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https://www.readbyqxmd.com/read/28523130/the-development-of-uniportal-video-assisted-thoracoscopic-surgery-in-s%C3%A3-o-paulo-from-diagnosis-to-lobectomy
#1
Alexandre de Oliveira, Thais Amarante P P Couto
BACKGROUND: The use of uniportal video-assisted thoracoscopic surgery (VATS) has been increasing worldwide. Our main goal was to describe the evolution of uniportal surgery in the biggest private hospital in Latin America that is located in São Paulo, Brazil. METHODS: This descriptive and retrospective study included patients who underwent uniportal VATS in the thoracic surgical department of Beneficencia Portuguesa Hospital, after being referred to our team to undergo the aforementioned procedure within the period from February 2012 to March 2016...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28515170/respiratory-function-and-mechanics-in-pinnipeds-and-cetaceans
#2
REVIEW
Andreas Fahlman, Michael J Moore, Daniel Garcia-Parraga
In this Review, we focus on the functional properties of the respiratory system of pinnipeds and cetaceans, and briefly summarize the underlying anatomy; in doing so, we provide an overview of what is currently known about their respiratory physiology and mechanics. While exposure to high pressure is a common challenge among breath-hold divers, there is a large variation in respiratory anatomy, function and capacity between species - how are these traits adapted to allow the animals to withstand the physiological challenges faced during dives? The ultra-deep diving feats of some marine mammals defy our current understanding of respiratory physiology and lung mechanics...
May 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28508919/cognitive-development-of-school-age-hypoplastic-left-heart-syndrome-survivors-a-single-center-study
#3
REVIEW
Raphael D Oberhuber, Sonja Huemer, Rudolf Mair, Eva Sames-Dolzer, Michaela Kreuzer, Gerald Tulzer
Neurological and radiologic research results show an abnormal cerebral microstructure as well as abnormal neurodevelopment in patients treated for hypoplastic left heart syndrome. The aim of this study was to assess the varying cognitive performance these children have developed in dependence upon prenatal diagnosis, surgical techniques, surgical learning effects, anatomy, perfusion techniques, gender, pedagogic, and sociodemographic parameters in comparison to age-adjusted normative values. School-age children (6...
May 16, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28492127/obstructive-pulmonary-disease-in-patients-with-previous-tuberculosis-pathophysiology-of-a-community-based-cohort
#4
Brian W Allwood, Rencia Gillespie, Maya Galperin-Aizenberg, Mary Bateman, Helena Olckers, Luis Taborda-Barata, Gregory L Calligaro, Qonita Said-Hartley, Richard Van Zyl-Smit, Christopher B Cooper, Eva Van Rikxoort, Jonathan Goldin, Nulda Beyers, Eric D Bateman
BACKGROUND: An association between chronic airflow limitation (CAL) and a history of pulmonary tuberculosis (PTB) has been confirmed in epidemiological studies, but the mechanisms responsible for this association are unclear. It is debated whether CAL in this context should be viewed as chronic obstructive pulmonary disease (COPD) or a separate phenotype. OBJECTIVE: To compare lung physiology and high-resolution computed tomography (HRCT) findings in subjects with CAL and evidence of previous (healed) PTB with those in subjects with smoking-related COPD without evidence of previous PTB...
April 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28479938/statistical-shape-modeling-for-cavopulmonary-assist-device-development-variability-of-vascular-graft-geometry-and-implications-for-hemodynamics
#5
Jan L Bruse, Giuliano Giusti, Catriona Baker, Elena Cervi, Tain-Yen Hsia, Andrew M Taylor, Silvia Schievano
Patients born with a single functional ventricle typically undergo three-staged surgical palliation in the first years of life, with the last stage realizing a cross-like total cavopulmonary connection (TCPC) of superior and inferior vena cavas (SVC and IVC) with both left and right pulmonary arteries, allowing all deoxygenated blood to flow passively back to the lungs (Fontan circulation). Even though within the past decades more patients survive into adulthood, the connection comes at the prize of deficiencies such as chronic systemic venous hypertension and low cardiac output, which ultimately may lead to Fontan failure...
