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https://www.readbyqxmd.com/read/28231647/outcome-of-acl-reconstruction-for-chronic-acl-injury-in-knees-without-the-posterior-horn-of-the-medial-meniscus-comparison-with-acl-reconstructed-knees-with-an-intact-medial-meniscus
#1
Kevin Syam, Devendra K Chouhan, Mandeep Singh Dhillon
Purpose: Cadaveric studies have shown that deficiency of the posterior horn of the medial meniscus (PHMM) increases strain on the anterior cruciate ligament (ACL) graft. However, its influence on the clinical and radiological outcome after ACL reconstruction is less discussed and hence evaluated in this study. Materials and Methods: This study included 77 cases of ACL reconstruction with a minimum 18-month follow-up. Of the 77 cases, 41 patients with intact menisci were compared clinically and radiologically with 36 patients with an injury to the PHMM that required various grades of meniscectomy...
March 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28231638/comparison-of-the-shock-absorption-capacities-of-different-mouthguards
#2
Melina Simonetta Bochnig, Min-Jung Oh, Theresa Nagel, Fred Ziegler, Paul-Georg Jost-Brinkmann
BACKGROUND/AIMS: In this in vitro study the protective qualities of different mouthguard types were examined during small hard object collisions. The aim was to investigate inconclusive aspects of hard inserts, nylon nets and air spaces as reinforcements in the anterior region and the protection qualities of ethylene vinyl acetate (EVA). MATERIALS AND METHODS: Five different mouthguards with a labial thickness between 2 mm and 11 mm made of materials of varying stiffness were investigated...
February 23, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28230752/impact-of-particulate-matter-exposure-and-surrounding-greenness-on-chronic-absenteeism-in-massachusetts-public-schools
#3
Piers MacNaughton, Erika Eitland, Itai Kloog, Joel Schwartz, Joseph Allen
Chronic absenteeism is associated with poorer academic performance and higher attrition in kindergarten to 12th grade (K-12) schools. In prior research, students who were chronically absent generally had fewer employment opportunities and worse health after graduation. We examined the impact that environmental factors surrounding schools have on chronic absenteeism. We estimated the greenness (Normalized Difference Vegetation Index (NDVI)) and fine particulate matter air pollution (PM2.5) within 250 m and 1000 m respectively of each public school in Massachusetts during the 2012-2013 academic year using satellite-based data...
20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28230747/dynamic-method-of-neutral-axis-position-determination-and-damage-identification-with-distributed-long-gauge-fbg-sensors
#4
Yongsheng Tang, Zhongdao Ren
The neutral axis position (NAP) is a key parameter of a flexural member for structure design and safety evaluation. The accuracy of NAP measurement based on traditional methods does not satisfy the demands of structural performance assessment especially under live traffic loads. In this paper, a new method to determine NAP is developed by using modal macro-strain (MMS). In the proposed method, macro-strain is first measured with long-gauge Fiber Bragg Grating (FBG) sensors; then the MMS is generated from the measured macro-strain with Fourier transform; and finally the neutral axis position coefficient (NAPC) is determined from the MMS and the neutral axis depth is calculated with NAPC...
February 20, 2017: Sensors
https://www.readbyqxmd.com/read/28230405/getting-what-you-expect-future-self-views-predict-the-valence-of-life-events
#5
Peggy Voss, Anna E Kornadt, Klaus Rothermund
Views on aging have been shown to predict the occurrence of events related to physical health in previous studies. Extending these findings, we investigated the relation between aging-related future self-views and life events in a longitudinal study across a range of different life domains. Participants (N = 593, age range 30-80 years at t1) completed a survey at 2 measurement occasions that were separated by a 4-year interval (t1: 2009, t2: 2013), providing information on domain-specific future self-views as well as on life events that had occurred in the respective domains in-between the 2 measurement occasions...
