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https://www.readbyqxmd.com/read/27922448/the-second-randomised-evaluation-of-the-effectiveness-cost-effectiveness-and-acceptability-of-computerised-therapy-reeact-2-trial-does-the-provision-of-telephone-support-enhance-the-effectiveness-of-computer-delivered-cognitive-behaviour-therapy-a-randomised
#1
Sally Brabyn, Ricardo Araya, Michael Barkham, Peter Bower, Cindy Cooper, Ana Duarte, David Kessler, Sarah Knowles, Karina Lovell, Elizabeth Littlewood, Richard Mattock, Stephen Palmer, Jodi Pervin, David Richards, Debbie Tallon, David White, Simon Walker, Gillian Worthy, Simon Gilbody
BACKGROUND: Computerised cognitive behaviour therapy (cCBT) is an efficient form of therapy potentially improving access to psychological care. Indirect evidence suggests that the uptake and effectiveness of cCBT can be increased if facilitated by telephone, but this is not routinely offered in the NHS. OBJECTIVES: To compare the clinical effectiveness and cost-effectiveness of telephone-facilitated free-to-use cCBT [e.g. MoodGYM (National Institute for Mental Health Research, Australian National University, Canberra, ACT, Australia)] with minimally supported cCBT...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27916278/2016-revisions-to-the-2010-2011-fibromyalgia-diagnostic-criteria
#2
Frederick Wolfe, Daniel J Clauw, Mary-Ann Fitzcharles, Don L Goldenberg, Winfried Häuser, Robert L Katz, Philip J Mease, Anthony S Russell, Irwin Jon Russell, Brian Walitt
OBJECTIVES: The provisional criteria of the American College of Rheumatology (ACR) 2010 and the 2011 self-report modification for survey and clinical research are widely used for fibromyalgia diagnosis. To determine the validity, usefulness, potential problems, and modifications required for the criteria, we assessed multiple research reports published in 2010-2016 in order to provide a 2016 update to the criteria. METHODS: We reviewed 14 validation studies that compared 2010/2011 criteria with ACR 1990 classification and clinical criteria, as well as epidemiology, clinical, and databank studies that addressed important criteria-level variables...
August 30, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27902745/utility-of-the-health-of-the-nation-outcome-scales-honos-in-predicting-mental-health-service-costs-for-patients-with-common-mental-health-problems-historical-cohort-study
#3
Conal Twomey, A Matthew Prina, David S Baldwin, Jayati Das-Munshi, David Kingdon, Leonardo Koeser, Martin J Prince, Robert Stewart, Alex D Tulloch, Alarcos Cieza
BACKGROUND: Few countries have made much progress in implementing transparent and efficient systems for the allocation of mental health care resources. In England there are ongoing efforts by the National Health Service (NHS) to develop mental health 'payment by results' (PbR). The system depends on the ability of patient 'clusters' derived from the Health of the Nation Outcome Scales (HoNOS) to predict costs. We therefore investigated the associations of individual HoNOS items and the Total HoNOS score at baseline with mental health service costs at one year follow-up...
2016: PloS One
https://www.readbyqxmd.com/read/27891430/study-of-barrier-to-help-seeking-and-its-relationships-with-disability-in-patients-with-headache
#4
Deepa John, Dushad Ram, Harsha Sundarmurthy, Harshal Rathod, Snehal Rathod
INTRODUCTION: Headache is among the first three most prevalent disorders with a wide treatment gap due to barriers in help seeking. Headache has been associated with disability. However, the relationship of barriers to help-seeking and disability are unexplored. AIM: To find out the barriers to help seeking and its relationship with headache related disability in patients with headache. MATERIALS AND METHODS: In this hospital based cross-sectional study, 200 consecutive subjects with headache attending a tertiary care centre were recruited as per selection criteria and assessed with Sociodemographic & Clinical Proforma, Mini International Neuropsychiatric Interview (MINI), Barriers to Help Seeking Scale (BHSS), The Henry Ford Hospital Headache Disability Inventory (HDI)...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890783/the-proline-glycine-rich-region-of-the-biofilm-adhesion-protein-aap-forms-an-extended-stalk-that-resists-compaction
#5
Alexander E Yarawsky, Lance R English, Steven T Whitten, Andrew B Herr
Staphylococcus epidermidis is one of the primary bacterial species responsible for healthcare-associated infections. The most significant virulence factor for S. epidermidis is its ability to form a biofilm, which renders the bacteria highly resistant to host immune responses and antibiotic action. Intercellular adhesion within the biofilm is mediated by the accumulation-associated protein (Aap), a cell wall-anchored protein that self-assembles in a zinc-dependent manner. The C-terminal portion of Aap contains a proline/glycine-rich, 135 amino acid-long region that has not yet been characterized...
