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https://www.readbyqxmd.com/read/28539403/sec23b-is-required-for-pancreatic-acinar-cell-function-in-adult-mice
#1
Rami Khoriaty, Nancy Vogel, Mark J Hoenerhoff, M Dolors Sans, Guojing Zhu, Lesley Everett, Bradley Nelson, Haritha Durairaj, Brooke McKnight, Bin Zhang, Stephen A Ernst, David Ginsburg, John A Williams
Mice with germline absence of SEC23B die perinatally, exhibiting massive pancreatic degeneration. We generated mice with tamoxifen-inducible, pancreatic acinar cell-specific Sec23b deletion. Inactivation of Sec23b exclusively in the pancreatic acinar cells of adult mice results in decreased overall pancreatic weights from pancreatic cell loss (decreased pancreatic DNA, RNA, and total protein content), as well as degeneration of exocrine cells, decreased zymogen granules, and alterations in the endoplasmic reticulum (ER), ranging from vesicular ER to markedly expanded cisternae with accumulation of moderate density content or intracisternal granules...
May 24, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28538557/safety-of-outpatient-circumferential-body-lift-evidence-from-42-consecutive-cases
#2
J John Makipour, Erik Nuveen, Diana Abbott
BACKGROUND: Circumferential lower body lifts have become more prevalent with the rise of massive weight loss surgery. This has historically required inpatient admission. Only three previous groups have published their experience with outpatient lower body lifts. METHODS: The authors reviewed their experience with 42 consecutive outpatient circumferential body lifts from 2010 to 2016, and report patient demographics, operative details, and postoperative outcomes...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28514314/infected-tibia-defect-fractures-treated-with-the-masquelet-technique
#3
Julia Mühlhäusser, Jörg Winkler, Reto Babst, Frank J P Beeres
The treatment after open and infected fractures with extensive soft tissue damage and bone deficit remains a challenging clinical problem. The technique described by Masquelet, using a temporary cement spacer to induce a membrane combined with reconstructive soft tissue coverage, is a possible solution. This study describes the work-up, operative procedure, complications, and the outcome of a homogenous group of patients with an open and infected tibia fracture and segmental bone loss treated with the Masquelet technique (MT)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28491474/the-role-of-race-and-gender-in-nutrition-habits-and-self-efficacy-results-from-the-young-adult-weight-loss-study
#4
Janna D Stephens, Andrew Althouse, Alai Tan, Bernadette Mazurek Melnyk
Overweight and obesity are a massive public health problem and young adults are at high risk for gaining weight once they enter a college. This study sought to examine gender and race as they relate to nutrition habits and self-efficacy in a population of diverse young adults from the Young Adult Weight Loss Study. Participants (N = 62) were 29% males, 38.7% white, 33.8% Asian, and 12.9% African American. Males had lower self-efficacy for healthy eating (mean score = 92.5, SD = 17.1) compared to females (mean = 102...
2017: Journal of Obesity
https://www.readbyqxmd.com/read/28476513/animal-models-of-cachexia-and-sarcopenia-in-chronic-illness-cardiac-function-body-composition-changes-and-therapeutic-results
#5
REVIEW
Junichi Ishida, Masakazu Saitoh, Wolfram Doehner, Stephan von Haehling, Markus Anker, Stefan D Anker, Jochen Springer
Cachexia is defined as a complex metabolic syndrome associated with underlying illness that is characterized by the loss of body weight consisting of muscle and fat mass wasting. Sarcopenia is defined as the ageing related loss of muscle mass in health and disease that may not have an effect on body weight. As millions of patients are in cachectic or sarcopenic states, both conditions contribute to high numbers to death worldwide. A number of treatments have been proposed for cachexia and sarcopenia, but these are either in the preclinical stage or in clinical trials and hence not available to the general population...
April 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28467614/autologous-breast-reconstruction-in-the-postbariatric-patient-population
#6
Andrew R Bauder, Fares Samra, Suhail K Kanchwala, Joseph M Serletti, Stephen J Kovach, Liza C Wu
BACKGROUND: Over 175,000 Americans underwent bariatric surgery in 2013 alone, resulting in rapid growth of the massive weight loss population. As obesity is a known risk factor for breast cancer, plastic surgeons are increasingly challenged to reconstruct the breasts of massive weight loss patients after oncologic resection. The goal of this study is to assess the outcomes of autologous breast reconstruction in postbariatric surgery patients at a single institution. METHODS: Patients who underwent autologous breast reconstruction between 2008 and 2014 were identified...
