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https://www.readbyqxmd.com/read/28918457/effects-of-menthol-and-its-interaction-with-nicotine-conditioned-cue-on-nicotine-seeking-behavior-in-rats
#1
Erin Harrison, Lisa Biswas, Ramachandram Avusula, Meiyu Zhang, Yongzhen Gong, Xiu Liu
RATIONALE: Increasing clinical evidence suggests that menthol, a significant flavoring additive in tobacco products, may contribute to smoking and nicotine dependence. Relapse to smoking behavior presents a formidable challenge for the treatment of tobacco addiction. An unresolved issue is whether the mentholation of tobacco products precipitates relapse to tobacco use in abstinent smokers. OBJECTIVES: The present study examined the effects of menthol on the perseverance and relapse of nicotine-seeking behavior in rats...
September 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28918312/-reinforcement-learning-to-forage-optimally
#2
REVIEW
Nils Kolling, Thomas Akam
Foraging effectively is critical to the survival of all animals and this imperative is thought to have profoundly shaped brain evolution. Decisions made by foraging animals often approximate optimal strategies, but the learning and decision mechanisms generating these choices remain poorly understood. Recent work with laboratory foraging tasks in humans suggest their behaviour is poorly explained by model-free reinforcement learning, with simple heuristic strategies better describing behaviour in some tasks, and in others evidence of prospective prediction of the future state of the environment...
September 14, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28917921/effect-of-oxidized-chitin-nanocrystals-isolated-by-ammonium-persulfate-method-on-the-properties-of-carboxymethyl-cellulose-based-films
#3
Ahmed A Oun, Jong-Whan Rhim
Oxidized chitin nanocrystals (ChNCs) were isolated from crab shell chitin using ammonium persulfate (APS) method. The oxidized ChNCs were in needle shape with a diameter of 15nm, the length of 400-500nm, and crystallinity index of 93.5%. Carboxymethyl cellulose (CMC)-based films reinforced with the ChNCs (0, 1, 5, and 10wt.%) were flexible and transparent. The mechanical strength of the CMC film increased significantly (p<0.05) after blending with the ChNCs. The tensile strength (TS) and elastic modulus (EM) increased by 88% and 243% when 10wt...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917918/chitosan-composite-hydrogels-reinforced-with-natural-clay-nanotubes
#4
Biao Huang, Mingxian Liu, Changren Zhou
Here, chitosan composites hydrogels were prepared by addition of halloysite nanotubes (HNTs) in the chitosan KOH/LiOH/urea solution. The raw chitosan and chitosan/HNTs composite hydrogels were obtained by heat treatment at 60°C for 8h and then regeneration in ethanol solution. The viscosity of the composite solution is increased with HNTs content. The Fourier transform infrared spectroscopy (FT-IR) shows that the hydrogen bonds interactions exist between the HNTs and the chitosan. X-ray diffraction (XRD) results show that the crystal structure of HNT is not changed in the composite hydrogels...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917900/mineralized-agar-based-nanocomposite-films-potential-food-packaging-materials-with-antimicrobial-properties
#5
Ivana Malagurski, Steva Levic, Aleksandra Nesic, Miodrag Mitric, Vladimir Pavlovic, Suzana Dimitrijevic-Brankovic
New mineralized, agar-based nanocomposite films (Zn-carbonate and Zn-phosphate/agar) were produced by a combination of in situ precipitation and a casting method. The presence of minerals significantly influenced the morphology, properties and functionality of the obtained nanocomposites. Reinforcement with the Zn-mineral phase improved the mechanical properties of the carbonate-mineralized films, but had a negligible effect on the phosphate-mineralized samples. Both nanocomposites showed improved optical and thermal properties, better Zn(II) release potential in a slightly acidic environment and exhibited antimicrobial activity against S...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917873/bionanocomposites-produced-from-cassava-starch-and-oil-palm-mesocarp-cellulose-nanowhiskers
#6
Adriana de Campos, Alfredo R de Sena Neto, Vanessa B Rodrigues, Bruno R Luchesi, Francys K V Moreira, Ana Carolina Correa, Luiz H C Mattoso, José M Marconcini
