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Optic nerve ischemia

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https://www.readbyqxmd.com/read/29552298/synergistic-neuroprotective-effect-of-rasagiline-and-idebenone-against-retinal-ischemia-reperfusion-injury-via-the-lin28-let-7-dicer-pathway
#1
Dawei Lei, Zhengbo Shao, Xinrong Zhou, Huiping Yuan
Retinal ischemia-reperfusion (RIR) injury causes neuronal degeneration and initiates various optic nerve diseases. This study aimed to investigate the synergistic neuroprotective effect of rasagiline and idebenone against RIR injury. A combination of rasagiline and idebenone was administered intraperitoneally immediately after establishment of the RIR model. Treatment with the combination of the two drugs resulted in a significant restoration of retinal thickness and retinal ganglion cells. Apoptosis of cells in ganglion cell layers was also ameliorated, suggesting that the effect of the two drugs was synergistic and the expression of brain-derived neurotrophic factor increased...
February 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29551422/incidence-risk-factors-and-management-of-blindness-after-orbital-surgery
#2
Sarah M Jacobs, Colin P McInnis, Matthew Kapeles, Shu-Hong Chang
PURPOSE: Severe vision loss is a risk of orbital surgery which physicians should counsel patients about, but the overall risk rate is unknown. This research was conducted to determine the risk of severe vision loss related to orbital surgery. DESIGN: Retrospective review. PARTICIPANTS: Patients who underwent orbital surgery at either of 2 academic medical centers between January 1994 and December 2014. METHODS: A billing database search was conducted to identify all patients who had orbital surgery during the study period, cross-checked against diagnostic codes related to vision loss...
March 15, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29490340/retinal-and-choroidal-microvasculature-in-nonarteritic-anterior-ischemic-optic-neuropathy-an-optical-coherence-tomography-angiography-study
#3
Edouard Augstburger, Pierre Zéboulon, Chafik Keilani, Christophe Baudouin, Antoine Labbé
Purpose: To analyze retinal and choroidal microvasculature in patients with nonarteritic anterior ischemic optic neuropathy (NAION) by using optical coherence tomography angiography (OCT-A). Methods: In this case-control retrospective observational study, patients with atrophic NAION (at least 3 months after onset of symptoms) and normal subjects underwent a complete ophthalmic examination including spectral-domain OCT, visual field (VF), and OCT-A. Whole en face image vessel density (wiVD) was used to assess retinal blood flow of the radial peripapillary capillaries (RPCs), circumpapillary RPC vessel density (cpVD), superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC)...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29412501/region-specific-ischemia-neovascularization-and-macular-edema-in-treatment-na%C3%A3-ve-proliferative-diabetic-retinopathy
#4
Jason Lange, Majda Hadziahmetovic, Jingfa Zhang, Weiye Li
IMPORTANCE: Region-specific pathology in proliferative diabetic retinopathy enhances our understanding and management of this disease. BACKGROUND: To investigate non-perfusion, neovascularization, and macular edema. DESIGN: A cross-sectional, observational, non-randomized study. PARTICIPANTS: Consecutive 43 eyes of 27 treatment-naïve patients. METHODS: Ultra-widefield fluorescein angiography for studying specific zones, i...
February 7, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29392314/leucine-rich-%C3%AE-2-glycoprotein-1-lrg-1-expression-in-retinoblastoma
#5
Radgonde Amer, Liran Tiosano, Jacob Pe'er
Purpose: Retinoblastomas' growth rate is dependent on their ability to induce neovascularization. Leucine-rich α-2-glycoprotein-1 (LRG-1) was recently reported to be upregulated in human retinal disease with neovascular pathology. The purpose of the study was to determine LRG-1 expression in human retinoblastoma and to correlate it with clinical and histopathologic parameters and to assess how its expression correlates with vascular endothelial growth factor (VEGF) expression. Methods: LRG-1 expression was immunohistochemically evaluated in 34 retinoblastoma sections...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29320503/pattern-of-peripapillary-capillary-density-loss-in-ischemic-optic-neuropathy-compared-to-that-in-primary-open-angle-glaucoma
#6
Masoud Aghsaei Fard, Yanin Suwan, Sasan Moghimi, Lawrence S Geyman, Toco Y Chui, Richard B Rosen, Robert Ritch
PURPOSE: Both non-arteritic anterior ischemic optic neuropathy (NAION) and primary open-angle glaucoma (POAG) damage retinal ganglion cell axons, which are perfused by the radial peripapillary capillaries. To evaluate the pattern of ischemia, we compared peripapillary capillary density (PCD) in NAION eyes to POAG eyes matched for visual field mean deviation and retinal nerve fiber layer thickness. METHODS: 31 chronic NAION (>6 months after the acute event) and unaffected fellow eyes (31 subjects), 42 moderate and severe POAG eyes (27 subjects), and 77 control eyes (46 healthy subjects) were imaged with a commercial optical coherence tomography angiography system (AngioVue, Avanti RTVue-XR, Optovue, CA) at two academic institutions...
