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https://www.readbyqxmd.com/read/29333689/2d-black-phosphorus-reinforced-3d-printed-scaffolds-a-stepwise-countermeasure-for-osteosarcoma
#1
Bowen Yang, Junhui Yin, Yu Chen, Shanshan Pan, Heliang Yao, Youshui Gao, Jianlin Shi
With the ever-deeper understanding of nano-bio interactions and the development of fabrication methodologies of nanomaterials, various therapeutic platforms based on nanomaterials have been developed for next-generation oncological applications, such as osteosarcoma therapy. In this work, a black phosphorus (BP) reinforced 3D-printed scaffold is designed and prepared to provide a feasible countermeasure for the efficient localized treatment of osteosarcoma. The in situ phosphorus-driven, calcium-extracted biomineralization of the intra-scaffold BP nanosheets enables both photothermal ablation of osteosarcoma and the subsequent material-guided bone regeneration in physiological microenvironment, and in the meantime endows the scaffolds with unique physicochemical properties favoring the whole stepwise therapeutic process...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333677/diminished-alternative-reinforcement-as-a-mechanism-linking-conduct-problems-and-substance-use-in-adolescence-a-longitudinal-examination
#2
Rubin Khoddam, Junhan Cho, N J Jackson, Adam M Leventhal
AIMS: To determine whether diminished alternative reinforcement (i.e., engagement and enjoyment from substance-free activities) mediated the longitudinal association of conduct problems with substance use in early-mid adolescence. DESIGN: Structural equation modeling tested whether the association between Wave 1 (baseline) conduct problems and Wave 3 (24-month follow-up) substance use outcomes was mediated by diminished alternative reinforcement at Wave 2 (12-month follow-up)...
January 14, 2018: Addiction
https://www.readbyqxmd.com/read/29333629/surface-engineering-for-extremely-enhanced-charge-separation-and-photocatalytic-hydrogen-evolution-on-g-c3-n4
#3
Yu Yu, Wei Yan, Xiaofang Wang, Pei Li, Wenyu Gao, Haihan Zou, Songmei Wu, Kejian Ding
Reinforcing the carrier separation is the key issue to maximize the photocatalytic hydrogen evolution (PHE) efficiency of graphitic carbon nitride (g-C3 N4 ). By a surface engineering of gradual doping of graphited carbon rings within g-C3 N4 , suitable energy band structures and built-in electric fields are established. Photoinduced electrons and holes are impelled into diverse directions, leading to a 21-fold improvement in the PHE rate.
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333196/brief-report-reduced-anxiety-following-pivotal-response-treatment-in-young-children-with-autism-spectrum-disorder
#4
Jiedi Lei, Denis G Sukhodolsky, Sebiha M Abdullahi, Megan L Braconnier, Pamela Ventola
Up to 40% of children with Autism Spectrum Disorder (ASD) exhibit co-occurring anxiety symptoms. Despite recent success in mitigating anxiety symptoms in school-aged children with ASD (mean age >9 years) using adapted versions of Cognitive Behavioural Therapy, little is known about potential treatment outcomes for younger children. To address the gap in the literature, this open-label study evaluated change in anxiety following a 16-week open-label trial of Pivotal Response Treatment (PRT) in children with ASD aged 4-8 years...
November 2017: Research in Autism Spectrum Disorders
https://www.readbyqxmd.com/read/29333057/family-counts-deciding-when-to-murder-among-the-icelandic-vikings
#5
Markel Palmstierna, Anna Frangou, Anna Wallette, Robin Dunbar
In small scale societies, lethal attacks on another individual usually invite revenge by the victim's family. We might expect those who perpetrate such attacks to do so only when their own support network (mainly family) is larger than that of the potential victim so as to minimise the risk of retaliation. Using data from Icelandic family sagas, we show that this prediction holds whether we consider biological kin or affinal kin (in-laws): on average, killers had twice as many relatives as their victims. These findings reinforce the importance of kin as a source of implicit protection even when they are not physically present...
