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Antiplatelet therapy

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https://www.readbyqxmd.com/read/29928625/antiplatelet-therapy-and-bladder-tumor-resection
#1
EDITORIAL
Apul Goel, Rohan Patel
No abstract text is available yet for this article.
May 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29928315/non-vitamin-k-antagonist-oral-anticoagulant-after-acute-coronary-syndrome-is-there-a-role
#2
REVIEW
Paul Guedeney, Birgit Vogel, Roxana Mehran
Despite dual antiplatelet therapy (DAPT) including potent P2Y12 inhibitors, recurrent ischaemic events occur in a significant number of patients after acute coronary syndrome (ACS), warranting new antithrombotic strategies. Combinations of non-vitamin K antagonist oral anticoagulant (NOAC) with antiplatelet therapy have been tested in several large phases II and III randomised trials. Overall, current evidence suggests that the use of NOACs on top of DAPT after ACS reduces the rate of recurrent ischaemic events, albeit at the price of increased risk for major bleeding...
May 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29928314/anticoagulant-therapy-for-acute-coronary-syndromes
#3
REVIEW
Eunice Nc Onwordi, Amr Gamal, Azfar Zaman
Anticoagulation in conjunction with antiplatelet therapy is central to the management of acute coronary syndromes (ACS). When used effectively it is associated with a reduction in recurrent ischaemic events including myocardial infarction and stent thrombosis as well as a reduction in death. Effective ischaemic risk reduction whilst balancing bleeding risk remains a clinical challenge. This article reviews the current available evidence for anticoagulation in ACS and recommendations from the European Society of Cardiology...
May 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29928161/the-role-of-proton-pump-inhibitors-in-the-management-of-upper-gastrointestinal-disorders
#4
Muhammad Ali Khan, Colin W Howden
Proton pump inhibitors (PPIs) have been in use since the early 1990s and play a crucial role in the management of a number of conditions affecting the upper gastrointestinal tract, including gastroesophageal reflux disease, Barrett esophagus, eosinophilic esophagitis, and dyspepsia. PPIs also play an important role in the treatment of Helicobacter pylori infection and in the prevention of upper gastrointestinal tract ulcers and bleeding among patients taking antiplatelet therapy and/or nonsteroidal anti-inflammatory drugs...
March 2018: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29925802/possible-molecular-targets-of-novel-ruthenium-complexes-in-antiplatelet-therapy
#5
REVIEW
Thanasekaran Jayakumar, Chia-Yuan Hsu, Themmila Khamrang, Chih-Hsuan Hsia, Chih-Wei Hsia, Manjunath Manubolu, Joen-Rong Sheu
In oncotherapy, ruthenium (Ru) complexes are reflected as potential alternatives for platinum compounds and have been proved as encouraging anticancer drugs with high efficacy and low side effects. Cardiovascular diseases (CVDs) are mutually considered as the number one killer globally, and thrombosis is liable for the majority of CVD-related deaths. Platelets, an anuclear and small circulating blood cell, play key roles in hemostasis by inhibiting unnecessary blood loss of vascular damage by making blood clot...
June 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29924777/-vascular-stents-approaches-used-to-increase-their-clinical-efficacy
#6
K A Kuznetsov, M V Khar'kova, A A Karpenko, P P Laktionov
Using stents for endovascular restoration of blood flow made a revolution in vascular surgery, however, despite numerous variants of stents presented on the pharmacological market, there are no stents which would completely solve the problem of restenosis in the area of stent placement. In order to decrease growth of the neointima of the stented portions of vessels, stents coated with cytostatic and cytotoxic agents were worked out. To optimize the rate of drug release it was suggested to apply them in a mixture with biodegradable or biostable polymers...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924734/clinical-validation-of-s100b-in-the-management-of-a-mild-traumatic-brain-injury-issues-from-an-interventional-cohort-of-1449-adult-patients
#7
Gautier Allouchery, Farès Moustafa, Jean Roubin, Bruno Pereira, Jeannot Schmidt, Julien Raconnat, Daniel Pic, Vincent Sapin, Damien Bouvier
BACKGROUND: This study's primary objective was to validate the routine use of S100B via a prospective study. The aim was a reduction of cranial computed tomography (CCT) scans by 30%. The secondary goal was to investigate the influence of age and associated risk factors on the reduction of CCT. METHODS: S100B (sampling within 3 h postinjury) was used for patients with mild traumatic brain injury (mTBIs) presenting a medium risk of complications and requiring a CCT scan...