June 2017: Journal of Medical Devices
https://www.readbyqxmd.com/read/28476219/dose-to-heart-substructures-is-associated-with-non-cancer-death-after-sbrt-in-stage-i-ii-nsclc-patients
#6
Barbara Stam, Heike Peulen, Matthias Guckenberger, Frederick Mantel, Andrew Hope, Maria Werner-Wasik, Jose Belderbos, Inga Grills, Nicolette O'Connell, Jan-Jakob Sonke
BACKGROUND AND PURPOSE: To investigate potential associations between dose to heart (sub)structures and non-cancer death, in early stage non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT). METHODS: 803 patients with early stage NSCLC received SBRT with predominant schedules of 3×18Gy (59%) or 4×12Gy (19%). All patients were registered to an average anatomy, their planned dose deformed accordingly, and dosimetric parameters for heart substructures were obtained...
May 2, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28475739/a-step-by-step-development-of-real-size-chest-model-for-simulation-of-thoracoscopic-surgery
#7
Toshiaki Morikawa, Makoto Yamashita, Makoto Odaka, Yo Tsukamoto, Takamasa Shibasaki, Shohei Mori, Hisatoshi Asano, Tadashi Akiba
OBJECTIVES: For the purpose of simulating thoracoscopic surgery, we have conducted stepwise development of a life-like chest model including thorax and intrathoracic organs. METHODS: First, CT data of the human chest were obtained. First-generation model: based on the CT data, each component of the chest was made from a 3D printer. A hard resin was used for the bony thorax and a rubber-like resin for the vessels and bronchi. Lung parenchyma, muscles and skin were not created...
May 4, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28466969/microscopic-anatomy-of-the-visceral-fasciae
#8
Carla Stecco, Maria Martina Sfriso, Andrea Porzionato, Anna Rambaldo, Giovanna Albertin, Veronica Macchi, Raffaele De Caro
The term 'visceral fascia' is a general term used to describe the fascia lying immediately beneath the mesothelium of the serosa, together with that immediately surrounding the viscera, but there are many types of visceral fasciae. The aim of this paper was to identify the features they have in common and their specialisations. The visceral fascia of the abdomen (corresponding to the connective tissue lying immediately beneath the mesothelium of the parietal peritoneum), thorax (corresponding to the connective tissue lying immediately beneath the mesothelium of the parietal pleura), lung (corresponding to the connective tissue under the mesothelium of the visceral pleura), liver (corresponding to the connective tissue under the mesothelium of the visceral peritoneum), kidney (corresponding to the Gerota fascia), the oesophagus (corresponding to its adventitia) and heart (corresponding to the fibrous layer of the pericardial sac) from eight fresh cadavers were sampled and analysed with histological and immunohistochemical stains to evaluate collagen and elastic components and innervation...
May 3, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28463164/individualized-selection-of-beam-angles-and-treatment-isocenter-in-tangential-breast-intensity-modulated-radiation-therapy
#9
Joan Penninkhof, Sara Spadola, Sebastiaan Breedveld, Margreet Baaijens, Nico Lanconelli, Ben Heijmen
PURPOSE AND OBJECTIVE: Propose a novel method for individualized selection of beam angles and treatment isocenter in tangential breast intensity modulated radiation therapy (IMRT). METHODS AND MATERIALS: For each patient, beam and isocenter selection starts with the fully automatic generation of a large database of IMRT plans (up to 847 in this study); each of these plans belongs to a unique combination of isocenter position, lateral beam angle, and medial beam angle...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28450046/pulmonary-surfactant-and-nanocarriers-toxicity-versus-combined-nanomedical-applications
#10
REVIEW
Alberto Hidalgo, Antonio Cruz, Jesús Pérez-Gil
Pulmonary surfactant is a membrane-based lipid-protein system essential for the process of breathing, which coats and stabilizes the whole respiratory surface and possesses exceptional biophysical properties. It constitutes the first barrier against the entry of pathogens and harmful particles in the alveolar region, extended through the lungs, but on the other hand, it can offer novel possibilities as a shuttle for the delivery of drugs and nanocarriers. The advances in nanotechnology are opening the doors to new diagnostic and therapeutic avenues, which are not accessible by means of the current approaches...
