Manuel Rey-Funes, Daniela S Contartese, Rafael Peláez, Josune García-Sanmartín, Judit Narro-Íñiguez, Manuel Soliño, Juan Carlos Fernández, Aníbal Sarotto, Nicolás S Ciranna, Juan José López-Costa, Verónica B Dorfman, Ignacio M Larrayoz, C Fabián Loidl, Alfredo Martínez
Perinatal asphyxia (PA) can cause retinopathy and different degrees of visual loss, including total blindness. In a rat model of PA, we have previously shown a protective effect of hypothermia on the retina when applied simultaneously with the hypoxic insult. In the present work, we evaluated the possible protective effect of hypothermia on the retina of PA rats when applied immediately after delivery. Four experimental groups were studied: Rats born naturally as controls (CTL), animals that were exposed to PA for 20 min at 37°C (PA), animals exposed to PA for 20 min at 15°C (HYP), and animals that were exposed to PA for 20 min at 37°C and, immediately after birth, kept for 15 min at 8°C (HYP-PA)...
2021: Frontiers in Pharmacology