March 2017: Evolution and Human Behavior: Official Journal of the Human Behavior and Evolution Society
https://www.readbyqxmd.com/read/29332937/improving-immune-vascular-crosstalk-for-cancer-immunotherapy
#6
REVIEW
Yuhui Huang, Betty Y S Kim, Charles K Chan, Stephen M Hahn, Irving L Weissman, Wen Jiang
The vasculature of tumours is highly abnormal and dysfunctional. Consequently, immune effector cells have an impaired ability to penetrate solid tumours and often exhibit compromised functions. Normalization of the tumour vasculature can enhance tissue perfusion and improve immune effector cell infiltration, leading to immunotherapy potentiation. However, recent studies have demonstrated that the stimulation of immune cell functions can also help to normalize tumour vessels. In this Opinion article, we propose that the reciprocal regulation between tumour vascular normalization and immune reprogramming forms a reinforcing loop that reconditions the tumour immune microenvironment to induce durable antitumour immunity...
January 15, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29332531/supporting-rape-survivors-through-the-criminal-injuries-compensation-scheme-an-exploration-of-english-and-welsh-independent-sexual-violence-advisors-experiences
#7
Olivia Smith, Jessica Galey
English and Welsh responses to rape have long been critically examined, leading to attempted improvements in the criminal justice system. Despite this, little attention has been paid to the Criminal Injuries Compensation Scheme (CICS) and the difficulties applying it to rape. To begin addressing this gap, researchers interviewed three, and qualitatively surveyed 22, Independent Sexual Violence Advisors. The findings suggest that CICS may not only reinforce rape myths and disadvantage vulnerable survivors, but is also a source of validation and contributes to survivor justice...
October 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29331756/-you-re-repulsive-limits-to-acceptable-drunken-comportment-for-young-adults
#8
Sarah MacLean, Amy Pennay, Robin Room
BACKGROUND: Researchers have described a 'culture of intoxication' among young people. Yet drunkenness remains a socially risky practice with potential to evoke emotions of irritation and even disgust. We consider intoxicated practices that young adults in Melbourne, Australia, described as distasteful, to identify contemporary cultural forces that constrain intoxication and limit how it is enacted. METHOD: Interviews were conducted with 60 participants in Melbourne, Australia, each with recent drinking experience...
January 11, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29331699/simultaneous-social-causation-and-social-drift-longitudinal-analysis-of-depression-and-poverty-in-south-africa
#9
Crick Lund, Annibale Cois
BACKGROUND: Two theories have been proposed to explain the observed association between depression and poverty, namely social causation and social drift. Little is known regarding the relative importance of social causation and social drift in low and middle-income countries, where poverty is more severe and where most of the world's depressed individuals live. METHODS: We analysed nationally representative longitudinal data from the National Income Dynamics Study in South Africa and simultaneously tested social causation and social drift hypotheses using structural equation modelling across three waves...
December 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331656/effect-of-a-wearable-patient-sensor-on-care-delivery-for-preventing-pressure-injuries-in-acutely-ill-adults-a-pragmatic-randomized-clinical-trial-ls-hapi-study
#10
David Pickham, Nic Berte, Mike Pihulic, Andre Valdez, Barbara Mayer, Manisha Desai
IMPORTANCE: Though theoretically sound, studies have failed to demonstrate the benefit of routine repositioning of at-risk patients for the prevention of hospital acquired pressure injuries. OBJECTIVE: To assess the clinical effectiveness of a wearable patient sensor to improve care delivery and patient outcomes by increasing the total time with turning compliance and preventing pressure injuries in acutely ill patients. DESIGN: Pragmatic, investigator initiated, open label, single site, randomized clinical trial...
December 30, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29331537/preparation-of-acetylated-nanofibrillated-cellulose-from-corn-stalk-microcrystalline-cellulose-and-its-reinforcing-effect-on-starch-films
#11
Li Cheng, Dongli Zhang, Zhengbiao Gu, Zhaofeng Li, Yan Hong, Caiming Li
Acetylated nanofibrillated cellulose (ANFC) with different degrees of substitution (DS) was prepared from corn-stalk microcrystalline cellulose (MCC) using chemical-mechanical combined processes. The physicochemical properties of nanofibrillated cellulose (NFC) and ANFC were investigated together with the influence of added nanoparticles on the mechanical properties of starch films. The acetylation reaction was monitored by Fourier transform infrared (FT-IR) and titration. Particle size and morphological of NFC and ANFC were studied by atomic force microscope (AFM)...
