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https://www.readbyqxmd.com/read/28100166/smite-an-r-bioconductor-package-that-identifies-network-modules-by-integrating-genomic-and-epigenomic-information
#1
N Ari Wijetunga, Andrew D Johnston, Ryo Maekawa, Fabien Delahaye, Netha Ulahannan, Kami Kim, John M Greally
BACKGROUND: The molecular assays that test gene expression, transcriptional, and epigenetic regulation are increasingly diverse and numerous. The information generated by each type of assay individually gives an insight into the state of the cells tested. What should be possible is to add the information derived from separate, complementary assays to gain higher-confidence insights into cellular states. At present, the analysis of multi-dimensional, massive genome-wide data requires an initial pruning step to create manageable subsets of observations that are then used for integration, which decreases the sizes of the intersecting data sets and the potential for biological insights...
January 18, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28065237/predictors-for-massive-blood-loss-during-posterior-correction-of-congenital-scoliosis-in-pre-school-children-a-retrospective-observation
#2
Le Shen, Wei-Yun Chen, Wu-Tao Wang, Hao-Nan Xu, Xue-Rong Yu, Xiu-Hua Zhang, Yu-Guang Huang
Objective To investigate the predictors for massive blood loss during posterior correction of congenital scoliosis in pre-school children. Methods Totally 124 children under six years of age,who received posterior correction of congenital scoliosis,were divided into two groups according to the ratio of intraoperative blood loss (BL) and estimated blood volume (EBV). Massive blood loss was defined as BL/EBV>0.15,and minor or moderate blood loss as BL/EBV≤0.15. All the records,including demographics,intraoperative fluids,pre- or postoperative laboratory parameters,and the length of hospital stay,were compared between these two groups...
December 20, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28042838/a-comparison-study-of-classifier-algorithms-for-cross-person-physical-activity-recognition
#3
Yago Saez, Alejandro Baldominos, Pedro Isasi
Physical activity is widely known to be one of the key elements of a healthy life. The many benefits of physical activity described in the medical literature include weight loss and reductions in the risk factors for chronic diseases. With the recent advances in wearable devices, such as smartwatches or physical activity wristbands, motion tracking sensors are becoming pervasive, which has led to an impressive growth in the amount of physical activity data available and an increasing interest in recognizing which specific activity a user is performing...
December 30, 2016: Sensors
https://www.readbyqxmd.com/read/28027231/the-lipo-body-lift-a-new-circumferential-body-contouring-technique-useful-after-bariatric-surgery
#4
Nicolas Bertheuil, Benoit Chaput, Antoine De Runz, Paul Girard, Raphael Carloni, Eric Watier
BACKGROUND: After bariatric surgery, lifting of the lower body involves a contouring technique used to achieve optimal lower trunk reconstruction. The authors describe an innovative procedure applicable after massive weight loss: the lipo-body lift method. The authors describe their experience with this novel, safe procedure. METHODS: Twenty-five abdominal body-contouring reconstructions following massive weight loss were treated by means of circumferential lipo-body lift...
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28002278/reply-concomitant-liposuction-reduces-complications-of-vertical-medial-thigh-lift-in-massive-weight-loss-patients
#5
Christopher D Knotts, Joseph P Hunstad
No abstract text is available yet for this article.
December 16, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28002275/re-complications-of-vertical-medial-thigh-lift-in-massive-weight-loss-patients
#6
Manfred Schmidt, Dominik Duscher, Georg M Huemer
No abstract text is available yet for this article.
December 16, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27988455/delayed-diagnosis-of-wernicke-encephalopathy-with-irreversible-neural-damage-after-subtotal-gastrectomy-for-gastric-cancer-a-case-of-medical-liability
#7
Pamela Tozzo, Luciana Caenazzo, Daniele Rodriguez, Matteo Bolcato
INTRODUCTION: Wernicke's encephalopathy (WE) is a neurological syndrome caused by thiamine deficiency, and clinically characterized by ophthalmoplegia, ataxia and acute confusion. In developed countries, most cases of WE have been seen in alcohol misusers. Other reported causes are gastrointestinal tract surgery, hyperemesis gravidarum, chronic malnutrition, prolonged total parenteral nutrition without thiamine supplementation, and increased nutrient requirements as in trauma or septic shock...