April 25, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28449533/can-mathematics-replace-anatomy-to-establish-recommendations-in-lung-cancer-surgery
#11
EDITORIAL
Marc Riquet, Ciprian Pricopi, Antoine Legras, Alex Arame, Alain Badia, Françoise Le Pimpec Barthes
The greater the number of lymph node (LN) sampled (NLNsS) during lung cancer surgery, the lower the risk of underestimating the pN-status and the better the outcome of the pN0-patients due to stage-migration. Thus, regarding LN sampling "to be or not to be", number is the question. Recent studies advocate removing 10 LNs. The most suitable NLNsS is unfortunately impossible to establish by mathematics. A too high NLNsS variability exists, based on anatomy, surgery and pathology. The methodology may vary according to Inter-institutional differences in the surgical approach regarding LN inspection and number sampling...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28433482/variations-of-target-volume-definition-and-daily-target-volume-localization-in-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-patients-under-abdominal-compression
#12
Chunhui Han, Sagus Sampath, Timothy E Schultheisss, Jeffrey Y C Wong
We aimed to compare gross tumor volumes (GTV) in 3-dimensional computed tomography (3DCT) simulation and daily cone beam CT (CBCT) with the internal target volume (ITV) in 4-dimensional CT (4DCT) simulation in stereotactic body radiotherapy (SBRT) treatment of patients with early-stage non-small cell lung cancer (NSCLC) under abdominal compression. We retrospectively selected 10 patients with NSCLC who received image-guided SBRT treatments under abdominal compression with daily CBCT imaging. GTVs were contoured as visible gross tumor on the planning 3DCT and daily CBCT, and ITVs were contoured using maximum intensity projection (MIP) images of the planning 4DCT...
April 19, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28408698/reproducibility-of-lobar-perfusion-and-ventilation-quantification-using-a-spect-ct-segmentation-software-in-lung-cancer-patients
#13
Karine Provost, Antoine Leblond, Annie Gauthier Lemire, Edith Fillion, Houda Bahig, Martin Lord
Planar perfusion scintigraphy with Tc99m-labelled macroaggregated albumin (Tc99m-MAA) is often used for pre-therapy quantification of regional lung perfusion in lung cancer patients, particularly in patients with poor respiratory function. However, subdividing lung parenchyma in rectangular regions of interests, as done on planar images, is a poor reflection of true lobar anatomy. New tridimensional methods using SPECT and SPECT/CT have been introduced, including a semi-automatic lung segmentation software (Hermes Medical Solutions)...
April 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28405393/lung-anatomy-and-histology-of-the-extant-coelacanth-shed-light-on-the-loss-of-air-breathing-during-deep-water-adaptation-in-actinistians
#14
Camila Cupello, François J Meunier, Marc Herbin, Gaël Clément, Paulo M Brito
Lungs are specialized organs originated from the posterior pharyngeal cavity and considered as plesiomorphic for osteichthyans, as they are found in extant basal actinopterygians (i.e. Polypterus) and in all major groups of extant sarcopterygians. The presence of a vestigial lung in adult stages of the extant coelacanth Latimeria chalumnae is the result of allometric growth during ontogeny, in relation with long-time adaptation to deep water. Here, we present the first detailed histological and anatomical description of the lung of Latimeria chalumnae, providing new insights into its arrested differentiation in an air-breathing complex, mainly represented by the absence of pneumocytes and of compartmentalization in the latest ontogenetic stages...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28398630/mitigating-differential-baseline-shifts-in-locally-advanced-lung-cancer-patients-using-an-average-anatomy-model
#15
Mehrsima Abdoli, Simon R van Kranen, Uros Stankovic, Maddalena M G Rossi, Jose S A Belderbos, Jan-Jakob Sonke
BACKGROUND AND PURPOSE: Differential baseline shifts between primary tumor and involved lymph nodes in locally advanced lung cancer patients compromise the accuracy of radiotherapy. The purpose of this study was to evaluate the performance of an average anatomy model (AAM) derived from repeat imaging and deformable registration to reduce these geometrical uncertainties. METHODS AND MATERIALS: An in-house implementation of a B-Spline deformable image registration (DIR) algorithm was first validated using three different validation approaches: 1) a circle method to test the consistency of the DIR, 2) fiducial marker target registration error, and 3) the recovery of a known deformation vector field (DVF)...
