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Keywords
Autism anxiety bipolar disorde...
Autism anxiety bipolar disorder attention deficit disorder
#21
JOURNAL ARTICLE
Xuping Gao, Xin Su, Xue Han, Huiyan Wen, Chen Cheng, Shiwen Zhang, Wanlin Li, Jun Cai, Lu Zheng, Junrong Ma, Minqi Liao, Wanze Ni, Tao Liu, Dan Liu, Wenjun Ma, Shasha Han, Sui Zhu, Yanbin Ye, Fang-Fang Zeng
Unsaturated fatty acids might be involved in the prevention of and improvement in mental disorders, but the evidence on these associations has not been comprehensively assessed. This umbrella review aimed to appraise the credibility of published evidence evaluating the associations between unsaturated fatty acids and mental disorders. In this umbrella review, systematic reviews and meta-analyses of studies comparing unsaturated fatty acids (including supplementation, dietary intake, and blood concentrations) in participants with mental disorders with healthy individuals were included...
November 2022: Advances in Nutrition
#22
JOURNAL ARTICLE
Hui Ding, Minyao Xie, Jinyi Wang, Mengyuan Ouyang, Yanyuan Huang, Fangzheng Yuan, Yunhan Jia, Xuedi Zhang, Na Liu, Ning Zhang
BACKGROUND: Individuals with psychiatric disorders have elevated rates of type 2 diabetes comorbidity. Although little is known about the shared genetics and causality of this association. Thus, we aimed to investigate shared genetics and causal link between different type 2 diabetes and psychiatric disorders. METHODS: We conducted a large-scale genome-wide cross-trait association study(GWAS) to investigate genetic overlap between type 2 diabetes and anorexia nervosa, attention deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, obsessive-compulsive disorder, schizophrenia, anxiety disorders and Tourette syndrome...
March 2023: Journal of Psychiatric Research
#23
Yingjie Shi, Barbara Franke, Nina Roth Mota, Emma Sprooten
IMPORTANCE: Psychiatric disorders can have an immense impact on socioeconomic, physical, and social-psychological facets of life. Psychiatric disorders are also highly heritable. Under a liability threshold model, an important question arises as to what extent genetic liability for psychiatric disorders relates to, and possibly impacts on, different aspects of quality of life in the general population. OBJECTIVE: To characterize the link between psychiatric genetic liability and diverse aspects of quality of life in childhood and adulthood...
January 18, 2023: medRxiv
#24
JOURNAL ARTICLE
Arvin Haghighatfard, Amir Hossein Ghaderi, Parmida Mostajabi, Seyedeh Sara Kashfi, Hediyeh Mohabati Somehsarayee, Maryam Shahrani, Mahla Mehrasa, Saba Haghighat, Mahdi Farhadi, Maryam Momayez Sefat, Atena Alsadat Shiryazdi, Naghmeh Ezzati, Masoume Ghasemzadeh Qazvini, Atie Alizadenik, Elham Rastegari Moghadam
BACKGROUND: Internet addiction disorder (IAD) is listed as a disorder requiring further studies in the diagnostic and statistical manual of mental disorders (DSM-V). Psychological studies showed significant co-morbidity of IAD with depression, alcohol abuse, and anxiety disorder. Etiology and genetic bases of IAD are unclear. AIMS: Present study aimed to investigate the genetic, psychological, and cognitive bases of a tendency to internet addiction. METHODS AND PROCEDURES: DNA was extracted from blood samples of IADs (N = 16,520) and 18,000 matched non-psychiatric subjects...
December 23, 2022: Research in Developmental Disabilities
#25
JOURNAL ARTICLE
Ce Wang, Yi Qi, Zhenhua Chen
Mental health conditions have the potential to be worsened by air pollution or other climate-sensitive factors. Few studies have empirically examined those associations when we faced to co-exposures, as well as interaction effects. There would be an urgent need to use deep learning to handle complex co-exposures that might interact in multiple ways, and the model performance reinforced by SHapely Additive exPlanations (SHAP) enabled our predictions interpretable and hence actionable. Here, to evaluate the mixed effect of short-term co-exposure, we conducted a time-series analysis using approximately 1...
