keyword
https://read.qxmd.com/read/38534437/post-traumatic-trigeminal-neuropathy-neurobiology-and-pathophysiology
#1
REVIEW
Tal Eliav, Rafael Benoliel, Olga A Korczeniewska
Painful traumatic trigeminal neuropathy (PTTN) is a chronic neuropathic pain that may develop following injury to the trigeminal nerve. Etiologies include cranio-orofacial trauma that may result from dental, surgical, or anesthetic procedures or physical trauma, such as a motor vehicle accident. Following nerve injury, there are various mechanisms, including peripheral and central, as well as phenotypic changes and genetic predispositions that may contribute to the development of neuropathic pain. In this article, we review current literature pertaining to the cellular processes that occur following traumatic damage to the trigeminal nerve, also called cranial nerve V, that results in chronic neuropathic pain...
March 4, 2024: Biology
https://read.qxmd.com/read/38531121/a-next-generation-peripherally-restricted-cav%C3%AE-2%C3%AE-1-ligand-with-inhibitory-action-on-cav2-2-channels-and-utility-in-neuropathic-pain
#2
JOURNAL ARTICLE
Franz Kricek, Christine Ruf, Premji Meghani, Ivana A Souza, Maria A Gandini, Gerald W Zamponi, George Skouteris
The Voltage-Gated Calcium Channel (VGCC) auxiliary subunit Cavα2δ-1 (CACNA2D1) is the target/receptor of gabapentinoids which are known therapeutics in epilepsy and neuropathic pain. Following damage to the peripheral sensory nervous system, Cavα2δ-1 is upregulated in dorsal root ganglion (DRG) neurons in several animal models of chronic neuropathic pain. Gabapentinoids, such as gabapentin and pregabalin, engage with Cavα2δ-1 via binding an arginine residue (R241) within an RRR motif located at the N-terminus of human Cavα2δ-1...
March 25, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38528611/effects-of-alendronate-on-cartilage-lesions-and-micro-architecture-deterioration-of-subchondral-bone-in-patellofemoral-osteoarthritic-ovariectomized-rats-with-patella-baja
#3
JOURNAL ARTICLE
Mingjian Bei, Zhiyuan Zheng, Yaping Xiao, Ning Liu, Xuehui Cao, Faming Tian, Liu Zhang, Xinbao Wu
BACKGROUND: Patellofemoral osteoarthritis (PFJOA) is a subtype of knee OA, which is one of the main causes of anterior knee pain. The current study found an increased prevalence of OA in postmenopausal women, called postmenopausal OA. Therefore, we designed the ovariectomized rat model of patella baja-induced PFJOA. Alendronate (ALN) inhibits osteoclast-mediated bone loss, and has been reported the favorable result of a potential intervention option of OA treatment. However, the potential effects of ALN treatment on PFJOA in the ovariectomized rat model are unknown and need further investigation prior to exploration in the clinical research setting...
March 25, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38526120/chronic-constriction-injury-of-the-distal-infraorbital-nerve-dion-cci-in-mice-to-study-trigeminal-neuropathic-pain
#4
JOURNAL ARTICLE
Kristof R Deseure, Guy H Hans
Animal models remain necessary tools to study neuropathic pain. This manuscript describes the distal infraorbital nerve chronic constriction injury (DIoN-CCI) model to study trigeminal neuropathic pain in mice. This includes the surgical procedures to perform the chronic constriction injury and the postoperative behavioral tests to evaluate the changes in spontaneous and evoked behavior that are signs of ongoing pain and mechanical allodynia. The methods and behavioral readouts are similar to the infraorbital nerve chronic constriction injury (IoN-CCI) model in rats...
March 8, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38525396/therapeutic-effects-of-tretinoin-and-caffeine-treated-bone-marrow-derived-mesenchymal-stem-cell-on-immunological-features-of-ulcerative-colitis-an-animal-model-study
#5
JOURNAL ARTICLE
Behnaz Movaffaghbani, Hadi Esmaeili Gouvarchinghaleh, Mahdieh Farzanehpour, Jalal Shayegh
BACKGROUND: Ulcerative colitis (UC) is one of the inflammatory gastrointestinal diseases. It causes irritation, inflammation, and ulcers in the digestive tract. UC is distinguished clinically by abdominal and rectal pain and intestinal secretion abnormalities. Mesenchymal stem cell (MSC) therapy could be the underlying treatment for UC. This study aimed to compare the results of MSC therapy with tretinoin and caffeine in an animal model. MATERIALS AND METHODS: Sixty male BALB/c mice were randomly divided into six equal groups...
