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Propofol elderly

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https://www.readbyqxmd.com/read/27903341/-the-application-of-conscious-sedation-with-a-small-dose-of-dexmedetomidine-and-sufentanil-in-elderly-patients-undergoing-multiple-intestinal-polyps-resection
#1
C M Shi, Y D Zhou, M Xu, X D Wang, L M Meng, X J Liu, X Y Guo
Objective: To explore the effectiveness and feasibility of conscious sedation with a low dose of dexmedetomidine and sufentanil during multiple intestinal polyps resection in elderly patients. Methods: Sixty elderly patients who underwent multiple intestinal polyps resection in Peking University Third Hospital from Janurary to May 2016 were randomly divided into dexmedetomidine group (D group, n=30) and propofol group (P group, n=30). There were 28 males and 32 females with a mean age of (70.4±4.5) years old (range: 65-80 years old)...
November 22, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27903339/-effect-of-goal-directed-haemodynamic-management-on-the-postoperative-outcome-in-elderly-patients-with-fragile-cardiac-function-undergoing-abdominal-surgery
#2
L S Zheng, E W Gu, X H Peng, L Zhang, Y Y Cao
Objective: To investigate the effect of goal-directed haemodynamic management based on stroke volume variation (SVV), cardiac index (CI) and mean arterial blood pressure (MAP) on the postoperative outcome in elderly patients with fragile cardiac function undergoing gastrointestinal surgery. Methods: Ninety patients with fragile cardiac function, aged 65-90 years old, ASAⅡ or Ⅲ, NYHA Ⅱor Ⅲ, scheduled for abdominal surgery were enrolled in this study.The patients were randomly assigned to two groups: Experience anesthesia group (group E, n=45) and goal-directed hemodynamic management group (G group, n=45)...
November 22, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27871553/fascia-iliaca-block-associated-only-with-deep-sedation-in-high-risk-patients-taking-p2y12-receptor-inhibitors-for-intramedullary-femoral-fixation-in-intertrochanteric-hip-fracture-a-series-of-3-cases
#3
Carlos Rodrigues Almeida, Emília Milheiro Francisco, Vítor Pinho-Oliveira, José Pedro Assunção
OBJECTIVE: We present a series of 3 cases in which the impact in outcome was, first of all, related to the capacity to offer early and safer treatment to some hip fracture high-risk patients using a fascia iliaca block (FIB; ropivacaine 0,5% 20 cc and mepivacaine 1,3% 15 cc, given 30 minutes before incision) associated only with deep sedation, contributing to better practice and outcome. CASE REPORTS: All elderly patients were American Society of Anesthesiologists IV patients, under P2Y12 receptor inhibitors, suffering from an intertrochanteric fracture, and purposed for intramedullary femoral fixation (IMF)...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27818803/eminectomy-for-habitual-luxation-of-the-temporomandibular-joint-with-sedation-and-local-anesthesia-a-case-series
#4
Joe Iwanaga, Yoshiaki Nakamura, Jingo Kusukawa, R Shane Tubbs
Eminectomy which is one of the popular and most effective treatments for habitual temporomandibular joint luxation was first described by Myrhaug in 1951. There are few reports which described eminectomy being performed under local anesthesia and conscious sedation. We present a case series of habitual luxation of the TMJ treated by eminectomy performed under local anesthesia and conscious sedation and general anesthesia. Five patients were examined and found to have recurrent luxation of the TMJ. The age of patients ranged from 18 to 93 years...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27746542/a-randomized-controlled-study-between-fentanyl-and-butorphanol-with-low-dose-intrathecal-bupivacaine-to-facilitate-early-postoperative-ambulation-in-urological-procedures
#5
Arvind Kumar, Ritesh Kumar, Vinod Kumar Verma, Chandrakant Prasad, Rajesh Kumar, Shashi Kant, Gunjan Kumar, Neha Singh, Rupam Kumari
INTRODUCTION: Opioids are widely used in conjunction with local anesthetics as they permit the use of lower dose of local anesthetics while providing adequate anesthesia and analgesia. It both provides adequate anesthesia as well as lower drug toxicity neuraxial administration of opioids in conjunction with local anesthetics improves the quality of intraoperative analgesia and prolongs the duration of postoperative analgesia. Bupivacaine is the most commonly used drug for subarachnoid block due to its lesser side effects...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27646937/effects-of-different-doses-of-remifentanil-on-hemodynamic-response-to-anesthesia-induction-in-healthy-elderly-patients
#6
Nilay Boztas, Sermin Oztekin, Sevda Ozkardes, Mert Akan, Sule Ozbilgin, Ayse Baytok
OBJECTIVE: We compared the effects of three different doses of remifentanil infusion, which were performed for the induction of anesthesia in elder patients, on cardiovascular response. RESEARCH DESIGN AND METHODS: The present study was designed as a randomized, prospective and double-blind study. A total of 90 ASA I-II patients over the age of 65 years were enrolled. The patients were randomly (by lot) assigned to receive one of the three doses of remifentanil infusion (0...