December 9, 2022: Environment International
#26
REVIEW
Samuele Cortese, Frank Mc Besag, Bruce Clark, Chris Hollis, Joseph Kilgariff, Carmen Moreno, Dasha Nicholls, Paul Wilkinson, Marc Woodbury-Smith, Aditya Sharma
The British Association for Psychopharmacology course on child and adolescent psychopharmacology has been run for more than 20 years and is currently a very popular course, attracting around 140 delegates/year from across the United Kingdom and abroad. As Faculty of recent sessions of the course, we have selected the most common questions we have been asked in recent years and provided evidence-based and/or expert-informed answers. We have included 27 questions and answers related to attention-deficit/hyperactivity disorder, anxiety and depressive disorders, autism spectrum disorder, bipolar disorder, eating disorders, epilepsy (in differential diagnosis or comorbid with mental health conditions), obsessive-compulsive disorder, personality disorders, psychotic spectrum disorders, and tics/Tourette syndrome in children and young people...
February 2023: Journal of Psychopharmacology
#27
REVIEW
Nikita van de Burgt, Willem van Doesum, Mirjam Grevink, Stephanie van Niele, Tom de Koning, Nicole Leibold, Pilar Martinez-Martinez, Therese van Amelsvoort, Danielle Cath
Inborn errors of metabolism (IEMs) are characterized by deficits in metabolic enzymes as a result of an inherited disease, leading to the accumulation or decreased excretion of proteins, carbohydrates and lipids. Although IEMs are often diagnosed during childhood, adolescent and adult onset variants may be accompanied by less somatic and more psychiatric manifestations, which often hampers recognition by psychiatrists of the distinction between a primary and secondary psychiatric disorder. To help clinicians in the diagnostic process, we aimed to provide an overview of psychiatric manifestations in IEMs...
January 2023: Neuroscience and Biobehavioral Reviews
#28
JOURNAL ARTICLE
Ray M Merrill, Andrew W Merrill, Miranda Madsen
BACKGROUND: To describe the influence of attention-deficit hyperactivity disorder (ADHD) and comorbid mental health conditions on the risk of selected injuries. METHODS: A retrospective cohort study design was employed using medical claim data from the Deseret Mutual Benefit Administrators (DMBA). Mental health conditions, injury, medication, and demographic data were extracted from claim files for ages 4-64, years 2016-2020. RESULTS: Approximately 51...
2022: Psychiatry Journal
#29
JOURNAL ARTICLE
Yi-Ling Chien, Chi-Shin Wu, Yen-Chen Chang, Mei-Leng Cheong, Tsung-Chieh Yao, Hui-Ju Tsai
Whether parental psychiatric disorders are associated with autism spectrum disorder (ASD) in offspring has remained inconclusive. We examined the associations of parental psychiatric disorders with ASD in offspring. This population-based case-control study used Taiwan's National Health Insurance Research Database to identify a cohort of children born from 2004 to 2017 and their parents. A total of 24,279 children with ASD (diagnostic ICD-9-CM code: 299.x or ICD-10 code F84.x) and 97,715 matched controls were included...
October 17, 2022: Autism Research: Official Journal of the International Society for Autism Research
#30
REVIEW
Eunsoo Moon, Kyungwon Kim, Timo Partonen, Outi Linnaranta
PURPOSE OF REVIEW: We present a review of research on the role of melatonin in the management of sleep and circadian disorders, stressing current overall view of the knowledge across psychiatric disorders. RECENT FINDINGS: Dysregulation of sleep and circadian rhythms has been established in several psychiatric and neurocognitive disorders for long. Recent research confirms this finding consistently across disorders. The secretion of melatonin in schizophrenia and neurocognitive disorders is reduced due to a smaller volume and enlarged calcification of the pineal gland...
November 2022: Current Psychiatry Reports
#31
JOURNAL ARTICLE
Jack F G Underwood, Marcos DelPozo-Banos, Aura Frizzati, Dheeraj Rai, Ann John, Jeremy Hall
BACKGROUND: Co-occurring psychiatric disorders are common in autism, with previous studies suggesting 54-94% of autistic individuals develop a mental health condition in their lifetime. Most studies have looked at clinically-recruited cohorts, or paediatric cohorts followed into adulthood, with less known about the autistic community at a population level. We therefore studied the prevalence of co-occurring psychiatric and neurological conditions in autistic individuals in a national sample...
