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https://www.readbyqxmd.com/read/28346923/gut-brain-axis-and-behavior
#1
Clair R Martin, Emeran A Mayer
In the last 5 years, interest in the interactions among the gut microbiome, brain, and behavior has exploded. Preclinical evidence supports a role of the gut microbiome in behavioral responses associated with pain, emotion, social interactions, and food intake. Limited, but growing, clinical evidence comes primarily from associations of gut microbial composition and function to behavioral and clinical features and brain structure and function. Converging evidence suggests that the brain and the gut microbiota are in bidirectional communication...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28346726/predictive-value-of-p63-ki-67-and-survivin-expression-in-oral-leukoplakia-a-tissue-microarray-study
#2
Kelly Bienk Dias, Anacláudia Pereira Costa Flores, Márcia Gaiger Oliveira, Pantelis Varvaki Rados, Manoel Sant'ana Filho
The aim of this study was to analyze the immunohistochemical expression of survivin, ki-67, and p63 in oral leukoplakic lesions, histopathologically differentiated into dysplastic and nondysplastic. A tissue microarray containing 57 samples of biopsies from clinically classified lesions, such as leukoplakia, was immunolabeled for survivin, ki-67, and p63. Samples were scored for percentage of positively stained. Scores were designated as follows: low = less than 25% of positive cells; and high = more than 25% of positive cells...
March 27, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28346056/alcohol-and-drug-use-and-aberrant-drug-related-behavior-among-patients-on-chronic-opioid-therapy
#3
Cynthia I Campbell, Andrea H Kline-Simon, Michael Von Korff, Kathleen W Saunders, Constance Weisner
OBJECTIVE: To better identify individuals on chronic opioid therapy (COT) at high risk for aberrant-drug related behavior (ADRB). We examine whether patients with low level alcohol and drug use have similar characteristics to those with alcohol and drug disorders. We then examined the relationship of alcohol and drug use to ADRBs among COT patients. METHODS: The sample was 972 randomly selected COT patients (age 21-80 years old) from a large health system in Northern California, USA, and interviewed in 2009...
March 27, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28346007/lipid-emulsion-improves-survival-in-animal-models-of-local-anesthetic-toxicity-a-meta-analysis
#4
Michael R Fettiplace, Daniel J McCabe
INTRODUCTION: The Lipid Emulsion Therapy workgroup, organized by the American Academy of Clinical Toxicology, recently conducted a systematic review, which subjectively evaluated lipid emulsion as a treatment for local anesthetic toxicity. We re-extracted data and conducted a meta-analysis of survival in animal models. METHODS: We extracted survival data from 26 publications and conducted a random-effect meta-analysis based on odds ratio weighted by inverse variance...
February 17, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28345866/biocompatible-hydroxylated-boron-nitride-nanosheets-polyvinyl-alcohol-interpenetrating-hydrogels-with-enhanced-mechanical-and-thermal-responses
#5
Lin Jing, Hongling Li, Roland Yingjie Tay, Bo Sun, Siu Hon Tsang, Olivier Cometto, Jinjun Lin, Edwin Hang Tong Teo, Alfred Iing Yoong Tok
Polyvinyl alcohol (PVA) hydrogels with tissue-like viscoelasticity, excellent biocompatibility and high hydrophilicity have been considered as promising cartilage replacement materials. However, lack of sufficient mechanical properties is a critical barrier to their usage as load-bearing cartilage substitutes. Herein, we report hydroxylated boron nitride nanosheets (OH-BNNS)/PVA interpenetrating hydrogels by cyclically freezing/thawing the aqueous mixture of PVA and highly hydrophilic OH-BNNS (up to 0.6 mg/mL, two times the highest reported so far)...
March 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28345686/-effectiveness-of-physical-activity-intervention-at-workplace
#6
REVIEW
Marzena Malińska
A physical activity is a key factor contributing to the improvement and maintenance of one's general health. Although this issue is by no means limited to the workplace, it is precisely the work environment that can provide the basis for keeping and reinforcing more health-conscious attitudes and lifestyles, including programs promoting a physical activity. The paper presents an analysis of the literature on the effectiveness of physical activity intervention at the workplace. Particular attention is paid to the impact of the physical activity programs on musculoskeletal disorders, absenteeism, work ability, physical capacity and body weight of the participants...
March 24, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28345310/individual-factors-that-influence-experiences-and-perceptions-of-stigma-and-discrimination-towards-people-with-mental-illness-in-ghana
#7
Sebastian Gyamfi, Kathy Hegadoren, Tanya Park
People with a mental illness often encounter stigma and discrimination from a variety of sources, reinforcing negative self-perceptions and influencing their health and well-being. Even though support systems and attitudes of the general public act as powerful sources of stigma, views and perceptions held by people with mental illness also influence their sensitivity to the experiences they encounter. The aim of the present qualitative study was to examine perceptions of stigma and discrimination and self-stigma in individuals diagnosed with a mental illness...