Cassava starch films reinforced with cellulose nanowhiskers from oil palm mesocarp fibers were produced by casting. Nanowhiskers were obtained by sulphuric acid hydrolysis followed by microfluidization and incorporated in starch films at various loadings (1-10wt%). Morphological and mechanical characterizations showed that the reinforcing effect of oil palm cellulose nanowhiskers was significant at loadings of up to 6wt%, which was determined to be the nanowhiskers percolation threshold. Above this content, formation of agglomerates became more significant, causing a decrease in mechanical properties of starch bionanocomposites...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917367/perceptions-of-hatha-yoga-amongst-persistently-depressed-individuals-enrolled-in-a-trial-of-yoga-for-depression
#7
Lisa A Uebelacker, Morganne Kraines, Monica K Broughton, Geoffrey Tremont, L Tom Gillette, Gary Epstein-Lubow, Ana M Abrantes, Cynthia Battle, Ivan W Miller
OBJECTIVES: To understand depressed individuals' experiences in a 10-week hatha yoga program. DESIGN: In a randomized controlled trial, participants were assigned to either 10 weeks of hatha yoga classes or a health education control group. This report includes responses from participants in yoga classes. At the start of classes, average depression symptom severity level was moderate. MAIN OUTCOME MEASURES: After 10 weeks of yoga classes, we asked participants (n=50) to provide written responses to open-ended questions about what they liked about classes, what they did not like or did not find helpful, and what they learned...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28917168/occurrence-and-distribution-of-microplastics-at-selected-coastal-sites-along-the-southeastern-united-states
#8
Xubiao Yu, Samantha Ladewig, Shaowu Bao, Catherine A Toline, Stefanie Whitmire, Alex T Chow
To investigate the occurrence and distribution of microplastics in the southeastern coastal region of the United States, we quantified the amount of microplastics in sand samples from multiple coastal sites and developed a predictive model to understand the drift of plastics via ocean currents. Sand samples from eighteen National Park Service (NPS) beaches in the Southeastern Region were collected and microplastics were isolated from each sample. Microplastic counts were compared among sites and local geography was used to make inferences about sources and modes of distribution...
September 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28917089/the-trehalose-specific-transporter-lpqy-sugabc-is-required-for-antimicrobial-and-anti-biofilm-activity-of-trehalose-analogues-in-mycobacterium-smegmatis
#9
Jeffrey M Wolber, Bailey L Urbanek, Lisa M Meints, Brent F Piligian, Irene C Lopez-Casillas, Kailey M Zochowski, Peter J Woodruff, Benjamin M Swarts
Mycobacteria, including the bacterial pathogen that causes human tuberculosis, possess distinctive pathways for synthesizing and utilizing the non-mammalian disaccharide trehalose. Trehalose metabolism is essential for mycobacterial viability and has been linked to in vitro biofilm formation, which may bear relevance to in vivo drug tolerance. Previous research has shown that some trehalose analogues bearing modifications at the 6-position inhibit growth of various mycobacterial species. In this work, 2-, 5-, and 6-position-modified trehalose analogues were synthesized using our previously reported one-step chemoenzymatic method and shown to inhibit growth and biofilm formation in the two-to three-digit micromolar range in Mycobacterium smegmatis...
August 9, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28917059/direct-modulation-of-aberrant-brain-network-connectivity-through-real-time-neurofeedback
#10
Michal Ramot, Sara Kimmich, Javier Gonzalez-Castillo, Vinai Roopchansingh, Haroon Popal, Emily White, Stephen J Gotts, Alex Martin
The existence of abnormal connectivity patterns between resting state networks in neuropsychiatric disorders, including Autism Spectrum Disorder (ASD), has been well established. Traditional treatment methods in ASD are limited, and do not address the aberrant network structure. Using real-time fMRI neurofeedback, we directly trained 3 brain nodes in participants with ASD, in which the aberrant connectivity has been shown to correlate with symptom severity. Desired network connectivity patterns were reinforced in real-time, without participants' awareness of the training taking place...