October 17, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27602075/safety-and-efficacy-of-etomidate-and-propofol-anesthesia-in-elderly-patients-undergoing-gastroscopy-a-double-blind-randomized-clinical-study
#7
Qing-Tao Meng, Chen Cao, Hui-Min Liu, Zhong-Yuan Xia, Wei Li, Ling-Hua Tang, Rong Chen, Meng Jiang, Yang Wu, Yan Leng, Chris C Lee
The aim of the present study is to compare the safety, efficacy and cost effectiveness of anesthetic regimens by compound, using etomidate and propofol in elderly patients undergoing gastroscopy. A total of 200 volunteers (65-79 years of age) scheduled for gastroscopy under anesthesia were randomly divided into the following groups: P, propofol (1.5-2.0 mg/kg); E, etomidate (0.15-0.2 mg/kg); P+E, propofol (0.75-1 mg/kg) followed by etomidate (0.075-0.1 mg/kg); and E+P, etomidate (0.075-0.01 mg/kg) followed by propofol (0...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27581549/a-retrospective-observational-study-of-anesthetic-induction-dosing-practices-in-female-elderly-surgical-patients-are-we-overdosing-older-patients
#8
Shamsuddin Akhtar, Joseph Heng, Feng Dai, Robert B Schonberger, Mathew M Burg
BACKGROUND/OBJECTIVES: Despite guidelines suggesting a 25-50 % reduction in induction doses of intravenous anesthetic agents in the elderly (≥65 years), we hypothesized that practitioners were not sufficiently correcting drug administration for age, contributing to an increased incidence of hypotension in older patients undergoing general anesthesia. STUDY DESIGN: We conducted a retrospective, observational study in a tertiary-care academic hospital. The study included 768 female patients undergoing gynecologic surgeries who received propofol-based induction of general anesthesia...
August 31, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27562690/anaesthetics-and-analgesics-neurocognitive-effects-organ-protection-and-cancer-reoccurrence-an-update
#9
I Sellbrant, M Brattwall, P Jildenstål, M Warren-Stomberg, S Forsberg, J G Jakobsson
Available general and local anaesthetics, third generation inhaled anaesthetics, propofol and amide class local anaesthetics are effective and reassuringly safe. They are all associated to low incidence of toxicology and or adverse-effects. There is however a debate whether anaesthetic drug and technique could exhibit effects beyond the primary effects; fully reversible depression of the central nervous system, dose dependent anaesthesia. Anaesthetics may be involved in the progression of neurocognitive side effects seen especially in the elderly after major surgery, so called Postoperative Cognitive Dysfunction...
August 22, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27555205/total-intravenous-anesthesia-with-propofol-is-associated-with-a-lower-rate-of-postoperative-delirium-in-comparison-with-sevoflurane-anesthesia-in-elderly-patients
#10
Koji Ishii, Tetsuji Makita, Hikoma Yamashita, Shoji Matsunaga, Daiji Akiyama, Kouko Toba, Katsumi Hara, Koji Sumikawa, Tetsuya Hara
STUDY OBJECTIVE: Postoperative delirium (POD) is a common complication of anesthesia. The incidence of POD in elderly patients ranges from 37% to 53%, and POD increases the morbidity and mortality of elderly patients. However, the effects of anesthetics on POD are not well known. The present study aimed to compare the incidence of POD resulting from propofol and sevoflurane anesthesia. DESIGN: Double-blind prospective study. SETTING: Operating room and postoperative recovery area...