January 10, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29331530/a-qualitative-synthesis-of-pharmacist-other-health-professional-and-lay-perspectives-on-the-role-of-community-pharmacy-in-facilitating-care-for-people-with-long-term-conditions
#12
N J Hall, G Donovan, S Wilkes
BACKGROUND: There is increasing interest in an enhanced role for community pharmacy (CP) in facilitating care for people with long-term conditions (LTCs). It is important to understand the perspectives of stakeholders in order to identify key issues that may impact on future development of the role and related services. OBJECTIVES: Explore pharmacist, other health professional and lay perspectives on the role of CP in facilitating care for people with LTCs. METHODS: Synthesis of qualitative research from UK based studies published between 2007 and January 2017 using a meta-ethnographic interpretative approach...
January 4, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29331491/investigating-the-relationship-between-cardiac-interoception-and-autonomic-cardiac-control-using-a-predictive-coding-framework
#13
Andrew P Owens, Karl J Friston, David A Low, Christopher J Mathias, Hugo D Critchley
Predictive coding models, such as the 'free-energy principle' (FEP), have recently been discussed in relation to how interoceptive (afferent visceral feedback) signals update predictions about the state of the body, thereby driving autonomic mediation of homeostasis. This study appealed to 'interoceptive inference', under the FEP, to seek new insights into autonomic (dys)function and brain-body integration by examining the relationship between cardiac interoception and autonomic cardiac control in healthy controls and patients with forms of orthostatic intolerance (OI); to (i) seek empirical support for interoceptive inference and (ii) delineate if this relationship was sensitive to increased interoceptive prediction error in OI patients during head-up tilt (HUT)/symptom provocation...
January 9, 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29331488/a-potential-utilization-of-end-of-life-tyres-as-recycled-carbon-black-in-epdm-rubber
#14
M Sagar, K Nibedita, N Manohar, K Raj Kumar, S Suchismita, A Pradnyesh, A Babul Reddy, E Rotimi Sadiku, U N Gupta, P Lachit, J Jayaramudu
End-of-life (EOL) tyres and their decomposition present severe environmental concern due to their resistance to moisture, oxygen, natural degradation, etc. Pyrolysis is considered to be the most effective and sustainable process for recycling, due to its eco-friendly process. The current work studied the effect of recycled carbon black (rCB), obtained from the pyrolysis of EOL tyres, on the properties of ethylene propylene diene rubber (EPDM). The rCB was characterized by scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and chemical methods...
January 10, 2018: Waste Management
https://www.readbyqxmd.com/read/29330982/assessment-of-safety-levels-in-operation-rooms-at-two-major-tertiary-care-public-hospitals-of-karachi-safe-surgery-saves-life
#15
Muhammad Saeed Minhas, Muhammad Muzzammil, Jahanzeb Effendi
BACKGROUND: The objectives of this study are to determine the knowledge and attitude towards surgical safety among the health care professionals including surgeons, anaesthetist, hospital administrators, and operation room personnel and raise awareness towards the importance of safe surgery. METHODS: A pilot cross- sectional study of 543 healthcare providers working in the operating rooms and the surgical intensive care units was conducted in two tertiary care hospitals, within a study period of one month...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29330920/macronutrient-and-fibre-intake-of-young-spanish-children-with-reference-to-their-in-utero-growth-status-are-they-eating-a-healthy-diet
#16
Rozina Nuruddin, Mireia Urpi-Sarda, Merida Rodriguez-Lopez, Dolores Garcia-Arenas, Eduard Gratacos, Fatima Crispi, Ruthy Acosta-Rojas
AIM: To compare macronutrient and fibre intake by pre-school children born with intra-uterine growth restriction (IUGR) or as appropriate for gestational age (AGA) and to compare their intake with paediatric nutritional recommendations for identification of potential areas of modification during early life. METHODS: A parental 3-day dietary record was obtained for children of age 1-6 years, born at Hospital Clinic, Barcelona, Spain (2002-2007) with IUGR (n = 37) or AGA (n = 53)...