May 3, 2017: Microsurgery
https://www.readbyqxmd.com/read/28445359/the-impact-of-body-contouring-procedures-on-urologic-outcomes-in-massive-weight-loss-patients
#7
Oren P Mushin, Franca S Kraenzlin, Anees Fazili, Ahmed Ghazi, Ronald P Bossert
BACKGROUND: Post-massive weight loss body contouring is a growing area of plastic surgery. Studies have shown preexisting urinary incontinence amelioration in patients undergoing abdominal body-contouring procedures. These studies are small, focus on cosmetic abdominoplasties, and lack use of standardized surveys. The purpose of this study was to evaluate urinary incontinence endpoints in massive weight loss patients undergoing body-contouring procedures. METHODS: A retrospective review was conducted over a 6-year period...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445358/discussion-the-challenges-of-augmentation-mastopexy-in-the-massive-weight-loss-patient-technical-considerations
#8
Bernard L Markowitz
No abstract text is available yet for this article.
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445357/the-challenges-of-augmentation-mastopexy-in-the-massive-weight-loss-patient-technical-considerations
#9
Demetrius M Coombs, Udayan Srivastava, Dalit Amar, J Peter Rubin, Jeffrey A Gusenoff
BACKGROUND: Augmentation mastopexy in the massive weight loss population is challenging because of poor skin elasticity and lack of inframammary support. Despite several large studies of augmentation mastopexy in the literature, few data exist regarding this unique patient population. The authors examine early postoperative ptosis, implant malposition, and strategies to optimize outcomes. METHODS: A retrospective review of massive weight loss patients who underwent augmentation mastopexy from 2003 to 2011 was performed to record age, body mass index, implant characteristics, postoperative ptosis, and implant malposition...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28416007/disseminated-alveolar-echinococcosis-resembling-metastatic-malignancy-a-case-report
#10
Laura Caire Nail, Ezequiel Rodríguez Reimundes, Christelle Weibel Galluzzo, Dan Lebowitz, Yasmine Lucile Ibrahim, Johannes Alexander Lobrinus, François Chappuis
BACKGROUND: Alveolar echinococcosis is a potentially lethal zoonosis caused by larval forms of the tapeworm Echinococcus multilocularis. Humans are aberrant intermediate hosts who become infected by ingestion of egg-contaminated food or water or via physical contact with domestic or wild animals that carry the parasite in their small intestine. In humans, the disease usually affects the liver and can spread to other organs causing metastatic infiltration. In this report, we describe an advanced presentation of human alveolar echinococcosis mimicking metastatic malignancy...
April 18, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28403899/hepato-bronchial-fistula-secondary-to-perforated-sigmoid-diverticulitis-a-case-report
#11
Jun Sunny Yin, Shaylan Govind, Daniele Wiseman, Richard Inculet, Raymond Kao
BACKGROUND: Patients with diverticulitis are predisposed to hepatic abscesses via seeding through the portal circulation. Hepatic abscesses are well-documented sequelae of diverticulitis, however instances of progression to hepato-bronchial fistulization are rare. We present a case of diverticulitis associated with hepatic abscess leading to hepato-bronchial fistulization, which represents a novel disease course not yet reported in the literature. CASE PRESENTATION: A 61-year-old Caucasian man presented with a history of unintentional weight loss and dyspnea both at rest and with exertion...
April 13, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28398515/gluteal-implants-versus-autologous-flaps-in-patients-with-postbariatric-surgery-weight-loss-a-prospective-comparative-study-of-3-dimensional-gluteal-projection-after-lower-body-lift
#12
Philippe Levan, Samer Bassilios Habre
Background: Deformities and excess skin resulting from massive weight loss are corrected with circumferential lower body lift (LBL). The gluteal area is frequently flattened due to aggressive skin excision during LBL. Gluteal implants can circumvent this problem. Objectives: We aimed to objectively evaluate the outcomes of gluteal augmentation with implants versus flap surgery performed simultaneously with LBL. Methods: Between January 2014 and June 2015, twenty-seven patients underwent LBL with gluteal implants (10 patients), flaps (14 patients), or no gluteal augmentation (3 patients) in our hospital...
April 7, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28393217/antitumor-agent-25-epi-ritterostatin-gn1n-induces-endoplasmic-reticulum-stress-and-autophagy-mediated-cell-death-in-melanoma-cells
#13
Kausar Begam Riaz Ahmed, Ananda Kumar Kanduluru, Li Feng, Philip L Fuchs, Peng Huang
Metastatic melanoma is the most aggressive of all skin cancers and is associated with poor prognosis owing to lack of effective treatments. 25-epi Ritterostatin GN1N is a novel antitumor agent with yet undefined mechanisms of action. We sought to delineate the antitumor mechanisms of 25-epi Ritterostatin GN1N in melanoma cells to determine the potential of this compound as a treatment for melanoma. Activation of the endoplasmic reticulum (ER) stress protein glucose-regulated protein 78 (GRP78) has been associated with increased melanoma progression, oncogenic signaling, drug resistance, and suppression of cell death...