December 1, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27965594/lack-of-adrenomedullin-results-in-microbiota-changes-and-aggravates-azoxymethane-and-dextran-sulfate-sodium-induced-colitis-in-mice
#8
Sonia Martínez-Herrero, Ignacio M Larrayoz, Judit Narro-Íñiguez, María J Villanueva-Millán, Emma Recio-Fernández, Patricia Pérez-Matute, José A Oteo, Alfredo Martínez
The link between intestinal inflammation, microbiota, and colorectal cancer is intriguing and the potential underlying mechanisms remain unknown. Here we evaluate the influence of adrenomedullin (AM) in microbiota composition and its impact on colitis with an inducible knockout (KO) mouse model for AM. Microbiota composition was analyzed in KO and wild type (WT) mice by massive sequencing. Colitis was induced in mice by administration of azoxymethane (AOM) followed by dextran sulfate sodium (DSS) in the drinking water...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27940965/high-aminopeptidase-a-activity-contributes-to-blood-pressure-control-in-ob-ob-mice-by-at2-receptor-dependent-mechanism
#9
Rafael Leite Morais, Aline M Hilzendeger, Bruna Visniauskas, Mihail Todiras, Natalia Alenina, Marcelo A Mori, Ronaldo C Araujo, Clovis R Nakaie, Jair Ribeiro Chagas, Adriana K Carmona, Michael Bader, João Bosco Pesquero
Obesity is assumed to be a major cause of human essential hypertension, however the mechanisms responsible for weight-related increase in blood pressure (BP) are not fully understood. The prevalence of hypertension induced by obesity has grown over the years and the role of the renin-angiotensin-aldosterone system (RAAS) in this process continues to be elucidated. In this scenario, the ob/ob mice are a genetic obesity model generally used for metabolic disorders studies. These mice are normotensive even though they present several metabolic conditions that predispose them to hypertension...
December 9, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27931170/abdominoplasty-and-gluteoplasty-after-massive-weight-loss-an-all-in-one-technique
#10
Britt Colebunders, Koenraad Van Landuyt
INTRODUCTION: Patients requesting body-contouring surgery after massive weight loss often present with abdominal and lumbar skin excess as well as gluteal ptosis and loss of gluteal projection. In order to restore gluteal projection a circular abdominoplasty in combination with an autologous gluteal augmentation (all-in-one technique) can be performed. OBJECTIVE: To compare outcomes for patients who underwent a circular abdominoplasty with or without autologous gluteal augmentation...
December 8, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27915052/massive-localized-lymphedema-a-case-control-study
#11
Reid Maclellan, David Zurakowski, Frederick D Grant, Arin K Greene
BACKGROUND: Massive localized lymphedema (MLL) is an area of skin and subcutaneous overgrowth associated with obesity. The purpose of this project was to determine whether MLL results from obesity-induced lymphedema (OIL), and to characterize the prevalence and risk factors for the condition. STUDY DESIGN: Patients evaluated in our Lymphedema Program between 2009 and 2016 were reviewed for obese individuals [body mass index (BMI) > 30 kg/m(2)] who had lower extremity lymphatic function evaluated by lymphoscintigraphy...
November 10, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27911903/transfected-babesia-bovis-expressing-a-tick-gst-as-a-live-vector-vaccine
#12
Daiane P Oldiges, Jacob M Laughery, Nelson Junior Tagliari, Ronaldo Viana Leite Filho, William C Davis, Itabajara da Silva Vaz, Carlos Termignoni, Donald P Knowles, Carlos E Suarez
The Rhipicephalus microplus tick is a notorious blood-feeding ectoparasite of livestock, especially cattle, responsible for massive losses in animal production. It is the main vector for transmission of pathogenic bacteria and parasites, including Babesia bovis, an intraerythrocytic apicomplexan protozoan parasite responsible for bovine Babesiosis. This study describes the development and testing of a live B. bovis vaccine expressing the protective tick antigen glutathione-S-transferase from Haemaphysalis longicornis (HlGST)...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27902772/relation-between-birth-weight-and-intraoperative-hemorrhage-during-cesarean-section-in-pregnancy-with-placenta-previa
#13
Hiroaki Soyama, Morikazu Miyamoto, Hiroki Ishibashi, Masashi Takano, Hidenori Sasa, Kenichi Furuya
BACKGROUND: Placenta previa, one of the most severe obstetric complications, carries an increased risk of intraoperative massive hemorrhage. Several risk factors for intraoperative hemorrhage have been identified to date. However, the correlation between birth weight and intraoperative hemorrhage has not been investigated. Here we estimate the correlation between birth weight and the occurrence of intraoperative massive hemorrhage in placenta previa. MATERIALS AND METHODS: We included all 256 singleton pregnancies delivered via cesarean section at our hospital because of placenta previa between 2003 and 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27889486/abdominoplasty-with-scarpa-fascia-preservation-comparative-study-in-a-bariatric-population
#14
Inês Correia-Gonçalves, Rita Valença-Filipe, Jorge Carvalho, Marco Rebelo, Helena Peres, José Amarante, António Costa-Ferreira
BACKGROUND: Abdominoplasty techniques using a more superficial plane of dissection with Scarpa fascia preservation have been shown to improve recovery and reduce complications in nonbariatric patients. Patients who have experienced massive weight loss frequently need body contour procedures and represent a high-risk group. OBJECTIVE: To evaluate the effect of this technique in patients with massive weight loss after bariatric surgery. SETTING: University hospital, Portugal...
