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Mammary gland

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https://www.readbyqxmd.com/read/29142456/secretory-carcinoma-impact-of-translocation-and-gene-fusions-on-salivary-gland-tumor
#1
Ryoko Inaki, Masanobu Abe, Liang Zong, Takahiro Abe, Aya Shinozaki-Ushiku, Tetsuo Ushiku, Kazuto Hoshi
Secretory carcinoma (SC), previously described as mammary analogue secretory carcinoma (MASC), is a recently described salivary gland tumor which morphologically resembles mammary secretory carcinoma. The first description of SC/MASC, reported by Skálová et al. in 2010, was as a rare salivary carcinoma imitating secretory carcinoma of the breast. SC/MASC is a unique salivary gland tumor with morphological overlap with acinic cell carcinoma (AciCC), mucoepidermoid carcinoma (MEC), and adenocarcinoma not otherwise specified (ADC-NOS)...
October 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29139009/lfm-a13-a-potent-inhibitor-of-polo-like-kinase-inhibits-breast-carcinogenesis-by-suppressing-proliferation-activity-and-inducing-apoptosis-in-breast-tumors-of-mice
#2
Kazim Sahin, Mehmet Tuzcu, Mehmet Yabas, Cemal Orhan, Nurhan Sahin, Ibrahim H Ozercan
The goals of the present study were to define the anticancer activity of LFM-A13 (α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)-propenamide), a potent inhibitor of Polo-like kinase (PLK), in a mouse mammary cancer model induced by 7,12-dimethylbenz(a)anthracene (DMBA) in vivo and explore its anticancer mechanism(s). We also examined whether the inhibition of PLK by LFM-A13 would improve the efficiency of paclitaxel in breast cancer growth in vivo. To do this, female BALB/c mice received 1 mg of DMBA once a week for 6 weeks with oral gavage...
November 15, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29137220/stromal-cyclin-d1-promotes-heterotypic-immune-signaling-and-breast-cancer-growth
#3
Timothy G Pestell, Xuanmao Jiao, Mukesh Kumar, Amy R Peck, Marco Prisco, Shengqiong Deng, Zhiping Li, Adam Ertel, Mathew C Casimiro, Xiaoming Ju, Agnese Di Rocco, Gabriele Di Sante, Sanjay Katiyar, Alison Shupp, Michael P Lisanti, Pooja Jain, Kongming Wu, Hallgeir Rui, Douglas C Hooper, Zuoren Yu, Aaron R Goldman, David W Speicher, Lisa Laury-Kleintop, Richard G Pestell
The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that drives cell autonomous cell cycle progression and proliferation. Herein we show cyclin D1 abundance is increased >30-fold in the stromal fibroblasts of patients with invasive breast cancer, associated with poor outcome. Cyclin D1 transformed hTERT human fibroblast to a cancer-associated fibroblast phenotype. Stromal fibroblast expression of cyclin D1 (cyclin D1(Stroma)) in vivo, enhanced breast epithelial cancer tumor growth, restrained apoptosis, and increased autophagy...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136922/immunosensing-system-for-rapid-multiplex-detection-of-mastitis-causing-pathogens-in-milk
#4
Delia Juronen, Ave Kuusk, Kairi Kivirand, Ago Rinken, Toonika Rinken
Mastitis, an inflammation of the mammary gland and udder tissue, is the major endemic disease of dairy cattle. In addition to causing health problems to the animals, mastitis leads to the reduction of milk production and quality, representing a significant economic burden for farmers. To enable timely treatment of infected animals with pathogen-specific antibiotics, the development of automated analytical methods for rapid on-site identification and quantification of mastitis-causing pathogens in milk is particularly important...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29134942/intramammary-infusion-of-a-live-culture-of-lactococcus-lactis-in-ewes-to-treat-staphylococcal-mastitis
#5
Sebastian Alessandro Mignacca, Simone Dore, Liliana Spuria, Pietro Zanghì, Benedetta Amato, Ilaria Duprè, Federica Armas, Elena Biasibetti, Cristina Camperio, Stefano A Lollai, Maria Teresa Capucchio, Eugenia Agnese Cannas, Vincenzo Di Marco Lo Presti, Cinzia Marianelli
PURPOSE: Alternatives to antibiotic therapy for mastitis in ruminants are needed. We present an evaluation, in two trials, of the efficacy of an intramammary infusion of a live culture of Lactococcus lactis for the treatment of subclinical and clinical mastitis in ewes. METHODOLOGY: In total, 67 animals were enrolled: 19 lactating ewes (study 1), including healthy (N=6) and coagulase-negative staphylococci (CNS)-infected ewes (N=13); and 48 lactating ewes (study 2) with either CNS mastitis (N=32), or Staphylococcus aureus mastitis (N=16), for a total of 123 mammary glands...
