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https://www.readbyqxmd.com/read/27816934/development-of-the-harvey-bradshaw-index-pro-hbi-pro-score-to-assess-endoscopic-disease-activity-in-crohn-s-disease
#1
E Zittan, B Kabakchiev, O B Kelly, R Milgrom, G C Nguyen, K Croitoru, A H Steinhart, M S Silverberg
BACKGROUND: There is a need for better, less-invasive disease activity indices that provide a representative assessment of endoscopic disease activity. We developed a new clinical score that incorporates the Harvey-Bradshaw index (HBI) with modified patient-reported outcomes (PROp), and physician (clinician) reported outcomes (PROc) and assessed its ability to measure endosopic disease activity in ileocolonic Crohn's disease (CD). METHODS: A cohort of 88 CD patients undergoing colonoscopy was accrued in a prospective fashion...
November 5, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27585992/assessing-second-look-tumour-resectability-in-childhood-posterior-fossa-ependymoma-a-centralised-review-panel-and-staging-tool-for-future-studies
#2
Christopher P Millward, Conor Mallucci, Tim Jaspan, Donald Macarthur, Richard Heyward, Tim Cox, Kung Chong, Richard G Grundy
PURPOSE: To improve uniformity in radiological review/reporting and discussion of surgical resection status in the forthcoming SIOP Ependymoma II trial, a central review of imaging and resection status will be carried out prior to treatment stratification. We present a review of surgical decision-making from the UKCCSG/SIOP Ependymoma trial for very young children (<3 years) (Lancet Oncol 8:696-705, 2007) and propose a primary surgical staging system for residual disease that could be used for Ependymoma II...
September 1, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27508676/-op-lb01-03-benefits-of-early-blood-pressure-control-on-cardiovascular-outcomes-a-subgroup-analysis-of-the-felodipine-event-reduction-fever-study
#3
Y Zhang, X Zhang, L Liu, A Zanchetti
OBJECTIVE: In the setting of rapidly increasing trend of hypertension, a post-hoc subgroup analysis of the Felodipine Event Reduction (FEVER) Study was conducted to determine the effects of early blood pressure control on cardiovascular (CV) outcomes. DESIGN AND METHOD: The FEVER Study was a double-blind randomized trial conducted in 9711 Chinese hypertensive patients in which the CV outcomes were significantly reduced by felodipine compared with placebo. In this analysis, patients were regrouped to either the uncontrolled BP group (SBP/DBP, > = 140/90 mmHg) or the controlled BP group (<140/90 mmHg) at 1 and 6 months...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508642/-op-2d-07-the-effects-of-alpha-1-adrenoceptor-blockade-by-doxazosin-or-ace-inhibition-by-ramipril-on-endothelial-function-in-primary-hypertension-the-dora-study
#4
A Jekell, M Kalani, T Kahan
OBJECTIVE: To study whether reducing noradrenergic sympathetic vascular tone by doxazosin or blocking the renin-angiotensin-aldosterone system by ramipril will alter endothelial function in patients with uncomplicated hypertension. DESIGN AND METHOD: Mild-to-moderate hypertensive patients (age 54 ± 12 years, 34% women, blood pressure (BP) 148 ± 11/88 ± 9 mmHg) were randomized double-blind to ramipril (10 mg od, n = 33) or doxazosin (8 mg od, n = 28) for 12 weeks...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508627/-op-2b-08-etiology-of-renal-infarctions-a-retrospective-analysis-of-229-consecutive-cases-admitted-to-a-single-tertiary-center-over-15-years
#5
A Faucon, G Bobrie, A S Jannot, A Azarine, L Amar, P F Plouin, M Azizi
OBJECTIVE: Renal infarction (RI) is a rare disease (0.004% of patients admitted to emergency units), due to a disruption of renal blood flow of the main ipsilateral renal artery (RA) or of one of its segmental branches due to either a local in-situ or a general mechanism. The local mechanism includes RA occlusion, dissection, aneurysm or stenosis which 1) may lead to in-situ RA thrombosis or renal emboli and 2) can be due to various etiologies including atherosclerosis disease (ASD), fibromuscular dysplasia (FMD), dissecting hematoma (DH), extension of an aortic dissection (AoD) to the RA, miscellaneous arterial disease (AD), iatrogenic post-RA catheterization/surgery complication (IC) or post-renal trauma complication (T)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27261719/detection-of-pseudarthrosis-in-adult-spinal-deformity-the-use-of-health-related-quality-of-life-outcomes-to-predict-pseudarthrosis
#6
Eric Klineberg, Munish Gupta, Ian McCarthy, Richard Hostin
STUDY DESIGN: Single-center, retrospective study of consecutive surgeries. OBJECTIVE: Evaluate the reliability of previously published anterior fusion grading systems and assess the ability of health-related quality-of-life (HRQOL) outcomes to predict pseudarthrosis (PSAR). SUMMARY OF BACKGROUND DATA: Despite existing radiographic indicators, PSAR may still go unidentified on biplanar radiographs, and little data is available on the reliability of such grading systems in adult spinal deformity patients...