2018: PloS One
https://www.readbyqxmd.com/read/29290065/pathophysiology-of-primary-open-angle-glaucoma-from-a-neuroinflammatory-and-neurotoxicity-perspective-a-review-of-the-literature
#7
REVIEW
Karine Evangelho, Maria Mogilevskaya, Monica Losada-Barragan, Jeinny Karina Vargas-Sanchez
PURPOSE: Glaucoma is the leading cause of blindness in humans, affecting 2% of the population. This disorder can be classified into various types including primary, secondary, glaucoma with angle closure and with open angle. The prevalence of distinct types of glaucoma differs for each particular region of the world. One of the most common types of this disease is primary open-angle glaucoma (POAG), which is a complex inherited disorder characterized by progressive retinal ganglion cell death, optic nerve head excavation and visual field loss...
December 30, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29260067/severe-bilateral-optic-nerve-and-retinal-hypoperfusion-in-a-patient-with-acute-respiratory-distress-syndrome-and-septic-shock
#8
Wei Gui, Erika Tanaka Friesen, Laura Bonelli, Ye Elaine Wang, Anthony C Arnold
Purpose: To report a case of bilateral central retinal artery occlusion with both anterior and posterior ischemic optic neuropathy. Observations: A 65-year-old Caucasian woman presented with acute respiratory distress syndrome and septic shock. After treatment with vasopressors and prolonged prone positioning, she was noted to be bilaterally completely blind on hospitalization day 12. Evaluation revealed evidence of bilateral central retinal artery occlusion and bilateral ischemic optic neuropathy...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29208469/an-elastomeric-polymer-matrix-peuu-tac-delivers-bioactive-tacrolimus-transdurally-to-the-cns-in-rat
#9
Yolandi van der Merwe, Anne E Faust, Ian Conner, Xinzhu Gu, Firuz Feturi, Wenchen Zhao, Bianca Leonard, Souvik Roy, Vijay S Gorantla, Raman Venkataramanan, Kia M Washington, William R Wagner, Michael B Steketee
Central nervous system (CNS) neurons fail to regrow injured axons, often resulting in permanently lost neurologic function. Tacrolimus is an FDA-approved immunosuppressive drug with known neuroprotective and neuroregenerative properties in the CNS. However, tacrolimus is typically administered systemically and blood levels required to effectively treat CNS injuries can lead to lethal, off-target organ toxicity. Thus, delivering tacrolimus locally to CNS tissues may provide therapeutic control over tacrolimus levels in CNS tissues while minimizing off-target toxicity...
December 2017: EBioMedicine
https://www.readbyqxmd.com/read/29144506/soluble-p-selectin-promotes-retinal-ganglion-cell-survival-through-activation-of-nrf2-signaling-after-ischemia-injury
#10
Kishan Kapupara, Yao-Tseng Wen, Rong-Kung Tsai, Shun-Ping Huang
Retinal ischemic injuries play an important role in the pathogenesis of several eye disorders. Inflammation and oxidative stress are key players in ischemic injuries. Following retinal ischemia, vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, such as selectins and cell adhesion molecules. P-selectin stimulates leukocyte recruitment to platelet aggregates and has an important role in vascular homeostasis and inflammatory leukocyte extravasation. Soluble P-selectin can be neuroprotective through competitive binding to the receptors of endogenous P-selectin molecules...