November 14, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29134542/influence-of-the-menstrual-cycle-on-compression-induced-pain-during-mammography-correlation-with-the-thickness-and-volume-of-the-mammary-gland
#6
Hitomi Kitaoka, Hiroko Kawashima
In mammography, breast compression is necessary and an important factor influencing image quality. The purpose of this study was to determine the influence of the menstrual cycle on compression-induced pain during mammography and to evaluate the association between the thickness and volume of the mammary gland and pain. We examined basal body temperature and categorized the menstrual cycle into five phases. We executed breast compression in the craniocaudal view using a customized compression plate, to which we introduced an opening...
November 13, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29130403/urinary-iodine-perchlorate-and-thiocyanate-concentrations-in-u-s-lactating-women
#7
Sun Y Lee, Alicia M McCarthy, Hindi E Stohl, Sherrine A Ibrahim, Christina Jeong, Lewis E Braverman, Wendy Siqian Ma, Xuemei He, Jorge H Mestman, Kristin E Schuller, Katherine A Jahreis, Elizabeth N Pearce, Angela M Leung
BACKGROUND: Iodine is an essential micronutrient for thyroid hormone production. Adequate iodine intake and normal thyroid function are important during early development, and breastfed infants rely on maternal iodine excreted in breast milk for their iodine nutrition. The proportion of U.S. women of childbearing age with urinary iodine concentration (UIC) <50µg/L has been increasing, and a subset of lactating women may have inadequate iodine intake. UIC may also be influenced by environmental exposure to perchlorate and thiocyanate, competitive inhibitors of iodine transport into thyroid and lactating mammary glands...
November 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29128804/hexachlorobenzene-as-a-persistent-organic-pollutant-toxicity-and-molecular-mechanism-of-action
#8
REVIEW
Beata Starek-Świechowicz, Bogusława Budziszewska, Andrzej Starek
Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the environment. Chronic exposure of humans to HCB leads to a number of effects, such as triggering of porphyria, microsomal enzyme induction, thyroid dysfunctions, neurological symptoms, and immunological disorders. In animals, HCB induced hepatic porphyria, neurotoxic effects, and toxic effects on the thyroid function, reproductive system, and immune system. HCB as a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR) is a hormonal disruptor...
July 1, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29128221/short-communication-genetic-association-of-variations-in-the-osteopontin-gene-spp1-with-lactation-persistency-in-dairy-cattle
#9
Nathalie Bissonnette
Improving lactation persistency (LP) in dairy cattle has a beneficial effect on animal health and fertility and herd productivity. A complex trait, LP not only reflects the cow's ability to maintain milk secretion activity after the lactation peak but is also a function of the postcalving development of the mammary gland and, later on, of tissue remodeling as lactation declines. This decline is a consequence of an imbalance between cell proliferation and cell removal. In a previous study, single nucleotide polymorphisms were identified in the osteopontin (OPN) gene, SPP1...
November 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29123193/characterization-of-mammary-specific-disruptions-for-tph1-and-lrp5-during-murine-lactation
#10
Samantha R Weaver, Nicholas J Jury, Karen A Gregerson, Nelson D Horseman, Laura L Hernandez
Serotonin is a homeostatic regulator of the mammary gland during lactation. The contribution of mammary-derived serotonin to circulating serum serotonin concentrations was previously unknown. We have developed mice with mammary-specific disruptions of tryptophan hydroxylase 1 (Tph1) or low-density lipoprotein receptor-related protein 5 (Lrp5) that are induced during late pregnancy and lactation via use of the whey acidic protein (WAP)-Cre cre-lox system. Our objective was to characterize dams with a lactation- and mammary-specific disruption of Lrp5 (WAP-Cre × Lrp5 (FL/FL)) or Tph1 (WAP-Cre × Tph1 (FL/FL))...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122055/extruded-linseed-alone-or-in-combination-with-fish-oil-modifies-mammary-gene-expression-profiles-in-lactating-goats
#11
Y Faulconnier, L Bernard, C Boby, J Domagalski, Y Chilliard, C Leroux
Nutrition is a major factor that regulates ruminant milk components, particularly its fatty acid (FA) composition, which is an important determinant of milk nutritional quality. In the mammary gland, milk component biosynthesis involves a large number of genes under nutritional regulation that are not well understood. Thus, the objective of the present study was to evaluate the effects of extruded linseeds (EL) alone or in combination with fish oil (ELFO) on goat mammary gene expression. In total, 14 goats were fed one of the following three diets: a natural grassland hay basal diet (CTRL) alone, CTRL supplemented with 530 g/day of EL, or 340 g/day of EL plus 39 g/day of fish oil (ELFO)...