March 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28230346/high-strength-stereolithographic-3d-printed-nanocomposites-graphene-oxide-metastability
#6
Jill Z Manapat, Joey Dacula Mangadlao, Brylee David Buada Tiu, Grace C Tritchler, Rigoberto C Advincula
The weak thermomechanical properties of commercial 3D printing plastics have limited the technology's application mainly to rapid prototyping. In this report, we demonstrate a simple approach that takes advantage of the metastable, temperature-dependent structure of graphene oxide (GO) to enhance the mechanical properties of conventional 3D-printed resins produced by stereolithography (SLA). A commercially available SLA resin was reinforced with minimal amounts of GO nanofillers and thermally annealed at 50 °C and 100 °C for 12 hours...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28229956/development-of-a-thermosensitive-hama-containing-bio-ink-for-the-fabrication-of-composite-cartilage-repair-constructs
#7
Vivian Hilda Maria Mouser, Anna Abbadessa, Riccardo Levato, Wim Hennink, Tina Vermonden, Debby Gawlitta, Jos Malda
Fine-tuning of bio-ink composition and material processing parameters is crucial for the development of biomechanically relevant cartilage constructs. This study aims to design and develop cartilage constructs with tunable internal architectures and relevant mechanical properties. More specifically, the potential of methacrylated hyaluronic acid (HAMA) added to thermosensitive hydrogels composed of methacrylated poly[N-(2-hydroxypropyl)methacrylamide mono/dilactate] (pHPMA-lac)/polyethylene glycol (PEG) triblock copolymers, to optimize cartilage-like tissue formation by embedded chondrocytes, and enhance printability was explored...
February 23, 2017: Biofabrication
https://www.readbyqxmd.com/read/28229895/impulse-control-disorders-and-levodopa-induced-dyskinesias-in-parkinson-s-disease-an-update
#8
REVIEW
Valerie Voon, T Celeste Napier, Michael J Frank, Veronique Sgambato-Faure, Anthony A Grace, Maria Rodriguez-Oroz, Jose Obeso, Erwan Bezard, Pierre-Olivier Fernagut
Dopaminergic medications used in the treatment of patients with Parkinson's disease are associated with motor and non-motor behavioural side-effects, such as dyskinesias and impulse control disorders also known as behavioural addictions. Levodopa-induced dyskinesias occur in up to 80% of patients with Parkinson's after a few years of chronic treatment. Impulse control disorders, including gambling disorder, binge eating disorder, compulsive sexual behaviour, and compulsive shopping occur in about 17% of patients with Parkinson's disease on dopamine agonists...
March 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28229477/-why-not-you-discourses-of-widening-access-on-uk-medical-school-websites
#9
Kirsty Alexander, Tania Fahey Palma, Sandra Nicholson, Jennifer Cleland
CONTEXT: In the UK, applications to medicine from those in lower socio-economic groups remain low despite significant investments of time, interest and resources in widening access (WA) to medicine. This suggests that medical schools' core messages about WA may be working to embed or further reinforce marginalisation, rather than to combat this. Our objective was to investigate how the value of WA is communicated by UK medical schools through their websites, and how this may create expectations regarding who is 'suitable' for medicine...
February 22, 2017: Medical Education
https://www.readbyqxmd.com/read/28229178/the-consummatory-and-motivational-behaviors-for-natural-rewards-following-long-term-withdrawal-from-morphine-no-anhedonia-but-persistent-maladaptive-behaviors-for-high-value-rewards
#10
Yingying Li, Xigeng Zheng, Na Xu, Yue Zhang, Zhengkui Liu, Yunjing Bai
RATIONALE: The negative affective state, e.g., anhedonia, emerges after abstinence from abused drugs may be linked to the motivational processes of drug craving and relapse. Although anhedonia diminishes over time with drug abstinence, it is not yet rather explicit whether anhedonia exists or not following protracted withdrawal. OBJECTIVES: The behavioral responses to natural rewards were examined after 2 to 3 weeks withdrawal from morphine. Male rats were pretreated with either a binge-like morphine paradigm or daily saline injection for 5 days...