June 20, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29922880/the-effect-of-cessation-of-2nd-generation-p-2-y-12-inhibitor-therapy-on-platelet-reactivity-in-patients-1-year-after-acute-myocardial-infarction
#8
Guy Witberg, Jalal Bathish, Tamir Bental, Dorit Leshem-Lev, Abid Assali, Ran Kornowski, Eli Lev
To assess the effect of cessation of dual antiplatelet therapy (DAPT) regimens containing 2nd generation P2 Y12 inhibitors on platelet reactivity, in patients who completed 12 months of DAPT following an acute myocardial infarction. Clinical data has shown an increased cardiovascular risk in the 90 days following cessation of DAPT. One possible explanation is a transient platelet hyper-reactivity after cessation of treatment. Data from patients treated with 2nd generation P2 Y12 inhibitors is scarce. Patients who completed 12 month DAPT with prasugrel/ticagrelor underwent serial assessment of platelet reactivity (on DAPT and 1, 4 and 12 weeks post cessation)...
June 19, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29921034/antiplatelet-and-anticoagulation-therapy-during-percutaneous-coronary-interventions-a-review-for-the-interventionalist
#9
REVIEW
Craig Basman, Afnan Tariq, Yuvrajsinh J Parmar, Deepak Asti, Neil L Coplan, Varinder P Singh, Carl D Reimers
Pharmacotherapy for percutaneous coronary interventions is essential to optimize the balance between thrombosis and bleeding. Currently, choices abound for the selection of antiplatelet and anticoagulation therapies during percutaneous intervention (PCI). This review article discusses the mechanisms, pharmacokinetics/dynamics, and clinical data behind the various pharmacotherapies including; aspirin, thienopyridines, glycoprotein IIb/IIIa inhibitors, vorapaxar, heparin, direct thrombin inhibitors, and factor Xa inhibitors...
June 19, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29920547/efficacy-and-safety-of-triple-therapy-versus-dual-antiplatelet-therapy-in-patients-with-atrial-fibrillation-undergoing-coronary-stenting-a-meta-analysis
#10
Liyao Liu, Jietao Huang, Xiaogang Zhang, Xiaoman Tang
BACKGROUND: The optimal antithrombotic therapy for atrial fibrillation (AF) patients undergoing coronary stenting is unknown. The present meta-analysis sought to investigate the efficacy and safety of triple therapy (TT; warfarin, clopidogrel and aspirin) vs dual antiplatelet therapy (DAPT; clopidogrel plus aspirin) in those patients. METHODS: PubMed and Cochrane Library were searched for studies enrolling AF patients undergoing coronary stenting on TT and DAPT up to September 2016, and fourteen studies were included...
2018: PloS One
https://www.readbyqxmd.com/read/29915905/antithromboembolic-strategies-for-patients-with-atrial-fibrillation-undergoing-percutaneous-coronary-intervention
#11
REVIEW
Ayesha Ather, Benjamin Laliberte, Brent N Reed, Ashley Schenk, Kristin Watson, Sandeep Devabhakthuni, Vincent Y See
We set out to synthesize available data on antithrombotic strategies for patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI), with a focus on triple antithrombotic therapy (triple therapy [TT]; dual antiplatelet therapy plus an anticoagulant) versus dual therapy (DT; one antiplatelet agent and an anticoagulant). We searched OVID MEDLINE and PubMed from January 2005 to September 2017 using the search terms oral anticoagulant, triple therapy, dual therapy, acute coronary syndrome, percutaneous coronary intervention, and atrial fibrillation (limited to randomized controlled trials, observational studies, English language, minimum 6-12 months of follow-up, minimum 100 human patients)...