2024: Advanced Biomedical Research
https://read.qxmd.com/read/38524856/recent-advances-in-the-understanding-and-management-of-chronic-pancreatitis-pain
#6
REVIEW
Jessica Walker, Olivia L Babyok, Jami L Saloman, Anna Evans Phillips
Abdominal pain is the most common symptom of chronic pancreatitis (CP) and is often debilitating for patients and very difficult to treat. To date, there exists no cure for the disease. Treatment strategies focus on symptom management and on mitigation of disease progression by reducing toxin exposure and avoiding recurrent inflammatory events. Traditional treatment protocols start with medical management followed by consideration of procedural or surgical intervention on selected patients with severe and persistent pain...
March 2024: Journal of pancreatology
https://read.qxmd.com/read/38520257/molecular-docking-of-quercetin-a-promising-approach-for-the-development-of-new-anti-inflammatory-and-analgesic-drugs
#7
JOURNAL ARTICLE
Amina Ettitaou, Hamid Kabdy, Khadija Oubella, Karima Raoui, Mehdi Oubahmane, Rachida Aboufatima, Loubna Elyazouli, Stefania Garzoli, Abderrahman Chait
The aim of this study is to investigate the antinociceptive, anti-inflammatory and antipyretic effects of quercetin. Additionally, molecular docking studies were conducted to evaluate potential interactions between quercetin and various molecular targets. Animal models were used to conduct a comprehensive pharmacological investigation of quercetin. Evaluation of analgesic activity revealed a reduction in the number of abdominal cramps during the twisting test and inhibition of pain during the second phase of the formaldehyde test...
March 23, 2024: Natural Product Research
https://read.qxmd.com/read/38518392/tinnitus-related-increases-in-single-unit-activity-in-awake-rat-auditory-cortex-correlate-with-tinnitus-behavior
#8
JOURNAL ARTICLE
Rui Cai, Lynne Ling, Madan Ghimire, Kevin A Brownell, Donald M Caspary
Tinnitus is known to affect 10-15 % of the population, severely impacting 1-2 % of those afflicted. Canonically, tinnitus is generally a consequence of peripheral auditory damage resulting in maladaptive plastic changes in excitatory/inhibitory homeostasis at multiple levels of the central auditory pathway as well as changes in diverse nonauditory structures. Animal studies of primary auditory cortex (A1) generally find tinnitus-related changes in excitability across A1 layers and differences between inhibitory neuronal subtypes...
March 16, 2024: Hearing Research
https://read.qxmd.com/read/38517617/roles-of-kcna2-in-neurological-diseases-from-physiology-to-pathology
#9
REVIEW
Changning Xie, Miriam Kessi, Fei Yin, Jing Peng
Potassium voltage-gated channel subfamily a member 2 (Kv1.2, encoded by KCNA2) is highly expressed in the central and peripheral nervous systems. Based on the patch clamp studies, gain-of function (GOF), loss-of-function (LOF), and a mixed type (GOF/LOF) variants can cause different conditions/disorders. KCNA2-related neurological diseases include epilepsy, intellectual disability (ID), attention deficit/hyperactive disorder (ADHD), autism spectrum disorder (ASD), pain as well as autoimmune and movement disorders...
March 22, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38516674/3d-printed-hydrogels-dressings-with-bioactive-borate-glass-for-continuous-hydration-and-treatment-of-second-degree-burns
#10
JOURNAL ARTICLE
Fateme Fayyazbakhsh, Michael J Khayat, Candy Sadler, Delbert Day, Yue-Wern Huang, Ming C Leu
Recent advances in additive manufacturing have led to the development of innovative solutions for tissue regeneration. Hydrogel materials have gained significant attention for burn wound treatment in clinical practice among various advanced dressings due to their soothing and moisturizing activity. However, prolonged healing, pain, and traumatic removal due to the lack of long-term wound hydration are some of the challenges in the treatment of second-degree burn wounds. In this study, 3D-printed dressings were fabricated using gelatin, alginate, and bioactive borate glass (BBG) using an extrusion-based bioprinter...
October 15, 2023: International journal of bioprinting
https://read.qxmd.com/read/38514040/peptide-derived-ligands-for-the-discovery-of-safer-opioid-analgesics
#11
REVIEW
Abbe Eliasof, Lee-Yuan Liu-Chen, Yangmei Li
Drugs targeting the μ-opioid receptor (MOR) remain the most efficacious analgesics for the treatment of pain, but activation of MOR with current opioid analgesics also produces harmful side effects, notably physical dependence, addiction, and respiratory depression. Opioid peptides have been accepted as promising candidates for the development of safer and more efficacious analgesics. To develop peptide-based opioid analgesics, strategies such as modification of endogenous opioid peptides, development of multifunctional opioid peptides, G protein-biased opioid peptides, and peripherally restricted opioid peptides have been reported...
