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https://www.readbyqxmd.com/read/28522358/self-tolerance-and-autoimmunity-in-a-minimal-model-of-the-idiotypic-network
#1
Stefan Landmann, Nicolas Preuss, Ulrich Behn
We consider self-tolerance and its failure -autoimmunity- in a minimal mathematical model of the idiotypic network. A node in the network represents a clone of B-lymphocytes and its antibodies of the same idiotype which is encoded by a bitstring. The links between nodes represent possible interactions between clones of almost complementary idiotype. A clone survives only if the number of populated neighbored nodes is neither too small nor too large. The dynamics is driven by the influx of lymphocytes with randomly generated idiotype from the bone marrow...
May 15, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28518111/using-enzyme-based-biosensors-to-measure-tonic-and-phasic-glutamate-in-alzheimer-s-mouse-models
#2
Holly C Hunsberger, Sharay E Setti, Ryan T Heslin, Jorge E Quintero, Greg A Gerhardt, Miranda N Reed
Neurotransmitter disruption is often a key component of diseases of the central nervous system (CNS), playing a role in the pathology underlying Alzheimer's disease, Parkinson's disease, depression, and anxiety. Traditionally, microdialysis has been the most common (lauded) technique to examine neurotransmitter changes that occur in these disorders. But because microdialysis has the ability to measure slow 1-20 minute changes across large areas of tissue, it has the disadvantage of invasiveness, potentially destroying intrinsic connections within the brain and a slow sampling capability...
May 3, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28505487/heroin-refusal-self-efficacy-and-preference-for-medication-assisted-treatment-after-inpatient-detoxification
#3
Shannon R Kenney, Genie L Bailey, Bradley J Anderson, Michael D Stein
OBJECTIVE: An individual's self-efficacy to refuse using heroin in high-risk situations is believed to minimize the likelihood for relapse. However, among individuals completing inpatient heroin detoxification, perceived refusal self-efficacy may also reduce one's perceived need for medication-assisted treatment (MAT), an effective and recommended treatment for opioid use disorder. In the current study, we examined the relationship between heroin refusal self-efficacy and preference for MAT following inpatient detoxification...
May 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28502243/a-60-week-prospective-rct-of-a-self-management-intervention-for-individuals-with-serious-mental-illness-and-diabetes-mellitus
#4
Martha Sajatovic, Douglas D Gunzler, Stephanie W Kanuch, Kristin A Cassidy, Curtis Tatsuoka, Richard McCormick, Carol E Blixen, Adam T Perzynski, Douglas Einstadter, Charles L Thomas, Mary E Lawless, Siobhan Martin, Corinna Falck-Ytter, Eileen L Seeholzer, Christine L McKibben, Mark S Bauer, Neal V Dawson
OBJECTIVES: A 60-week randomized controlled trial assessed the effects of targeted training in illness management (TTIM) versus treatment as usual among 200 individuals with serious mental illness and diabetes mellitus. METHODS: The study used the Clinical Global Impression (CGI), the Montgomery-Asberg Depression Rating Scale (MADRS), and the Brief Psychiatric Rating Scale (BPRS) to assess psychiatric symptoms; the Global Assessment of Functioning (GAF) and the Sheehan Disability Scale (SDS) to assess functioning; the 36-Item Short-Form Health Survey (SF-36) to assess general health, and serum glycosylated hemoglobin (HbA1c) to assess diabetes control...
May 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28499521/investigating-clinically-and-scientifically-useful-cut-points-on-the-compulsive-sexual-behavior-inventory
#5
Michael H Miner, Nancy Raymond, Eli Coleman, Rebecca Swinburne Romine
INTRODUCTION: One of the major obstacles to conducting epidemiologic research and determining the incidence and prevalence of compulsive sexual behavior (CSB) has been the lack of relevant empirically derived cut points on the various instruments that have been used to measure the concept. AIM: To further develop the Compulsive Sexual Behavior Inventory (CSBI) through exploring predictive validity and developing an empirically determined and clinically useful cut point for defining CSB...
May 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28497683/a-kinetic-pathway-towards-high-density-ordered-n-doping-of-epitaxial-graphene-on-cu-111-using-c5ncl5-precursors
#6
Ping Cui, Jin-Ho Choi, Changgan Zeng, Zhenyu Li, Jinlong Yang, Zhenyu Zhang
Pristine graphene possesses high electrical mobility, but its low charge carrier density severely limits its technological significance. Past efforts to increase graphene's carrier density via chemical doping have shown limited successes, accompanied by substantial reductions in the mobility caused by disordered dopants. Here, based on first-principles calculations, we propose to grow graphene on Cu(111) via self-assembly of C5NCl5 molecular precursors to achieve high-density (1/6) and highly ordered nitrogen doping...