January 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29330594/coding-valence-in-touchscreen-interactions-hand-dominance-and-lateral-movement-influence-valence-appraisals-of-emotional-pictures
#17
Sergio Cervera Torres, Susana Ruiz Fernández, Martin Lachmair, Peter Gerjets
The Body-Specificity Hypothesis postulates that the space surrounding the dominant hand is perceived as positive due to the motor fluency of this hand, whereas the space surrounding the non-dominant hand is perceived as negative. Experimental studies based on this theoretical framework also revealed associations between affective valence and hand dominance (i.e., dominant hand-positive; non-dominant hand-negative), or lateral movements of the hands (i.e., right hand toward the right space-positive; left hand toward the left space-positive)...
January 12, 2018: Psychological Research
https://www.readbyqxmd.com/read/29330439/induction-of-protein-citrullination-and-auto-antibodies-production-in-murine-exposed-to-nickel-nanomaterials
#18
Bashir M Mohamed, Noreen T Boyle, Anja Schinwald, Bruno Murer, Ronan Ward, Omar K Mahfoud, Tatsiana Rakovich, Kieran Crosbie-Staunton, Steven G Gray, Ken Donaldson, Yuri Volkov, Adriele Prina-Mello
Citrullination, or the post-translational deimination of polypeptide-bound arginine, is involved in several pathological processes in the body, including autoimmunity and tumorigenesis. Recent studies have shown that nanomaterials can trigger protein citrullination, which might constitute a common pathogenic link to disease development. Here we demonstrated auto-antibody production in serum of nanomaterials-treated mice. Citrullination-associated phenomena and PAD levels were found to be elevated in nanomaterials -treated cell lines as well as in the spleen, kidneys and lymph nodes of mice, suggesting a systemic response to nanomaterials injection, and validated in human pleural and pericardial malignant mesothelioma (MM) samples...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330014/frequency-of-red-blood-cell-genotypes-in-multi-transfused-patients-and-blood-donors-from-minas-gerais-southeast-brazil
#19
Vitor Mendonça Alves, Fernanda Bernadelli De Vito, Paulo Roberto Juliano Martins, Sheila Soares Silva, Lilian Castilho, Helio Moraes-Souza
BACKGROUND AND OBJECTIVES: The frequency of red blood cell (RBC) antigens in Brazil varies due to differences in the ethnic groups in different regions; however, these studies have not been performed in Minas Gerais, where African admixture is more prevalent in comparison with other states. Due to these facts, this study aimed to determine the frequency of RBC genotypes on Rh, Kell, Duffy and Kidd systems in blood donors and multi-transfused patients from Minas Gerais, Southeast Brazil...
December 16, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29329890/pain-motion-and-function-comparison-of-two-exercise-protocols-for-the-rotator-cuff-and-scapular-stabilizers-in-patients-with-subacromial-syndrome
#20
Eva Vallés-Carrascosa, Tomás Gallego-Izquierdo, José Jesús Jiménez-Rejano, Gustavo Plaza-Manzano, Daniel Pecos-Martín, Fidel Hita-Contreras, Alexander Achalandabaso Ochoa
STUDY DESIGN: Randomized clinical trial. INTRODUCTION: Eccentric exercise (EE) was shown to be an effective treatment in tendinopathies. However, the evidence of its effectiveness in subacromial syndrome (SS) is scarce. Moreover, consensus has not been reached on whether best results for SS are obtained by means of EE with or without pain. PURPOSE OF THE STUDY: The purpose of this is to compare the effect on pain, active range of motion (AROM), and shoulder function of an exercise protocol performed with pain <40 mm Visual Analog Scale (VAS) and without pain, in patients with SS...
January 9, 2018: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
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