November 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29109681/tenascins-in-retinal-and-optic-nerve-neurodegeneration
#11
REVIEW
Jacqueline Reinhard, Lars Roll, Andreas Faissner
Tenascins represent key constituents of the extracellular matrix (ECM) with major impact on central nervous system (CNS) development. In this regard, several studies indicate that they play a crucial role in axonal growth and guidance, synaptogenesis and boundary formation. These functions are not only important during development, but also for regeneration under several pathological conditions. Additionally, tenascin-C (Tnc) represents a key modulator of the immune system and inflammatory processes. In the present review article, we focus on the function of Tnc and tenascin-R (Tnr) in the diseased CNS, specifically after retinal and optic nerve damage and degeneration...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/29101167/transient-denervation-of-viable-myocardium-after-myocardial-infarction-does-not-alter-arrhythmia-susceptibility
#12
Diana C Parrish, Samantha D Francis Stuart, Antoinette Olivas, Lianguo Wang, Anders Nykjaer, Crystal M Ripplinger, Beth A Habecker
Cardiac sympathetic nerves stimulate heart rate and force of contraction. Myocardial infarction (MI) leads to the loss of sympathetic nerves within the heart, and clinical studies have indicated that sympathetic denervation is a risk factor for arrhythmias and cardiac arrest. Two distinct types of denervation have been identified in the mouse heart after MI caused by ischemia-reperfusion: transient denervation of peri-infarct myocardium and sustained denervation of the infarct. Sustained denervation is linked to increased arrhythmia risk, but it is not known whether acute nerve loss in peri-infarct myocardium also contributes to arrhythmia risk...
March 1, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29062875/ocular-coherence-tomography-image-data-of-the-retinal-laminar-structure-in-a-mouse-model-of-oxygen-induced-retinopathy
#13
Wendy A Dailey, Kimberly A Drenser, Sui Chien Wong, Mei Cheng, Joseph Vercellone, Kevin K Roumayah, Erin V Feeney, Mrinalini Deshpande, Alvaro E Guzman, Michael Trese, Kenneth P Mitton
The data presented in this article are related to the research paper entitled "Norrin treatment improves ganglion cell survival in an oxygen-induced model of retinal ischemia" (Dailey et al., 2017) [1] This article describes treatment with the human Norrin protein, an atypical Wnt-protein, to improve the survival of retinal ganglion cells in a murine model of Oxygen-Induced Retinopathy (OIR). That study utilized Optical coherence tomography (OCT) to visualize retinal layers at high resolution in vivo , and to quantify changes to nerve fiber layer thickness...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/28923584/seeing-the-difference-painless-progressive-vision-loss-in-a-vasculopath
#14
Jenny L Lauschke, Katherine Masselos, Jennifer Sandbach, Clare L Fraser
A 78-year-old Caucasian man with significant vascular disease reported sudden onset of worsened vision during a routine wound-care appointment for non-healing necrotic leg ulcers. He described painless blurring of vision with grey scotomas in his RE, his only well-seeing eye, following trauma to the LE as a child. He presented with retinal ischemia, a cotton-wool spot and optic nerve swelling. Temporal artery biopsy showed myxoid degeneration and extensive calcium deposition which also was shown on imaging throughout his carotid and vertebral arterial system, the clinical picture of calciphylaxis...