November 10, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29122042/peroxisome-proliferator-activated-receptor-gamma-ppar%C3%AE-agonist-fails-to-overcome-trans-10-cis-12-conjugated-linoleic-acid-cla-inhibition-of-milk-fat-in-dairy-sheep
#12
E C Sandri, M Camêra, E M Sandri, K J Harvatine, D E De Oliveira
The trans-10, cis-12 conjugated linoleic acid (CLA) causes milk fat depression by downregulating expression of genes and transcription factors involved in lipogenesis and it has been proposed that peroxisome proliferator-activated receptor gamma (PPARγ) can be inhibited by trans-10, cis-12 CLA. The PPARγ is a nuclear receptor activated by natural or synthetic ligands and promotes expression of lipogenic genes and its effect on mammary lipogenesis and the interaction with trans-10, cis-12 CLA in lactating ewes was evaluated using thiazolidinedione (TZD), a chemical PPARγ agonist...
November 10, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29119572/use-of-skin-stretchers-for-single-stage-bilateral-mastectomies-in-a-dog-and-a-cat
#13
Yuta Miyazaki, Takeshi Aikawa, Taichi Shimatsu, Masaaki Nishimura, Shigeo Sadahiro
OBJECTIVE: To describe the application of skin stretchers for closure of single-stage bilateral mastectomies in a dog and a cat. STUDY DESIGN: Clinical case report. ANIMALS: A 12-year-old intact female Miniature Dachshund and a 13-year-old spayed female domestic short-hair cat. METHODS: Skin stretchers were applied to the site of the skin adjacent to mammary glands for 2-4 days before surgery. Cable tension was adjusted every 6-8 hours to elongate the skin and to achieve primary closure of single-stage bilateral mastectomy without tension...
November 9, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29119128/whole-mammary-gland-transplantation-in-mice-protocol
#14
Hayley Hansford, Yan Hong, Frances Kittrell, Daniel Medina, Fariba Behbod
Whole Mammary Gland Transplantation involves transplanting an excised mammary gland into another, more suitable host. This method can be used to extend the life of a mammary gland past the mouse's life span by transplanting the mammary gland of an older mouse into a young healthy mouse. As you can see in the video below (Video 1), by attaching it to the abdomen of the mouse, the gland will receive a steady blood supply and both epithelial and stromal cells will remain viable for up to one year. Although this method is not used often, it has been part of several experiments including determining whether the stroma or epithelium is the primary target in chemically induced mouse mammary tumorigenesis (Medina and Kittrell, 2005)...
June 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29117179/a-mutation-in-the-viral-sensor-2-5-oligoadenylate-synthetase-2-causes-failure-of-lactation
#15
Samantha R Oakes, David Gallego-Ortega, Prudence M Stanford, Simon Junankar, Wendy Wing Yee Au, Zoya Kikhtyak, Anita von Korff, Claudio M Sergio, Andrew M K Law, Lesley E Castillo, Stephanie L Allerdice, Adelaide I J Young, Catherine Piggin, Belinda Whittle, Edward Bertram, Matthew J Naylor, Daniel L Roden, Jesse Donovan, Alexei Korennykh, Christopher C Goodnow, Moira K O'Bryan, Christopher J Ormandy
We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in healthy mice with otherwise normally developed mammary glands, characterized by greatly reduced milk protein synthesis coupled with epithelial cell death, inhibition of proliferation and a robust interferon response. Expression of mutant but not wild type Oas2 in cultured HC-11 or T47D mammary cells recapitulated the phenotypic and transcriptional effects observed in the mouse...
November 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29115671/fatty-acid-elongase-7-is-regulated-via-sp1-and-is-involved-in-lipid-accumulation-in-bovine-mammary-epithelial-cells
#16
Si Chen, Zhigang Hu, Hua He, Xiaolin Liu
Fatty Acid Elongase 7 (ELOVL7) is the newly discovered protein on human that catalyzes the rate-limiting step towards the synthesis of very long-chain fatty acids and exhibits the highest activity toward C18:3 (n-3) acyl-CoAs, which is the precursor of eicosapentaenoic acid (EPA, 20:5n-3). However, in ruminants, an overall understanding of ELOVLs gene family and the transcriptional regulation of ELOVL7 remain unknown. The purpose of this study is to investigate the transcriptional regulation and the influence of bovine ELOVL7 in bovine mammary epithelial cells (bMECs)...