September 16, 2017: ELife
https://www.readbyqxmd.com/read/28917000/routine-use-of-mesh-during-hiatal-closure-is-safe-with-no-increase-in-adverse-sequelae
#11
Walid K Abu Saleh, Lee M Morris, Nabil Tariq, Min P Kim, Edward Y Chan, Leonora M Meisenbach, Brian J Dunkin, Vadim Sherman, Wade Rosenberg, Barbara L Bass, Edward A Graviss, Duc T Nguyen, Patrick Reardon, Puja G Khaitan
BACKGROUND: Primary laparoscopic hiatal repair with fundoplication is associated with a high recurrence rate. We wanted to evaluate the potential risks posed by routine use of onlay-mesh during hiatal closure, when compared to primary repair. METHODS: Utilizing single-institutional database, we identified patients who underwent primary laparoscopic hiatal repair from January 2005 through December 2014. Retrospective chart review was performed to determine perioperative morbidity and mortality...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28916995/effects-of-environmental-enrichment-on-self-administration-of-the-short-acting-opioid-remifentanil-in-male-rats
#12
Rebecca S Hofford, Jonathan J Chow, Joshua S Beckmann, Michael T Bardo
BACKGROUND: Opioid abuse is a major problem around the world. Identifying environmental factors that contribute to opioid abuse and addiction is necessary for decreasing this epidemic. In rodents, environmental enrichment protects against the development of low dose stimulant self-administration, but studies examining the effect of enrichment and isolation (compared to standard housing) on the development of intravenous opioid self-administration have not been conducted. The present study investigated the role of environmental enrichment on self-administration of the short-acting μ-opioid remifentanil...
September 15, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28916545/serologic-evidence-of-gut-driven-systemic-inflammation-in-juvenile-idiopathic-arthritis
#13
Lampros Fotis, Nurmohammad Shaikh, Kevin W Baszis, Charles M Samson, Raffi Lev-Tzion, Anthony R French, Phillip I Tarr
OBJECTIVE: Accumulating evidence links juvenile idiopathic arthritis (JIA) to nonhost factors such as gut microbes. We hypothesize that children with new-onset JIA have increased intestinal bacterial translocation and circulating lipopolysaccharide (LPS). METHODS: We studied systemic treatment-naive patients with JIA [polyarticular JIA, n = 22, oligoarticular JIA, n = 31, and spondyloarthropathies (SpA), n = 16], patients with established inflammatory bowel disease-related arthritis (IBD-RA, n = 11), and 34 healthy controls...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28916534/pretreatment-behavior-and-subsequent-medication-effects-in-childhood-absence-epilepsy
#14
Ruth C Shinnar, Shlomo Shinnar, Avital Cnaan, Peggy Clark, Dennis Dlugos, Deborah G Hirtz, Fengming Hu, Chunyan Liu, David Masur, Erica F Weiss, Tracy A Glauser
OBJECTIVE: To characterize pretreatment behavioral problems and differential effects of initial therapy in children with childhood absence epilepsy (CAE). METHODS: The Child Behavior Checklist (CBCL) was administered at baseline, week 16-20, and month 12 visits of a randomized double-blind trial of ethosuximide, lamotrigine, and valproate. Total problems score was the primary outcome measure. RESULTS: A total of 382 participants at baseline, 310 participants at the week 16-20 visit, and 168 participants at the month 12 visit had CBCL data...
September 15, 2017: Neurology
https://www.readbyqxmd.com/read/28915990/-a-boy-would-be-friends-with-boys-%C3%A2-and-a-girl-%C3%A2-with-girls-gender-norms-in-early-adolescent-friendships-in-egypt-and-belgium
#15
Ghada Al-Attar, Sara De Meyer, Omaima El-Gibaly, Kristien Michielsen, Lydia H Animosa, Kristin Mmari
PURPOSE: A gender analysis was conducted to illuminate the key elements of friendships highlighted by early adolescent girls and boys in two sites for the purpose of better understanding the impact of gender norms on adolescent friendships in different contexts. METHODS: Narrative interviews with early adolescents were conducted in two sites: Assiut, Egypt (n = 37) and Ghent, Belgium (n = 30). The interviews were recorded, transcribed, translated into English, and coded using Atlas...