June 19, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29914573/stent-thrombosis-associated-with-drug-eluting-stents-on-addition-of-cilostazol-to-the-standard-dual-antiplatelet-therapy-following-percutaneous-coronary-intervention-a-systematic-review-and-meta-analysis-of-published-randomized-controlled-trials
#12
Feng Huang
BACKGROUND: In this analysis, we aimed to systematically compare stent thrombosis (ST) and its different subtypes following treatment with DAPT (aspirin + clopidogrel) versus TAPT (aspirin + clopidogrel + cilostazol). METHODS: Studies were included if: they were randomized controlled trials (RCTs) comparing TAPT (cilostazol + aspirin + clopidogrel) with DAPT (aspirin + clopidogrel); they reported ST or its subtype including definite, probable, acute, sub-acute and late ST as their clinical outcomes...
June 18, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29914560/predictive-factors-of-intracranial-bleeding-in-head-trauma-patients-receiving-antiplatelet-therapy-admitted-to-an-emergency-department
#13
Farès Moustafa, Jean Roubin, Bruno Pereira, Alain Barres, Jennifer Saint-Denis, Christophe Perrier, Marine Mondet, Frederic Dutheil, Jeannot Schmidt
BACKGROUND: In head trauma cases involving antiplatelet agent treatment, the French Society of Emergency Medicine recommends performing computed tomography (CT) scans to detect brain lesions, 90% of which are normal. The value of CT is still debatable given the scarce number of studies and controversial results. METHODS: We used the RATED registry (Registry of patient with Antithrombotic agents admitted to an Emergency Department, NCT02706080) to assess factors of cerebral bleeding related to antiplatelet agents following head trauma...
June 19, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29914380/vasodilator-stimulated-phosphoprotein-guided-clopidogrel-maintenance-therapy-reduces-cardiovascular-events-in-atrial-fibrillation-patients-requiring-anticoagulation-therapy-and-scheduled-for-percutaneous-coronary-intervention-a-prospective-cohort-study
#14
Chaoyue Hu, Xumin Zhang, Yonghua Liu, Yang Gao, Xiaohong Zhao, Hua Zhou, Yu Luo, Yaling Liu, Xiaodong Wang
BACKGROUND: In a previous study, we found that titrating clopidogrel maintenance doses (MDs) according to vasodilator-stimulated phosphoprotein (VASP) monitoring minimised the rate of major adverse cardiovascular and cerebral events (MACCE) after percutaneous coronary intervention (PCI) without increasing bleeding in patients with high on-treatment platelet reaction to clopidogrel. This study aimed to investigate whether VASP-guided clopidogrel MD could reduce thromboembolism and bleeding in atrial fibrillation (AF) patients requiring anticoagulation and scheduled for PCI...
June 18, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29912422/age-and-outcomes-following-guided-de-escalation-of-antiplatelet-treatment-in-acute-coronary-syndrome-patients-undergoing-percutaneous-coronary-intervention-results-from-the-randomized-tropical-acs-trial
#15
Dirk Sibbing, Lisa Gross, Dietmar Trenk, Claudius Jacobshagen, Tobias Geisler, Martin Hadamitzky, Béla Merkely, Róbert Gábor Kiss, András Komócsi, Radoslaw Parma, Stephan B Felix, Franz-Josef Neumann, Jörg Hausleiter, Monika Baylacher, Lukasz Koltowski, Julinda Mehilli, Kurt Huber, Zenon Huczek, Dániel Aradi, Steffen Massberg
Aims: Guided de-escalation of P2Y12-inhibitor treatment was recently identified as an effective alternative treatment strategy in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention. Safety and efficacy of this strategy may differ in relation to patient's age. This pre-specified analysis of the TROPICAL-ACS trial aimed to assess the impact of age on clinical outcomes following guided de-escalation of antiplatelet treatment in ACS patients. Methods and results: Patients were randomly assigned in a 1:1 fashion to either standard treatment with prasugrel for 12 months (control group) or to a guided de-escalation regimen (1 week prasugrel followed by 1 week clopidogrel and platelet function testing guided maintenance therapy with clopidogrel or prasugrel from day 14 after hospital discharge; guided de-escalation group)...