September 15, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28901515/vulnerability-study-of-myelinated-and-unmyelinated-nerve-fibers-in-acute-ocular-hypertension-in-rabbit
#15
Jiying Shen, Qiang Yang, Daoyi Yu, Jihong Wu, Yuanfang Zhu, Wenyi Guo
In the current study, it was aimed to evaluate the changes in myelinated and unmyelinated nerve fibers in retinal ischemia‑reperfusion injuries caused by acute ocular hypertension and to determine the sequence of these changes. Adult healthy New Zealand white rabbits were randomized to the hemodynamic group [n=12; used to determine the optimal intraocular pressure (IOP) for the subsequent experiments] and the hypertension group (n=6; 70‑mmHg hypertension induced in one eye). IOP was adjusted using a cannula and saline...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28878627/optic-nerve-degeneration-after-retinal-ischemia-reperfusion-in-a-rodent-model
#16
Marina Renner, Gesa Stute, Mohammad Alzureiqi, Jacqueline Reinhard, Susanne Wiemann, Heiko Schmid, Andreas Faissner, H Burkhard Dick, Stephanie C Joachim
Retinal ischemia is a common pathomechanism in many ocular disorders such as age-related macular degeneration (AMD), diabetic retinopathy, glaucoma or retinal vascular occlusion. Several studies demonstrated that ischemia/reperfusion (I/R) leads to morphological and functional changes of different retinal cell types. However, little is known about the ischemic effects on the optic nerve. The goal of this study was to evaluate these effects. Ischemia was induced by raising the intraocular pressure (IOP) in one eye of rats to 140 mmHg for 1 h followed by natural reperfusion...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28768527/bilateral-blindness-secondary-to-optic-nerve-ischemia-from-severe-amlodipine-overdose-a-case-report
#17
Raymond Kao, Yves Landry, Genevieve Chick, Andrew Leung
BACKGROUND: Calcium channel blockers are commonly prescribed medications; calcium channel blocker overdose is becoming increasingly prevalent. The typical presentation of a calcium channel blocker overdose is hypotension and decreased level of consciousness. We describe a case of a calcium channel blocker overdose that led to bilateral cortical blindness, a presentation that has not previously been reported. CASE PRESENTATION: A 49-year-old white woman with known bilateral early optic atrophy presented to our hospital with hypotension and obtundation following a known ingestion of 150 mg of amlodipine...
August 3, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28730074/protection-of-retinal-ganglion-cells-against-optic-nerve-injury-by-induction-of-ischemic-preconditioning
#18
Xia Liu, Jiu-Ping Liang, Ou Sha, Song-Juan Wang, Heng-Guo Li, Eric Y P Cho
AIM: To explore if ischemic preconditioning (IPC) can enhance the survival of retinal ganglion cells (RGCs) after optic nerve axotomy. METHODS: Twenty-four hours prior to retinal ischemia 60min or axotomy, IPC was applied for ten minutes in groups of (n=72) animals. The survival of RGCs, the cellular expression of heat shock protein 27 (HSP27) and heat shock protein 70 (HSP70) and the numbers of retinal microglia in the different groups were quantified at 7 and 14d post-injury...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28700390/bartonella-henselae-neuroretinitis-associated-with-central-retinal-vein-occlusion-choroidal-ischemia-and-ischemic-optic-neuropathy
#19
Quraish Ghadiali, Larissa K Ghadiali, Lawrence A Yannuzzi
PURPOSE: We describe a healthy 37-year-old man with Bartonella henselae (B. henselae) neuroretinitis with concurrent central retinal vein occlusion and ischemic optic neuropathy resulting in optic atrophy and choroidal ischemia. METHODS: Case report. RESULTS: A 37-year-old man presented with unilateral decreased vision and a fundus examination consistent with neuroretinitis. Further imaging review supported a concurrent diagnosis of central retinal vein occlusion...
July 11, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28669743/evidence-that-activation-of-p2x7r-does-not-exacerbate-neuronal-death-after-optic-nerve-transection-and-focal-cerebral-ischemia-in-mice
#20
Berrak Caglayan, Ahmet B Caglayan, Mustafa C Beker, Esra Yalcin, Merve Beker, Taha Kelestemur, Elif Sertel, Gürkan Ozturk, Ulkan Kilic, Fikrettin Sahin, Ertugrul Kilic
Conflicting data in the literature about the function of P2X7R in survival following ischemia necessitates the conductance of in-depth studies. To investigate the impacts of activation vs inhibition of the receptor on neuronal survival as well as the downstream signaling cascades, in addition to optic nerve transection (ONT), 30min and 90min of middle cerebral artery occlusion (MCAo) models were performed in mice. Intracellular calcium levels were assessed in primary cortical neuron cultures. Here, we show that P2X7R antagonist Brilliant Blue G (BBG) decreased DNA fragmentation, infarct volume, brain swelling, neurological deficit scores and activation of microglial cells after focal cerebral ischemia...
October 2017: Experimental Neurology
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