May 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28489808/mental-health-status-after-living-donor-hepatectomy
#7
Szu-Han Wang, Ping-Yi Lin, Jiun-Yi Wang, Mei-Feng Huang, Hui-Chuan Lin, Chia-En Hsieh, Ya-Lan Hsu, Yao-Li Chen
Donor safety and preservation of donor health after living liver donation are of paramount importance. In addition, the preoperative mental state of a donor is an important factor in determining the psychological impact of donor hepatectomy. Thus, we aimed to explore the mental health status of living liver donors after hepatectomy. We enrolled 60 donors who were scheduled to undergo living donor hepatectomy during the period January 2014 to March 2015 at a single medical center. Mental health status was measured before and 3 months after surgery using 3 self-report questionnaires, namely the Center for Epidemiologic Studies Depression Scale (CES-D) to assess depressive symptoms, the World Health Organization Quality of Life (WHOQOL-BREF) questionnaire to measure quality of life, and the Chinese Health Questionnaire (CHQ) to screen for minor psychiatric disorders...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28487216/patient-specific-factors-predicting-outcome-of-temporomandibular-joint-arthroscopy-a-6-year-retrospective-study
#8
Mattias Ulmner, Carina Kruger-Weiner, Bodil Lund
PURPOSE: Although indications for the surgical treatment of internal derangement of the temporomandibular joint (TMJ) and the choice of treatment are debated, arthroscopy seems generally accepted as a minimally invasive alternative. The objective of this study was to investigate various factors and their possible correlation with an unsuccessful outcome of arthroscopic lysis and lavage in patients diagnosed with chronic closed lock, arthralgia with or without concomitant osteoarthritis of the TMJ, or systemic rheumatologic disease with involvement of the TMJ...
April 13, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28485718/transcriptional-profile-of-hippocampal-dentate-granule-cells-in-four-rat-epilepsy-models
#9
Raymond Dingledine, Douglas A Coulter, Brita Fritsch, Jan A Gorter, Nadia Lelutiu, James McNamara, J Victor Nadler, Asla Pitkänen, Michael A Rogawski, Pate Skene, Robert S Sloviter, Yu Wang, Wytse J Wadman, Claude Wasterlain, Avtar Roopra
Global expression profiling of neurologic or psychiatric disorders has been confounded by variability among laboratories, animal models, tissues sampled, and experimental platforms, with the result being that few genes demonstrate consistent expression changes. We attempted to minimize these confounds by pooling dentate granule cell transcriptional profiles from 164 rats in seven laboratories, using three status epilepticus (SE) epilepsy models (pilocarpine, kainate, self-sustained SE), plus amygdala kindling...
May 9, 2017: Scientific Data
https://www.readbyqxmd.com/read/28474374/mobile-phone-messaging-for-illicit-drug-and-alcohol-dependence-a-systematic-review-of-the-literature
#10
Babak Tofighi, Joseph M Nicholson, Jennifer McNeely, Frederick Muench, Joshua D Lee
ISSUES: Mobile phone use has increased dramatically and concurrent with rapid developments in mobile phone-based health interventions. The integration of text messaging interventions promises to optimise the delivery of care for persons with substance dependence with minimal disruption to clinical workflows. We conducted a systematic review to assess the acceptability, feasibility and clinical impact of text messaging interventions for persons with illicit drug and alcohol dependence...
May 5, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28468556/suicidality-in-autistic-spectrum-disorders
#11
Sofia Zahid, Rachel Upthegrove
BACKGROUND: It is suggested that people with autistic spectrum disorders (ASD) may be at increased risk of suicide; however, research on this topic has been minimal and there are conflicting reports in existing studies. AIM: To bring together research investigating the prevalence, risk factors, and comorbid factors of suicidality in ASD. METHOD: A systematic search was performed of Medline, Psych Info, Embase, and the Web of Science following PRISMA guidelines...
May 3, 2017: Crisis
https://www.readbyqxmd.com/read/28464751/minimally-important-change-measurement-error-and-responsiveness-for-the-self-reported-foot-and-ankle-score
#12
Maria C Cöster, Anna Nilsdotter, Lars Brudin, Ann Bremander
Background and purpose - Patient-reported outcome measures (PROMs) are increasingly used to evaluate results in orthopedic surgery. To enhance good responsiveness with a PROM, the minimally important change (MIC) should be established. MIC reflects the smallest measured change in score that is perceived as being relevant by the patients. We assessed MIC for the Self-reported Foot and Ankle Score (SEFAS) used in Swedish national registries. Patients and methods - Patients with forefoot disorders (n = 83) or hindfoot/ankle disorders (n = 80) completed the SEFAS before surgery and 6 months after surgery...
June 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28438464/association-of-medial-prefrontal-cortex-connectivity-with-consciousness-level-and-its-outcome-in-patients-with-acquired-brain-injury
#13
Xiaoyan Liu, Jingqi Li, Jian Gao, Zhen Zhou, Fanxia Meng, Gang Pan, Benyan Luo
Medial prefrontal cortex (mPFC) is usually known for participating in virtually all self related processing. However, few have investigated the role of mPFC in modulating conscious awareness. This study aimed to depict the relationship between the mPFC connectivity and the severity and outcome of the disorders of consciousness (DOC) among patients with acquired brain injury. Thirty-four patients with DOC (17 in a minimally conscious state and 17 in an unresponsive wakefulness syndrome/vegetative state) and 11 healthy controls were recruited, underwent clinical assessment and resting-state functional MRI scan, and were further followed up to evaluate recovery outcome using the Glasgow Outcome Scale...
