services provided, and determine the smoking cessation success. Methods: Data from all hospitals affiliated with the Beyoglu Public Hospitals Union were obtained between January 1, 2015 and December 31, 2015. Data from Sisli Hamidiye Etfal Training and Research Hospital were reviewed via retrospective chart review in the same period...
November 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29485655/hypoxia-activates-enhanced-invasive-potential-and-endogenous-hyaluronic-acid-production-by-glioblastoma-cells
#9
Jee-Wei Emily Chen, Jan Lumibao, Audrey Blazek, H Rex Gaskins, Brendan Harley
Glioblastoma (GBM) is the most common, aggressive, and deadly form of adult brain cancer, and is associated with a short survival rate (median 12-15 months, 5+ year less than 5%). The complex tumor microenvironment includes matrix transitions at the tumor margin, such as gradations in hyaluronic acid (HA). In addition, metabolic stress induced by decreased oxygen content across the tumor may contribute to tumor progression. However, cross-talk between matrix composition and metabolic stress remains unclear...
March 26, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29466026/opposition-based-memetic-algorithm-and-hybrid-approach-for-sorting-permutations-by-reversals
#10
José Luis Soncco-Álvarez, Daniel M Muñoz, Mauricio Ayala-Rincón
Sorting unsigned permutations by reversals is a difficult problem; indeed, it was proved to be NP-hard by Caprara (1997). Because of its high complexity, many approximation algorithms to compute the minimal reversal distance were proposed until reaching the nowadays best-known theoretical ratio of 1.375. In this article, two memetic algorithms to compute the reversal distance are proposed. The first one uses the technique of opposition-based learning leading to an opposition-based memetic algorithm; the second one improves the previous algorithm by applying the heuristic of two breakpoint elimination leading to a hybrid approach...
February 21, 2018: Evolutionary Computation
https://www.readbyqxmd.com/read/29392421/the-effect-of-magnetic-resonance-imaging-on-neural-tube-development-in-an-early-chicken-embryo-model
#11
Emrah Kantarcioglu, Gokmen Kahilogullari, Murat Zaimoglu, Esin Ozlem Atmis, Elif Peker, Zeynep Yigman, Deniz Billur, Sevim Aydin, Ilhan Memet Erden, Agahan Unlü
PURPOSE: We aimed to determine whether varying the magnetic field during magnetic resonance imaging would affect the development of chicken embryos and neural tube defects. METHODS: Following incubation for 24 h, we exposed chicken embryos to varying magnetic fields for 10 min to assess the impact on development. Three magnetic resonance imaging devices were used, and the eggs were divided into four groups: group 1 is exposed to 1 T, group 2 is exposed to 1.5 T, group 3 is exposed to 3 T, and group 4, control group, was not exposed to magnetic field...
May 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29386849/re-histologic-evidence-of-new-collagen-formulation-using-platelet-rich-plasma-in-skin-rejuvenation-a-prospective-controlled-clinical-study-authors-reply
#12
Ozlem Karabudak Abuaf, Hamza Yildiz, Hüseyin Baloglu, Memet Ersan Bilgili, Hasan Aktug Simsek, Bilal Dogan
No abstract text is available yet for this article.
February 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29373583/zinc-stimulates-glucose-oxidation-and-glycemic-control-by-modulating-the-insulin-signaling-pathway-in-human-and-mouse-skeletal-muscle-cell-lines
#13
Shaghayegh Norouzi, John Adulcikas, Sukhwinder Singh Sohal, Stephen Myers
Zinc is a metal ion that is an essential cell signaling molecule. Highlighting this, zinc is an insulin mimetic, activating cellular pathways that regulate cellular homeostasis and physiological responses. Previous studies have linked dysfunctional zinc signaling with several disease states including cancer, obesity, cardiovascular disease and type 2 diabetes. The present study evaluated the insulin-like effects of zinc on cell signaling molecules including tyrosine, PRSA40, Akt, ERK1/2, SHP-2, GSK-3β and p38, and glucose oxidation in human and mouse skeletal muscle cells...
2018: PloS One
https://www.readbyqxmd.com/read/29354851/correction-to-biomonitoring-of-trace-metals-in-the-keban-dam-reservoir-turkey-using-mussels-unio-elongatulus-eucirrus-and-crayfish-astacus-leptodactylus
#14
Memet Varol, Muhammet Raşit Sünbül
The original version of this article contained mistakes: the units mg/kg-1 and μg/kg-1 found on tables 1, 2, 4, 5 and 6 should be mg kg-1 and μg kg-1 , respectively.