February 22, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28229141/functionalized-diamond-nanothreads-from-benzene-derivatives
#11
J F R V Silveira, A R Muniz
Diamond nanothreads (DNTs) are fully sp(3)-bonded one-dimensional carbon nanostructures, synthesized recently through compression of crystalline benzene. They possess outstanding mechanical strength, suitable for the development of novel nanostructured reinforced materials. In this article, we use density functional theory calculations to investigate the feasibility and physical properties of functionalized DNTs. We show that the stacking and covalent bonding of benzene derivative molecules (toluene, aniline, phenol and fluorobenzene) may lead to stable configurations analogous to benzene-derived DNTs, with functional groups (-CH3, -NH2, -OH, -F) covalently attached to the surface...
February 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28229020/an-open-source-device-for-operant-licking-in-rats
#12
Matthew Longley, Ethan L Willis, Cindy X Tay, Hao Chen
We created an easy-to-use device for operant licking experiments and another device that records environmental variables. Both devices use the Raspberry Pi computer to obtain data from multiple input devices (e.g., radio frequency identification tag readers, touch and motion sensors, environmental sensors) and activate output devices (e.g., LED lights, syringe pumps) as needed. Data gathered from these devices are stored locally on the computer but can be automatically transferred to a remote server via a wireless network...
2017: PeerJ
https://www.readbyqxmd.com/read/28228734/%C3%AE-subunits-functionally-differentiate-human-kv4-3-potassium-channel-splice-variants
#13
Geoffrey W Abbott
The human ventricular cardiomyocyte transient outward K(+) current (Ito) mediates the initial phase of myocyte repolarization and its disruption is implicated in Brugada Syndrome and heart failure (HF). Human cardiac Ito is generated primarily by two Kv4.3 splice variants (Kv4.3L and Kv4.3S, diverging only by a C-terminal, S6-proximal, 19-residue stretch unique to Kv4.3L), which are differentially remodeled in HF, but considered functionally alike at baseline. Kv4.3 is regulated in human heart by β subunits including KChIP2b and KCNEs, but their effects were previously assumed to be Kv4...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28228667/three-new-species-of-the-killifish-genus-melanorivulus-from-the-central-brazilian-cerrado-savanna-cyprinodontiformes-aplocheilidae
#14
Wilson J E M Costa
Three new species are described from the Neotropical region comprising the Cerrado savannas of the central Brazilian plateaus, which is among the most important biodiversity centres in the world. These species are considered closely related to Melanorivulus dapazi from the same region, with which they share the presence of a rudimentary interarcual cartilage and a dark reddish brown distal margin on the male anal fin. The group comprising Melanorivulus dapazi and the three new species is here named as the Melanorivulus dapazi species group...
2017: ZooKeys
https://www.readbyqxmd.com/read/28228514/differentiating-causality-and-correlation-in-allometric-scaling-ant-colony-size-drives-metabolic-hypometry
#15
James S Waters, Alison Ochs, Jennifer H Fewell, Jon F Harrison
Metabolic rates of individual animals and social insect colonies generally scale hypometrically, with mass-specific metabolic rates decreasing with increasing size. Although this allometry has wide ranging effects on social behaviour, ecology and evolution, its causes remain controversial. Because it is difficult to experimentally manipulate body size of organisms, most studies of metabolic scaling depend on correlative data, limiting their ability to determine causation. To overcome this limitation, we experimentally reduced the size of harvester ant colonies (Pogonomyrmex californicus) and quantified the consequent increase in mass-specific metabolic rates...