September 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27545305/pharmacokinetics-and-pharmacodynamics-of-rocuronium-in-young-adult-and-elderly-patients-undergoing-elective-surgery
#11
Renan M Varrique, Gabriela R Lauretti, Julia A Matsumoto, Vera L Lanchote, Natalia V de Moraes
OBJECTIVE: To evaluate the impact of advanced age on rocuronium kinetic disposition in ASA I-III patients undergoing elective surgeries. METHODS: Young adult (20-50 years, n = 15) and elderly patients (65-85 years, n = 14) submitted to surgery under general anaesthesia were investigated. All patients were induced with individual intravenous doses of midazolam, rocuronium, fentanyl and propofol. Rocuronium-induced neuromuscular block was monitored by train of four stimulations of the adductor muscle of the thumb on the ulnar nerve...
August 21, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27282224/clinical-testing-of-propofol-geriatic-dose-for-sedation-designed-via-in-silico-trial
#12
Ana Gabriela Gallardo-Hernandez, Ana Luisa Hernandez-Perez, German Ordoñez-Espinosa, Antonio Sanchez-Lopez, Cristina Revilla-Monsalve, Sergio Islas-Andrade
The geriatric population shows significant physiological changes due to aging and the multiple co-morbidities that they often present. Conventionally the propofol sedation dose for patients older than 65 years is 80% of the adult dose. We performed an in silico trial for elderly population and the results showed that the necessary simulated dose of propofol was lower than the conventional dose; therefore, a clinical trial was implemented to test three different propofol doses, two of them lower than the conventional dose, during a pacemaker implantation...
August 2016: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27247916/anesthetic-considerations-of-sporadic-inclusion-body-myositis-in-an-elderly-man-with-orthopedic-trauma
#13
Dominik T Steck, Christine Choi, Suneeta Gollapudy, Paul S Pagel
INTRODUCTION: Sporadic inclusion body myositis (IBM) is an inflammatory myopathy characterized by progressive asymmetric extremity weakness, oropharyngeal dysphagia, and the potential for exaggerated sensitivity to neuromuscular blockers and respiratory compromise. The authors describe their management of a patient with IBM undergoing urgent orthopedic surgery. CASE PRESENTATION: An 81-year-old man with IBM suffered a left intertrochanteric femoral fracture after falling down stairs...
April 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27247017/propofol-sedation-administered-by-cardiologists-for-patients-undergoing-catheter-ablation-for-ventricular-tachycardia
#14
Helge Servatius, Thormen Höfeler, Boris A Hoffmann, Arian Sultan, Jakob Lüker, Benjamin Schäffer, Stephan Willems, Daniel Steven
AIMS: Propofol sedation has been shown to be safe for atrial fibrillation ablation and internal cardioverter-defibrillator implantation but its use for catheter ablation (CA) of ventricular tachycardia (VT) has yet to be evaluated. Here, we tested the hypothesis that VT ablation can be performed using propofol sedation administered by trained nurses under a cardiologist's supervision. METHODS AND RESULTS: Data of 205 procedures (157 patients, 1.3 procedures/patient) undergoing CA for sustained VT under propofol sedation were analysed...
August 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27222065/electroacupuncture-ameliorates-propofol-induced-cognitive-impairment-via-an-opioid-receptor-independent-mechanism
#15
Yan Liu, Xin-Juan Wang, Na Wang, Cai-Lian Cui, Liu-Zhen Wu
While general anesthesia is known to induce cognitive deficits in elderly and pediatric patients, its influence on adults is less well-characterized. The present study was designed to evaluate the influence of propofol on the learning and memory of young adult rats, as well as the potential neuroprotective role of electroacupuncture (EA) in propofol-induced cognitive impairment. Intravenous anesthesia with propofol was administered to young adult male Sprague-Dawley (SD) rats for 6 h, and EA was administered three times before and after anesthesia...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27145558/the-state-of-uk-dental-anaesthesia-results-from-the-nap5-activity-survey-a-national-survey-by-the-5th-national-audit-project-of-the-royal-college-of-anaesthetists-and-the-association-of-anaesthetists-of-great-britain-and-ireland
#16
COMPARATIVE STUDY
Michael R J Sury, James H MacG Palmer, Tim M Cook, Jaideep J Pandit
The National Health Service anaesthesia annual activity (2013) was recently reported by the Fifth National Audit Program of the Royal College of Anaesthetists and the Association of Anaesthetists of Great Britain and Ireland. Within a large dataset were 620 dental cases. Here, we describe this data subset. The estimated annual dental caseload was 111,600:60% were children (< 16 y), 38.5% adults (16 - 65y) and 1.5% the elderly (> 65y). Almost all were elective day procedures (97%) and ASA 1 or 2 patients (95%)...