November 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29115583/unfavorable-effect-of-calcitriol-and-its-low-calcemic-analogs-on-metastasis-of-4t1-mouse-mammary-gland-cancer
#17
Artur Anisiewicz, Agata Pawlik, Beata Filip-Psurska, Eliza Turlej, Stanisław Dzimira, Magdalena Milczarek, Katarzyna Gdesz, Diana Papiernik, Joanna Jarosz, Dagmara Kłopotowska, Andrzej Kutner, Andrzej Mazur, Joanna Wietrzyk
Low vitamin D status is considered as a risk factor for breast cancer and has prognostic significance. Furthermore, vitamin D deficiency increases after adjuvant cancer therapy, which alters bone metabolism increasing the risk of osteoporosis. It is now postulated that vitamin D supplementation in breast cancer treatment delays the recurrence of cancer thereby extending survival. We evaluated the impact of calcitriol and its low-calcemic analogs, PRI‑2191 and PRI‑2205, on the tumor growth, angiogenesis, and metastasis of 4T1 mouse mammary gland cancer...
November 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29114036/zinc-transporter-2-interacts-with-vacuolar-atpase-and-is-required-for-polarization-vesicle-acidification-and-secretion-in-mammary-epithelial-cells
#18
Sooyeon Lee, Olivia C Rivera, Shannon L Kelleher
An important feature of the mammary gland is its ability to undergo profound morphological, physiological, and intracellular changes to establish and maintain secretory function. During this process, key polarity proteins and receptors are recruited to the surface of mammary epithelial cells (MECs), and the vesicle transport system develops and matures. However, the intracellular mechanisms responsible for the development of secretory function in these cells are unclear. The vesicular zinc (Zn) transporter ZnT2 is critical for appropriate mammary gland architecture, and ZnT2 deletion is associated with cytoplasmic Zn accumulation, loss of secretory function and lactation failure...
November 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29113806/cynatratoside-c-from-cynanchum-atratum-displays-anti-inflammatory-effect-via-suppressing-tlr4-mediated-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways-in-lps-induced-mastitis-in-mice
#19
Ge Hu, Dong Hong, Tao Zhang, Huiqin Duan, Panying Wei, Xinxin Guo, Xiang Mu
The present study was conducted to isolate anti-inflammatory compound from Cynanchum atratum and investigate the molecular mechanisms of active compound against lipopolysaccharide (LPS)-induced mastitis in mice. Bioassay-guided fractionations and isolation (via ex vivo tests) of compounds with anti-inflammatory activity were performed on roots of C. atratum yielding a pure bioactive compound: Cynatratoside-C, identified by comparing spectral data (EI-MS, (1)H NMR and (13)C NMR) with literature values. Ex vivo tests showed that Cynatratoside-C inhibited the expression of TLR4 and pro-inflammatory cytokine (TNF-α, IL-6 and IL-1β) production in LPS-stimulated primary mouse mammary epithelial cells...
November 4, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29109696/low-dose-alkylphenol-exposure-promotes-mammary-epithelium-alterations-and-transgenerational-developmental-defects-but-does-not-enhance-tumorigenic-behavior-of-breast-cancer-cells
#20
Clémence Chamard-Jovenin, Charlène Thiebaut, Amand Chesnel, Emmanuel Bresso, Chloé Morel, Malika Smail-Tabbone, Marie-Dominique Devignes, Taha Boukhobza, Hélène Dumond
Fetal and neonatal exposure to long-chain alkylphenols has been suspected to promote breast developmental disorders and consequently to increase breast cancer risk. However, disease predisposition from developmental exposures remains unclear. In this work, human MCF-10A mammary epithelial cells were exposed in vitro to a low dose of a realistic (4-nonylphenol + 4-tert-octylphenol) mixture. Transcriptome and cell-phenotype analyses combined to functional and signaling network modeling indicated that long-chain alkylphenols triggered enhanced proliferation, migration ability, and apoptosis resistance and shed light on the underlying molecular mechanisms which involved the human estrogen receptor alpha 36 (ERα36) variant...
2017: Frontiers in Endocrinology
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