October 3, 2022: Psychological Medicine
#32
JOURNAL ARTICLE
Hui Ding, Mengyuan Ouyang, Jinyi Wang, Minyao Xie, Yanyuan Huang, Fangzheng Yuan, Yunhan Jia, Xuedi Zhang, Na Liu, Ning Zhang
AIMS: Epidemiological studies demonstrate an association between classes of obesity and psychiatric disorders, although little is known about shared genetics and causality of association. Thus, we aimed to investigate shared genetics and causal link between different classes of obesity and psychiatric disorders. METHODS: We used genome-wide association study (GWAS) summary data range from 9725 to 500,199 sample sizes of European descent, conducted a large-scale genome-wide cross-trait association study to investigate genetic overlap between the classes of obesity and anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, obsessive-compulsive disorder, schizophrenia, anxiety disorders and Tourette syndrome...
September 6, 2022: Journal of Psychosomatic Research
#33
JOURNAL ARTICLE
Shi-Heng Wang, Chi-Shin Wu, Le-Yin Hsu, Mei-Chen Lin, Pei-Chun Chen, Wesley K Thompson, Chun-Chieh Fan
Although paternal age has been linked to certain psychiatric disorders, the nature of any causal relationship remains elusive. Here, we aimed to comprehensively assess the magnitude of a wide range of offspring's psychiatric risk conferred by paternal age, leveraging a pedigree inferred from covered-insurance relationship (accuracy >98%) in Taiwan's single-payer compulsory insurance program. We also examined whether there is an independent role of paternal age and explored the potential effect of parental age difference...
August 30, 2022: Molecular Psychiatry
#34
REVIEW
Xuping Gao, Xin Su, Xue Han, Huiyan Wen, Chen Cheng, Shiwen Zhang, Wanlin Li, Jun Cai, Lu Zheng, Junrong Ma, Minqi Liao, Wanze Ni, Tao Liu, Dan Liu, Wenjun Ma, Shasha Han, Sui Zhu, Yanbin Ye, Fang-Fang Zeng
Unsaturated fatty acids might be involved in the prevention of and improvement in mental disorders, but the evidence on these associations has not been comprehensively assessed. This umbrella review aimed to appraise the credibility of published evidence evaluating the associations between unsaturated fatty acids and mental disorders. In this umbrella review, systematic reviews and meta-analyses of studies comparing unsaturated fatty acids (including supplementation, dietary intake, and blood concentrations) in participants with mental disorders with healthy individuals were included...
December 22, 2022: Advances in Nutrition
#35
JOURNAL ARTICLE
Ann Genovese, Trevena Moore, Pete Charlie Haynes, Marilyn Augustyn
Tony is a five and a half-year-old boy who has been a patient in your primary care practice since he was adopted at birth. He has been treated by a child and adolescent psychiatrist for behavioral concerns starting at age 3 years and has been diagnosed with autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD) combined type, anxiety disorder, and insomnia. He presents today with complaints of repeated emesis and refusal to eat or drink over the past 2 weeks and is now dehydrated. Tony was born at 30 weeks' gestational age by vaginal delivery with a birth weight of 4lbs 15oz and was described as minimally responsive at birth...
August 30, 2022: Journal of Developmental and Behavioral Pediatrics: JDBP
#36
JOURNAL ARTICLE
Joy Wan, Daniel B Shin, Maha N Syed, Katrina Abuabara, Adina R Lemeshow, Joel M Gelfand
BACKGROUND: Paediatric atopic dermatitis (AD) has been linked to neuropsychiatric comorbidities such as depression, anxiety and attention-deficit/hyperactivity disorder (ADHD). However, longitudinal data are limited, and the effect of AD severity on neuropsychiatric outcomes requires further characterization. OBJECTIVES: To determine the risk of several major neuropsychiatric conditions in children with AD. METHODS: We analysed UK health records data in a population-based cohort study...
