K E Mittauer, M F Bassetti, J J Meudt, M Graham, M W Wood, J Miller, M Lawless, J M Frank, R Ward, A J Van Der Kogel, D Shanmuganayagam, J Bayouth
PURPOSE/OBJECTIVE(S): Daily variations in abdominal anatomy introduce significant uncertainty in estimating the maximum tolerated dose (MTD). We investigated the gastroduodenal toxicity using stereotactic MR-guided online adaptive radiotherapy (SMART) to precisely control the dose to a novel swine model that closely matches human physiology and can be maintained at 80 kg. We hypothesized for a cumulative SMART course of 50 Gy in 5 fractions to the pancreas, the duodenum MTD is significantly > 37 Gy to 0...
November 1, 2021: International Journal of Radiation Oncology, Biology, Physics