March 27, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28344515/burnout-among-nurses-working-in-social-welfare-centers-for-the-disabled
#8
Eleni Lahana, Konstantina Papadopoulou, Olga Roumeliotou, Andreas Tsounis, Pavlos Sarafis, Dimitris Niakas
BACKGROUND: In the healthcare sector, we often come across the burnout syndrome. It is an occupational syndrome which causes, physical and emotional exhaustion. More information is needed on the dangers of burnout and how often it occurs in healthcare. The purpose of this study was to investigate burnout and factors associated with the syndrome among nurses working with people that are mentally challenged. METHODS: A cross-sectional survey was conducted, among 180 nurses working in public health centers for the disabled in multiple regions of Greece...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28344348/metal-homeostasis-and-resistance-in-bacteria
#9
REVIEW
Pete Chandrangsu, Christopher Rensing, John D Helmann
Metal ions are essential for many reactions, but excess metals can be toxic. In bacteria, metal limitation activates pathways that are involved in the import and mobilization of metals, whereas excess metals induce efflux and storage. In this Review, we highlight recent insights into metal homeostasis, including protein-based and RNA-based sensors that interact directly with metals or metal-containing cofactors. The resulting transcriptional response to metal stress takes place in a stepwise manner and is reinforced by post-transcriptional regulatory systems...
March 27, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28343989/social-interaction-food-scent-or-toys-a-formal-assessment-of-domestic-pet-and-shelter-cat-felis-silvestris-catus-preferences
#10
Kristyn R Vitale Shreve, Lindsay R Mehrkam, Monique A R Udell
Domestic cats (Felis silvestris catus) engage in a variety of relationships with humans and can be conditioned to engage in numerous behaviors using Pavlovian and operant methods Increasingly cat cognition research is providing evidence of their complex socio-cognitive and problem solving abilities. Nonetheless, it is still common belief that cats are not especially sociable or trainable. This disconnect may be due, in part, to a lack of knowledge of what stimuli cats prefer, and thus may be most motivated to work for...
March 23, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28343963/maternally-inherited-stable-intronic-sequence-rna-triggers-a-self-reinforcing-feedback-loop-during-development
#11
Mandy Li-Ian Tay, Jun Wei Pek
Maternally inherited noncoding RNAs (ncRNAs) can regulate zygotic gene expression across generations [1-4]. Recently, many stable intronic sequence RNAs (sisRNAs), which are byproducts of pre-mRNA splicing, were found to be maternally deposited and persist till zygotic transcription in Xenopus and Drosophila [5-7]. In various organisms, sisRNAs can be in linear or circular conformations, and they have been suggested to regulate host gene expression [5-10]. It is unknown whether maternally deposited sisRNAs can regulate zygotic gene expression in the embryos...
March 17, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28343924/properties-of-discontinuous-s2-glass-fiber-particulate-reinforced-resin-composites-with-two-different-fiber-length-distributions
#12
Qiting Huang, Sufyan Garoushi, Zhengmei Lin, Jingwei He, Wei Qin, Fang Liu, Pekka Kalevi Vallittu, Lippo Veli Juhana Lassila
PURPOSE: To investigate the reinforcing efficiency and light curing properties of discontinuous S2-glass fiber-particulate reinforced resin composite and to examine length distribution of discontinuous S2-glass fibers after a mixing process into resin composite. METHODS: Experimental S2-glass fiber-particulate reinforced resin composites were prepared by mixing 10wt% of discontinuous S2-glass fibers, which had been manually cut into two different lengths (1.5 and 3...
March 23, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28343837/gastrointestinal-cancers-screening-and-early-detection
#13
REVIEW
Joyce P Griffin-Sobel
OBJECTIVE: To present an overview of current practices in the screening and early detection of gastrointestinal cancers. DATA SOURCES: Literature reviews. CONCLUSION: Screening for gastrointestinal cancers is less than desirable, particularly in underserved populations. There are inadequate methods of screening for early detection of esophageal and gastric cancers. IMPLICATIONS FOR NURSING PRACTICE: Education of patients is needed to reinforce the importance of screening for gastrointestinal cancers...
March 23, 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/28343697/modeling-avoidance-in-mood-and-anxiety-disorders-using-reinforcement-learning
#14
Anahit Mkrtchian, Jessica Aylward, Peter Dayan, Jonathan P Roiser, Oliver J Robinson
BACKGROUND: Serious and debilitating symptoms of anxiety are the most common mental health problem worldwide, accounting for around 5% of all adult years lived with disability in the developed world. Avoidance behavior-avoiding social situations for fear of embarrassment, for instance-is a core feature of such anxiety. However, as for many other psychiatric symptoms the biological mechanisms underlying avoidance remain unclear. METHODS: Reinforcement learning models provide formal and testable characterizations of the mechanisms of decision making; here, we examine avoidance in these terms...