June 3, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27097833/does-an-early-home-based-progressive-resistance-training-program-improve-function-following-total-hip-replacement-results-of-a-randomized-controlled-study
#7
Tosan Okoro, Rhiannon Whitaker, Andrew Gardner, Peter Maddison, John G Andrew, Andrew Lemmey
BACKGROUND: In-hospital progressive resistance training (PRT) has been shown to be an effective method of rehabilitation following hip surgery. The aim of this study was to assess whether a home-based PRT program would be beneficial in improving patients' muscle strength and physical function compared to standard rehabilitation. METHODS: Subjects (n = 49) either received home-based PRT rehabilitation (n = 25) or standard rehabilitation (n = 24) in a prospective single blinded randomized trial carried out over a two-year period...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/26609642/multicenter-prospective-randomized-study-comparing-the-technique-of-using-a-bovine-pericardium-biological-prosthesis-reinforcement-in-parietal-herniorrhaphy-tutomesh-tutogen-with-simple-parietal-herniorrhaphy-in-a-potentially-contaminated-setting
#8
Marius Nedelcu, Pierre Verhaeghe, Mehdi Skalli, Gerard Champault, Christophe Barrat, Hugues Sebbag, Fabian Reche, Laurent Passebois, Daniel Beyrne, Jean Gugenheim, Stephane Berdah, Amine Bouayed, Jean Michel Fabre, David Nocca
The use of parietal synthetic prosthetic reinforcement material in potentially contaminated settings is not recommended, as there is a risk that the prosthesis may become infected. Thus, simple parietal herniorrhaphy, is the conventional treatment, even though there is a significant risk that the hernia may recur. Using new biomaterials of animal origin presently appears to offer a new therapeutic solution, but their effectiveness has yet to be demonstrated. The purpose of this multicenter prospective randomized single-blind study was to compare the surgical treatment of inguinal hernia or abdominal incisional hernia by simple parietal herniorrhaphy without prosthetic reinforcement (Group A), with Tutomesh TUTOGEN biological prosthesis reinforcement parietal herniorrhaphy (Group B), in a potentially contaminated setting...
March 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/26363164/post-operative-budesonide-irrigations-for-patients-with-polyposis-a-blinded-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Rounak B Rawal, Allison M Deal, Charles S Ebert, Vishal H Dhandha, Candace A Mitchell, Anna X Hang, Mitchell R Gore, Brent A Senior, Adam M Zanation
OBJECTIVE: To compare normal saline (NS) vs. NS+budesonide irrigations in post- functional endoscopic sinus surgery (FESS) patients with chronic rhinosinusitis with polyposis (CRSwNP). Currently, no evidence exists for NS+budesonide irrigation over NS irrigation alone. STUDY DESIGN: Prospective, single-blind, randomized controlled trial. METHODS: Subjects were prospectively enrolled to NS or NS+budesonide arms. Patients were evaluated at pre-operative and three post-operative visits (POV): POV1 (1-2 weeks post-op), POV2 (3-8 weeks post-op), and POV3 (3-6 months post-op)...
September 2015: Rhinology
https://www.readbyqxmd.com/read/26114790/antibiotic-prophylaxis-for-dental-implant-placement
#10
COMMENT
James R Keenan, Analia Veitz-Keenan
DATA SOURCES: Electronic searches without time or language restrictions were performed in PubMed, Web of Science and the Cochrane Oral Health Group trials Register. A vast manual search was done in many dental implant-related journals. Reference lists were scanned for possible additional studies. Ongoing clinical trials were also searched. STUDY SELECTION: Titles and abstracts of the reports identified were read independently by the three authors. Disagreements were resolved by discussion...