August 26, 2022: Journal of the European Academy of Dermatology and Venereology: JEADV
#37
JOURNAL ARTICLE
Alexander Neumann, Ilja M Nolte, Irene Pappa, Tarunveer S Ahluwalia, Erik Pettersson, Alina Rodriguez, Andrew Whitehouse, Catharina E M van Beijsterveldt, Beben Benyamin, Anke R Hammerschlag, Quinta Helmer, Ville Karhunen, Eva Krapohl, Yi Lu, Peter J van der Most, Teemu Palviainen, Beate St Pourcain, Ilkka Seppälä, Anna Suarez, Natalia Vilor-Tejedor, Carla M T Tiesler, Carol Wang, Amanda Wills, Ang Zhou, Silvia Alemany, Hans Bisgaard, Klaus Bønnelykke, Gareth E Davies, Christian Hakulinen, Anjali K Henders, Elina Hyppönen, Jakob Stokholm, Meike Bartels, Jouke-Jan Hottenga, Joachim Heinrich, John Hewitt, Liisa Keltikangas-Järvinen, Tellervo Korhonen, Jaakko Kaprio, Jari Lahti, Marius Lahti-Pulkkinen, Terho Lehtimäki, Christel M Middeldorp, Jackob M Najman, Craig Pennell, Chris Power, Albertine J Oldehinkel, Robert Plomin, Katri Räikkönen, Olli T Raitakari, Kaili Rimfeld, Lærke Sass, Harold Snieder, Marie Standl, Jordi Sunyer, Gail M Williams, Marian J Bakermans-Kranenburg, Dorret I Boomsma, Marinus H van IJzendoorn, Catharina A Hartman, Henning Tiemeier
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0...
2022: PloS One
#38
JOURNAL ARTICLE
Joanna Martin, Matthew Wray, Sharifah Shameem Agha, Katie J S Lewis, Richard J L Anney, Michael C O'Donovan, Anita Thapar, Kate Langley
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is highly heritable, but little is known about the relative effects of transmitted (i.e., direct) and nontransmitted (i.e., indirect) common variant risks. Using parent-offspring trios, we tested whether polygenic liability for neurodevelopmental and psychiatric disorders and lower cognitive ability is overtransmitted to ADHD probands. We also tested for indirect or genetic nurture effects by examining whether nontransmitted ADHD polygenic liability is elevated...
June 14, 2022: Biological Psychiatry
#39
RANDOMIZED CONTROLLED TRIAL
Douglas Teixeira Leffa, Eugenio Horacio Grevet, Claiton Henrique Dotto Bau, Maitê Schneider, Carolina Prietto Ferrazza, Roberta Francieli da Silva, Marina Silva Miranda, Felipe Picon, Stefania Pigatto Teche, Paulo Sanches, Danton Pereira, Katya Rubia, André Russowsky Brunoni, Joan A Camprodon, Wolnei Caumo, Luis Augusto Rohde
IMPORTANCE: Transcranial direct current stimulation (tDCS) may improve symptoms of inattention in adults with attention-deficit/hyperactivity disorder (ADHD). However, previous trials are characterized by small sample sizes, heterogeneous methodologies, and short treatment periods using clinic-based tDCS. OBJECTIVE: To determine the efficacy and safety of home-based tDCS in treating inattention symptoms in adult patients with ADHD. DESIGN, SETTING, AND PARTICIPANTS: Randomized, double-blind, parallel, sham-controlled clinical trial (tDCS for the Treatment of Inattention Symptoms in Adult Patients With ADHD [TUNED]), conducted from July 2019 through July 2021 in a single-center outpatient academic setting...
September 1, 2022: JAMA Psychiatry
#40
JOURNAL ARTICLE
Carla Carnovale, Cristiana Perrotta, Sara Baldelli, Dario Cattaneo, Cristina Montrasio, Silvia S Barbieri, Giulio Pompilio, Chiara Vantaggiato, Emilio Clementi, Marco Pozzi
A bidirectional relationship exists between hypertension and psychiatric disorders, including unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis, schizophrenia, mania, and dementia/cognitive decline. Repurposing of antihypertensive drugs to treat mental disorders is thus being explored. A systematic knowledge of the mechanisms of action and clinical consequences of the use of antihypertensive agents on neuropsychiatric functions has not been achieved yet. In this article, we review the putative role of antihypertensive agents in psychiatric disorders, discuss the targets and mechanisms of action, and examine how and to what extent specific drug classes/molecules may trigger, worsen, or mitigate psychiatric symptoms...
July 27, 2022: Cardiovascular Research
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