January 22, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29322117/oncoplastic-breast-conserving-surgery-aesthetic-satisfaction-and-oncological-outcomes
#15
Sevgi Kurt Yazar, Dinçer Altınel, Merdan Serin, Şefika Aksoy, Memet Yazar
Objective: Oncoplastic breast conserving surgery (BCS) involves radical excision of tumors while maintaining the natural breast contours. In this study, we present the results of the oncoplastic BCS surgeries performed in our clinic. Material and Methods: 13 breast cancer patients who had undergone oncoplastic BCS were included in this retrospective study. Postoperative photographs and retrospective chart reviews were used to evaluate the results. Aesthetic satisfaction level was verbally obtained from the patients...
January 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29299829/biomonitoring-of-trace-metals-in-the-keban-dam-reservoir-turkey-using-mussels-unio-elongatulus-eucirrus-and-crayfish-astacus-leptodactylus
#16
Memet Varol, Muhammet Raşit Sünbül
Freshwater mussels and crayfish are commonly used as biomonitors of trace metals. In the present study, the concentrations of ten metals were determined in mussels (Unio elongatulus eucirrus) and crayfish (Astacus leptodactylus) collected from the Keban Dam Reservoir in Turkey. The significant spatial differences in concentrations of studied metals except As in mussels were not found. However, Co, Cr, Cu, and Zn concentrations in mussels and As, Co, Cu, Fe, Pb, and Zn concentrations in crayfish showed significant seasonal differences...
January 3, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29298679/sequence-motif-finder-using-memetic-algorithm
#17
Jader M Caldonazzo Garbelini, André Y Kashiwabara, Danilo S Sanches
BACKGROUND: De novo prediction of Transcription Factor Binding Sites (TFBS) using computational methods is a difficult task and it is an important problem in Bioinformatics. The correct recognition of TFBS plays an important role in understanding the mechanisms of gene regulation and helps to develop new drugs. RESULTS: We here present Memetic Framework for Motif Discovery (MFMD), an algorithm that uses semi-greedy constructive heuristics as a local optimizer. In addition, we used a hybridization of the classic genetic algorithm as a global optimizer to refine the solutions initially found...
January 3, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29279963/malignant-triton-tumor-of-trigeminal-nerve-case-report
#18
Fahmida Arab Mallah, Bahattin Tanrıkulu, Funda Çorapçıoğlu, M Memet Özek
INTRODUCTION: Here we are presenting a unique case of malignant triton tumor of the trigeminal nerve in a 4-year-old boy who presented with diplopia and ptosis. INTERVENTION: Near total excision of the tumor was performed, and adjuvant chemotherapy and radiotherapy were administered. RESULTS: The patient is in good health and has no evidence of clinical and radiological tumor recurrence for 22  months.
December 26, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28991792/automatic-control-of-the-effluent-turbidity-from-a-chemically-enhanced-primary-treatment-with-microsieving
#19
J Väänänen, S Memet, T Günther, M Lilja, M Cimbritz, J la Cour Jansen
For chemically enhanced primary treatment (CEPT) with microsieving, a feedback proportional integral controller combined with a feedforward compensator was used in large pilot scale to control effluent water turbidity to desired set points. The effluent water turbidity from the microsieve was maintained at various set points in the range 12-80 NTU basically independent for a number of studied variations in influent flow rate and influent wastewater compositions. Effluent turbidity was highly correlated with effluent chemical oxygen demand (COD)...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28968180/immunomodulatory-properties-of-brucella-melitensis-lipopolysaccharide-determinants-on-mouse-dendritic-cells-in-vitro-and-in-vivo
#20
Yun Zhao, Sean Hanniffy, Vilma Arce-Gorvel, Raquel Conde-Alvarez, SangKon Oh, Ignacio Moriyón, Sylvie Mémet, Jean-Pierre Gorvel
The lipopolysaccharide (LPS) is a major virulence factor of Brucella, a facultative intracellular pathogenic Gram-negative bacterium. Brucella LPS exhibits a low toxicity and its atypical structure was postulated to delay the host immune response, favouring the establishment of chronic disease. Here we carried out an in-depth in vitro and in vivo characterisation of the immunomodulatory effects of Brucella LPS on different dendritic cell (DC) subpopulations. By using LPSs from bacteria that share some of Brucella LPS structural features, we demonstrated that the core component of B...
January 1, 2018: Virulence
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