November 24, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27875416/comparison-of-structural-disease-burden-to-health-related-quality-of-life-scores-in-264-adult-spinal-deformity-patients-with-2-year-follow-up-novel-insights-into-drivers-of-disability
#6
Joshua Bakhsheshian, Justin K Scheer, Jeffrey L Gum, Lance Horner, Richard Hostin, Virginie Lafage, Shay Bess, Themistocles S Protopsaltis, Douglas C Burton, Malla Keefe, Robert A Hart, Gregory M Mundis, Christopher I Shaffrey, Frank Schwab, Justin S Smith, Christopher P Ames
STUDY DESIGN: This is a review of a prospective multicenter database. OBJECTIVE: To investigate the relationship between preoperative disability and sagittal deformity in patients with high Oswestry Disability Index (ODI) and no sagittal malalignment, or low ODI and high sagittal malalignment. SUMMARY OF BACKGROUND DATA: The relationship between ODI and sagittal malalignment varies between each adult spinal deformity (ASD) patient. METHODS: A prospective multicenter database of 365 patients with ASD undergoing surgical reconstruction was analyzed...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27863322/sleep-patterns-and-problems-among-early-adolescents-associations-with-alcohol-use
#7
Naomi R Marmorstein
INTRODUCTION: Sleep and sleep-related problems are associated with alcohol use and related problems among adults. However, existing research on associations between sleep and alcohol use among early adolescents is minimal, and potential individual and family factors that may affect this association remain largely unexplored. We examined potential associations between frequency of alcohol use and initial insomnia, subjective daytime sleepiness, sleep irregularity, and disturbed sleep among a low-income, ethnic minority sample of early adolescents; we also considered whether psychopathology symptoms and/or parental monitoring accounted for any associations found...
November 3, 2016: Addictive Behaviors
https://www.readbyqxmd.com/read/27837101/phase-ii-randomised-controlled-trial-of-a-6-month-self-managed-community-exercise-programme-for-people-with-parkinson-s-disease
#8
Johnny Collett, Marloes Franssen, Andy Meaney, Derick Wade, Hooshang Izadi, Martin Tims, Charlotte Winward, Marko Bogdanovic, Andrew Farmer, Helen Dawes
BACKGROUND: Evidence for longer term exercise delivery for people with Parkinson's disease (PwP) is deficient. AIM: Evaluate safety and adherence to a minimally supported community exercise intervention and estimate effect sizes (ES). METHODS: 2-arm parallel phase II randomised controlled trial with blind assessment. PwP able to walk ≥100 m and with no contraindication to exercise were recruited from the Thames valley, UK, and randomised (1:1) to intervention (exercise) or control (handwriting) groups, via a concealed computer-generated list...
November 11, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27836391/diagnosing-and-treating-depression-in-epilepsy
#9
Christian E Elger, Samantha A Johnston, Christian Hoppe
At least one third of patients with active epilepsy suffer from significant impairment of their emotional well-being. A targeted examination for possible depression (irrespective of any social, financial or personal burdens) can identify patients who may benefit from medical attention and therapeutic support. Reliable screening instruments such as the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) are suitable for the timely identification of patients needing help. Neurologists should be capable of managing mild to moderate comorbid depression but referral to mental health specialists is mandatory in severe and difficult-to-treat depression, or if the patient is acutely suicidal...