May 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28342593/taxocoenosis-of-epibenthic-dinoflagellates-in-the-coastal-waters-of-the-northern-yucatan-peninsula-before-and-after-the-harmful-algal-bloom-event-in-2011-2012
#14
Ana C Aguilar-Trujillo, Yuri B Okolodkov, Jorge A Herrera-Silveira, Fany Del C Merino-Virgilio, Citlalli Galicia-García
Eutrophication causes the major impact in the coastal waters of the state of Yucatan. In general, loss of water quality and biological communities and massive development of toxic microorganisms are some of the consequences of this phenomenon. To reveal changes in species composition and cell abundance of the taxocoenosis of epibenthic dinoflagellates before and after a harmful algal bloom event in the water column that lasted about 150days (August-December 2011) in the Dzilam - San Crisanto area (northern Yucatan Peninsula, southeastern Gulf of Mexico) were the main objectives of the present study...
March 22, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28302520/complex-hernias-with-loss-of-domain-in-morbidly-obese-patients-role-of-laparoscopic-sleeve-gastrectomy-in-a-multi-step-approach
#15
Yves Borbély, Jens Zerkowski, Julia Altmeier, Anna Eschenburg, Dino Kröll, Philipp Nett
BACKGROUND: Morbid obesity and its associated co-morbidities are risk factors for the development of abdominal hernias, add complexity to their repair, and increase perioperative risk. Repair of hernias with loss of domain (LoD) is further complicated by risk of abdominal compartment syndrome. A staged concept with an initial weight loss procedure might enable a reposition of the herniated viscera, improve co-morbidities for, and prohibit abdominal compartment syndrome in the subsequent repair...
January 27, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28301361/modified-fleur-de-lis-abdominoplasty-for-massive-weight-loss-patients
#16
Ulrich Eugen Ziegler, Selina Nora Ziegler, Philip Helge Zeplin
INTRODUCTION: Fleur-de-lis abdominoplasty is an effective procedure for correcting abdominal contour abnormalities in both the vertical and horizontal orientation. Tension on the approximated tissue edges and reduced microvascular perfusion is mainly responsible for wound dehiscence and delayed wound healing in the T-point area and seroma formation. To reduce these complications, we developed a modification of the fleur-de-lis abdominoplasty technique forming upper abdominal skin flaps with deepithelialized mediocaudal edges...
March 16, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28283671/obesity-energy-balance-and-spermatogenesis
#17
Pedro Fontes Oliveira, Mario Sousa, Branca M Silva, Mariana P Monteiro, Marco G Alves
Obesity has grown to pandemic proportions. It affects an increasing number of children, adolescents and young adults exposed to the silent co-morbidities of this disorder for a longer period. Infertility has arisen as one important comorbidity associated with the energy dysfunction promoted by obesity. Spermatogenesis is a highly regulated process that is determined by specific energetic requirements. The reproductive potential of males relies on hormonal-dependent and independent stimuli that control sperm quality...
March 10, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28275690/intestinal-epithelial-specific-mtorc1-activation-enhances-intestinal-adaptation-after-small-bowel-resection
#18
Lauren Barron, Raphael C Sun, Bola Aladegbami, Christopher R Erwin, Brad W Warner, Jun Guo
BACKGROUND & AIMS: Intestinal adaptation is a compensatory response to the massive loss of small intestine after surgical resection. We investigated the role of intestinal epithelial cell-specific mammalian target of rapamycin complex 1 (i-mTORC1) in intestinal adaptation after massive small bowel resection (SBR). METHODS: We performed 50% proximal SBR on mice to study adaptation. To manipulate i-mTORC1 activity, Villin-Cre(ER) transgenic mice were crossed with tuberous sclerosis complex (TSC)1(flox/flox) or Raptor(flox/flox) mice to inducibly activate or inactivate i-mTORC1 activity with tamoxifen...
March 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28274706/increased-joint-pain-after-massive-weight-loss-is-there-an-association-with-joint-hypermobility
#19
Monika Fagevik Olsén, Sofie Brunnegård, Sofia Sjöström, Christina Biörserud, Gunilla Kjellby-Wendt
BACKGROUND: Obesity is associated with an increased risk of pain in weight-bearing joints. Although pain often decreases after obesity surgery, this is the reverse for some patients. Hypermobility is described as an excessive range of motion in joints and has been suggested to be a possible cause of joint pain. It is not known whether there is an association between increased joint pain after weight loss and hypermobility. OBJECTIVES: The objective of this study was to investigate whether there is an association between hypermobility and increased joint pain after massive weight loss...
January 10, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28272273/the-lipo-bodylift-an-ideal-technique-for-type-i-and-ii-massive-weight-loss-patients-reply-to-dast-et-al
#20
Nicolas Bertheuil, Benoit Chaput, Paul Girard, Raphael Carloni, Eric Watier, Antoine De Runz
No abstract text is available yet for this article.
March 7, 2017: Plastic and Reconstructive Surgery
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