February 22, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28228205/long-term-surgical-outcome-of-trocar-site-hernia-repair
#16
Yoon-Hye Kwon, Eun Kyung Choe, Seung-Bum Ryoo, Jeong-Ki Kim, Kyu Joo Park
Port site hernias are emerging as a problematic complication of laparoscopic surgery. The aim of this study was to elucidate the characteristics of port site hernias and determine the long-term outcomes based on the interval between primary surgery and hernia occurrence. Twenty-four patients were surgically treated for trocar site hernia between 1997 and 2013. The patients were grouped into early-onset group (EOG; less than one month) and late-onset group (LOG; more than one month) based on the interval between laparoscopic surgery and hernia onset...
February 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28227964/cross-entropy-optimization-for-neuromodulation
#17
Harleen K Brar, Yunpeng Pan, Babak Mahmoudi, Evangelos A Theodorou, Harleen K Brar, Yunpeng Pan, Babak Mahmoudi, Evangelos A Theodorou, Yunpeng Pan, Harleen K Brar, Babak Mahmoudi, Evangelos A Theodorou
This study presents a reinforcement learning approach for the optimization of the proportional-integral gains of the feedback controller represented in a computational model of epilepsy. The chaotic oscillator model provides a feedback control systems view of the dynamics of an epileptic brain with an internal feedback controller representative of the natural seizure suppression mechanism within the brain circuitry. Normal and pathological brain activity is simulated in this model by adjusting the feedback gain values of the internal controller...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227165/reward-value-is-encoded-in-primary-somatosensory-cortex-and-can-be-decoded-from-neural-activity-during-performance-of-a-psychophysical-task
#18
David B McNiel, John S Choi, John P Hessburg, Joseph T Francis, David B McNiel, John S Choi, John P Hessburg, Joseph T Francis, John P Hessburg, Joseph T Francis, John S Choi, David B McNiel
Encoding of reward valence has been shown in various brain regions, including deep structures such as the substantia nigra as well as cortical structures such as the orbitofrontal cortex. While the correlation between these signals and reward valence have been shown in aggregated data comprised of many trials, little work has been done investigating the feasibility of decoding reward valence on a single trial basis. Towards this goal, one non-human primate (macaca radiata) was trained to grip and hold a target level of force in order to earn zero, one, two, or three juice rewards...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227163/maximum-correntropy-based-attention-gated-reinforcement-learning-designed-for-brain-machine-interface
#19
Hongbao Li, Fang Wang, Qiaosheng Zhang, Shaomin Zhang, Yiwen Wang, Xiaoxiang Zheng, Jose C Principe, Hongbao Li, Fang Wang, Qiaosheng Zhang, Shaomin Zhang, Yiwen Wang, Xiaoxiang Zheng, Jose C Principe, Yiwen Wang, Jose C Principe, Xiaoxiang Zheng, Qiaosheng Zhang, Shaomin Zhang, Hongbao Li, Fang Wang
Reinforcement learning is an effective algorithm for brain machine interfaces (BMIs) which interprets the mapping between neural activities with plasticity and the kinematics. Exploring large state-action space is difficulty when the complicated BMIs needs to assign credits over both time and space. For BMIs attention gated reinforcement learning (AGREL) has been developed to classify multi-actions for spatial credit assignment task with better efficiency. However, the outliers existing in the neural signals still make interpret the neural-action mapping difficult...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227144/optimal-medication-dosing-from-suboptimal-clinical-examples-a-deep-reinforcement-learning-approach
#20
Shamim Nemati, Mohammad M Ghassemi, Gari D Clifford, Shamim Nemati, Mohammad M Ghassemi, Gari D Clifford, Gari D Clifford, Mohammad M Ghassemi
Misdosing medications with sensitive therapeutic windows, such as heparin, can place patients at unnecessary risk, increase length of hospital stay, and lead to wasted hospital resources. In this work, we present a clinician-in-the-loop sequential decision making framework, which provides an individualized dosing policy adapted to each patient's evolving clinical phenotype. We employed retrospective data from the publicly available MIMIC II intensive care unit database, and developed a deep reinforcement learning algorithm that learns an optimal heparin dosing policy from sample dosing trails and their associated outcomes in large electronic medical records...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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