April 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28397961/the-association-between-wedging-of-the-aorta-and-cardiac-structural-anatomy-as-revealed-using-multidetector-row-computed-tomography
#16
Shumpei Mori, Robert H Anderson, Tomofumi Takaya, Takayoshi Toba, Tatsuro Ito, Sei Fujiwara, Yoshiaki Watanabe, Tatsuya Nishii, Atsushi K Kono, Ken-Ichi Hirata
The aortic root is wedged within the cardiac base. The precise extent of aortic wedging, however, and its influence on the surrounding cardiac structures, has not been systematically investigated. We analysed 100 consecutive patients, who underwent coronary arterial computed tomographic angiography. We assessed the extent of aortic wedging by measuring the vertical distance between the non-adjacent aortic sinus and the inferior epicardium. A shorter distance indicates deeper aortic wedging. We assessed the tilt angle and diameter of the ascending aorta, the relative heights of the left atrial roof and the oval fossa, the shape of the proximal right coronary artery, the angle of the aorta relative to the left ventricular axis, and the lung volume...
April 11, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28321268/caudal-fluoroscopy-to-guide-venous-access-for-pacemaker-device-implantation-should-this-now-be-standard-practice
#17
Hitesh C Patel, Carl Hayward, Shane Nanayakkara, Archer Broughton, Justin A Mariani
We describe a technique that uses both posterior-anterior and caudal fluoroscopy to achieve venous access for pacemaker device implantation. A significant advantage of this technique is the ability to clearly demarcate both the anatomy of venous drainage and the lung border. We would encourage all centres to adopt this technique as a safe approach to venous access.
2017: Heart Asia
https://www.readbyqxmd.com/read/28320428/a-topology-based-method-to-mitigate-the-dosimetric-uncertainty-caused-by-the-positional-variation-of-the-boost-volume-in-breast-conservative-radiotherapy
#18
Peng-Yi Lee, Chih-Yuan Lin, Shang-Wen Chen, Chun-Ru Chien, Chun-Nan Chu, Hsiu-Ting Hsu, Ji-An Liang, Ying-Jun Lin, An-Cheng Shiau
BACKGROUND: To improve local control rate in patients with breast cancer receiving adjuvant radiotherapy after breast conservative surgery, additional boost dose to the tumor bed could be delivered simultaneously via the simultaneous integrated boost (SIB) modulated technique. However, the position of tumor bed kept changing during the treatment course as the treatment position was aligned to bony anatomy. This study aimed to analyze the positional uncertainties between bony anatomy and tumor bed, and a topology-based approach was derived to stratify patients with high variation in tumor bed localization...
March 20, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28297347/geometric-dose-prediction-model-for-hemithoracic-intensity-modulated-radiation-therapy-in-mesothelioma-patients-with-two-intact-lungs
#19
LiCheng Kuo, Ellen D Yorke, Vishruta A Dumane, Amanda Foster, Zhigang Zhang, James G Mechalakos, Abraham J Wu, Kenneth E Rosenzweig, Andreas Rimner
The presence of two intact lungs makes it challenging to reach a tumoricidal dose with hemithoracic pleural intensity-modulated radiation therapy (IMRT) in patients with malignant pleural mesothelioma (MPM) who underwent pleurectomy/decortications or have unresectable disease. We developed an anatomy-based model to predict attainable prescription dose before starting optimization. Fifty-six clinically delivered IMRT plans were analyzed regarding correlation of prescription dose and individual and total lung volumes, planning target volume (PTV), ipsilateral normal lung volume and ratios: contralateral/ipsilateral lung (CIVR); contralateral lung/PTV (CPVR); ipsilateral lung /PTV (IPVR); ipsilateral normal lung /total lung (INTLVR); ipsilateral normal lung/PTV (INLPVR)...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295386/an-integrated-segmentation-and-shape-based-classification-scheme-for-distinguishing-adenocarcinomas-from-granulomas-on-lung-ct
#20
Mehdi Alilou, Niha Beig, Mahdi Orooji, Prabhakar Rajiah, Vamsidhar Velcheti, Sagar Rakshit, Niyoti Reddy, Michael Yang, Frank Jacono, Robert C Gilkeson, Philip Linden, Anant Madabhushi
PURPOSE: Distinguishing between benign granulmoas and adenocarcinomas is confounded by their similar visual appearance on routine CT scans. Unfortunately, owing to the inability to discriminate these lesions radigraphically, many patients with benign granulomas are subjected to unnecessary surgical wedge resections and biopsies for pathologic confirmation of cancer presence or absence. This suggests the need for improved computerized characterization of these nodules in order to distinguish between these two classes of lesions on CT scans...
March 14, 2017: Medical Physics
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