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Nrf2 AND protandim

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https://www.readbyqxmd.com/read/27618111/protandim-protects-oligodendrocytes-against-an-oxidative-insult
#1
Jamie L Lim, Susanne M A van der Pol, Wia Baron, Joe M McCord, Helga E de Vries, Jack van Horssen
Oligodendrocyte damage and loss are key features of multiple sclerosis (MS) pathology. Oligodendrocytes appear to be particularly vulnerable to reactive oxygen species (ROS) and cytokines, such as tumor necrosis factor-α (TNF), which induce cell death and prevent the differentiation of oligodendrocyte progenitor cells (OPCs). Here, we investigated the efficacy of sulforaphane (SFN), monomethyl fumarate (MMF) and Protandim to induce Nrf2-regulated antioxidant enzyme expression, and protect oligodendrocytes against ROS-induced cell death and ROS-and TNF-mediated inhibition of OPC differentiation...
September 7, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27463229/elucidating-the-role-of-protandim-and-6-gingerol-in-protection-against-osteoarthritis
#2
Jamilah Abusarah, Houda Abir Benabdoun, Qin Shi, Bertrand Lussier, Johanne Martel-Pelletier, Michel Malo, Julio C Fernandes, Fátima Pereira de Souza, Hassan Fahmi, Mohamed Benderdour
Protandim and 6-gingerol, two potent nutraceuticals, have been shown to decrease free radicals production through enhancing endogenous antioxidant enzymes. In this study, we evaluated the effects of these products on the expression of different factors involved in osteoarthritis (OA) process. Human OA chondrocytes were treated with 1 ng/ml IL-1β in the presence or absence of protandim (0-10 μg/ml) or 6-gingerol (0-10 μM). OA was induced surgically in mice by destabilization of the medial meniscus (DMM)...
July 27, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27312235/longer-lifespan-in-male-mice-treated-with-a-weakly-estrogenic-agonist-an-antioxidant-an-%C3%AE-glucosidase-inhibitor-or-a-nrf2-inducer
#3
Randy Strong, Richard A Miller, Adam Antebi, Clinton M Astle, Molly Bogue, Martin S Denzel, Elizabeth Fernandez, Kevin Flurkey, Karyn L Hamilton, Dudley W Lamming, Martin A Javors, João Pedro de Magalhães, Paul Anthony Martinez, Joe M McCord, Benjamin F Miller, Michael Müller, James F Nelson, Juliet Ndukum, G Ed Rainger, Arlan Richardson, David M Sabatini, Adam B Salmon, James W Simpkins, Wilma T Steegenga, Nancy L Nadon, David E Harrison
The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to increase healthy lifespan in genetically heterogeneous mice. Each compound is tested in parallel at three sites, and all results are published. We report the effects of lifelong treatment of mice with four agents not previously tested: Protandim, fish oil, ursodeoxycholic acid (UDCA) and metformin - the latter with and without rapamycin, and two drugs previously examined: 17-α-estradiol and nordihydroguaiaretic acid (NDGA), at doses greater and less than used previously...
October 2016: Aging Cell
https://www.readbyqxmd.com/read/23722164/nrf2-activation-a-potential-strategy-for-the-prevention-of-acute-mountain-sickness
#4
Christina Lisk, Joe McCord, Swapan Bose, Tim Sullivan, Zoe Loomis, Eva Nozik-Grayck, Thies Schroeder, Karyn Hamilton, David C Irwin
Reactive oxygen species (ROS) formed during acute high altitude exposure contribute to cerebral vascular leak and development of acute mountain sickness (AMS). Nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) is a transcription factor that regulates expression of greater than 90% of antioxidant genes, but prophylactic treatment with Nrf2 activators has not yet been tested as an AMS therapy. We hypothesized that prophylactic activation of the antioxidant genome with Nrf2 activators would attenuate high-altitude-induced ROS formation and cerebral vascular leak and that some drugs currently used to treat AMS symptoms have an additional trait of Nrf2 activation...
October 2013: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/23201694/upregulation-of-phase-ii-enzymes-through-phytochemical-activation-of-nrf2-protects-cardiomyocytes-against-oxidant-stress
#5
Danielle J Reuland, Shadi Khademi, Christopher J Castle, David C Irwin, Joe M McCord, Benjamin F Miller, Karyn L Hamilton
Increased production of reactive oxygen species has been implicated in the pathogenesis of cardiovascular disease (CVD), and enhanced endogenous antioxidants have been proposed as a mechanism for regulating redox balance. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a transcriptional regulator of phase II antioxidant enzymes, and activation of Nrf2 has been suggested to be an important step in attenuating oxidative stress associated with CVD. A well-defined combination of five widely studied medicinal plants derived from botanical sources (Bacopa monniera, Silybum marianum (milk thistle), Withania somnifera (Ashwagandha), Camellia sinensis (green tea), and Curcuma longa (turmeric)) has been shown to activate Nrf2 and induce phase II enzymes through the antioxidant response element...