June 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29912233/-2017-update-on-dual-antiplatelet-therapy-what-s-new
#16
Guido Parodi, Giuseppe Nusdeo, Pierfranco Terrosu
No abstract text is available yet for this article.
April 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29910193/closure-anticoagulation-or-antiplatelet-therapy-for-cryptogenic-stroke-with-patent-foramen-ovale-systematic-review-of-randomized-trials-sequential-meta-analysis-and-new-insights-from-the-close-study
#17
REVIEW
Guillaume Turc, David Calvet, Patrice Guérin, Marjorie Sroussi, Gilles Chatellier, Jean-Louis Mas
BACKGROUND: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing patent foramen ovale (PFO) closure, anticoagulation, and antiplatelet therapy to prevent stroke recurrence in patients with PFO-associated cryptogenic stroke. METHODS AND RESULTS: We searched Medline, Cochrane Library, and EMBASE through March 2018. The primary outcome was stroke recurrence. Pooled incidences, hazard ratios, and risk ratios (RRs) were calculated in random-effects meta-analyses...
June 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29909378/delayed-ischemic-stroke-due-to-stent-marker-band-occlusion-after-stent-assisted-coiling
#18
Shuhei Kawabata, Hirotoshi Imamura, Keita Suzuki, Shoichi Tani, Hidemitsu Adachi, Nobuyuki Sakai
A middle-aged patient with an internal carotid-posterior communicating artery aneurysm and basilar artery tip aneurysm was treated by stent-assisted coiling. One ischemic infarction and two transient ischemic attacks occurred with the same symptoms (inability to walk unassisted and tendency to fall to the left) during the first 2 years post-treatment. The ischemic infarction was found in the right side of the pons, consistent with the vascular territory of the stent-containing vessel. The cause of the delayed ischemic stroke was investigated on DSA and cone beam CT, which revealed that the proximal end of the stent, one marker band, was just covering a small perforating artery of the basilar artery trunk...
June 16, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29908967/platelet-reactivity-and-risk-of-ischemic-stroke-after-coronary-drug-eluting-stent-implantation-from-the-adapt-des-study
#19
Gennaro Giustino, Björn Redfors, Ajay J Kirtane, Roxana Mehran, George D Dangas, Bernhard Witzenbichler, Franz-Josef Neumann, Giora Weisz, Philippe Généreux, Akiko Maehara, Thomas McAndrew, Serdar Farhan, Michael J Rinaldi, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Ernest L Mazzaferri, Bruce R Brodie, Thomas D Stuckey, Paul Gurbel, Ori Ben-Yehuda, Gregg W Stone
OBJECTIVES: The authors sought to investigate the association between P2Y12 reaction units (PRU) and the risk of ischemic stroke (IS) after successful coronary drug-eluting stents (DES) implantation. BACKGROUND: The association between platelet reactivity on clopidogrel and the risk for ischemic cerebrovascular events remains unclear. METHODS: Incidence, predictors, and prognostic impact of IS were evaluated among patients enrolled in the multicenter, prospective ADAPT-DES (Assessment of Dual AntiPlatelet Therapy With Drug Eluting Stents) study...
June 8, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29907259/there-seems-to-be-a-low-risk-of-experiencing-postoperative-bleeding-in-patients-undergoing-dental-extractions-or-minor-oral-surgery-who-continue-using-antiplatelet-therapy
#20
Romina Brignardello-Petersen
No abstract text is available yet for this article.
June 11, 2018: Journal of the American Dental Association
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