June 2015: Evidence-based Dentistry
https://www.readbyqxmd.com/read/25753162/evaluation-of-fully-biodegradable-nasal-packings-in-functional-endoscopic-sinus-surgery-%C3%A2-a-multi-centre-study
#11
Dariusz Jurkiewicz, Henryk Kaźmierczak, Marek Rogowski, Paweł K Burduk, Barbara Gałusza, Wojciech Kaźmierczak, Bartosz Piszczatowski, Małgorzata Różańska, Rafał Sienicki, Kornel Szczygielski, Małgorzata Wierzchowska, Joanna Kuśmierczyk
THE AIM: This work was to compare an innovative solution, i.e. a fully biodegradable nasal packing Nasopore®, with a traditional one, in the aftercare of patients subjected to functional endoscopic sinus surgery. MATERIAL AND METHOD: Prospective, blinded study with sequential enrollment conducted at three study centres. One of the investigators evaluated during surgery the level of bleeding in each of the nasal cavities and at the end of surgery he applied the test packing, the biodegradable dressing Nasopore®, to one randomly chosen nasal cavity, and a control packing to the other one...
2015: Otolaryngologia Polska. the Polish Otolaryngology
https://www.readbyqxmd.com/read/25501785/evaluation-of-aquacel-ag-for-autogenous-skin-donor-sites
#12
RANDOMIZED CONTROLLED TRIAL
Linwood R Haith, Megan E Stair-Buchmann, Bruce H Ackerman, Diane Herder, Cynthia L Reigart, Marla Stoering, Robert E Guilday, Mary Lou Patton, Kerry M Ross
An ongoing objective of burn research is to evaluate wound dressings and develop new treatments to expedite wound healing. This was a single-center, prospective, randomized, controlled study to evaluate the effectiveness of Aquacel Ag as a dressing for autogenous skin donor sites compared with Xeroform. We hypothesized that donor sites treated with Aquacel Ag would heal faster. Patients were considered for enrollment if they required skin grafting with two donor sites >100 cm at least 2 inches apart. Dressings were observed daily starting on post-op day #2 until discharge and then weekly in the outpatient burn clinic...
November 2015: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/25490570/the-orbital-volume-measurement-in-patients-with-ventriculoperitoneal-shunt
#13
COMPARATIVE STUDY
Jong-Min Kim, Moo-Hwan Chang, Sungeun E Kyung
Enophthalmos occurs from the increased bony volume or decreased soft tissue volume in the orbit and can be caused in patients with long-term ventriculoperitoneal (VP) shunt. This study tried to find out the change of orbital volume by measuring the orbital volume before and after operation in adult patients who underwent VP shunt for hydrocephalus. The 2 evaluators measured orbital volume by using ITK-SNAP 2.4 program with double-blind test for computed tomography images before and after operation targeting 36 patients over the age of 18 who underwent VP shunt with pressure-controlled valve from 2003 to 2011...
January 2015: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/25416738/combined-cognitive-strategy-and-task-specific-training-improve-transfer-to-untrained-activities-in-subacute-stroke-an-exploratory-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Sara McEwen, Helene Polatajko, Carolyn Baum, Jorge Rios, Dianne Cirone, Meghan Doherty, Timothy Wolf
PURPOSE: The purpose of this study was to estimate the effect of the Cognitive Orientation to daily Occupational Performance (CO-OP) approach compared with usual outpatient rehabilitation on activity and participation in people <3 months poststroke. METHODS: An exploratory, single-blind, randomized controlled trial, with a usual-care control arm, was conducted. Participants referred to 2 stroke rehabilitation outpatient programs were randomized to receive either usual care or CO-OP...
July 2015: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/25096770/-a-randomized-double-blind-trial-of-prophylactic-fibrinogen-to-reduce-bleeding-in-cardiac-surgery
#15
Mostafa Sadeghi, Reza Atefyekta, Omid Azimaraghi, Seyed Mojtaba Marashi, Yasaman Aghajani, Fatemeh Ghadimi, Donat R Spahn, Ali Movafegh
BACKGROUND AND OBJECTIVES: Postoperative bleeding has a great clinical importance and can contribute to increased mortality and morbidity in patients undergoing coronary artery bypass graft surgery. In this prospective, randomized, double-blind study, we evaluated the effect of prophylactic administration of fibrinogen concentrate on post-coronary artery bypass graft surgery bleeding. METHODS: A total of 60 patients undergoing coronary artery bypass surgery were randomly divided into two groups...