October 31, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27816046/is-the-deliberate-self-induction-of-alcohol-tolerance-associated-with-negative-alcohol-outcomes
#10
REVIEW
Angela M Haeny, Cameron C Weaver, Julia A Martinez, Douglas Steinley, Kenneth J Sher
Research indicates 10% of college student drinkers report deliberately training to increase alcohol tolerance (a diagnostic criterion for alcohol use disorder) to avoid passing out early or to keep up with peers. Given that tolerance training may be considered a harm reduction technique designed to reduce acute aversive consequences, we examined the associations between tolerance training and the use of protective behavioral strategies (PBS) more generally. A cross-sectional survey of 1080 lifetime drinkers was conducted at a large Midwestern university...
February 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/27797546/uncontrolled-pilot-study-of-an-acceptance-and-commitment-therapy-and-health-at-every-size-intervention-for-obese-depressed-women-accept-yourself
#11
Margit I Berman, Stephanie N Morton, Mark T Hegel
Depression and obesity frequently co-occur, but providing adequate treatment to depressed obese women is challenging because existing treatments for each problem in isolation are suboptimal, and treatments to address one problem may exacerbate the other. This study used an uncontrolled, pretreatment-to-posttreatment design, with 3-month follow-up, to evaluate the feasibility and outcome of a novel, self-acceptance-based treatment for obese women with depression, "Accept Yourself!" Accept Yourself! is an 11-week manualized, group-based intervention that integrates Health At Every Size (an evidence-based paradigm to enhance physical health) and Acceptance and Commitment Therapy (an evidence-based psychotherapy often used to treat depression and eating-related concerns) to improve the physical and mental health of obese, depressed women without encouraging weight loss...
December 2016: Psychotherapy
https://www.readbyqxmd.com/read/27795986/reluctance-to-accept-alcohol-treatment-by-alcoholic-liver-disease-transplant-patients-a-qualitative-study
#12
Cathy M Heyes, Toni Schofield, Robert Gribble, Carolyn A Day, Paul S Haber
BACKGROUND: Liver transplantation (LT) is the optimum treatment for patients with end-stage alcoholic liver disease (ALD). However, despite a recognized risk of relapse to harmful drinking, ALD transplant patients are reluctant to use speciality alcohol treatment to support their abstinence, even when offered within the LT context. This study aimed to understand and identify factors contributing to alcohol treatment reluctance by ALD patients undergoing transplantation. METHODS: We conducted an in-depth qualitative study of ALD transplant patients...
October 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27761610/avoiding-psychological-pitfalls-in-aesthetic-medical-procedures
#13
Qiuyu Wang, Chuan Cao, Rui Guo, Xiaoge Li, Lele Lu, Wenping Wang, Shirong Li
OBJECTIVE: To assess the prevalence of body dysmorphic disorder (BDD) in an aesthetic surgery setting in the region of Southwest China, and to ascertain the differences in terms of body images between patients in the aesthetic setting and general Chinese population. This study tracked patient satisfaction with their body image changes while undergoing aesthetic medical procedures to identify whether the condition of patients who were presenting with BDD symptoms or their psychological symptoms could be improved by enhancing their appearance...
December 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/27746700/effects-of-maternal-symptom-ratings-and-other-clinical-features-on-short-term-treatment-response-to-oros-methylphenidate-in-children-and-adolescents-with-adhd-in-a-naturalistic-clinical-setting
#14
Esra Cop Tasgin, Ozgur Oner, Pinar Yurtbasi, Kerim Munir
OBJECTIVE: To investigate the effect of Attention Deficit Hyperactivity Disorder (ADHD), antisocial behavior and anxiety/depression ratings of mothers, and child and adolescents' age, gender, ADHD subtype, and comorbidity on one-month drug treatment response to OROS methylphenidate in ADHD in a naturalistic setting. METHODS: The analyses included 223 subjects (191 boys, 32 girls; age 6-15 years, mean: 9.4) treated with OROS methylphenidate (18-72 mg/day, mean: 31 mg/d; 0...
2016: Bulletin of Clinical Psychopharmacology [Klinik Psikofarmakoloji Bülteni]
https://www.readbyqxmd.com/read/27739813/looping-probability-of-random-heteropolymers-helps-to-understand-the-scaling-properties-of-biopolymers
#15
Y Zhan, L Giorgetti, G Tiana
Random heteropolymers are a minimal description of biopolymers and can provide a theoretical framework to the investigate the formation of loops in biophysical experiments. The looping probability as a function of polymer length was observed to display in some biopolymers, like chromosomes in cell nuclei or long RNA chains, anomalous scaling exponents. Combining a two-state model with self-adjusting simulated-tempering calculations, we calculate numerically the looping properties of several realizations of the random interactions within the chain...