February 8, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28343626/the-rat-a-gorical-imperative-moral-intuition-and-the-limits-of-affective-learning
#15
Joshua D Greene
Decades of psychological research have demonstrated that intuitive judgments are often unreliable, thanks to their inflexible reliance on limited information (Kahneman, 2003, 2011). Research on the computational underpinnings of learning, however, indicates that intuitions may be acquired by sophisticated learning mechanisms that are highly sensitive and integrative. With this in mind, Railton (2014) urges a more optimistic view of moral intuition. Is such optimism warranted? Elsewhere (Greene, 2013) I've argued that moral intuitions offer reasonably good advice concerning the give-and-take of everyday social life, addressing the basic problem of cooperation within a "tribe" ("Me vs...
March 23, 2017: Cognition
https://www.readbyqxmd.com/read/28343173/fast-track-protocols-using-highly-sensitive-troponin-assays-for-ruling-out-and-ruling-in-non-st-elevation-acute-coronary-syndrome
#16
Simona Ferraro, Alberto Dolci, Mauro Panteghini
The introduction of "highly sensitive" cardiac troponin assays (hsTn) has reinforced the evidence that only serial testing incorporated in running algorithms allows a more accurate diagnosis of acute myocardial infarction. In this report, we consider the available evidence supporting the use of fast track protocols for ruling out and ruling in non-ST elevation myocardial infarction (NSTEMI) and compare it with the content of recently released guideline by the European Society of Cardiology, noting some uncomfortable aspects that need urgent clarification and/or revision...
March 27, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28343062/the-material-moral-and-affective-worlds-of-dealing-and-crime-among-young-men-entrenched-in-an-inner-city-drug-scene
#17
Danya Fast, Jean Shoveller, Thomas Kerr
A large body of previous research has elucidated how involvement in drug dealing and crime among marginalized urban youth who use drugs is shaped by the imperatives of addiction and survival in the context of poverty. However, a growing body of research has examined how youth's involvement in these activities is shaped by more expansive desires and moralities. In this paper, we examine the material, moral, and affective worlds of loosely gang affiliated, street level dealing and crime among one group of young men in Vancouver, Canada...
March 23, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28342694/nursing-led-home-visits-post-hospitalization-for-children-with-medical-complexity
#18
Sarah Wells, Margaret O'Neill, Jayne Rogers, Kevin Blaine, Amy Hoffman, Sarah McBride, Meghan M Tschudy, Igor Shumskiy, Sangeeta Mauskar, Jay G Berry
PURPOSE: Hospital discharge for children with medical complexity (CMC) can be challenging for families. Home visits could potentially benefit CMC and their families after leaving the hospital. We assessed the utility of post-discharge home visits to identify and address health problems for recently hospitalized CMC. DESIGN AND METHODS: A prospective study of 36 CMC admitted to a children's hospital from 4/15/2015 to 4/14/2016 identified with a possible high risk of hospital readmission and offered a post-discharge home visit within 72h of discharge...
March 23, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28342615/effect-of-increasing-body-condition-on-oxidative-stress-and-mitochondrial-biogenesis-in-subcutaneous-adipose-tissue-depot-of-nonlactating-dairy-cows
#19
L Laubenthal, L Ruda, N Sultana, J Winkler, J Rehage, U Meyer, S Dänicke, H Sauerwein, S Häussler
With the onset of lactation, dairy cows with a body condition score >3.5 are sensitive to oxidative stress and metabolic disorders. Adipose tissue (AT) can adapt to varying metabolic demands and energy requirements by the plasticity of its size during lactation. In AT, angiogenesis is necessary to guarantee sufficient oxygen and nutrient supply for adipocytes. Cellular energy metabolism is reflected mainly by mitochondria, which can be quantified by the mitochondrial DNA copy number per cell. In the present study, we aimed to investigate the effect of overconditioning on angiogenesis and mitochondrial biogenesis in AT of nonlactating cows, irrespective of the physiological influences of lactation and pregnancy...
March 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28342472/-the-room-of-errors-a-fun-learning-tool
#20
Émilie Estival, Justine Sinoquet, Franck Cluzel
Simulation in health care, a source of innovative pedagogical developments, is particularly well-suited to the training of nursing teams. It enables them to acquire or reinforce their knowledge, without any risk for the patients, in a calm and reassuring environment. In psychiatry in particular, the use of a room of errors constitutes a useful learning tool for professionals.
March 2017: Soins; la Revue de Référence Infirmière
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