March 19, 2024: Drug Discovery Today
https://read.qxmd.com/read/38508691/evaluation-of-efficacy-of-2-extended-release-bupivacaine-products-in-a-porcine-model-of-incisional-pain
#12
JOURNAL ARTICLE
Peggy Yang, Stephanie Yang, Laura B Durham, Patrick A Lester, Daniel D Myers
Extended-release (ER) local anesthetics are often incorporated in multi-modal analgesia or as an alternative when the effect of systemic analgesics may confound research. In this study, we compared the analgesic efficacy of 2 ER bupivacaine anesthetics with different ER mechanisms, a slow-release bupivacaine-meloxicam polymer (BMP) and a sucrose acetate isobutyrate bupivacaine (SABER-B) system. We used a full-thickness unilateral skin incision porcine model to evaluate the efficacy of these 2 ER bupivacaine analgesics...
March 20, 2024: Journal of the American Association for Laboratory Animal Science: JAALAS
https://read.qxmd.com/read/38508592/fluoroscopy-guided-high-intensity-focused-ultrasound-ablation-of-the-lumbar-medial-branch-nerves-dose-escalation-study-and-comparison-with-radiofrequency-ablation-in-a-porcine-model
#13
JOURNAL ARTICLE
Michael Gofeld, Thomas Tiennot, Eric Miller, Niv Rebhun, Stephen Mobley, Suzanne Leblang, Ron Aginsky, Arik Hananel, Jean-Francois Aubry
BACKGROUND: Radiofrequency ablation (RFA) is a common method for alleviating chronic back pain by targeting and ablating of facet joint sensory nerves. High-intensity focused ultrasound (HIFU) is an emerging, non-invasive, image-guided technology capable of providing thermal tissue ablation. While HIFU shows promise as a potentially superior option for ablating sensory nerves, its efficacy needs validation and comparison with existing methods. METHODS: Nine adult pigs underwent fluoroscopy-guided HIFU ablation of eight lumbar medial branch nerves, with varying acoustic energy levels: 1000 (N=3), 1500 (N=3), or 2000 (N=3) joules (J)...
March 20, 2024: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/38504162/photobiomodulation-combination-therapy-as-a-new-insight-in-neurological-disorders-a-comprehensive-systematic-review
#14
JOURNAL ARTICLE
Narmin Farazi, Hanieh Salehi-Pourmehr, Fereshteh Farajdokht, Javad Mahmoudi, Saeed Sadigh-Eteghad
Preclinical and clinical studies have indicated that combining photobiomodulation (PBM) therapy with other therapeutic approaches may influence the treatment process in a variety of disorders. The purpose of this systematic review was to determine whether PBM-combined therapy provides additional benefits over monotherapies in neurologic and neuropsychiatric disorders. In addition, the review describes the most commonly used methods and PBM parameters in these conjunctional approaches.To accomplish this, a systematic search was conducted in Google Scholar, PubMed, and Scopus databases through January 2024...
March 19, 2024: BMC Neurology
https://read.qxmd.com/read/38503831/effect-of-chronic-vapor-nicotine-exposure-on-affective-and-cognitive-behavior-in-male-mice
#15
JOURNAL ARTICLE
Laura B Murdaugh, Cristina Miliano, Irene Chen, Christine L Faunce, Luis A Natividad, Ann M Gregus, Matthew W Buczynski
Nicotine use is a leading cause of preventable deaths worldwide, and most of those who attempt to quit will relapse. While electronic cigarettes and other electronic nicotine delivery systems (ENDS) were presented as a safer alternative to traditional cigarettes and promoted as devices to help traditional tobacco smokers reduce or quit smoking, they have instead contributed to increasing nicotine use among youths. Despite this, ENDS also represent a useful tool to create novel preclinical animal models of nicotine exposure that more accurately represent human nicotine use...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38502437/research-progress-on-the-experimental-model-and-underlying-mechanistic-studies-of-tension-type-headaches
#16
REVIEW
Guo-Jing Fu, Liu-Ding Wang, Xian-Su Chi, Xiao Liang, Jing-Jing Wei, Zhi-Hong Huang, Wei Shen, Yun-Ling Zhang
PURPOSE OF REVIEW: Tension-type headaches (TTH) significantly diminish patients' quality of life and increase absenteeism, thereby imposing a substantial economic burden. Animal models are essential tools for studying disease mechanisms and drug development. However, until now, little focus has been placed on summarizing the animal models of TTH and associated mechanistic studies. This narrative review discusses the current animal models of TTH and related mechanistic studies to provide insights into the pathophysiological mechanisms of and treatments for TTH...
