Saveliy A Sheetikov, Alexandra A Khmelevskaya, Ksenia V Zornikova, Ivan V Zvyagin, Alina S Shomuradova, Yana V Serdyuk, Naina T Shakirova, Iuliia O Peshkova, Aleksei Titov, Dmitrii S Romaniuk, Irina A Shagina, Dmitry M Chudakov, Dmitry O Kiryukhin, Olga V Shcherbakova, Ekaterina G Khamaganova, Vitalina Dzutseva, Andrei Afanasiev, Apollinariya V Bogolyubova, Grigory A Efimov
Adenovirus vaccines, particularly the COVID-19 Ad5-nCoV adenovirus vaccine, have emerged as promising tools in the fight against infectious diseases. In this study, we investigated the structure of the T cell response to the Spike protein of the SARS-CoV-2 virus used in the COVID-19 Ad5-nCoV adenoviral vaccine in a phase 3 clinical trial (NCT04540419). In 69 participants, we collected peripheral blood samples at four time points after vaccination or placebo injection. Sequencing of T cell receptor repertoires from Spike-stimulated T cell cultures at day 14 from 17 vaccinated revealed a more diverse CD4+ T cell repertoire compared to CD8+ ...
2024: Frontiers in Immunology