September 28, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27865752/reconstruction-of-massive-localized-lymphedema-of-the-scrotum-results-complications-and-quality-of-life-improvements
#15
Eric Wisenbaugh, Dena Moskowitz, Joel Gelman
OBJECTIVE: To review the surgical technique, outcomes and complications of surgical excision of massive localized lymphedema of the scrotum, and to determine changes in weight and quality of life after excision. MATERIALS AND METHODS: A retrospective review was performed for all patients who have undergone excision of MLL of the scrotum at our institution between 2008 and 2014. Standard baseline characteristics, complications, pre- and postoperative weight and quality of life data were recorded...
November 16, 2016: Urology
https://www.readbyqxmd.com/read/27853087/mycobacterium-shigaense-causes-lymph-node-and-cutaneous-lesions-as-immune-reconstitution-syndrome-in-an-aids-patient-the-third-case-report-of-a-novel-strain-non-tuberculous-mycobacterium
#16
Yusuke Koizumi, Kaoru Shimizu, Masayo Shigeta, Hitoshi Minamiguchi, Keiko Hodohara, Akira Andoh, Toshihide Tanaka, Kinuyo Chikamatsu, Satoshi Mitarai, Hiroshige Mikamo
A 40-year-old man complaining of progressive body weight loss was diagnosed to have acquired immunodeficiency syndrome. Within 2 weeks after the initiation of combination antiretroviral therapy, he developed fever, massive cervical lymphadenopathy and a protruding subcutaneous abscess. A lymph node biopsy and abscess drainage revealed non-caseous granuloma and mycobacterium. The mycobacterium belonged to Runyon II group, but it showed no matches to any previously reported species. According to sequence analyses, the strain was identified as Mycobacterium shigaense...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27842634/a-review-of-the-peri-operative-management-of-paediatric-burns-identifying-adverse-events
#17
H Rode, C Brink, K Bester, M P Coleman, T Baisey, R Martinez
BACKGROUND: Burn injuries are common in poverty-stricken countries. The majority of patients with large and complex burns are referred to burn centres. Of the children who qualify for admission, according to burn admission criteria, about half require some kind of surgical procedure to obtain skin cover. These range from massive full-thickness fire burns to skin grafts for small, residual unhealed wounds. Burn anaesthetic procedures are of the most difficult to perform and are known for high complication rates...
November 2, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27785316/pharyngoesophageal-obstruction-on-the-killian-laimer-triangle-by-zenker-s-diverticulum-case-report-and-clinical-significance
#18
Tulio F Leite, Carlos A A Chagas, Lucas A S Pires, Rafael Cisne, Marcio A Babinski
Zenker's diverticulum is a form of esophageal and pharyngeal obstruction located at the Killian-Laimer triangle. It is relatively common in elderly man (seventh or eighth decade of life), and its pathophysiology is not completely understood, albeit theories regarding dysfunction of the upper esophageal sphincter were reported. The main symptoms are dysphagia and odynophagia, but it can complicate to aspiration and perforation of the pharyngeal pouch; also, it can be asymptomatic. Diagnosis is provided through a barium esophagogram...
December 2015: Gastroenterology Research
https://www.readbyqxmd.com/read/27784224/detection-of-unilateral-hearing-loss-by-stationary-wavelet-entropy
#19
Yudong Zhang, Deepak Ranjan Nayak, Ming Yang, Ying Shao, Bin Liu, Shuihua Wang
(Aim) Sensorineural hearing loss is correlated to massive neurological or psychiatric disease. (Materials) T1-weighted volumetric images were acquired from fourteen subjects with right-sided hearing loss (RHL), fifteen subjects with left-sided hearing loss (LHL), and 20 healthy controls (HC). (Method) We treat this a three-class classification problem: HC, LHL, and RHL. Stationary wavelet entropy was employed to extract global features from magnetic resonance images of each subject. Those stationary wavelet entropy features are used as input to a single-hidden layer feedforward neural-network classifier...
October 26, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27780812/the-impact-of-abdominal-contouring-with-monsplasty-on-sexual-function-and-urogenital-distress-in-women-following-massive-weight-loss
#20
Michael R Bykowski, J Peter Rubin, Jeffrey A Gusenoff
BACKGROUND: Monsplasty treats massive weight loss (MWL) patients with redundant tissues in the mons region. Monsplasty, however, is not a routine component of abdominal contouring. OBJECTIVES: The goal of this study was to evaluate the changes in urinary and sexual functioning in patients who undergo abdominal contouring with monsplasty vs non-operated controls. METHODS: A prospective study was performed of patients who underwent abdominal contouring + monsplasty or no surgery...
January 2017: Aesthetic Surgery Journal
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