March 19, 2024: Current Pain and Headache Reports
https://read.qxmd.com/read/38501615/assessment-of-rat-brain-morphofunctional-state-in-a-parkinson-s-model-influence-of-therapeutic-agents-of-animal-and-synthetic-origins
#17
JOURNAL ARTICLE
M Danielyan, K Nebogova, Z Avetisyan, V Khachatryan, J Sarkissian, M Poghosyan, K Karapetyan
In neurodegenerative diseases, particularly in Parkinson's disease (PD), antinociceptive centers are often implicated in neurodegeneration, leading to persistent pain unresponsive to narcotic substances. This study investigated the periaqueductal gray matter (PAG) and the nucleus raphe magnus (NRM), components of the brain's antinociceptive system. In conditions of rotenone intoxication (an experimental PD model), morphological changes in intracellular structures were observed in PAG and NRM neurons, indicating metabolic disorders characteristic of PD (alterations in the shape and size of neuronal bodies and processes, disruption of acid phosphatase activity in neuron cytoplasm)...
January 2024: Georgian Medical News
https://read.qxmd.com/read/38494412/safety-and-immunogenicity-of-a-novel-trivalent-recombinant-mva-based-equine-encephalitis-virus-vaccine-a-phase-1-clinical-trial
#18
JOURNAL ARTICLE
Carlos Fierro, Heinz Weidenthaler, Sanja Vidojkovic, Darja Schmidt, Zarina Gafoor, Daria Stroukova, Susan Zwiers, Jutta Müller, Ariane Volkmann
BACKGROUND: Three encephalitic alphaviruses-western, eastern, and Venezuelan equine encephalitis virus (WEEV, EEEV and VEEV)-can cause severe disease and have the potential to be used as biological weapons. There are no approved vaccines for human use. A novel multivalent MVA-BN-WEV vaccine encodes the envelope surface proteins of the 3 viruses and is thereby potentially able to protect against them all, as previously demonstrated in animal models. This first-in-human study assessed the safety, tolerability, and immunogenicity of MVA-BN-WEV vaccine in healthy adult participants...
March 16, 2024: Vaccine
https://read.qxmd.com/read/38493143/low-intensity-pulsed-ultrasound-delays-the-progression-of-osteoarthritis-by-regulating-the-yap-ripk1-nf-%C3%AE%C2%BAb-axis-and-influencing-autophagy
#19
JOURNAL ARTICLE
Chunran Pan, Fan Lu, Xiaoxia Hao, Xiaofeng Deng, Jiawei Liu, Kai Sun, Wenjie Hou, Xingru Shang, Ruimin Chi, Fengjing Guo, Tao Xu
BACKGROUND: Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint. As the disease progresses, patients will gradually develop symptoms such as pain, physical limitations and even disability. The risk factors for OA include genetics, gender, trauma, obesity, and age. Unfortunately, due to limited understanding of its pathological mechanism, there are currently no effective drugs or treatments to suspend the progression of osteoarthritis. In recent years, some studies found that low-intensity pulsed ultrasound (LIPUS) may have a positive effect on osteoarthritis...
March 16, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38490726/pharmacokinetics-fecal-output-and-grimace-scores-in-rabbits-given-long-acting-buprenorphine-or-fentanyl-for-postsurgical-analgesia
#20
JOURNAL ARTICLE
Michelle R Farkas, Shanelle Dorn, Liam Muller, Vikram Pal Singh, Yadira J Sepulveda, Raymond T Suhandynata, Jeremiah D Momper, Koichi Masuda, Philip J Richter
The New Zealand white rabbit ( Oryctolagus cuniculus ) is a frequently used surgical model. Pain management after surgery is a critical aspect of animal welfare. Recently, a long-acting buprenorphine formulation (Ethiqa XR; EXR) was approved for use in rats and mice but has not yet been investigated in rabbits. The current study aimed to determine whether a single subcutaneous dose of 0.15 mg/kg of EXR could achieve and maintain therapeutic buprenorphine plasma concentrations (0.1 ng/mL) for 72 h in male and female rabbits...
March 15, 2024: Journal of the American Association for Laboratory Animal Science: JAALAS
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