October 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28915495/impact-of-chemotherapy-on-metabolic-reprogramming-characterization-of-the-metabolic-profile-of-breast-cancer-mda-mb-231-cells-using-1-h-hr-mas-nmr-spectroscopy
#16
Roberta M Maria, Wanessa F Altei, Heloisa S Selistre-de-Araujo, Luiz A Colnago
Doxorubicin, cisplatin, and tamoxifen are part of many chemotherapeutic regimens. However, studies investigating the effect of chemotherapy on the metabolism of breast cancer cells are still limited. We used (1)H high-resolution magic angle spinning (HR-MAS) NMR spectroscopy to study the metabolic profile of human breast cancer MDA-MB-231 cells either untreated (control) or treated with tamoxifen, cisplatin, and doxorubicin. (1)H HR-MAS NMR single pulse spectra evidenced signals from all mobile cell compounds, including fatty acids (membranes), water-soluble proteins, and metabolites...
September 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28915468/spectral-and-computational-features-of-the-binding-between-riparins-and-human-serum-albumin
#17
Cintia Ramos Camargo, Ícaro Putinhon Caruso, Stanley Juan Chavez Gutierrez, Marcelo Andres Fossey, José Maria Barbosa Filho, Marinônio Lopes Cornélio
The green Brazilian bay leaf, a spice much prized in local cuisine (Aniba riparia, Lauraceae), contains chemical compounds presenting benzoyl-derivatives named riparins, which have anti-inflammatory, antimicrobial and anxiolytic properties. However, it is unclear what kind of interaction riparins perform with any molecular target. As a profitable target, human serum albumin (HSA) is one of the principal extracellular proteins, with an exceptional capacity to interact with several molecules, and it also plays a crucial role in the transport, distribution, and metabolism of a wide variety of endogenous and exogenous ligands...
September 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28915314/-1-h-mrs-processing-parameters-affect-metabolite-quantification-the-urgent-need-for-uniform-and-transparent-standardization
#18
Alex A Bhogal, Remmelt R Schür, Lotte C Houtepen, Bart van de Bank, Vincent O Boer, Anouk Marsman, Peter B Barker, Tom W J Scheenen, Jannie P Wijnen, Christiaan H Vinkers, Dennis W J Klomp
Proton magnetic resonance spectroscopy ((1) H-MRS) can be used to quantify in vivo metabolite levels, such as lactate, γ-aminobutyric acid (GABA) and glutamate (Glu). However, there are considerable analysis choices which can alter the accuracy or precision of (1) H-MRS metabolite quantification. It is currently unknown to what extent variations in the analysis pipeline used to quantify (1) H-MRS data affect outcomes. The purpose of this study was to evaluate whether the quantification of identical (1) H-MRS scans across independent and experienced research groups would yield comparable results...
September 15, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28915279/first-consensus-on-primary-prevention-and-early-intervention-in-aesthetic-medicine
#19
Marina Landau, Chytra V Anand, Thierry Besins, Yates Yen Yu Chao, Sabrina Guillen Fabi, Uliana Gout, Martina Kerscher, Tatjana Pavicic, Peter Hsien Li Peng, Berthold Rzany, Gerhard Sattler, Tunk Tiryaki, Heidi A Waldorf, Andre Braz
BACKGROUND: Facial aging is a complex interplay of extrinsic and intrinsic factors leading to progressive changes in the skin, subcutaneous tissue, and bone. Clinical experience suggests that early aesthetic intervention may slow the signs of aging, but treatment in the absence of symptoms or with minimal signs of aging has not yet been properly addressed. OBJECTIVES: To provide treatment recommendations for primary prevention and early intervention in individuals with no or minimal signs of aging...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28914796/enhanced-interface-structure-and-properties-of-titanium-carbonitride-based-cermets-with-the-extra-solid-phase-reaction
#20
Nan Lin, Yuehui He, Xiyue Kang
In this paper, the influence of the extra solid phase reaction on the interface structure and mechanical properties of titanium carbonitride-based cermets were investigated. The extra solid phase reaction in the preparation process of cermets could induce the formation of a core/rim/binder interface with the coherent structure and reinforce the interface bonding strength in cermets. The existence of a coherent structure interface can inhibit crack spread and improve the toughness and abrasion resistance of titanium carbonitride-based cermets significantly...
September 15, 2017: Materials
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