January 2016: SAAD Digest
https://www.readbyqxmd.com/read/27117991/prolonged-transesophageal-echocardiography-during-percutaneous-closure-of-the-left-atrial-appendage-without-general-anesthesia-the-utility-of-the-janus-mask
#17
Alberto Zangrillo, Patrizio Mazzone, Carmine D Votta, Nicola Villari, Paolo Della Bella, Fabrizio Monaco
PURPOSE: Left atrial appendage (LAA) closure is an interventional procedure increasingly used to prevent stroke in patients with permanent atrial fibrillation and contraindications to anticoagulation therapy. As this procedure requires a relatively immobile patient and performance of continuous and prolonged transesophageal echocardiography (TEE), it is usually performed under general anesthesia. In this case series, we describe the feasibility of prolonged TEE for percutaneous LAA closure using a new noninvasive ventilation device that can avoid the need for endotracheal intubation and general anesthesia...
August 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27106691/the-median-effective-concentration-ec50-of-propofol-with-different-doses-of-fentanyl-during-colonoscopy-in-elderly-patients
#18
Shiyang Li, Fang Yu, Huichen Zhu, Yuting Yang, Liqun Yang, Jianfeng Lian
BACKGROUND: Propofol and fentanyl are the most widely administered anesthesia maintaining drugs during colonoscopy. In this study, we determined the median effective concentration (EC50) of propofol required for colonoscopy in elderly patients, and the purpose of this study was to describe the pharmacodynamic interaction between fentanyl and propofol when used in combination for colonoscopy in elderly patients. METHODS: Ninety elderly patients scheduled for colonoscopy were allocated into three groups in a randomized, double-blinded manner as below, F0...
2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/26955495/amlodipine-and-the-successful-management-of-post-electroconvulsive-therapy-agitation
#19
Ali Shahriari, Maryam Khooshideh, Mahdi Sheikh
Electroconvulsive therapy (ECT) is a highly effective nonpharmacologic treatment for the management of depression and some other psychiatric disorders. Post-ECT agitation occurs in up to 12% of ECT treatments and is characterized by motor restlessness, irritability, disorientation, and panic-like behaviors. The severity of post-ECT agitation ranges from mild and self-limited to serious and severe forms requiring prompt medical intervention to protect the patient and the medical staff. In severe agitation medical management may be necessary which consists of using sedative agents, either benzodiazepines or propofol...
2016: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/26879014/changes-in-the-bispectral-index-in-response-to-loss-of-consciousness-and-no-somatic-movement-to-nociceptive-stimuli-in-elderly-patients
#20
Ning Yang, Yun Yue, Jonathan Z Pan, Ming-Zhang Zuo, Yu Shi, Shu-Zhen Zhou, Wen-Ping Peng, Jian-Dong Gao
BACKGROUND: Bispectral index (BIS) is considered very useful to guide anesthesia care in elderly patients, but its use is controversial for the evaluation of the adequacy of analgesia. This study compared the BIS changes in response to loss of consciousness (LOC) and loss of somatic response (LOS) to nociceptive stimuli between elderly and young patients receiving intravenous target-controlled infusion (TCI) of propofol and remifentanil. METHODS: This study was performed on 52 elderly patients (aged 65-78 years) and 52 young patients (aged 25-58 years), American Society of Anesthesiologists physical status I or II...
February 20, 2016: Chinese Medical Journal
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