March 2013: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/22870869/antioxidants-for-the-treatment-of-patients-with-severe-angioproliferative-pulmonary-hypertension
#6
REVIEW
Norbert F Voelkel, Harm J Bogaard, Aysar Al Husseini, Laszlo Farkas, Jose Gomez-Arroyo, Ramesh Natarajan
SIGNIFICANCE: Pathobiological mechanisms that contribute to pulmonary vasoconstriction, lung vascular remodeling, and the development of right heart failure include the generation of reactive oxygen and nitrogen species and the response of lung vascular and cardiac cells to these molecules. We review the information regarding oxidant stress balanced by antioxidant mechanisms and the role of oxidants and antioxidants in hypoxic pulmonary hypertension and their potential role in an animal model of severe pulmonary arterial hypertension (PAH)...
May 10, 2013: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/22685617/phytochemical-activation-of-nrf2-protects-human-coronary-artery-endothelial-cells-against-an-oxidative-challenge
#7
Elise L Donovan, Joe M McCord, Danielle J Reuland, Benjamin F Miller, Karyn L Hamilton
Activation of NF-E2-related factor 2 (Nrf2) is a potential therapeutic intervention against endothelial cell oxidative stress and associated vascular disease. We hypothesized that treatment with the phytochemicals in the patented dietary supplement Protandim would induce Nrf2 nuclear localization and phase II antioxidant enzyme protein in human coronary artery endothelial cells (HCAECs), protecting against an oxidant challenge in an Nrf2- dependent manner. Protandim treatment induced Nrf2 nuclear localization, and HO-1 (778% of control ± 82...
2012: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/22020111/oxidative-stress-in-health-and-disease-the-therapeutic-potential-of-nrf2-activation
#8
REVIEW
Brooks M Hybertson, Bifeng Gao, Swapan K Bose, Joe M McCord
For the past 40 years or so, oxidative stress has been increasingly recognized as a contributing factor in aging and in various forms of pathophysiology generally associated with aging. Our view of oxidative stress has been largely "superoxide-centric", as we focused on the pathological sources of this oxygen-derived free radical and the types of molecular havoc it can wreak, as well as on the protection provided by the antioxidant enzymes, especially the superoxide dismutases, catalases, and glutathione peroxidases...
August 2011: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/21167278/protandim-attenuates-intimal-hyperplasia-in-human-saphenous-veins-cultured-ex-vivo-via-a-catalase-dependent-pathway
#9
Binata Joddar, Rashmeet K Reen, Michael S Firstenberg, Saradhadevi Varadharaj, Joe M McCord, Jay L Zweier, Keith J Gooch
Human saphenous veins (HSVs) are widely used for bypass grafts despite their relatively low long-term patency. To evaluate the role of reactive oxygen species (ROS) signaling in intima hyperplasia (IH), an early stage pathology of vein-graft disease, and to explore the potential therapeutic effects of up-regulating endogenous antioxidant enzymes, we studied segments of HSV cultured ex vivo in an established ex vivo model of HSV IH. Results showed that HSV cultured ex vivo exhibit an ~3-fold increase in proliferation and ~3...
March 15, 2011: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/19056485/synergistic-induction-of-heme-oxygenase-1-by-the-components-of-the-antioxidant-supplement-protandim
#10
Kalpana Velmurugan, Jawed Alam, Joe M McCord, Subbiah Pugazhenthi
Protandim is an antioxidant supplement that consists of five ingredients, namely, ashwagandha, bacopa extract, green tea extract, silymarin, and curcumin, each with known therapeutic properties. Protandim was formulated with the objective of combining multiple phytochemicals at low nontoxic doses to gain synergy among them. A recent clinical study demonstrated the in vivo antioxidant effects of Protandim (S.K. Nelson et al., 2006, Free Radic. Biol. Med. 40, 341-347). The objective of the present study was to determine if the components of Protandim induce heme oxygenase-1 (HO-1) in a synergistic manner in cultured MIN6 cells, a mouse beta-cell line, and in SK-N-MC cells, a human neuroblastoma cell line...
February 1, 2009: Free Radical Biology & Medicine
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