September 2016: Physical Review. E
https://www.readbyqxmd.com/read/27723506/self-organizing-visualization-and-pattern-matching-of-vectorcardiographic-qrs-waveforms
#16
Hui Yang, Fabio Leonelli
QRS morphology is commonly used in the electrocardiographic diagnosis of ventricular depolarization such as left bundle branch block (LBBB) and ventricular septal infarction. We investigated whether pattern matching of QRS loops in the 3-dimensional vectorcardiogram (VCG) will improve the grouping of patients whose space-time electrical activity akin to each other, thereby assisting in clinical decision making. First, pattern dissimilarity of VCG QRS loops is qualitatively measured and characterized among patients, resulting in a 93×93 distance matrix of patient-to-patient dissimilarity...
September 28, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27719514/lifetime-alcohol-use-and-cognitive-performance-in-older-adults
#17
Raj K Kalapatapu, Maria I Ventura, Deborah E Barnes
Substance use is an important clinical issue in the older adult population. As older adults are susceptible to cognitive disorders, the intersection of the fields of substance use and cognitive neuroscience is an active area of research. Prior studies of alcohol use and cognitive performance are mixed, and inconsistencies may be due to under- or over-adjustment for confounders. This article adds to this literature by conducting a secondary analysis of self-reported lifetime history of alcohol use and cognitive performance in older adults (n = 133)...
October 8, 2016: Journal of Addictive Diseases
https://www.readbyqxmd.com/read/27690405/defining-a-physical-basis-for-diversity-in-protein-self-assemblies-using-a-minimal-model
#18
Srivastav Ranganathan, Samir K Maji, Ranjith Padinhateeri
Self-assembly of proteins into ordered, fibrillar structures is a commonly observed theme in biology. It has been observed that diverse set of proteins (e.g alpha-synuclein, insulin, TATA-box binding protein, Sup35, p53), independent of their sequence, native structure, or function could self-assemble into highly ordered structures known as amyloids. What are the crucial features underlying amyloidogenesis that make it so generic? Using coarse-grained simulations of peptide self-assembly, we argue that variation in two physical parameters- bending-stiffness of the polypeptide and strength of inter-molecular interactions- can give rise to many of the structural features typically associated with amyloid self-assembly...
October 3, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27683695/independent-predictors-of-reliability-between-full-time-employee-dependent-acquisition-of-functional-outcomes-compared-to-non-full-time-employee-dependent-methodologies-a-prospective-single-institutional-study
#19
Owoicho Adogwa, Aladine A Elsamadicy, Joseph Cheng, Carlos Bagley
BACKGROUND: The prospective acquisition of reliable patient-reported outcomes (PROs) measures demonstrating the effectiveness of spine surgery, or lack thereof, remains a challenge. The aims of this study are to compare the reliability of functional outcomes metrics obtained using full time employee (FTE) vs. non-FTE-dependent methodologies and to determine the independent predictors of response reliability using non FTE-dependent methodologies. METHODS: One hundred and nineteen adult patients (male: 65, female: 54) undergoing one- and two-level lumbar fusions at Duke University Medical Center were enrolled in this prospective study...
March 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/27670598/cultural-adaptation-of-minimally-guided-interventions-for-common-mental-disorders-a-systematic-review-and-meta-analysis
#20
Melissa Harper Shehadeh, Eva Heim, Neerja Chowdhary, Andreas Maercker, Emiliano Albanese
BACKGROUND: Cultural adaptation of mental health care interventions is key, particularly when there is little or no therapist interaction. There is little published information on the methods of adaptation of bibliotherapy and e-mental health interventions. OBJECTIVE: To systematically search for evidence of the effectiveness of minimally guided interventions for the treatment of common mental disorders among culturally diverse people with common mental disorders; to analyze the extent and effects of cultural adaptation of minimally guided interventions for the treatment of common mental disorders...
2016: JMIR Mental Health
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