July 2014: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/24998109/a-randomized-double-blind-trial-of-prophylactic-fibrinogen-to-reduce-bleeding-in-cardiac-surgery
#16
RANDOMIZED CONTROLLED TRIAL
Mostafa Sadeghi, Reza Atefyekta, Omid Azimaraghi, Seyed Mojtaba Marashi, Yasaman Aghajani, Fatemeh Ghadimi, Donat R Spahn, Ali Movafegh
BACKGROUND AND OBJECTIVES: Postoperative bleeding has a great clinical importance and can contribute to increased mortality and morbidity in patients undergoing coronary artery bypass graft surgery. In this prospective, randomized, double-blind study, we evaluated the effect of prophylactic administration of fibrinogen concentrate on post-coronary artery bypass graft surgery bleeding. METHODS: A total of 60 patients undergoing coronary artery bypass surgery were randomly divided into two groups...
July 2014: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/24993276/a-prospective-double-blinded-randomized-study-of-anterior-cruciate-ligament-reconstruction-with-hamstrings-tendon-and-spinal-anesthesia-with-or-without-femoral-nerve-block
#17
RANDOMIZED CONTROLLED TRIAL
Diego Costa Astur, Vinicius Aleluia, Ciro Veronese, Nelson Astur, Saulo Gomes Oliveira, Gustavo Gonçalves Arliani, Ricardo Badra, Camila Cohen Kaleka, Joicemar Tarouco Amaro, Moisés Cohen
BACKGROUND: Current literature supports the thought that anesthesia and analgesia administered perioperatively for an anterior cruciate ligament (ACL) reconstruction have a great influence on time to effective rehabilitation during the first week after hospital discharge. PURPOSE: The aim of this study is to answer the research question is there a difference in clinical outcomes between the use of a femoral nerve block with spinal anesthesia versus spinal analgesia alone for people undergoing ACL reconstruction? METHODS: ACL reconstruction with spinal anesthesia and patient sedation (Group one); and spinal anesthesia with patient sedation and an additional femoral nerve block (Group two)...
October 2014: Knee
https://www.readbyqxmd.com/read/24754798/to-infiltrate-or-not-acute-effects-of-local-anaesthetic-in-breast-surgery
#18
RANDOMIZED CONTROLLED TRIAL
Ian Campbell, Shelley Cavanagh, Jane Creighton, Rowan French, Shramana Banerjee, Emily Kerr, Rachel Shirley
BACKGROUND: There is limited evidence to support use of local anaesthetic (LA) wound infiltration in breast surgery. This study seeks to examine whether wound infiltration of bupivacaine (0.25%) decreases post-operative pain and analgesic use, without increasing post-operative complications. METHODS: A prospective single-blind study was undertaken of 90 patients undergoing breast lump excision, wide local excision and mastectomy with or without axillary surgery...
May 2015: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/24627988/persistent-occiput-posterior-outcomes-following-digital-rotation-a-pilot-randomised-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Kathryn Graham, Hala Phipps, Jon A Hyett, Joanne P Ludlow, Adam Mackie, Anthony Marren, Bradley De Vries
AIM: To determine the feasibility of a multicentre randomised controlled trial (RCT) to investigate whether digital rotation of the fetal head from occiput posterior (OP) position in the second stage of labour reduces the risk of operative delivery (defined as caesarean section (CS) or instrumental delivery). METHODS: We conducted the study between December 2010 and December 2011 in a tertiary referral hospital in Australia. A transabdominal ultrasound was performed early in the second stage of labour on women with cephalic, singleton pregnancies to determine the fetal position...
June 2014: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/24335722/detection-of-pseudarthrosis-in-adult-spinal-deformity-the-use-of-health-related-quality-of-life-outcomes-to-predict-pseudarthrosis
#20
Eric Klineberg, Munish Gupta, Ian McCarthy, Richard Hostin
STUDY DESIGN: Single-center, retrospective study of consecutive surgeries. OBJECTIVE: This study aimed to evaluate the reliability of previously published anterior fusion grading systems and assess the ability of health-related quality-of-life (HRQOL) outcomes to predict pseudarthrosis (PSAR). SUMMARY OF BACKGROUND DATA: Despite existing radiographic indicators, PSAR may still go unidentified on biplanar radiographs, and little data is available on the reliability of such grading systems in adult spinal deformity patients...
October 2016: Clinical Spine Surgery
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