April 21, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28436583/physical-activity-and-exercise-for-chronic-pain-in-adults-an-overview-of-cochrane-reviews
#14
REVIEW
Louise J Geneen, R Andrew Moore, Clare Clarke, Denis Martin, Lesley A Colvin, Blair H Smith
BACKGROUND: Chronic pain is defined as pain lasting beyond normal tissue healing time, generally taken to be 12 weeks. It contributes to disability, anxiety, depression, sleep disturbances, poor quality of life, and healthcare costs. Chronic pain has a weighted mean prevalence in adults of 20%.For many years, the treatment choice for chronic pain included recommendations for rest and inactivity. However, exercise may have specific benefits in reducing the severity of chronic pain, as well as more general benefits associated with improved overall physical and mental health, and physical functioning...
April 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28433195/predicting-successful-dental-examinations-for-children-with-autism-spectrum-disorder-in-the-context-of-a-dental-desensitization-program
#15
Travis Nelson, Amelia Chim, Barbara L Sheller, Christy M McKinney, JoAnna M Scott
BACKGROUND: The authors evaluated the effectiveness of a dental desensitization program for children with autism spectrum disorder (ASD) and determined characteristics associated with a successful dental examination. METHODS: The authors performed a retrospective review of clinical behavioral data and previsit questionnaires for 168 children with ASD who attended a university-based dental desensitization program. Data elements included demographic, treatment, and behavioral characteristics...
April 19, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28433091/internet-delivered-parenting-program-for-prevention-and-early-intervention-of-anxiety-problems-in-young-children-randomized-controlled-trial
#16
Amy J Morgan, Ronald M Rapee, Agus Salim, Nahal Goharpey, Elli Tamir, Lauren F McLellan, Jordana K Bayer
OBJECTIVE: The Cool Little Kids parenting group program is an effective intervention for preventing anxiety disorders in young children who are at risk because of inhibited temperament. The program has six group sessions delivered by trained psychologists to parents of 3- to 6-year-old children. An online adaptation (Cool Little Kids Online) has been developed to overcome barriers to its wide dissemination in the community. This study tested the efficacy of Cool Little Kids Online in a randomized controlled trial...
May 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28421749/design-of-multifunctional-nanogate-in-response-to-multiple-external-stimuli-using-amphiphilic-diblock-copolymer
#17
Kai Huang, Igal Szleifer
Nature uses the interplay between hydrophobic and electrostatic interactions of disordered proteins to orchestrate complicated molecular gates such as the nuclear pore complex to control the transport of biological masses. Inspired by nature, we here theoretically show that well-defined gate shape, sensitive response to pH and salt concentration, and selectivity in cargo transport can be simultaneously achieved by grafting amphiphilic diblock copolymers made of sequence-controlled hydrophobic and ionizable monomers on the inner surface of solid-state nanopore...
April 28, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28394020/-we-will-never-be-normal-the-experience-of-discovering-a-partner-has-autism-spectrum-disorder
#18
Laura F Lewis
Online forums and lay literature suggest that partners of individuals with Autism Spectrum Disorder (ASD) experience depression, distress, and trauma in their everyday lives, exacerbated during the time surrounding diagnosis. In this content analysis, 29 participants were provided with an online open-ended statement asking them to describe in writing their experiences of discovering that their partners had ASD during their relationships. Six themes emerged, including: facing unique challenges within relationships; insisting partners seek diagnosis; initial shock and relief; losing hope for normalcy; making accommodations within relationships; and wishing for professional support...
April 10, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28376829/preserved-gait-kinematics-during-controlled-body-unloading
#19
L Awai, M Franz, C S Easthope, H Vallery, A Curt, M Bolliger
BACKGROUND: Body weight supported locomotor training was shown to improve walking function in neurological patients and is often performed on a treadmill. However, walking on a treadmill does not mimic natural walking for several reasons: absent self-initiation, less active retraction of leg required and altered afferent input. The superiority of overground training has been suggested in humans and was shown in rats demonstrating greater plasticity especially in descending pathways compared to treadmill training...
April 4, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28356744/the-influence-of-depression-level-of-functioning-in-everyday-life-and-illness-acceptance-on-quality-of-life-in-patients-with-parkinson-s-disease-a-preliminary-study
#20
Joanna Rosińczuk, Aleksandra Kołtuniuk
BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, and its incidence will increase as the global population ages. Due to the multitude of symptoms, this disease clearly has a significant impact on decreasing quality of life for those with PD. We aimed to evaluate the effect of selected variables on quality of life in people with idiopathic PD treated pharmacologically. MATERIALS AND METHODS: This study was conducted among 50 patients with PD aged 47-85 years...
2017: Neuropsychiatric Disease and Treatment
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